• Advances in aircraft and spacecraft science
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• 제2권2호
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• pp.109-124
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• 2015

This paper deals with the aerodynamic and aerothermodynamic trade-off analysis of a hypersonic flying test bed. Such vehicle will have to be launched with an expendable launcher and shall re-enter the Earth atmosphere allowing to perform several experiments on critical re-entry phenomena. The demonstrator under study is a re-entry space glider characterized by a relatively simple vehicle architecture able to validate hypersonic aerothermodynamic design database and passenger experiments, including thermal shield and hot structures. A summary review of the aerodynamic characteristics of two flying test bed concepts, compliant with a phase-A design level, has been provided hereinafter. Several design results, based both on engineering approach and computational fluid dynamics, are reported and discussed in the paper.

• 한국음향학회:학술대회논문집
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• 한국음향학회 1994년도 FIFTH WESTERN PACIFIC REGIONAL ACOUSTICS CONFERENCE SEOUL KOREA
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• pp.1058-1063
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• 1994

In this study we developed monosyllable lists for articulation test for Korean. We sampled 103,581 colloquial monosyllables, applied them to five selection rules that based on Korean linguistic characteristics, and finally constructed five different lists with fifty monosyllables. The validity test using the monaural impairment factors such as S/N ratio and cut-off frequency showed that articulation scores were chanted systematically according to the level of impairment factors. In addition, we investigated the effect of azimuth of a single competing sound upon articulation scores. The syllables were always reproduced by the loudspeaker in front of the subject, while Hoth noise were reproduced by the loudspeaker with varying azimuth around subject. The result indicated that the articulation depended on the azimuth of competing sound sources. Finally, no significant differences among lists were found in all experimental conditions.

• IMMUNE NETWORK
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• 제6권1호
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• pp.43-51
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• 2006

Background: The DR-$70^{TM}$ immunoassay is a newly developed cancer diagnostic test which quantifies the serum fibrin degradation products (FDP), produced during fibrinolysis, by antibody reaction. The purpose of this study was to evaluate the potential of DR-$70^{TM}$ Immunoassay in screening malignant tumor. Methods: Sample subjects were 4,169 adults, both male and female, who visited the health promotion center of a general hospital from March 2004 to April 2005 and underwent the DR-$70^{TM}$ immunoassay test and other tests for cancer diagnosis. The patient group was defined as 42 adults out of the sample subjects who were newly diagnosed with cancer during the same time period when the DR-$70^{TM}$ immunoassay test was performed. Final confirmation of a malignant tumor was made by pathological analysis. Results: The mean DR-$70^{TM}$ level was $0.83{\pm}0.65{\mu}g/ml$ (range: 0.00 (0.0001)${\sim}7.42{\mu}g/ml)$ in the control group (n=4,127) as opposed to $2.70{\pm}2.33{\mu}g/ml$ (range: $0.12{\sim}9.30{\mu}g/ml)$ in the cancer group (n=42), and statistical significance was established (p<0.0001, Student t-test). When categorized by the type of malignant tumor, all cancer patients with the exception of the subgroups of colon and rectal cancer showed significantly higher mean DR-$70^{TM}$ levels compared with the control group (p<0.0001, Kruscal-Wallis test). The receiver operating characteristic (ROC) curve analysis revealed ${\geq}1.091{\mu}g/ml$ as the best cut-off value. Using this cut-off value, the DR-$70^{TM}$ immunoassay produced a sensitivity of 71.4%, a specificity of 70.1%, a positive predictability of 69.4%, and a negative predictability of 69.2% (1). Conclusion: A significant increase in the mean DR-$70^{TM}$ value was observed in the cancer group (thyroidal, gastric, breast, hepatic and ovarian) com pared with the control group. In particular, the specificity and sensitivity of the DR-$70^{TM}$ immunoassay was relatively high in the subgroups of breast, gastric, and thyroidal cancer patients. There is need for further studies on a large number of malignant tumor patients to see how the DR-$70^{TM}$ level might be changed according to the differentiation grade and postoperative prognosis of the malignant tumor.

