• Molecules and Cells
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• 제40권12호
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• pp.889-896
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• 2017

Nuclear bodies are subnuclear, spheroidal, and membraneless compartments that concentrate specific proteins and/or RNAs. They serve as sites of biogenesis, storage, and sequestration of specific RNAs, proteins, or ribonucleoprotein complexes. Recent studies reveal that a subset of nuclear bodies in various eukaryotic organisms is constructed using architectural long noncoding RNAs (arcRNAs). Here, we describe the unifying mechanistic principles of the construction and function of these bodies, especially focusing on liquid-liquid phase separation induced by architectural molecules that form multiple weakly adhesive interactions. We also discuss three possible advantages of using arcRNAs rather than architectural proteins to build the bodies: position-specificity, rapidity, and economy in sequestering nucleic acid-binding proteins. Moreover, we introduce two recently devised methods to discover novel arcRNA-constructed bodies; one that focuses on the RNase-sensitivity of these bodies, and another that focuses on "semi-extractability" of arcRNAs.

• Applied Microscopy
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• 제11권1호
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• pp.51-57
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• 1981

Autographa californica Nuclear Polyhedrosis Virus의 Nucleocapsids의 형성과 Polyhedra Occlusion Bodies의 형성을 Spodoptera frugiperda 세포에 감염된 후 3 일째 된 것을 관찰하였다. 1. A. californica NPV는 Spodoptera 세포의 핵내에서 분열복제되어 Nucleocapsid를 형성하여, 외투막을 얻은 후에 Polyhedra Occlusion Bodies 로 함입 되었다. 2. A. californica NPV가 감염된 세포의 핵은 팽창되어 핵막이 세포질까지 거의 신장되어 있었다. 3. Polyhedra Occlusion Bodies의 형성은 NPV로 감염된 세포에서 작은 엉성한 단백질 또는 Polypeptides가 점진적으로 커지면서 바이리스들이 함입되면서 더욱 덩치가 커지게 되고, 세포질내에 NPV 바이러스들이 없어지면 Polyhedra는 외부에 매끈한 막을 형성하는 것이 관찰되었다. 4. Polyhedra Occlusion Bodies의 형태는 바이러스 다발이 함입되어 있는 상태에 따라서 다양하였다. 5. Polyhedra 에 있는 바이러스 다발들은 외투막을 가지며 바이러스사이에도 기저물질이 존재하는 것을 볼 수 있었다.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2003년도 추계학술대회 및 총회
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• pp.24.1-24.1
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• 2003

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.346-351
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• 2005

The outlet feeder pipe thinning in a PHWR (Pressurized Heavy Water Reactor) is caused by high pressure steam flow inside the pipe, which is a well known degradation mechanism called FAC (Flow Assisted Corrosion). In order to monitor the degradation, the thickness of the outlet bends closed to the exit of the pressure tube should be measured and analyzed at every official overhaul. This paper develops a mobile feeder pipe inspection robot that can minimize the irradiation dose of human workers by automating the measurement process. The robot can move by itself on the feeder pipe by using an inch worm mechanism, which is constructed by two gripper bodies that can fix the robot body on the pipe, one extendable and contractable actuator, and a rotation actuator connected the two gripper bodies to move forward and backward, and to rotate in the circumferential direction

• International Journal of Control, Automation, and Systems
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• 제4권1호
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• pp.87-95
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• 2006

The outlet feeder pipe thinning in a PHWR (Pressurized Heavy Water Reactor) is caused by a high pressure steam flow inside the pipe, which is a well known degradation mechanism called a FAC (Flow Assisted Corrosion). In order to monitor the degradation, the thickness of the outlet bends close to the exit of the pressure tube should be measured and analyzed at every official overhaul. This paper describes a mobile feeder pipe inspection robot that can minimize the irradiation dose to human workers by automating the measurement process. The robot can move by itself on the feeder pipe by using an inch worm mechanism, which is constructed by two gripper bodies that can fix the robot body on to the pipe, one extendable and contractible actuator, and a rotation actuator connected to the two gripper bodies to move forward and backward, and to rotate in a circumferential direction.

