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The Protective Effects of Statins towards Vessel Wall Injury Caused by a Stent Retrieving Mechanical Thrombectomy Device : A Histological Analysis of the Rabbit Carotid Artery Model

  • Lee, Seung Hwan;Shin, Hee Sup;Oh, Inho
    • Journal of Korean Neurosurgical Society
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    • v.64 no.5
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    • pp.693-704
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    • 2021
  • Objective : Endovascular mechanical thrombectomy (MT) has been regarded as one of the standard treatments for acute ischemic stroke caused by large vessel occlusion. Despite the wide use of stent retrievers for MT, arterial intimal damage caused when deployed stent is pulled has been a certain disadvantage. We hypothesized that statin could protect and stabilize vessel damage after endovascular MT using a stent retriever. In this animal study, we observed the protective effects of the statins towards MT-induced vessel wall injury. Methods : Twenty-eight carotid arteries of fourteen rabbits were used in the experiments with MT using stent retriever. We divided the rabbits into four groups as follows : group 1, negative control; group 2, positive control; group 3, statin before MT; and group 4, statin after MT. After MT procedures, we harvested the carotid arteries and performed histomorphological and immunohistochemical analyses. Results : In histomorphological analysis with hematoxylin and eosin and Masson's trichrome stain, significant intimal thickening (p<0.05) was observed in the positive control (group 2), compared to in the negative control (group 1). Intimal thickening was improved in the statin-administered groups (groups 3 and 4 vs. group 2, p<0.05). We also observed that statin administration after MT (group 4) resulted in a more effective decrease in intimal thickness than statin administration before MT (group 3) (p<0.05). We performed immunohistochemical analysis with the antibodies for tumor necrosis factor-alpha (TNF-α), cluster of differentiation (CD)11b, and CD163. In contrast to the negative control (group 1), the stained percentage areas of all immunological markers were markedly increased in the positive control (group 2) (p<0.05). Based on statin administration, the percentage area of TNF-α staining was significantly reduced (p<0.05) in group 3, compared to the positive control group (group 2). However, significant differences were not observed for CD11b and CD163 staining. In group 4, no significant differences were observed for TNF-α, CD11b, and CD163 staining (p≥0.05). The differences in the percentage areas of the different markers between the statin-administered groups (groups 3 and 4) were also not revealed. Conclusion : We presented that statin administration before and after MT exerted protective effects towards vessel wall injury. The efficacy of statins was greater post-administration than pre-administration. Thus, statin administration in routine prescriptions in the peri-procedural period is strongly advised.

Basic Performance Evaluation of a Tack Coat Material for Use with a Spray Paver (동시포설 공법을 위한 택코트 재료의 기초 성능 평가 연구)

  • Jo, Shinheang;Kim, Kyungnam;Cui, Wenhui;Kim, Nakseok
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.41 no.6
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    • pp.737-744
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    • 2021
  • Spray paving minimizes material lost during the construction or repair of a road surface, and it can be done in conjunction with tack coating. This approach involves applying the asphalt mixture at the same time as spraying the tack coat by attaching a spraying device to the asphalt paver. When applying an asphalt overlay to an aged concrete surface, it is important to ensure the adhesion performance between different material properties. Accordingly, there is a need for a tack coat that can be applied by spray paving and that exhibits good adhesive performance on different materials. In this study, bonding strength tests under various conditions were performed to evaluate the basic performance of a tack coat developed for use with a spray paver. The bonding performance of the tack coat was observed to be affected by curing conditions and material lost during construction. The test results also showed that the tensile and shear bonding strengths of the developed tack coat were 1.21 and 1.99 times higher than those of a conventional one, respectively. As a result, the developed tack coat is considered suitable for application to spray paving.

Development of an abnormal road object recognition model based on deep learning (딥러닝 기반 불량노면 객체 인식 모델 개발)

  • Choi, Mi-Hyeong;Woo, Je-Seung;Hong, Sun-Gi;Park, Jun-Mo
    • Journal of the Institute of Convergence Signal Processing
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    • v.22 no.4
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    • pp.149-155
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    • 2021
  • In this study, we intend to develop a defective road surface object recognition model that automatically detects road surface defects that restrict the movement of the transportation handicapped using electric mobile devices with deep learning. For this purpose, road surface information was collected from the pedestrian and running routes where the electric mobility aid device is expected to move in five areas within the city of Busan. For data, images were collected by dividing the road surface and surroundings into objects constituting the surroundings. A series of recognition items such as the detection of breakage levels of sidewalk blocks were defined by classifying according to the degree of impeding the movement of the transportation handicapped in traffic from the collected data. A road surface object recognition deep learning model was implemented. In the final stage of the study, the performance verification process of a deep learning model that automatically detects defective road surface objects through model learning and validation after processing, refining, and annotation of image data separated and collected in units of objects through actual driving. proceeded.

