• Journal of Radiation Protection and Research
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• v.39 no.1
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• pp.1-6
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• 2014

A whole body counter (WBC) is used in nuclear power plants (NPP) to identify and measure internal radioactivity of workers who is likely to ingest or inhale radionuclides. WBC has several counting geometry, i.e. the thyroid, lung, whole body and gastrointestinal tract, considered with the location where radionuclides are deposited in the body. But only whole body geometry is used to detect internal radioactivity during whole body counting at NPPs. It is overestimated internal exposure dose because this measured values are indicated as the most conservative radioactivity values among the them of others geometry. In this study, experiments to measure radioactivity depending on the counting geometry of WBC were carried out using a WBC, a phantom, and standard radiation sources in order to improve overestimated internal exposure dose. Quantitative criteria, could be selected counting geometry according to ratio of count rates of the upper and lower detectors of the WBC, are provided through statistical analysis method.

• BMB Reports
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• v.29 no.2
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• pp.175-179
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• 1996

Viral surface proteins are known to play an essential role in attachment of the virus particle to the host cell membrane. In case of the hepatitis B virus (HBV) several reports have described potential receptors on the target cell side, but no definite receptor protein has been isolated yet. As for the viral side, it has been suggested that the preS region of the envelope protein, especially the preS1 region, is involved in binding of HBV to the host cell. In this study, preS1 region was recombinantly expressed in the form of a maltose binding protein (MBP) fusion protein and used to identify and visualize the expression of putative HBV receptor(s) on the host cell. Using laser scanned confocal microscopy and by FACS analysis, MBP-preS1 proteins were shown to bind to the human hepatoma cell line HepG2 in a receptor-ligand specific manner. The binding kinetic of MBP-preS1 to its cellular receptor was shown to be temperature and time dependent. In cells permeabilized with Triton X-100 and treated with the fusion protein, a specific staining of the nuclear membrane could be observed. To determine the precise location of the receptor binding site within the preS1 region, several short overlapping peptides from this region were synthesized and used in a competition assay. In this way the receptor binding epitope in preS1 was revealed to be amino acid residues 27 to 51, which is in agreement with previous reports. These results confirm the significance of the preS1 region in virus attachment in general, and suggest an internalization pathway mediated by direct attachment of the viral particle to the target cell membrane.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2002.05a
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• pp.134-139
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• 2002

Fracture behaviors of pipes with local wall thinning are very important for the integrity of nuclear power plant. However, effects of local wall thinning on strength and fracture behaviors of piping system were not well studied. Acoustic emission(AE) has been widely used in various fields because of its extreme sensitivity, dynamic detection ability and location of growing defects. In this study, we investigated failure modes of locally wall thinned pipes and AE signals by bending test. From test results, we could be divided four types of failure modes of ovalization, crack initiation after ovalization, local buckling and crack initiation after local buckling. And fracture behaviors such as elastic region, yielding range, plastic deformation range and crack progress could be evaluated by AE counts, accumulative counts and time-frequency analysis during bending test. It is expected to be basic data that can protect a risk according to local wall thinning of pipes, as a real time test of AE.

• Journal of the Korean earth science society
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• v.31 no.7
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• pp.673-680
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• 2010

A steel pile often utilized to bear heavy loads of the upper sub-structure, e. g., bridge constructions and tall buildings. As the steel piles are driven in the underground, it is not easy to detect the depth of the existing pile foundation when there is no detailed foundation information available. However, accurate informations of the depths of piles becomes critical required when reinforcing the existing structures or constructing new ones at the adjacent stage to assure the safety of existing structures. In this study, we tested the applicability of the three components borehole fluxgate magnetometer for detecting the depths and locations of steel piles which are commonly used in civil engineering. Results showed that the information of location as well as the depth of steel piles could be obtained by using data from the three components borehole fluxgate magnetometer.

• KIISE Transactions on Computing Practices
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• v.22 no.3
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• pp.145-150
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• 2016

Finding the exact location of faults in a program requires enormous time and effort. Several fault localization methods based on control flows of a program have been studied for decades. Unfortunately, these methods are not applicable to programs based on data-flow languages. A recently proposed mutation-based fault localization method is applicable to data-flow languages, as well as control-flow languages. However, there are no studies on the effectiveness of the mutation-based fault localization method for data-flow based programs. In this paper, we provided an experimental case study to evaluate the effectiveness of mutation-based fault localization on programs implemented in Function Block Diagram (FBD), a widely used data-flow based language in safety-critical systems implementation. We analyzed several real faults in the implementation of FBD programs of a nuclear reactor protection system, and evaluated the mutation-based fault localization effectiveness for each fault.

