• The Korea Journal of Herbology
• /
• v.25 no.3
• /
• pp.1-9
• /
• 2010

Objectives : This study was undertaken to verify the effects of Gyeongshingangjeehwan18 (GGEx18) on obesity using ob/ob male mice. Methods : Eight-week old mice (wild-type C57BL/6J and ob/ob) were used for all experiments. Wild-type C57BL/6J mice were used as lean control and obese ob/ob mice were randomly divided into 5 groups: obese control, GGEx15, GGEx16, GGEx17, and GGEx18. After mice were treated with several kinds of GGEx for 11 weeks, body weight gain, feeding efficiency ratio, plasma lipid and glucose metabolism. Results : 1. Compared with obese controls, GGEx-treated mice had lower body weight gain and feeding efficiency ratio, the magnitudes of which were prominent in GGEx16 and GGEx18. 2. Consistent with their effects on body weight gain, GGEx16 and GGEx18 not only decreased plasma triglycerides levels, but also increased HDL-cholesterol concentration. 3. CT analysis revealed that visceral fat areas were decreased in all treatment groups compared with obese control mice. The decrease in visceral fat area was prominent in GGEx16 and GGEx18, although they were not statistically significant. 4. The size of adipocytes were significantly decreased by GGEx18, whereas the adipocyte number per unit area was significantly increased, suggesting that GGEx18 decreased the number of large adipocytes. Hepatic lipid accumulation was decreased by GGEx16 and GGEx18, and the inhibitory effect was most effective in GGEx18. 5. Plasma GOT and GPT concentrations were significantly lower following GGEx16 and GGEx18 treatment compared with obese controls. Organ weights were not changed by GGEx treatment, indicating GGEx do not show any toxic effects. Conclusions : These results suggest that GGEx may regulate obesity. Of the 4 compositions, GGEx18 seems to be most effective in improving obesity and lipid disorders.

• Journal of the Korea Society of Computer and Information
• /
• v.27 no.6
• /
• pp.95-107
• /
• 2022

This study attempted to develop a bodice prototype suitable for the 20's obese male's trunk with a BMI of 25kg/m² or more, which is distinguished from the standard body type. Through this, it was intended to provide data to help the development of clothing for obese males. Patterns such as front bodice shoulder line and front sagging were modified through primary appearance and garment pressure evaluation. Through the second evaluation, corrections such as back armhole, back waistline, and front sagging were performed. Through the third evaluation, the final pattern drafting method was developed by removing the front sagging added through the second evaluation. In the case of obese male body types in their 20s, a drafting method distinguished from the standard body type was required in the method of setting the front and back waist lines, back armhole darts, and front shoulder lines due to protruding and posture of the abdomen. This study was meaningful in that it presented a bodice prototype drafting method suitable for the 20s obese males. In the follow-up study, it is thought that actual clothing experiments and studies to develop clothing patterns by applying them to obese male tops in their 20s should be conducted.

• The Korean Journal of Health Service Management
• /
• v.11 no.3
• /
• pp.65-78
• /
• 2017

Objectives : Obesity is a worldwide health concern due to an increasing obese population. This study proposed to analyze the differences in medical costs and care utilization between obese and normal group using propensity score matching. Methods : Data were collected from the sample cohort database by the Korea National Health Insurance Corporation. Propensity score matching(PSM) was applied to control selection bias, and factors affecting obesity were used as covariates in PSM. Results : The results showed higher medical costs and care utilization in the obese group than the normal group. According to gender and medical type, there were differences in the relationships between obesity and medical charges and utilization. In particular, the differences in the female population were larger in both outpatients and inpatients than the male population. Conclusions : It is important to manage obesity, because obesity has a negative effect on national health insurance costs. These findings suggest directions for future research.

• Fashion & Textile Research Journal
• /
• v.4 no.4
• /
• pp.383-393
• /
• 2002

The purpose of this study was to evaluate wearing evaluation method in order to propose well fitted bodice pattern. For this study, the subjects were drawn from obese boys at the ages 9 to 11. Wearing evaluation had use of 3 bodice type and 3 evaluative method. The appearance evaluation was to evaluate subjects by professional group. The functional evaluation was to valued subjects by self-evaluation. The quantitative evaluation was to estimate subjects through Electomyograph. Wearing evaluation was done through questionnaire of 32 item in objectivity, 36 item in subjectivity, and 36 item in quantity. The data were analyzed by using ANOVA. From wearing evaluation, appearance and functional evaluation had significant most of them but quantitative evaluation had not significant. It was known that the human sense was more sensitive the quantitative mechanism. And its obtained by both functional evaluation and quantitative evaluation, respectively was found to be significantly correlated, Independent relation was observed in the results from both appearance evaluation and functional evaluation as well as from both functional evaluation and quantitative evaluation. Therefore, we propose that it is proper to evaluate the propriety of bodice pattern for obese boys of school year, mutually compromising both appearance evaluation and functional evaluation or both functional evaluation and quantitative evaluation.

