• Ocean and Polar Research
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• 제29권2호
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• pp.87-99
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• 2007

This study was conducted to understand the source and behavior of organic matter using the fluorescent technique (excitation-emission matrix) as a part of environmental monitoring program in the Korea manganese nodule mining site in the Northeastern Pacific Ocean. Water samples were collected at $0^{\circ},\;6^{\circ}N$, and $10.5^{\circ}N$ along $131.5^{\circ}W$ in August 2005. The concentration of total organic carbon (TOC) ranged from 58.01 to $171.93\;{\mu}M-C$. The vertical distribution of TOC was characterized as higher in the surface layer and decreased with depth. At $6^{\circ}N$, depth-integrated (from surface to 200 m depth) TOC was $337.1\;gC/m^2$, which was 1.4 times higher value than other stations. The exponential decay curve fit of vertical profile of TOC indicated that 59% of organic carbon produced by primary production in the surface layer could be decomposed by bacteria in the water column. Dissolved organic matter is generally classified into two distinctive groups based on their fluorescence characteristics using three-dimensional excitation/emission (Ex/Em) fluorescence mapping technique. One is known as biomacromolecule (BM; protein-like substance; showing max. at Ex 280/Em 330), mainly originated from biological metabolism. The other is geomacromolecule (GM; humic-like substance; showing max. at Ex 330/Em 430), mainly originated from microbial degradation processes. The concentration of BM and GM was from 0.42 to 7.29 TU (tryptophan unit) and from 0.06 to 1.81 QSU (quinine sulfate unit), respectively. The vertical distribution of BM was similar to that of TOC as high in the surface and decreased with depth. However, the vertical distribution of GM showed the reverse pattern of that of BM. From these results, it appeared that BM occupied a major part of TOC and was rapidly consumed by bacteria in the surface layer. GM was mainly transformed from BM by microbial processes and was a dominant component of TOC in the deep-sea layer.

• 한국해양학회지:바다
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• 제24권1호
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• pp.79-91
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• 2019

동해 남서부 해역의 해양생태계에 큰 영향을 미치는 연안용승의 변화를 파악하기 위해 1948년 1월부터 2018년 9월까지의 NCEP/NCAR 재분석자료를 이용하여 용승지수를 계산하였다. 평균 용승지수는 4월부터 8월까지 용승이 발생하는 양의 값이 보이며 7월에 최대 값이 나타났다. 용승지수의 장기 변화는 6월과 7월에 통계적으로 유의미한 감소추세가 나타났으며, 5, 6, 7월 용승지수의 합도 통계적으로 유의미한 감소 경향을 보였다. 한반도 주변의 대기압 분석을 통하여 용승지수의 변화 추세는 동해남부해역을 기준으로 북서쪽 영역($35-50^{\circ}N$, $114-129^{\circ}E$)의 기압 변화 추세의 영향이라는 것을 밝혔다. 최근 7년간(2012년-2018년)의 용승지수 분석결과 2017년 7월에 용승지수가 표준편차의 3배 이상 높은 것을 발견하였다. 이것은 중국 북동쪽 지방에 평년과 다르게 저기압이 발달하였고 북태평양고기압이 일본과 대만 사이까지 영향을 주어 동해 남부에 큰 기압 차이가 발생했기 때문이었다. 반면에 평년에 비하여 북쪽의 저기압과 남쪽의 고기압의 영향이 적었던 2018년 7월은 용승지수가 음의 값이었다. 동해남부 연안용승지수는 기후변화에 따라 감소하는 경향을 보이고 경년변동이 커서 생태환경에 대한 영향을 파악하기 위해서는 지속적인 모니터링이 필요하다.

• 한국해양학회지
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• 제23권1호
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• pp.24-40
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• 1988

