• Journal of Convergence Korean Medicine
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• 제2권1호
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• pp.35-55
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• 2021

Objectives: To investigate the characteristics of topical agents including natural products using for atopic dermatitis treatment via a review on the cases and clinical trials. Methods: Through a search on Pubmed, EMBASE, Cochrane library, DBPIA, NDSL, and OASIS, we selected papers that applied natural products externally for atopic dermatitis and analyzed them. Results: Finally, Seventeen papers were selected. As the primary outcome, changes in the SCORAD and EASI, were the most used. The most frequent type of external formulation was cream. In terms of the frequency of use, it was used at least twice a day in all studies. When evaluated based on SCORAD, EASI, SH and TEWL, the improvement effect on atopic dermatitis was highest when the ointment formulation and the moisturizer formulation were used. A few side effects of topical agents including natural products were observed, but most were mild symptoms and no serious side effects occurred. Conclusion: This study is meaningful in that it has drawn a significant trend for studies that have been published in the last 5 years that contain a single intervention for topical agents including natural products, and that it presents the direction and evidence for the application of external therapy to increase the therapeutic effect of atopic dermatitis.

• Asian-Australasian Journal of Animal Sciences
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• 제30권9호
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• pp.1234-1238
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• 2017

Objective: The vertebral number is associated with body length and carcass traits, which represents an economically important trait in farm animals. The variation of vertebral number has been observed in a few mammalian species. However, the variation of vertebral number and quantitative trait loci in sheep breeds have not been well addressed. Methods: In our investigation, the information including gender, age, carcass weight, carcass length and the number of thoracic and lumbar vertebrae from 624 China Kazakh sheep was collected. The effect of vertebral number variation on carcass weight and carcass length was estimated by general linear model. Further, the polymorphic sites of Vertnin (VRTN) gene were identified by sequencing, and the association of the genotype and vertebral number variation was analyzed by the one-way analysis of variance model. Results: The variation of thoracolumbar vertebrae number in Kazakh sheep (18 to 20) was smaller than that in Texel sheep (17 to 21). The individuals with 19 thoracolumbar vertebrae (T13L6) were dominant in Kazakh sheep (79.2%). The association study showed that the numbers of thoracolumbar vertebrae were positively correlated with the carcass length and carcass weight, statistically significant with carcass length. To investigate the association of thoracolumbar vertebrae number with VRTN gene, we genotyped the VRTN gene. A total of 9 polymorphic sites were detected and only a single nucleotide polymorphism (SNP) (rs426367238) was suggested to associate with thoracic vertebral number statistically. Conclusion: The variation of thoracolumbar vertebrae number positively associated with the carcass length and carcass weight, especially with the carcass length. VRTN gene polymorphism of the SNP (rs426367238) with significant effect on thoracic vertebral number could be as a candidate marker to further evaluate its role in influence of thoracolumbar vertebral number.

• Journal of Society of Preventive Korean Medicine
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• 제21권1호
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• pp.83-93
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• 2017

Objectives : This study's aim is to investigate clinical studies of cold hypersensitivity of hands and feet (CHHF) published in Korea and to explore the direct of future research. Methods : We searched clinical studies of CHHF using the database, such as DBpia(http://www.dbpia.co.kr/), NDSL(www.ndsl.kr), OASIS(http://oasis.kiom.re.kr), and RISS(www.riss.kr). The search words were 'cold hypersensitivity(冷症)' and 'syncope(厥證)'. Inclusion criteria were randomized controlled trials (RCTs), non RCTs, Before and after clinical study (B&A) about CHHF. Selection journals and data extraction were conducted by HS Lee and SH Sun independently. Results : Total twenty-one articles were selected finally. RCTs, non-RCTs, and B&A were 3, 12, and 6, respectively. The topics for CHHF were classified into three categories: effect of treatment (n=2) characteristics (n=11), and diagnosis (n=8). Conclusions : This results showed that RCT about CHHF and treatment effect of cold hypersensitivity of hands and feet were small in number. Further systemic and larger studies about CHHF will be needed.

