• Korean Journal of Veterinary Research
• /
• v.51 no.4
• /
• pp.253-257
• /
• 2011

Amikacin is a semisynthetic derivative of kanamycin and primarily active against aerobic Gram-negative-pathogens with limited activity against Gram-positive bacteria. Meager study was reported on pharmacokinetic data on multi-days administration of amikacin. Hence, pharmacokinetics study was done in five clinically healthy goats (n = 5), after intravenous bolus injection of amikacin sulfate at the dose rate of 10 mg/kg body weight daily for three consecutive days. The amikacin concentrations in plasma and pharmacokinetics-parameters were analyzed by using microbiological assay technique and noncompartmental open-model, respectively. The mean peak plasma concentrations (Mean ${\pm}$ SD) of amikacin at time zero ($Cp^{0}$) was $114.19{\pm}20.78$ and $128.67{\pm}14.37{\mu}g/mL$, on day 1st and 3rd, respectively. The mean elimination half-life ($t_{1/2}ke$) was $1.00{\pm}0.28h$ on day 1st and $1.22{\pm}0.29h$ on day 3rd. Mean of area under concentration-time curve ($AUC_{0{\rightarrow}{\infty}}$) was $158.26{\pm}60.10$ and $159.70{\pm}22.74{\mu}g.h/mL$, on day 1st and 3rd respectively. The total body clearance ($Cl_{B}$) and volume of distribution at steady state (Vdss) on day 1st and 3rd were $Cl_{B}=0.07{\pm}0.02$ and $0.06{\pm}0.01L/h.kg$ and $Vdss=0.10{\pm}0.03$ and $0.11{\pm}0.05L/kg$, respectively. No-significant difference was noted in both drug-plasma concentration and pharmacokinetics-parameters, respectively. Amikacin concentration in plasma was found higher up-to 4 h and 6 h onward on down-ward trends favour to reduce toxicity. Which also support the pharmacokinetic-pharmacodynamic way of dosing of aminoglycosides and hence, amikacin may be administered 10 mg/kg intravenously daily to treat principally Gram-negative pathogens and limitedly Gram-positive-pathogens.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.32 no.1A
• /
• pp.19-30
• /
• 2012

Recently, vision-based dynamic deflection measurement techniques have significant interests and are getting more popular owing to development of the high-quality and low-price camcorder and also image processing algorithm. However, there are still several research issues to be improved including the self-vibration of vision device, i.e. camcorder, and the image processing algorithm in device aspect, and also the application area should be extended to measure three dimensional movement of floating structures in application aspect. In this study, vision-based dynamic motion measurement technique using multiple targets is proposed to measure three dimensional dynamic motion of floating structures. And also a new scheme to select threshold value to discriminate the background from the raw image containing targets. The proposed method is applied to measure the dynamic motion of large concrete floating quay in open sea area under several wave conditions, and the results are compared with the measurement results from conventional RTK-GPS(Real Time Kinematics-Global Positioning System) and MRU(Motion Reference Unit).

• The Journal of Asian Finance, Economics and Business
• /
• v.7 no.12
• /
• pp.819-829
• /
• 2020

This empirical research is aimed at testing the relationship of the big five personality traits namely openness to experience, extraversion, consciousness, agreeableness, neuroticism, and risk aversion with the investment intention of individual investors belonging to Balochistan, Pakistan. The primary data is collected through a self-administered questionnaire (a structured form that consists of a series of closed-ended and open-ended questions) from a sample of 397 active individual investors belonging to different districts of the province. The data is empirically analyzed by applying the Partial Least Square (PLS) path modeling technique by using the estimation package available in Smart-PLS. The findings of this study suggest that all the variables are statistically significant with investors' investment intention with risk aversion as the strongest predictor. Moreover, openness to experience, extraversion, consciousness, agreeableness, and risk are significantly and positively related to an investor's investment intention, whereas neuroticism is negatively related to an investor's investment intention. The results extended by this study can be used by financial planners and investment bankers to channelize the available financial resources in diversified portfolios. The results will help financial planners to make available diverse investment alternatives for investors in Balochistan, thus catering to their unique needs. Academia must offer courses on contemporary finance paradigm based on behavioral finance to enable future business graduates to make wise financial decisions.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.4 no.4
• /
• pp.39-50
• /
• 2001