해양연구소는 1983년에 한국 망간 노듈개발지역으로 선정된 태평양 북동 척도대의 크라리온-크리퍼톤 균열대사이에서 망간 노듈시료, 코아퇴적물시료를 비롯하여 3.5kHz음파탐사, 에어-건 음파탐사 그리고 지자기탐사등을 설시하였다. 에어-건 음파탐사기록에 의하면, 이 지역에서의 퇴적층은 이 지역내의 DSDP 163 지역 시추결과와 대비될 수 있는 2 내지 3의 층단위로 나뉠수 있다. 최상부 층단위 (Unit I)는 음파특성상 투명하며 후 올리고세에서 중기 에오세까지의 지올라이트 크레이와 방산충 연니로 이루어져 있다. 층단위 IIA는 음파총리가 확연하지만 하부로 갈수록 투명해지고 퇴적물은 팔레오세부터 초기 에오세까지의 방산충 연니로 이루어져 있으며 처어트층과 지올라이트 크레이가 협재되어 있다. 층단위 IIB는 음파 기저면 (해양 현무암) 위에서 음파총리가 뚜렷하고 고화된 백악기의 프린트-처어트질 Nannofossil백악으로 이루어 져있다. 층 단위 I과 IIB는 Line Islands 층군을 이루고 층군 IIB는 명명되어 있지 않다. 전체의 퇴적층과 층단위 I은 Line Islands Ridge 근처를 제외하고는 북쪽으로 갈수록 점차 얇아지는데, 이는 신생대 동안 척도대 CCD의 변화와 태평양판이 북쪽으로 이동하였기 때문이다. 판이 퇴적율이 높은 적도대를 가로질러 이동하는 동안 판이 침강함에 따른 CCD의 변화는 DSDP 시추공 163 퇴적물의 성분이 퇴적시대에 따라 변하도록 하는 요인이 되었다. 후백 악기의 퇴적층(층단위 IIB)는 적도 남쪽 CCD상부 깊이에서 형성 되었고, 층단위 IIA는 팔레오신동안 태평양 판이 CCD 깊이보다 더 깊은 심도로 급격히 침강한 결과이며 단지 서경 149도 서쪽에서만 나타난다. 층단위 IIA와 I은 판이 에오신초기부터 각각 척도지역을 통과하는 동안 또는 통과후에 형성되었다. 한국 망간노듈 개발지의 남쪽에서는 층단위 I이 크리퍼톤 균열대에 의해 동쪽으로 흐르도록 조절되는 남극 저층수의 한 지류에 의해 재분포되어 있는데 이 저총수의 활동은 지질시대의 상당 기간(최소한 에오세중기부터) 동안 작용하였다. 또한 Hawaiian Ridge에서 크라리온 균열대에 이르는 약 350Km에 달하는 거리에 터어바다이트층이 나타나는데, 이 층은 Hawaiian Ridge에서 직접 발생한 저탁류에 의한 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2333-2336
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• 2013

Background: The aim of this paper was to present the incidence rates of leukemia and multiple myeloma (MM) in Golestan province located in northeastern Iran during 2004-2009. Materials and Methods: This was a descriptive cross-sectional study. Data on newly diagnosed (incident) leukemia and MM cases were obtained from collected from Golestan population-based cancer registry. Data was entered into CanReg-4 software. Age standardized incidence rates (ASR) (per 100000 person-years) for leukemia and MM were calculated. Data on Golestan population was obtained from the data of Iranian national census in 2006. Results: Totally, 11036 new cancer cases were registered in GPRC from 2004-2009. Leukemia and MM accounted for 693 and 124 of cases, respectively. The mean age in patients with leukemia and MM was 43.8 and 62.4 years, respectively. The ASRs for leukemia among men and women were 10.4 and 7.8, respectively (p<0.001). The ASRs for MM were 2.1 and 2 in men and women, respectively (p=0.93). The rate of leukemia was significantly higher in rural areas (p=0.02) whereas the incidence of MM was higher in urban areas (p<0.001). Conclusions: Our results showed a high incidence rate of leukemia in Golestan province of Iran. The incidence of leukemia was significantly higher in males and residents of rural areas. High exposure to pesticides and other agricultural related products may be a possible explanation for epidemiological pattern of leukemia in this area. Determining and controlling important risk factors, especially environmental factors, of leukemia may lead to decrease in its burden in Golestan province of Iran.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5489-5495
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• 2012