• The Journal of Internal Korean Medicine
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• 제40권4호
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• pp.663-674
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• 2019

Objective: The purpose of this study was to investigate (using a systematic review) the effect of Banhasasim-tang in the treatment of chemotherapy-induced symptoms. Method: A systematic review was conducted to identify the effect of Banhasasim-tang for chemotherapy-induced symptoms. Electronic databases were used, including such as PubMed, Cochrane, CNKI, Wanfang, CiNii, J-STAGE, NDSL, and OASIS. Among others, the main search terms included "cancer", "Banhasasim-tang", "Banxia Xiexin Tang", and "Hangeshashin-to". This study only included randomized controlled trials (RCTs). Results: A total of 14 RCTs were selected. They all identified the effect of Banhasasim-tang in the treatment of chemotherapy-induced symptoms such as nausea, vomiting, and diarrhea. In addition, five of the studies evaluated the preventive effect of Banhasasim-tang on the symptoms. Conclusion: An analysis of 14 RCTs showed that Banhasasim-tang for chemotherapy-induced symptoms might be effective not only for treatment but also for prevention. However, due to the low quality and number of the selected original articles, the significance of this conclusion is somewhat limited. It is hoped that more systematic and rigorous clinical trials will be conducted.

• Journal of Korean Medicine Rehabilitation
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• 제24권1호
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• pp.47-53
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• 2014

Objectives The aim of this review is to analyse the study tendency in papers related with sibjeondaebotang (Shiquan dabutang) which are published in Korea from 2000 to 2013. Methods We searched the four electronic database (NSDL, RISS, Korean traditional knowledge portal, OASIS) and checked relevant Korean journals from 2000 to 2013. We classified the papers by publish date, speciality, study method, and field of study, and analysed the study tendency. Results 1. 4 papers were published annually on average. 2. After classifying papers by the speciality of journal, continuous study was followed not only in korean medicine, but also in many specialities like Dietetics, Biotechnology and Pharmacology. 3. In study methods, clinical case was 29%, in vivo was 26%, and in vitro was 26%. 4. After classifying papers by field of study, beneficial effect was 62%, toxicity was 14%, qualitative analysis was 9%, and adverse effect and pharmacology was 3%. 5. In beneficial effect, it is effective in antioxidation, treatment and prevention of neurologic disease, skin disease, gynecologic disease and so on. It has also an effect in enhancing the immune system, improving the dysfunction of organs, and it can also be used for anticancer and anti-metastatic purpose. Conclusions These results suggest that Sibjeondaebotang (Shiquan dabutang) can be used as cure medicine, not just as herbal tonic, but there are not sufficient evidence based papers, so there should be further studies in order to establish Sibjeondaebotang as a cure medicine.

• The Korea Journal of Herbology
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• 제30권5호
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• pp.29-43
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• 2015

Objectives : This study was aimed to analyze the correlation between the Herbology and contemporary research results, KCD-codes.Methods : Papers were searched in OASIS and PubMed, then they were categorized. Medicine or pharmacy articles about Menthae Herba were matched with the Herbology treatment and KCD-codes. Other articles were analyzed by abstract of the papers. KCD-codes and terms were arranged by the Herbology treatment. The Degree of Herbology research (HDR) was calculated by numbers of papers, study method, citation rates.Results : There were 97 articles about Menthae Herba. Among these there were 47 medicine and pharmacy articles about Menthae Herba, and 15 articles were matched to the Herbology treatment. Studies about Headache and Wind-warmth was more active than others. Analysis of other articles showed that studies about contraceptive and anti-oxidative effect, plant growth, protective effect from insect, component extraction technics were active, too. In HDR, headache was scored by 136, Wind-warmth by 104, Eye hemorrhage by 51, Discomport in the throat by 50, Distention and fullness in the chest and hypochondrium by 15, Rubella and Measles by 0.Conclusions : 97 articles about Menthae Herba were analyzed and 15 articles were matched to the Herbology treatment. Studies about headache, wind-warmth, eye-hemorrhage were more active than others of the Herbology treatment. And studies about contraceptive and anti-oxidative effect, plant growth, protective effect from insect, component extraction technics could be a new subject of the Herbology.

