• 한국임상수의학회지
• /
• 제29권4호
• /
• pp.277-282
• /
• 2012

본 연구는 건강한 개에서 혈장 homocysteine농도가 비만이나 비만 관련인자(예, 지방, 인슐린, 혈당, 글루카곤, fructosamine)들과 어떤 상관관계가 있는지를 확인하기 위해 실시되었다. 이를 위해, 절식시 혈당, 지방지수(예, total triglycerides [TG], total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C]과 low-density lipoprotein cholesterol [LDL-C]), fructosamine, insulin 및 glucagon 농도를 각각 측정하였다. 실험에 사용된 개들은 body condition score (BCS)에 따라 분류하였다. 평균 혈장 homocysteine 농도는 비만한 개 집단이 정상이나 마른 개 집단에 비해 상당히 높았다. 또한 혈장 homocysteine농도는 HDL-C농도 뿐아니라 TG, TC, 혈장 glucagon 및 fructosamine 농도와도 밀접한 상관관계를 가지고 있었다. 반대로 LDL-C 농도, 절식시 혈당농도 및 insulin농도는 아무런 상관관계가 확인되지 않았다. 본 연구 결과, homocysteine의 농도 상승이 비만견에서 생물학적으로 중요한 역할을 하는 것으로 추정된다.

• Annals of Occupational and Environmental Medicine
• /
• 제35권
• /
• pp.40.1-40.10
• /
• 2023

Background: Efforts for the prevention and management of cardiovascular diseases (CVDs) in workers have been actively pursued. Obesity is one of the important risk factors related to CVDs. Obesity has various metabolic characteristics, and some individuals can be metabolically healthy. Body composition including skeletal muscle mass is known to have protective effect in obesity. The study aims to investigate the association between skeletal muscle mass and Korea Occupational Safety and Health Agency (KOSHA) CVD risk among obese male manufacturing workers in Korea and to identify appropriate indicators of skeletal muscle mass for predicting risk of CVDs. Methods: The study was conducted on 2,007 obese male workers at a manufacturing industry aged more than 19 years. Skeletal muscle mass, skeletal muscle index (SMI), skeletal muscle mass percent (SMM%) and skeletal muscle to body fat ratio (MFR) were used to evaluate body composition and these indicators were divided into quartiles. The odds ratios (ORs) and 95% confidence intervals (CIs) for the KOSHA CVD risk groups according to quartiles of skeletal muscle mass indicators were estimated using ordinal logistic regression analysis. Results: The OR for the KOSHA CVD risk groups in the highest quartile of SMI was 1.67 (95% CI: 1.42-1.92), while the ORs for the KOSHA CVD risk groups in the highest quartiles of SMM%, SMM/body mass index (BMI), and MFR were 0.47 (95% CI: 0.22-0.72), 0.51 (95% CI: 0.05-0.76), and 0.48 (95% CI: 0.23-0.74), respectively. Conclusions: We found that high SMI increase the likelihood of high risk of CVDs, while high SMM%, SMM/BMI, and MFR lower the likelihood of high risk of CVDs. Accurate evaluation of skeletal muscle mass can help assess the cardiovascular risk in obese male workers.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제16권3호
• /
• pp.153-161
• /
• 2013

Polyunsaturated fatty acids (PUFAs) are the major components of brain and retina, and are the essential fatty acids with important physiologically active functions. Thus, PUFAs should be provided to children, and are very important in the brain growth and development for fetuses, newborn infants, and children. Omega-3 fatty acids decrease coronary artery disease and improve blood flow. PUFAs have been known to have anti-inflammatory action and improved the chronic inflammation such as auto-immune diseases or degenerative neurologic diseases. PUFAs are used for metabolic syndrome related with obesity or diabetes. However, there are several considerations related with intake of PUFAs. Obsession with the intake of unsaturated fatty acids could bring about the shortage of essential fatty acids that are crucial for our body, weaken the immune system, and increase the risk of heart disease, arrhythmia, and stroke. In this review, we discuss types, physiologic mechanism of action of PUFAs, intake of PUFAs for children, recommended intake of PUFAs, and considerations for the intake of PUFAs.

• 대한한방소아과학회지
• /
• 제22권2호
• /
• pp.19-35
• /
• 2008

Objectives : As obese children have been increased, the interest in the impact of obesity on growth also have been increased. This study is to examine relations between obesity and skeletal maturity by analyzing body compositions and bone age. Methods : Subjects were composed of 233 children from 6 years to 17 years of age, without any other diseases related to growth, who visited the department of pediatrics, OO oriental medicine hospital and measured their body composition (body mass index, body fat ratio, fitness score) and bone age. Results : 1. As body mass index was increased, the skeletal maturity significantly was also increased. 2. As the mean of bone maturity was increased, the BMI was increased from the underweight type to the normal type to the overweight type; the bone maturity was increased as the fat ratio was increased from the normal type to the obese type to the excessively obese type; and the bone maturity was higher in the weak, obese type than the normal type when classified according to the Fitness Score. 3. The bone maturity of the overweight group in the BMI classification and excessively obese group in the fat ratio classification significantly were increased. 4. Skeletal maturity significantly was increased in children who developed secondary sexual character. 5. The significance of obesity causing increase of the skeletal maturity was higher in boys than in girls. 6. Only in the case of children without development of secondary sexual character, obesity caused an significant increases in the skeletal maturity. Conclusions : Obesity could cause the increase of skeletal maturity, and the obesity could affect more to the boys than girls and more to the children than teenagers.