• 한국콘텐츠학회논문지
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• 제17권10호
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• pp.567-575
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• 2017

본 연구는 PET/CT 장비로 $^{18}F--FDG$ 방사성 의약품 주입 후 60분에서 검출된 췌장질환자 60명의 SUVm 데이터 분포를 정규분포 화 시키는 가설을 설정하여 PET/CT 이중시간 검사에서 지연 검사 시행을 결정할 수 있는 기준으로 제시하였다. 비정규분포를 나타내는 SUVm 데이터를 BOX-COX 변환과 Johnson 변환을 통해 정규분포 화 하였다. 정규 분포 95% 신뢰구간 하단에서 지연검사를 결정할 수 있는 경계값 SUVm 2.52를 제시하였다. 통계적 검증을 통해 제안된 경계값은 췌장암 구별을 위한 지연시간 검사에서 (120분, 180분)두 실험군 모두 적용할 수 있는 유의한 상관관계를 보였으며, 통계적으로 유의하다(p<0.05). C-Value는 췌장암 군과 췌장염 군을 감별에서는 췌장암 판별에 통계적으로 유의하다 (p<0.01). C-Value graph를 이용해서 지연시간 120분 검사가 지연시간 180분 검사보다 유용성이 있음을 확인하였다. 경계값 SUVm 2.52를 기준으로 이중시간 검사를 결정했을 때, 현재 대다수의 핵의학과 개설병원에서 시행하고 있는 단일 시간 PET/CT 검사보다, 췌장암 조기 발견과 감별에 도움을 줄 수 있을 것으로 사료된다.

• Journal of Yeungnam Medical Science
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• 제30권2호
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• pp.90-94
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• 2013

Background: This study was conducted to examine if basal luteinizing hormone (LH) levels could be useful for screening central precocious puberty (CPP) in girls. Methods: A total of 90 girls under the age of 8 years were included in this study. They underwent the gonadotropin-releasing hormone (GnRH) stimulation test at Good Gang-An Hospital from March 2008 to December 2012 for evaluation of premature sexual development. Patients were classified into two groups: the pubertal response group of patients who had 5 IU/L peak LH levels in the GnRH stimulation test, and the prepubertal response group of patients who had LH levels <5 IU/L. Chronological and bone ages, height, weight, body mass index, gonadotropin response to GnRH stimulation, and basal levels of LH, follicle-stimulating hormone, and estradiol were studied in both groups. The relationship between basal LH and peak-stimulated LH was evaluated using Spearman's correlation. To determine the optimal cut-off values of basal LH levels for differentiating between two groups, the receiver operating characteristic (ROC) curves were analyzed. Results: When the correlation between basal LH levels and peak LH after GnRH stimulation was analyzed in all subjects (N=90), basal LH levels had a statistically significant positive correlation with peak stimulated LH levels (rs=0.493, p<0.001). The cut-off level of optimal basal LH was 0.1 IU/L, according to the ROC curves. Its sensitivity was 73.3%, and its specificity was 77.8%. Conclusion: The study results showed that serum basal LH levels are useful for screening CPP in girls.

• 복식문화연구
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• 제17권1호
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• pp.1-14
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• 2009

The purpose of this study was to examine consumers' brand attachment of fashion luxury product by emotional approach of brand loyalty. The questionnaire developed through the literature search and a survey was conducted both in on-line and off-line questionnaire simultaneously. Finally, 218 data from women who had a buying experience of fashion luxury products were analyzed using frequency, factor analysis, ANOVA, t-test, regression analysis by SPSS for WIN program. The results were as follows; First, there were significant differences in brand loyalty according to consumers' age, marriage yes or no, occupation, education level, and income. Second, the consumers' brand attachment of fashion luxury products was composed of five factors; emotional, dependent, attractive, knowledge, interest. Third, there were significant differences in brand loyalty according to consumers' age, marriage yes or no, occupation, education level, and income. Fourth, there were significant differences in brand attachment according to consumers' age, marriage yes or no, occupation, education level, and income. There were significant differences in emotional, dependent, attractive, knowledge, interest dimension of brand attachment according to consumers' age, sex, marriage yes or no, occupation, education level, and income. Fifth, the brand attachment significantly influenced on the brand loyalty.