Effects of Size Illusion According to Distance Information Restriction on Time Perception (거리 정보 제한에 따른 크기 착시가 시간 지각에 미치는 영향)

  • Kim, Min-Kyu;Lee, Won-Seob;Kim, Shin-Woo;Li, Hyung-Chul O.
    • Science of Emotion and Sensibility
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    • v.25 no.1
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    • pp.79-90
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    • 2022
  • IThe perception of sub-second duration through the visual sensory system is affected by non-temporal characteristics (factors other than the duration of the stimulus). However, studies have shown that if distance information is abundant and size constancy maintained, the duration of the target is constantly perceived. The current study examined the relationship between size and time perception constancy in a three-dimensional environment with limited distance information. A device was constructed to limit the participants' bilateral and monocular cues. This prevented participants from maintaining size constancy, resulting in size illusions that could not accurately perceive physical size. In Experiment 1, the size of the physical stimulus of reference and test stimuli were the same at all viewing distances. The results suggest that, despite the same physical size, stimuli with close observations were perceived to be greater and lasted longer. In Experiment 2, the retinal size of the reference stimuli and test stimuli was controlled equally at all viewing distances. As a result, although the physical size of the stimuli increased as the observation increased, the perceived size of all the stimuli was the same. Therefore, the duration of the target was constantly perceived at all viewing distances. The results of this study demonstrate that even when distance information is limited, time perception is affected by the perceived size of the object. It also suggests that when rich distance information exists, the duration of the object can be constantly perceived even if the observation distance varies.

Unmanned Multi-Sensor based Observation System for Frost Detection - Design, Installation and Test Operation (서리 탐지를 위한 '무인 다중센서 기반의 관측 시스템' 고안, 설치 및 시험 운영)

  • Kim, Suhyun;Lee, Seung-Jae;Son, Seungwon;Cho, Sungsik;Jo, Eunsu;Kim, Kyurang
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.24 no.2
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    • pp.95-114
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    • 2022
  • This study presented the possibility of automatic frost observation and the related image data acquisition through the design and installation of a Multiple-sensor based Frost Observation System (MFOS). The MFOS is composed of an RGB camera, a thermal camera and a leaf wetness sensor, and each device performs complementary roles. Through the test operation of the equipment before the occurrence of frost, the voltage value of the leaf wetness sensor increased when maintaining high relative humidity in the case of no precipitation. In the case of Gapyeong- gun, the high relative humidity was maintained due to the surrounding agricultural waterways, so the voltage value increased significantly. In the RGB camera image, leaf wetness sensor and the surface were not observed before sunrise and after sunset, but were observed for the rest of the time. In the case of precipitation, the voltage value of the leaf wetness sensor rapidly increased during the precipitation period and decreased after the precipitation was terminated. In the RGB camera image, the leaf wetness sensor and surface were observed regardless of the precipitation phenomenon, but the thermal camera image was taken due to the precipitation phenomenon, but the leaf wetness sensor and surface were not observed. Through, where actual frost occurred, it was confirmed that the voltage value of leaf wetness sensor was higher than the range corresponding to frost, but frost was observed on the surface and equipment surface by the RGB camera.

A Study on the Realization of Dust Damage Compensation Calculation for the Prevention of Dust Damage in Construction Site (공사장 먼지피해 예방을 위한 먼지피해 배상액 산정 현실화 방안 연구)

  • Kim, Jinho
    • Journal of the Society of Disaster Information
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    • v.18 no.2
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    • pp.374-385
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    • 2022
  • Purpose: Even if a damage is applied to the dust of the construction site containing the first-class carcinogen, it is dismissed or 5~30% of the amount of noise damage compensation is paid., Because of such loopholes, some construction companies are neglecting the dust management of the construction site, and the damage of the workers and the residents in the construction site continues. Method: The purpose of this study is to examine the problems of the calculation criteria of damage compensation amount of construction site dust, the measurement of dust concentration, the analysis of measurement data (the data of electric signboard measuring device by the mining scattering method), the prediction and evaluation methods such as modeling, and to suggest improvement measures. Result: It is found that it is impossible to calculate the amount of damages from dust damage in the construction site by calculating the current dust damage compensation amount and dust concentration modeling and measurement. Conclusion: It will receive an application for compensation for damage within the site where damage is expected (about 100m in the straight line and the boundary line of the site), and present a method of calculating the amount of compensation that differentially evaluates dust damage to the degree of dust management and compliance with dust-related legal standards.

Analysis of Electrical Characteristics of CCFL Exit Light (CCFL유도등의 전기적 특성 분석)

  • Jung, Jong-Jin
    • Journal of the Society of Disaster Information
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    • v.17 no.1
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    • pp.184-193
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    • 2021
  • Purpose: In this study, since the operation principle of the CCFL Exit light is the same as that of general lighting equipment, the characteristics of the CCFL Exit light were analyzed by deriving test items that can affect the characteristics of the light source from the KS standard, which is the standard for lamp ballast performance certification of general lighting equipment. Method: The samples used in the experiment were performed on products of two manufacturers for each size, such as large, medium, and small, and the test items were power factor, crest factor, and current harmonic distortion. Result: As a result of the experiment, the power factor showed a value between 0.4 and 0.6 in all samples, which was smaller than the 0.9 value set by KS. The crest factor ranged from 3.6 to 3.7 for large, 4.4 to 4.7 for medium, and 3.5 to 3.7 for small. It showed a value more than two times higher than the KS standard of 1.7. Current total harmonic distortion ranged from 81% to 110%, and considering that the KS standard was less than 20%, it could be confirmed that all samples had a value significantly exceeding the KS standard. Conclusion: The crest factor and current total harmonic distortion may affect the temperature rise of the light source and the burnout of the device. When developing an exit light, if this item is developed within the scope of the KS standard, the quality improvement and maintenance of the exit light will be greatly improved.