• Nutrition Research and Practice
• /
• 제1권3호
• /
• pp.212-217
• /
• 2007

This study compared obese children's food group intakes with the new Dietary References Intakes for Koreans (KDRIs) food guides for 5th-6th grade school children. This study also determined the extent of sedentary life styles related with obesity in this area of children. This is it cross-sectional study of 799 school children. The dietitian sent a survey form describing the project and a questionnaire to the subject's family. The questionnaire included child demographics, family history of chronic diseases, the daily servings of five food groups, such as grains, meat and beans, dairy products, fruits, and vegetables. The daily or weekly hours of physical activity, television viewing, and computer usage were also surveyed. Obesity index (%) of the subjects was calculated, and children with an obesity index (%) equal to or greater than 20 were classified as the obese. Among the 799 participants, 50.7% were female. The percentages of the normal and the obese were 691 (86.5%) and 108 (13.5%) respectively. Obese children reported eating less vegetables (p<0.05), more high sugar snacks (p<0.05), and high fat snacks (p<0.05) than normal children. No significant differences in food servings of grains, meats and beans, and fruits, and dairy products between the normal and the obese were shown. Obese children reported fewer hours of physical activities (p<0.05) and more hours of computer usage (p<0.05) than normal children. Girls showed less likelihood of being obese (odds ratio, 0.575, CI (0.38, 0.87), p<0.05). More hours of physical activity significantly decreased the likelihood of being obese (odds ratio, 0.572, CI (0.35, 0.92), p<0.05). Family history of obesity almost doubled the likelihood of obesity in children (odds ratio, 2.653, CI (1.660, 4.241), p<0.05). In conclusion, frequent snacking, inadequate vegetable consumption, and sedentary lifestyle increased significantly the likelihood of obesity in children, which suggest that obesity intervention in this age group should focuse more on those variables.

• Journal of Preventive Medicine and Public Health
• /
• 제28권1호
• /
• pp.85-101
• /
• 1995

This study was carried out to evaluate the associations between lifestyles and Body Mass Index in a group of 349 male and 65 female medical students, ages 17 to 31 years. 20.0% of male students and 3.1% of female students showed the over weight in the classification of obesity by Japan Society for Study of Obesity. There was no statistically significance in the comparison of the height, body weight, body mass index, obesity index and body fat(%) according to grade in both sexes. But male students showed increasing tendency of waist-hip ratio with grade. According to obesity category, there was significant difference in the comparison of body weight, body mass index, obesity index, waist-hip ratio and body fat(%), but height. Body mass index was positively related with waist-hip ratio(r=0.6150, p=0.0001) and fat(%)(r=0.5101, p=0.0001) in males and waist-hip ratio (r=0.4734, p=0.001) and fat(%)(r=0.4522, p=0.002) in females. This study provides an opportunity to further examine the relationship of sociddemographic factors and health behaviors to obesity, and suggest the basic concept to match the obesity study to general epidemiological cohort studies for controlling of chronic adult diseases.

• 대한지역사회영양학회지
• /
• 제7권4호
• /
• pp.506-515
• /
• 2002

This study examined the state of health and weight maintenance according to the body mass index (BMI) , and explored demographic variables, diet variables, the degree of stress etc. The results presented were based on data collected from 428 women who are mothers of the middle school children in Jeongeup city. Using SPSS WIN (Ver 9.0) , the frequency, percentage, mean, standard deviation, chi-square, ANOVA, and correlation analysis were provided. The mean of BMI for the subjects was 22.6, the ratio of obese women (BMI $\geq$ 25) was 22.9%. The frequency of the reported circulation or respiratory related diseases was greater in the obese group compared to the normal weight ($20 \leq BMI \leq 25$) or the lean (BMI < 20) groups. The obese group had less awareness of obesity. Those who regard themselves obese had lower rates of satisfaction with their body shape and higher rates of interest in weight control. Approximately 65% of the subjects attempted weight reduction more than once. Subjects who were obese had the most undesirable dietary behavior. In particular, this group had the higher rates of rushed meals, overeating, meals while watching TV or newspapers, and snacking, and eating out. In analyzing the correlation of variables influencing obesity, there were positive correlations between obesity and overeating, obesity and the degree of stress. Correlations between obesity and satisfaction for life found to be negative. Moreover, stress had a positive correlation with obesity and overeating, and showed negative correlation with eating behavior. Consequently, stress seemed to induce undesirable eating behaviors and increase obesity. Of the demographic background variables, subjects who were obese tended to be older, had lower levels of education, higher rates of employment, longer period of marriage, the higher number of children, preschool children or children preparing for highschool or college, lower satisfaction with children and household life.