• Progress in Medical Physics
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• v.28 no.4
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• pp.181-189
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• 2017

The conventional delivery quality assurance (DQA) process for RapidArc (Varian Medical Systems, Palo Alto, USA), has the limitation that it measures and analyzes the dose in a phantom material and cannot analyze the dosimetric changes under the motional organ condition. In this study, a DQA method was designed to overcome the limitations of the conventional DQA process for internal target volume (ITV) based RapidArc. The dynamic DQA measurement device was designed with a moving phantom that can simulate variable target motions. The dose distribution in the real volume of the target and organ-at-risk (OAR)s were reconstructed using 3DVH with the ArcCHECK (SunNuclear, Melbourne, USA) measurement data under the dynamic condition. A total of 10 ITV-based RapidArc plans for liver-cancer patients were analyzed with the designed dynamic DQA process. The average pass rate of gamma evaluation was $81.55{\pm}9.48%$ when the DQA dose was measured in the respiratory moving condition of the patient. Appropriate method was applied to correct the effect of moving phantom structures in the dose calculation, and DVH data of the real volume of target and OARs were created with the recalculated dose by the 3DVH program. We confirmed the valid dose coverage of a real target volume in the ITV-based RapidArc. The variable difference of the DVH of the OARs showed that dose variation can occur differently according to the location, shape, size and motion range of the target. The DQA process devised in this study can effectively evaluate the DVH of the real volume of the target and OARs in a respiratory moving condition in addition to the simple verification of the accuracy of the treatment machine. This can be helpful to predict the prognosis of treatment by the accurate dose analysis in the real target and OARs.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.38 no.1
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• pp.81-88
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• 2014

An experimental study is performed to obtain an average heat transfer coefficient around the perimeter of a near horizontal tube. For the test a stainless steel tube of 50.8 mm diameter submerged in water at atmospheric pressure is used. Both subcooled and saturated pool boiling conditions are considered and the inclination angle of the tube is changed from the horizontal position to $9^{\circ}$ in steps of $3^{\circ}$. In saturated water, the local boiling heat transfer coefficient at the azimuthal angle of $90^{\circ}$ from the tube bottom can be regarded as the average of the coefficients regardless of the tube inclination angles. However, when the water is subcooled the location for the average heat transfer coefficient depends on the inclination angle and the heat flux. It is explained that the major mechanisms changing the heat transfer are closely related with the intensity of the liquid agitation and the generation of big size bubbles through bubble coalescence.

• Journal of the Korean Society for Nondestructive Testing
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• v.16 no.1
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• pp.29-33
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• 1996

The eddy current test(ECT) probe of differential encircling coil type was designed and fabricated, and the optimum condition of ECT was derived for the examination of the irradiated fuel rod. The correlation between ECT test frequency and phase & amplitude was derived by performing the test of the standard rig that includes inner notches, outer notches and through-holes. The defect of through-hole was predicted by ECT at the G33-N2 fuel rod irradiated in the Kori-1 nuclear power reactor. The metallographic examination on the G33-N2 fuel rod was Performed at the defect location predicted by ECT. The result of metallographic examination for the G33-N2 fuel rod was in good agreement with that of ECT. This proves that the evaluation for integrity of irradiated fuel rod by ECT is reliable.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.2
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• pp.668-675
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• 2018

The continuing urbanization and industrialization around the world has required a large amount of power. Therefore, construction of major infrastructure, including nuclear power plants in coastal areas, has accelerated. In addition, the intensity of natural disasters is increasing due to global warming and abnormal climate phenomena. Natural disasters are difficult to predict in terms of occurrence, location, and scale, resulting in human casualties and property damage. For these reasons, the disaster scale and damage estimation in coastal areas have become important issues. The present study examined the predictable weather data and regional ratings and developed estimating functions for wind wave damage based on the disaster statistics in the southern areas. The results of the present study are expected to help disaster management in advance of the wind wave damage. The NRMSE was used for verification. The accuracy of the NRMSE results ranged from 1.61% to 21.73%.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7339-7344
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• 2013

To analyze the effects of a new unknown peptide DEF on the growth of tumor cells, a fused polypeptide TAT-DV1-DEF was designed and synthesized. The lung adenocarcinoma cell line GLC-82 treated with TAT-DV1-DEF was analyzed with a cell counting kit 8, and the location of polypeptides in cells was observed under laser confocal microscopy. The efficiency of polypeptide transfection and changes in nuclear morphology were analyzed by flow cytometry and fluorescence microscopy, respectively. Finally, the mechanism of tumor cell growth inhibition was evaluated by Western blotting. We found that TAT-DV1-DEF could significantly inhibit the growth of the lung adenocarcinoma cell line GLC-82, but not the normal human embryonic kidney cell line HEK-293. Polypeptides were found to be mostly localized in the cytoplasm and some mitochondria. The efficiency of polypeptide transfection in the two cell types was approximately 99%. Apoptotic nuclei were observed under fluorescence microscopy upon treatment with polypeptides and DAPI staining. Western blot analyses indicated that the polypeptide inhibition of tumor cell growth was apoptosis dependent. In the present study, we demonstrated that fused polypeptides could induce apoptosis of the lung adenocarcinoma cell line GLC-82, indicating that the new unknown peptide DEF has antitumor effects.