• Korean Journal of Health Education and Promotion
• /
• v.26 no.2
• /
• pp.149-155
• /
• 2009

Metabolically obese but normal weight(MONW) syndrome is characterized, with potentially increased risks for development of the insulin resistance or metabolic syndrome despite their normal body mass index(BMI) < 25 kg/m2. Such characteristics could confer upon MONW individuals a type 2 diabetes mellitus and cardiovascular diseases(CVD) risk however, research on MONW is scarce. MONW individuals have metabolic disturbances typical of obese persons and are identified by having a high amount of visceral fat, a low BMI, a high fat mass, a low lean body mass, low insulin sensitivity, and high triglyceride concentrations. The purpose of this study is to review several markers as potential modulators in individuals displaying the "MONW". Body fat appears to be functionally comparable with a dynamic endocrine organ, producing and secreting various adipocy tokines, such as leptin, adiponectin, CRP, tumor necrosis factor(TNF-), interleukin(IL)-6, all of which play an important role in the onset of cardiovascular disease, and insulin resistance. Otherwise, physical activity and a lower inflammation state might be helped to reduce the number of persons at risk of diabetes, CVD complications, or premature mortality. We should provide a method to optimal treatments resolving the emerging public health problem to prevention of MONW by providing guideline for physical activity as an optimal treatment for the MONW Korean. Furthermore we expect to develop a new strategy to manage MONW Korean in this society in terms of reducing medical costs and enhancing public health care for uprising population with MONW.

• Natural Product Sciences
• /
• v.28 no.4
• /
• pp.161-167
• /
• 2022

Obesity is a complex metabolic disorder that increases the risk for type 2 diabetes, hyperlipidemia, hypertension, and atherosclerosis. In this study, we evaluated the anti-obesity effects of Nelumbo nucifera leaf (NL) extract in 3T3-L1 adipocytes and obese db/db mice. NL extract among various parts (leaf, seed, and root) of N. nucifera most effectively reduced adipogenesis via inhibiting CCAAT enhancer binding protein α (C/EBPα) and peroxisome proliferator activated receptor γ (PPARγ) expression in 3T3-L1 adipocytes. The addition of NL extract enhanced the protein expression of uncoupling protein 2 (UCP2) as compared to untreated 3T3-L1 adipocytes. The oral administration of NL extract (100 mg/kg BW) significantly reduced food efficacy ratio, body weight, and face or total cholesterol level in obese db /db mice. Also, administration of NL extract significantly decreased adipocyte size and C/EBPα or PPARγ expression in the adipose tissues as compared with control (obese db/db mice). Therefore, our results suggest that NL extract among various parts of N. nucifera could be used as a functional food ingredient for the prevention and treatment of metabolic diseases including obesity and diabetes.

• Journal of the Korean Society of Physical Medicine
• /
• v.13 no.1
• /
• pp.11-26
• /
• 2018

PURPOSE: The aim of this study was to review the effects of exercise intervention on blood glucose control in obese type 2 diabetic patients. METHODS: The PubMed and KERISS search engines were used and 61 papers that met the key questions were selected. RESULTS: Exercise is an effective intervention for the control of blood glucose in type 2 diabetic patients because it does not impair glucose transport in the skeletal muscle induced by muscle contractions. Insulin resistance, which is characteristic of type 2 diabetes, is caused by decreased insulin sensitivity or insulin responsiveness. Acute exercise improves the glucose metabolism by increasing the insulin-independent signaling pathways and insulin sensitivity in the skeletal muscle, and regular long-term exercise improves the skeletal muscle insulin responsiveness and systemic glucose metabolism by increasing the mitochondrial and GLUT4 protein expression in the skeletal muscle. CONCLUSION: The improvement of the glucose metabolism through exercise shows a dose-response pattern, and if exercise consumes the same number of calories, high intensity exercise will be more effective for the glucose metabolism. On the other hand, it is practically difficult for a patient with obese type 2 diabetes to control their blood glucose with high intensity or long-term exercise. Therefore, it will be necessary to study safe adjuvants (cinnamic acid, lithium) that can produce similar effects to high-intensity and high-volume exercises in low-intensity and low-volume exercises.