• Journal of the Korean Data and Information Science Society
• /
• 제27권5호
• /
• pp.1203-1214
• /
• 2016

비만은 그 자체가 질병이면서 다른 질병의 위험인자로 사회경제학적 요인과 관련성이 높다. 급증한 국내 비만인구에 대한 사회적 차원에서의 예방을 위하여 비만과 연관성이 있는 사회경제적 요인을 파악하는 것이 중요하다. 특히, 비만과 사회경제학적 요인간의 연관성은 성별에 따라 상이할 수 있으며 지역적 변동성 역시 존재한다. 본 논문에서는 공간적 상관성을 고려하여 비만율에 영향을 미치는 사회경제적 요인의 효과를 성별에 따라 추정하고자 한다. 공간적 상관성을 설명하기 위하여 베이지안 접근법을 기반으로 한 조건부 자기회귀모형을 고려하였다. 실증예제로 2010년 서울시 25개 자치구별 비만율 자료에 대하여 제안한 공간 모형과 공간적 상관성을 고려하지 않은 모형을 적합시켜본 결과, 공간적 상관성을 고려한 모형이 모형의 적합도와 예측력 측면에서 더 우수함을 알 수 있었다.

• 한국자원식물학회:학술대회논문집
• /
• 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
• /
• pp.55-55
• /
• 2023

With the COVID-19 pandemic, there is increasing interest in anti-obesity strategies. According to the National Statistical Office, the obesity rate in Korea was 38.3% in 2020 and 37.1% in 2021. Obesity is a risk factor for several severe diseases, including stroke, heart disease, type 2 diabetes, and certain types of cancer. Pinus rigida × Pinus taeda is a hybrid of Pinus rigida Mill and Pinus taeda Linn, and its cones are considered a by-product. Although previous studies have investigated their pharmacological effects on antioxidant activity and protection against oxidative DNA damage, few researchers have explored their potential as functional natural materials. Therefore, we evaluated the anti-obesity effects of the cone of ethyl acetate fraction of P. rigida × P. taeda (ERT), specifically its ability to inhibit lipid accumulation. Our analysis showed that ERT contains phytochemicals (catechin and caffeic acid) which are known to improve immune function and inhibit cell damage. ERT inhibited lipid droplet accumulation at the cellular levels through Oil Red O staining. Furthermore, ERT suppressed the expression of adipogenic transcription factors (PPARγ and CEBP/α) as well as downstream lipogenic target genes (FAS and SREBP-1) thereby inhibiting adipogenesis. ERT also down-regulated key adipogenic markers, including aP2α, while inducing the phosphorylation of AMPK. It has been reported that PPARγ and CEBP/α are expressed in the early stages of adipose differentiation, while SREBP-1 is expressed in the late stage. Therefore, our findings suggest that ERT activates AMPK signaling pathways, which inhibits adipogenic transcription factors (PPARγ, C/EBPα, and SREBP1) and lipogenic genes (FAS and aP2α), thereby blocking lipid accumulation and preventing obesity and related disorders. ERT showed potential as a new resource for developing a functional material for anti-obesity agents.

• 동서간호학연구지
• /
• 제14권2호
• /
• pp.47-53
• /
• 2008

Purpose: Metabolic syndrome (also known as insulin resistance syndrome) represents a constellation of hypertriglyceridemia, hypertension, impaired glucose tolerance, and obesity. Presently, the influence of various factors on metabolic syndrome was assessed in patients of a university hospital comprehensive medical examination center. Methods: Age, sex, blood pressure, height, weight, triglyceride level, high-density lipoprotein cholesterol, and glucose levels were measured in 67 people (37 males and 30 females). These factors were correlated with tobacco use, alcohol consumption, and exercise habits. Metabolic syndrome and abdominal obesity were assessed according to NCEP-ATP III criteria and the Asia-Pacific guidelines (male obesity defined as a waist circumference exceeding 90 cm), respectively. Data was analyzed using t-test, 2-test, and logistic regression. Results: Respective percentages were: tobacco use (14.9% of the 67 people), no tobacco use (85.1%), alcohol consumption (62.7%), no alcohol consumption (37.3%), regular exercise (25.4%), no regular exercise (74.6%). Logistic regression analysis revealed a gender-related odds ratio of 2.3 for metabolic syndrome and no exercise. Conclusions: Weight reduction and physical exercise may decrease the prevalence of metabolic syndrome. Early identification of metabolic syndrome and risk factor modification is prudent in cases of obesity, diabetes, hyperlipidemia, and hypertension.