The Formal Innovation and Social Reflection of Korean Web Fiction Fantasy -Centered on 'Book Traveler' Genre (한국 웹소설 판타지의 형식적 갱신과 사회적 성찰 -책빙의물을 중심으로)

  • Yu, In-Hyeok
    • Journal of Popular Narrative
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    • v.26 no.1
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    • pp.77-102
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    • 2020
  • This article analyzes 'book traveler' stories as a new sub-genre of Korean fantasy web fiction. Formal innovation is revealed as the major motivation of Korean fantasy web fiction's narratives. Furthermore, the imagination of social resistance was presented as the formal devices of the genre. These theses were performed during the analysis of the two characteristics of the genre. In this genre, the main character is the writer or reader of fantasy stories. He moves into a novel he is describing or reading. The original novel, which was entered by the main character, is a space characterized by the custom of a typical fantasy genre. Therefore, the main character actually experiences cliché, typical genre devices and plots. The most important action for the main character here is to 'bend' the custom of the original. Therefore, this genre is in the form of the main motive being the refraction of typology. Meanwhile, the main character is not the central character of the original, but a secondary figure. The central character of the original book is usually from the ruling class, which monopolizes the good resources of society. At this time, the genre creates a subversive situation in which the social underdog goes beyond the social power through plots that overwhelm the central figure. It converts the reader's social desire into a genre device. To summarize, the latest trend in Korean web novel fantasy has captured scenes of renewed Korean genre literature practices. It sensitively reflects the social context of the contemporaries and the reader's desire. Thus, the Korean web novel fantasy has reflected both its internal conditions and its social context.

Development and performance of inorganic thixotropic backfill for shield TBM tail voids (무기질계 가소성 TBM 뒤채움재 개발 및 성능)

  • Lee, Seongwoo;Park, Jinseong;Ryu, Yongsun;Choi, Byounghoon;Jung, Hyuksang
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.24 no.3
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    • pp.263-278
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    • 2022
  • This paper contains experimental study for the development and performance of TBM backfill material with thixotropic properties. The LW backfill material is widely applied to fill the cavity on the back side of the shield TBM excavation, but has disadvantages such as settlement caused by strength reduction, material separation by groundwater, and reduced plasticity. In this paper, laboratory tests and a model test were conducted to assess the performance of inorganic thixotropic backfill material proposed to improve these problems. The results of laboratory tests show that 1 hr-uniaxial compressive strength of ITB was 12 times higher than LW, and the rate of bleeding of 20 hr was 8.3 times lower, and the result of flow table test was more than 27 times higher. This result indicated that the inorganic thixotropic backfill material has superior properties to LW backfill in terms of strength reduction, material separation, and thixotropy. In the model experiment, a model injection device tester was manufactured and the injection performance and filling rate were verified. When material was injected in the water, it was visually checked whether material separation occurred, and it was confirmed that the filling rate was 96% or more. Comparison results with the test of LW and ITB materials was concluded that ITB can reduce the material separation by groundwater and the occurrence of tunnel cavity.

Development of Accelerator Control System for Wet Shotcrete Spraying Equipment (습식 숏크리트 뿜칠 장비의 급결제 유량 제어 시스템 개발)

  • Tae-Ho, Kang;Soo-Ho, Chang;Soon-Wook, Choi;Jin-Tae, Kim;Bong-Gyu, Kim;Chulho, Lee
    • Tunnel and Underground Space
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    • v.32 no.6
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    • pp.353-362
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    • 2022
  • The wet shotcrete refers to a method in which all materials are mixed and then supplied to the spraying device, compressed air is added to the nozzle, and the spraying speed is improved to spray on the target surface. In order to reproduce the amount of shotcrete used in the wet method in the field and the situation at the laboratory scale, it is essential to control the discharge amount of the equipment. In this study, in order to increase the reproducibility of field conditions at the laboratory scale, a flow control system for shotcrete mortar spraying equipment was developed and applied to the equipment. To verify the developed equipment, a discharge control test using water and mortar was performed. In the developed control system, the discharge was smoothly controlled according to the user input value for the mono pump, but the discharge was not properly controlled according to the input value for the screw pump because of a reducer. When a speed reducer is attached, it is necessary to adjust the operation rate of the screw pump close to the target flow rate by increasing the operation rate of the screw pump while lowering the operation rate of the mono pump.