• 한국추진공학회지
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• 제13권3호
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• pp.20-26
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• 2009

30톤급 액체로켓엔진용 터보펌프에 대하여 실매질을 사용하여 성능시험이 이루어졌다. 산화제펌프와 연료펌프에는 각각 액체산소, 케로신의 실매질을 사용하고 터빈에는 고압의 상온 수소가스가 사용되었다. 터보펌프는 설계점과 탈설계점의 전 영역에서 안정적으로 작동하였고 요구되는 성능 조건을 만족 시켰으며 이로써 엔진 서브시스템 수준의 터보펌프 개발이 성능 측면에서 검증되었다고 볼 수 있다. 본 논문에서는 단일 운전으로 세 운용점에서 총 75초간 작동된 경우의 시험결과를 소개하였다. 펌프와 터빈의 성능 특성 관점에서 터보펌프 조립체의 실매질 성능시험 결과와 터보펌프 구성품의 상사 성능시험 결과가 양호하게 일치하였다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년도 제31회 추계학술대회논문집
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• pp.359-365
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• 2008

30톤급 액체로켓엔진용 터보펌프에 대하여 실매질을 사용하여 성능시험이 이루어졌다. 산화제펌프와 연료펌프에는 각각 액체산소, 케로신의 실매질을 사용하고 터빈에는 고압의 상온 수소가스가 사용되었다. 터보펌프는 설계점과 탈설계점의 전 영역에서 안정적으로 작동하였고 요구되는 성능 조건을 만족시켰으며 이로써 엔진 서브시스템 수준의 터보펌프 개발이 성능 측면에서 검증되었다고 볼 수 있다. 본 논문에서는 단일 운전으로 세 운용점에서 총 75초간 작동된 경우의 시험결과를 소개하였다. 펌프와 터빈의 성능 특성 관점에서 터보펌프 조립체의 실매질 성능시험 결과와 터보펌프 구성품의 상사 성능 시험 결과가 양호하게 일치하였다.

• 대한임상독성학회지
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• 제16권2호
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• pp.68-74
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• 2018

Purpose: In 2012, a revised guideline for acute acetaminophen overdose was proposed in the UK, recommending that the treatment threshold should be lowered to 100 mcg/ml at 4 hours after ingestion without risk stratification of hepatotoxicity. However, the poison centers in some developing countries do not have laboratory resources to provide serum drug levels in time. The primary aim of the study is to evaluate the cut-off value of reported dose per kilogram to determine when N-acetylcysteine treatment is warranted under the revised guideline. Methods: Data were collected retrospectively from the toxicology registry of an urban emergency medical center between 1st January 2010 and 30th June 2017. Inclusion criteria were single acute overdose of more than 75 mg/kg in 15 hours from ingestion and over 14 years of age. Subgroups were created by 25 mg/kg increments of reported dose, then sensitivity, specificity, positive predictive value and negative predictive value were calculated for the cut-off values of 100 mg/kg, 125 mg/kg, 150 mg/kg and 175 mg/kg for toxic serum level over '100-treatment line'. Results: A total of 99 patients were enrolled in the study; 24 patients showed toxic serum levels (24.2%). Zero of 17 patients with an ingestion dose under 100 mg/kg showed toxic level (0%), and 0 of 15 under 125 mg/kg (0%), 2 of 14 under 150 mg/kg (14.3%), and 4 of 12 under 175 mg/kg (33.3%) had toxic levels. The higher the ingested dose per kilogram of weight, the higher the frequency of the toxic serum concentration on the first test (${\chi}^2$ test for trend, ${\chi}^2=22.66$, p-value<0.001) and the sensitivity of each value was 100%, 100%, 92% and 76%. Conclusion: In acute single acetaminophen intoxication, the ingestion dose of 100 mg/kg of weight will be useful in determining the need for the N-acetylcysteine antidote in the indigent laboratory environment.

• Advances in Automotive Engineering
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• 제1권1호
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• pp.21-39
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• 2018

Clutch energy is the thermal energy dissipated on the clutch disc, and it reaches its highest level during drive-off as a result of the difference between the angular speeds of the flywheel and clutch disc, and the torque transmitted. The thermal energy dissipated effects the clutch life. This study presents a new drive-off and thermal model to calculate the clutch energy for a rear wheel driven heavy-duty vehicle and to analyze the effects of clutch energy on temperatures of clutch pressure plate, flywheel and clutch housing. Three different driver profiles are used, based on the release of the clutch pedal in modulation zone: i) the pedal travels with the same speed all the way, ii) the travel speed of the pedal increases, iii) the travel speed of the pedal decreases. Vehicle test is performed to check the accuracy of the model. When compared to a simpler model that is widely used in the literature to calculate the clutch energy, the model used in this study calculates the clutch energy and angular speed behaviors of flywheel and transmission input shaft in better agreement with experimental results. Clutch wear and total clutch life are also estimated using the mean specific friction power.