• Nutrition Research and Practice
• /
• v.17 no.2
• /
• pp.241-256
• /
• 2023

BACKGROUND/OBJECTIVES: Diabetes-specific oral nutritional supplements (ONS) have anti-hyperglycemic effects, while D-allulose exerts anti-diabetic and anti-obesity effects. In this study, we investigated the efficacy and safety of diabetes-specific ONS, including allulose, on glycemic and weight changes in overweight or obese patients with type 2 diabetes mellitus (T2DM). SUBJECTS/METHODS: A single-arm, historical-control pilot clinical trial was conducted on 26 overweight or obese patients with T2DM (age range: 30-70 yrs). The participants were administered 2 packs of diabetes-specific ONS, including allulose (200 kcal/200 mL), every morning for 8 weeks. The glycemic profiles, obesity-related parameters, and lipid profiles were assessed to evaluate the efficacy of ONS. RESULTS: After 8 weeks, fasting blood glucose (FBG) level significantly decreased from 139.00 ± 29.66 mg/dL to 126.08 ± 32.00 mg/dL (P = 0.007) and glycosylated hemoglobin (HbA1c) improved (7.23 ± 0.82% vs. 7.03 ± 0.69%, P = 0.041). Moreover, the fasting insulin (δ: -1.81 ± 3.61 μU/mL, P = 0.017) and homeostasis model assessment for insulin resistance (HOMA-IR) (δ: -0.87 ± 1.57, P = 0.009) levels decreased at 8 weeks, and body weight significantly decreased from 67.20 ± 8.29 kg to 66.43 ± 8.12 kg (P = 0.008). Body mass index (BMI) also decreased in accordance with this (from 25.59 ± 1.82 kg/m² to 25.30 ± 1.86 kg/m², P = 0.009), as did waist circumference (δ: -1.31 ± 2.04 cm, P = 0.003). CONCLUSIONS: The consumption of diabetes-specific ONS with allulose in overweight or obese patients with T2DM improved glycemic profiles, such as FBG, HbA1c, and HOMA-IR, and reduced body weight and BMI.

• The Korean Journal of Food And Nutrition
• /
• v.9 no.4
• /
• pp.441-446
• /
• 1996

This study chosed the 3 groups(lean type(41), the normal type(48) and the obese type(58)) according the BMI and then by comparing the nutrition intake and eating behaviors of each 3 groups. The results obtained were summarized as follows: A significantly difference of nutrition-intake in 3 groups is shown in the take daily food-intake and calorie-intake of snack, which the obese type intakes of protein most, the normal type that intakes of calcium most. The food-habit shown in the self report of each subject, is the irregularity of the food-eating in all 3 groups. In terms of self-estimation by actual physique, the obese type estimates mostly correctly his own physique. To compared self-estimation of eating behaviors, The estimation of the unbalanced deities mostly correct.

• Journal of the Korean Society of Food Culture
• /
• v.8 no.1
• /
• pp.63-71
• /
• 1993

The purpose of this paper it to investigate the differences in prevalence of obesity and body fat distribution on the variances of age. Height, weight, skinfold thickness and girth circumference on about 422 women residing in Cheju, Korea were surveyed. The results of analysis of the survey are as follows : 1) All the antropometric measurements except height were shown to increase with age. Weight is at its highest level between the age of 50-59. The measurement of skinfold thickness and girth circumference between the ages of 20-39 of the female subjects are significantly higher than the above 40's. However, there is no significant difference among the middle aged women. 2) Physical indices tend to increase according to age. Both BMI and RBW of women in their 50's are at their highest values, however, the index values of the women in their 60's decreased slightly (p<0.05). On the contrary, there is no significant difference in the percentage of body fat and total body fat content among the middle aged women surveyed. 3) According to this survey, 15.6% of the 422 subjects are assessed as being obese ; more specifically 4.4% of women in their 20's, 12.6% in 30's, 25.6% in 40's, 22.5% in 50's and 17.3% in 60's. 4) 39.4% among obese women proved to be upper body type women. Because the frequency of upper body type women became higher as the obese women aged, there is possibility that the pattern of fat distribution can change. 5) Weight is the most highly correlated with BMI(r=0.91), whereas weight as correlated with RBW, percentage of BF and WHR are 0.8, 0.66 and 0.44 respectfully. The conclusion of this survey is that it is better to estimate the value of total body fat and percentage of body fat than the value of BMI in the analysis of prevalence of obesity and its related factors of middle aged women.