• Journal of Korean Medicine Rehabilitation
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• 제27권3호
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• pp.47-60
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• 2017

Objectives The aim of this research is to assess the effects of bee venom acupuncture for knee osteoarthritis. Methods For a systematic review, we constructed a key question as the effect of bee venom acupuncture for knee osteoarthritis and selected RCTs and nRCTs. We searched the following 15 databases without a language restriction: Pubmed, EMBASE, Cochrane CENTRAL (CENTRAL), CINAHL, AMED, seven Korean medical databases (KoreaMed, Kmbase, KISS, NDSL, KISTI, Koreantk, OASIS) and three Chinese databases including CNKI, Wanfang and VIP database. Results A total of 300 potentially relevant studies were identified; only 13 studies were selected for systematic review. Almost studies showed that bee venom acupuncture has significant effect on knee osteoarthritis. 5 studies comparing bee venom acupuncture with acupuncture were included in the meta-analysis. The effect size of standardized mean difference (SMD) was analyzed as 'small effect' with 0.47 (95% CI: 0.10~0.83, Z=2.49, p=0.01). Conclusions The research showed that bee venom acupuncture can significantly reduce pain, stiffness and improve the quality of life of patients with knee osteoarthritis. However, most of the studies included in the analysis were evaluated as methodologically high risk of bias. This suggests that there is limitation applying this study. In the future, more Randomized Controlled trial should be actively conducted.

• The Journal of Internal Korean Medicine
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• 제42권4호
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• pp.672-686
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• 2021

Objectives: The purpose of this study is to assess the efficacy and safety of Baekhogainsam-tang for type 2 diabetes without complications by systemic review and meta-analysis of randomized controlled trials (RCTs). Methods: For a systematic review and meta-analysis, we set a key question in accordance with PICOT-SD. We searched the following up to March 31. 2021: PubMed, EMBASE, The Cochrane Library, CNKI, CiNii, KISS, KMBASE, OASIS, and ScienceON. A meta-analysis was conducted by synthesizing the results, including fasting plasma glucose level, postprandial 2-hour plasma glucose level, and Glycated Hemoglobin (HbA1c). Results: A total of five trials are included in this systemic review. The treatment group (Baekhogainsam-tang plus conventional treatment) showed more statistically significant effect than did the control group (conventional treatment only) in fasting plasma glucose level, postprandial 2-hour plasma glucose level, and glycated hemoglobin (HbA1c). Conclusions: Baekhogainsam-tang showed statistically significant effects in hypoglycemic effect and in improving insulin resistance. However, the number of studies included in the meta-analysis was insufficient, and the BIT used in the included studies was not standardized. This topic requires further attention and more clinical research.

• The Journal of Internal Korean Medicine
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• 제35권3호
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• pp.343-353
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• 2014

Objectives: To discuss the application of the acupuncture therapy for the HIV-associated distal sensory neuropathy. Methods: We searched papers using KTKP, Oasis, CNKI, PubMed, Science Direct, CINAHL, J-STAGE, and CiNii with the keywords "HIV", "Peripheral neuropathy" and "acupuncture". The search range included randomized controlled trials (RCTs) and clinical case series. Reviews and animal experiments were not included. Not matched with inclusion criteria were excluded. Results: A total 675 studies were found. 670 were excluded by scanning titles and abstracts and finally 5 articles were selected. One of the five articles noted that acupuncture was not effective in HIV-SN, but two articles reanalyzing the former, pointed out the statistical errors and noted acupuncture significantly reduced pain, attrition and mortality. Other RCT and the other case series concluded acupuncture had a beneficial effect in HIV-SN. Conclusions: Acupuncture seems to be effective to improve HIV-SN symptoms, however further large-scale RCTs are warranted.