There has been considerable controversy over the changes in the size of the beaches in the Pusan area; any loss of beach area will have an immense effect on the tourism industry, which is an important source of income for the local economy. The best beaches in Korea are in the Pusan area and were visited by more than 8 million persons in 2000. It is expected that the number of visitors, drawn to the scenic vistas and convenient facilities of this area, will increase annually. Any loss in the size of these swimming beaches will have an important negative effect on tourism income. Therefore, the local governments have gone to great lengths to preserve these beaches, transporting tens of thousands of tons of sand to the beaches before they open each year at a cost of billions of won annually. In this study, we analyzed aerial photographs and tide data for the past 50 years using digital aerial photo analysis and GIS techniques for each 3-year interval. We abstracted beach DEM (digital elevation model) and ortho aerial photographs, and conducted a space analysis. As a result, we were able to identify changes in the area and width of sections of Haeundae Beach.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• v.32 no.2
• /
• pp.141-148
• /
• 2010

The bilateral sagittal split ramus osteotomy (BSSRO) is preferred method of surgical correction for mandibular prognathism, retrognathism and asymmetry. This technique performed from primarily an intraoral incision to avoid a scar. After forward movement of the distal segment of the mandible, healing of bone by primary or secondary intention is easily accomplished through large areas of cancellous bony overlap. When rigid fixation is used for the BSSRO, it is possible to open the mouth during the immediate post-operative period because it promotes the healing process. Although this surgical procedure has been well-documented, the incidence of postoperative trigeminal neurosensory disorder in the region of the inferior alveolar nerve and the mental nerve remains one of the major complication. However, evaluation of objective methods for sensory recovery patterns is insufficient although most patients find their sensory return. Neurometer electrodiagnostic device performs automated neuroselective sensory nerve conduction threshold evaluation by determining current perception threshold (CPT) measures. The purpose of this study was to evaluate the sensory recovery patterns of inferior alveolar and mental nerve over time. Nerve examination with a neurometer was performed in 30 patients undergoing the BSSRO at pre-operative, post-operative 1-, 2-, 4- week, and 2-, 3-, 4-, 5-, 6- month follow-up visits after the osteotomy to compare the differences of nerve injury and recovery patterns after the BSSRO with or without genioplasty and sensory recovery patterns associated with the kind of nerve fiber.

• Journal of Korea Spatial Information System Society
• /
• v.1 no.2 s.2
• /
• pp.137-149
• /
• 1999

Spatial database systems in client-server environment have network overload due to the large amount of spatial data transmission. Users use the window query that loads partial region of a whole map for quick response time in the environment. A series of window query such as screen movement, enlargement or shrinkage requires data in similar region and this increases network overload by re-transmitting the same data in intersected region with the earlier transmitted region. Removing the transmitted data from query results can solve this problem. In this paper, we design and implement a spatial object manager in order to remove the intersected region occurred by a series of window query. The spatial object manager manages the object identifiers of transmitted objects and removes transmitted objects from spatial objects of the query result by using the removal technique of the intersected region for the transmission and comparison. We utilize GEOMania Millennium server, an open client-server spatial database system, as spatial object manager in this paper. The result of the performance evaluation shows that the spatial object manager removes the transmission of the data redundancy, reduces network overload and improves the overall system performance.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• v.27 no.3
• /
• pp.205-217
• /
• 2005

Distraction osteogenesis is a technique of lengthening bone including soft tissue by gradual separation of surgically divided bone surfaces. Although the biomechanical, histological, and ultrastructural changes associated with distraction osteogenesis have been widely described, the molecular mechanisms governing the formation of new bone in distracted bone segments remain largely unclear. However, such information has significant clinical implications because it may enable targeted therapeutic manipulations designed to accelerate osseous regeneration. The purpose of this study was to evaluate the expression of TGF-$\beta$1, IGF-I and bFGF in distraction osteogenesis according to different distraction rates in a rabbit's mandible. When twenty-four adult rabbits underwent open osteotomy between the premolar and mental foramen, an external bilateral distraction device was applied. Latency was allowed for five days before distraction. Three different distraction rates were 0.7 mm/day (A, n=8), 1.4 mm/day (B, n=8) and 2.4 mm/day (C, n=8). The distraction device was activated with the same distraction rhythms of twice a day until 4.9 mm (A & B group) and 8.4 mm (C group) length gains was achieved. The animals were sacrificed at postoperative 3, 7, 14 and 28 days. The bony specimens were stained with H&E for histologic examination, and RT-PCR analysis was done for the identification of the expression of TGF-$\beta$1, IGF-I and bFGF. The results obtained from this study were as follows : The 0.7 mm/day and 1.4 mm/day distraction rate groups were shown to improve regenerative bone formation on radiographic and histologic examination. Also, TGF-$\beta$1, IGF-I and bFGF expression increased in the 0.7 mm/day and 1.4 mm/day distraction rate groups. But the 2.4 mm/day distraction rate group specimen was different with adjacent normal bone and hardly expressed of growth factors. These findings suggest that improved new bone formation in the 0.7 mm/day and 1.4 mm/day distraction rates is associated with enhanced expression of TGF-$\beta$1, IGF-I and bFGF by mechanical tension stress. Additionally, the 0.7 mm/day and 1.4 mm/day distraction rate groups were significantly different from the 2.4 mm/day distraction rate group in the expression of growth factors. According to the above results, it seems possible to apply a distraction rate of up to 1.4 mm/day a day in rabbit's mandible. And further studies are needed to evaluate growth factors of TGF-$\beta$1 and IGF-I, which are excellent in expression.