• Applied Microscopy
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• 제5권1호
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• pp.21-30
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• 1975

To investigate ultrastructural characteristics of cancer cell nucleus, 29 cases of malignant tumors of 9 different types were examined. The common findings were marked irregularity of nuclear membrane with pronounced infoldings, clumping of heterochromatin along inner nuclear membrane, enlargement and disturbance of configuration and composition of nucleolus, and frequent observations of nuclear bodies and nuclear inclusions. These findings confirm what have been observed by light microscopy, and are also the signes that can be observed in hyperactive cells. Thus, ultrastructural characteristics of cancerous nucleus are the great variability of nuclear size, shape and composition, but none of them appear to be specific.

• Structural Engineering and Mechanics
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• 제18권3호
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• pp.343-362
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• 2004

Rocking response of rigid bodies with rectangular footprint, freely standing on horizontal rigid plane is studied analytically. Bodies are subjected to simulated single component of horizontal earthquakes. The effect of baseline correction, applied to simulated excitations, on the rocking response is first examined. The sensitiveness of rocking motion to the details of earthquakes and geometric properties of rigid bodies is investigated. Due to the demonstrated sensitivity of rocking response to these factors, prediction of rocking stability must be made in the framework of probability theory. Therefore, using a large number of simulated earthquakes, the effects of duration and shape of intensity function of simulated earthquakes on overturning probability of rigid bodies are studied. In the case when a rigid body is placed on any floor of a building, the corresponding probability is compared to that of a body placed on the ground. For this purpose, several shear frames are employed. Finally, the viability of the energy balance equation, which was introduced by Housner in 1963 and widely used by nuclear power industry to estimate the rocking stability of bodies, is evaluated. It is found that the equation is robust. Examples are also given to show how this equation can be used.

• 대한기계학회논문집A
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• 제40권5호
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• pp.469-481
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• 2016

본 논문에서는 강체 간 충돌에 의해 발생하는 충격력을 얻는 수학적 방법이 이론적으로 연구되었다. 이 이론적 방법은 사고로 지면에 추락낙하 하는 고준위폐기물 처분용기에 가해지는 충격력을 구하는 데에 적용되었다. 이 연구로부터 고준위폐기물 처분용기의 구조 안전성 설계에 요구되는 충격력이 이론적으로 유도되었다. 이론연구의 주된 내용은 두 강체의 충돌 시 강체운동학과 운동방정식에 관한 것이다. 이를 토대로 두 물체 간 충돌 시 발생하는 충격력을 구하는 일반적인 충격이론이 개발되었다. 이 충격이론을 처분장에서 처분용기 운송 시 운반차량에서 사고로 추락낙하 하여 지면과 충돌하는 처분용기에 발생하는 충격력을 구하는 문제에 적용하여 충격력에 대한 수학적 근사해를 이론적으로 구하였다. 동시에 컴퓨터코드를 이용한 수치해석을 수행하여 구한 수치해를 수학적 근사해와 비교하였다.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2004년도 추계학술대회 및 총회
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• pp.395.1-395.1
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• 2004

• 대한핵의학회지
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• 제37권1호
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• pp.13-23
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• 2003

Neurodegenerative disorders cause a variety of dementia including Alzheimer disease, frontotemporal dementia, dementia with Lewy bodies, corticobasal degeneration, progressive supranuclear palsy, and Huntington's disease. PET scan is useful for early detection and differential diagnosis of these dementing disorders. Also, it provides valuable information about clinico-anatomical correlation, allowing better understanding of function of brain. Here we discuss recent achievements PET studies regarding these dementing disorders. Future progress in PET technology, new tracers, and image analysis will play an important role in further clarifying the disease pathophysiology and brain functions.