• Journal of Korean Foot and Ankle Society
• /
• v.8 no.1
• /
• pp.46-51
• /
• 2004

Purpose: Problematic late sequelae are common following a calcaneal fracture regardless of the initial treatment. We retrospectively evaluated the painful conditions and reviewed the results of the operative treatment in patients with previously treated calcaneal fractures. Materials and Methods: Between October 1996 and September 2001, forty-three patients who underwent subsequent surgical treatment for late sequelae of calcaneal fracture were reviewed. The initial treatment consisted of only immobilization in a cast in 7 patients, closed reduction with pin fixation (Essex-Lopresti technique) in 22 and open reduction and internal fixation in 14. Painful conditions in the hind foot included subtalar arthritis in 31 patients, calcaneofibular impingement in 13, peroneal tendinitis in 6, displaced posterior bony fragment in 3, sural neuritis in 2, subtalar and midtarsal arthritis in 1 and displaced plantar bony fragment in 1. The surgical procedures for the late complications were performed at a mean of 19 months (range, 6 to 35 months) after the injury and consisted of lateral wall ostectomy and in situ subtalar fusion in 28 patients, only lateral wall ostectomy in 5 patients, lateral wall ostectomy and subtalar distraction arthrodesis in 3, removal of displaced posterior bony fragment in 3, sural nerve transposition in the peroneus brevis in 2, triple arthrodesis in 1 and removal of displaced plantar bony fragment in 1. Mean postoperative follow up period was 57 months (range, 33 to 82 months). The results of treatment were evaluated on the basis of pain, improvement in the ability to perform activities of daily living, to return to work or to a pre-injury level of activity. Results: Pain was partially relieved in 38 patients (88%), but not relieved in 5. Function improved in 34 patients (79%), and 32 (74%) returned to work or to a pre-injury level of activity. There was a trend that the longer the interval between the injury and the operation, the longer the subsequent interval until the patient returned to full activities or work. Conclusion: Meticulous physical examination and intensive prompt treatment for remaining pain after initial treatment of calcaneal fractures are recommended for patient's satisfaction and returning to work.

• Journal of the Korean Geotechnical Society
• /
• v.29 no.10
• /
• pp.39-48
• /
• 2013

This paper presents an equation to depict the penetration behavior during the standard penetration test (SPT) in sandy deposits. An energy balance approach is considered and the driving mechanism of the SPT sampler is conceptually modeled as that of a miniature open-ended steel pipe pile into sands. The equation consists of three sets of input parameters including hyperbolic parameters (m and ${\lambda}$) which are difficult to determine. An iterative technique is thus applied to determine the optimized values of m and ${\lambda}$ using three measured values from a routine SPT data. It is verified from a well-documented record that the simulated penetration curves are in good agreement with the measured ones. At a given depth, the increase in m results in the decrease in ${\lambda}$ and the increase in the curvature of the penetration curve as well as the simulated N-value. Generally, the predicted penetration curve becomes nearly straight for the portion of exceeding the seating drive zone, which is more pronounced as soil density increases. Thus, the simulation method can be applied to extrapolating a prematurely completed test data, i.e., to determining the N value equivalent to a 30 cm penetration. A simple linear equation is considered for obtaining similar results.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.11 no.1
• /
• pp.97-108
• /
• 2016

The competition between countries became internationalized in the market. However, a situation in which globalization is concerned is important to domestic corporates. Corporate strategy to survive in the domestic market are also juggling the limit of survival. Technology transfer and commercialization at this point has important implications now. The same applies to the national level. Public-to-private technology transfer has been more important, in order to overcome the international competitions. Although various studies have been made to promote technology transfer, in the livestock sector rarely attempted. Taking into account that few previous research and theory development has been achieved, the paper explored the technology transfer phenomenon in the sector employing the grounded theory approach by Strauss & Corbin(1998). Corporates that licensed in technologies through the Foundation of Agri. Tech. Commercialization & Transfer, were targeted as informants or interviewees. Finally, eight informants were selected sequentially utilizing theoretical sampling technique to the saturation point. As the result of open coding and axial coding of the interview data using NVivo10 by QSR International, 77 concepts, 20 sub-categories, and 7 categories were derived while paradigm model was established. Through selective coding, 'the factors affecting technology transfer in livestock sector' was identified as core category. The story line about the core category was developed based on four main categories. Finally, it is expected that the concepts, categories, and the relationship between them can be an important basis for further research.