Cervical cancer is a serious public health problem in Thailand. We investigated possible risk factors for cervical cancer including HPV infection, p53 polymorphism, smoking and reproductive history among women in Northeast Thailand using a case control study with 177 cases and age-matched controls. Among the HPV carriers, a significantly increased risk for cervical cancer with an OR of 36.97(p<0.001) and an adjusted OR of 38.07(p<0.001) were observed. Early age at first sexual exposure, and multiple sexual partners increased the risk of cervical cancer with ORs ranging between 1.73-2.78(p<0.05). The interval between menarche and first sexual intercourse <6 years resulted in a significant increase in the risk for cervical cancer with ORs ranging between 3.32-4.09 and the respective adjusted OR range for the 4-5 and 2-3 year-old groups were 4.09 and 2.92. A higher risk was observed among subjects whose partner had smoking habits, whether currently or formerly; with respective ORs of 3.36(P<0.001) and 2.17(p<0.05); and respective adjusted ORs of 2.90(p<0.05) and 3.55(p<0.05). Other smoking characteristics of the partners including smoking duration ${\geq}20$ years, number of cigarettes smokes ${\geq}20$ pack-years and exposure time of the subject to passive smoking ${\geq}5$ hrs per day were found to be statistically significant risks for cervical cancer with adjusted ORs of 3.75, 4.04 and 11.8, respectively. Our data suggest that the risk of cervical cancer in Thai women is substantially associated with smoking characteristics of the partner(s), the interval between menarche and first sexual intercourse as well as some other aspects of sexual behavior.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.87-90
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• 2012

Cholangiocarcinoma (CCA) is the most common cancer in northeastern Thailand. At present, effective diagnosis of CCA either in humans or animals is not available. Monitoring the development and progression of CCA in animal models is essential for research and development of new promising chemotherapeutics. Ultrasonography has been widely used for screening of bile duct obstruction in CCA patients. In this study, we preliminarily investigated the applicability of ultrasonography to monitor the development and progression of CCA in Syrian golden hamsters (n=8) induced by Opisthorchis viverrini (OV)/dimethylnitrosamine (DMN) administration. Ultrasonography and histopathological examination of hamsters was performed at week 0, 20, 24 and 28 of OV infection or at the start of water/Tween-80 administration to controls. The ultrasonographic images of liver parenchyma and gallbladders of OV/DMN-induced CCA hamsters showed sediments in gallbladder, thickening of gallbladder wall, and hypoechogenicity of liver parenchyma cells. The ultrasonographic images of liver tissues were found to correlate well with histopathological examination. Although ultrasonography does not directly detect the occurrence of CCA, it reflects the thickening of bile ducts and abnormality of liver tissues. It may be applied as a reliable tool for monitoring the development and progression of CCA in animal models in research and development of new promising chemotherapeutics for CCA.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2439-2443
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• 2016

Purpose: To determine the risk factors, clinical symptoms and patterns of spread in laryngeal cancer. Materials and Methods: A cross sectional study was carried out in the Regional Cancer Centre, Imphal, Manipur, India. One hundred and sixteen patients with laryngeal cancer were retrospectively reviewed for epidemiological data and descriptive statistics were reported for various variables. Results: Median age at presentation was 65 years and 32.8% were undernourished at presentation. The male to female ratio was 5.4:1. Heavy smoking and tobacco chewing was associated in 91.4% and 33.6% of patients respectively. Tracheostomy was required in 21.5% leading to diagnosis of laryngeal cancer. Almost all were squamous cell carcinoma with neuroendocrine and verrucous carcinoma accounting for less than 2%. Supraglottic, glottic and trans-glottic tumors were 56.9%, 36.3% and 6.9% respectively. Nodal metastases were seen in 81.8% of supraglottic cancers and 31.6% of glottic cancers with supraglottic involvement. Level II neck nodes were the commonest site followed by level III. Distant metastases (only liver) were apparent in 1.7% at presentation. Including these liver metastases, unresectable cases were limited to 6% of the patients. Conclusions: Tobacco use is implicated in almost all of the cases and the sex ratio has also decreased due to increased female smokers. The supraglottis remains the commonest site and incidence of nodal metastases is higher than in other countries. There is also a higher requirement for tracheostomy at presentation in this region.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.767-770
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• 2016

Background: The proportion of aged Thais (${\geq}65$ years old) is expected to be 30% by 2030, leading to an increased number of elderly cancer cases. Older individuals have distinct patterns of cancer and treatment needs. We therefore conducted the present study of new cancer cases and trends to get a perspective on the elderly cancer situation in Northeast Thailand. Materials and Methods: All new elderly cancer cases (${\geq}65$ years) registered in the hospital-based cancer registry at the Faculty of Medicine, Srinagarind Hospital, Khon Kaen University during 1993-2012 were included in the study. Results: Elderly patients accounted for 31.6% of all cancer patients and new cancer cases in the older age group increased 46% from the first to second decades. The absolute number of oldest old (80+ years) doubled. The top three cancers in males were liver and bile duct, lung, and colorectal. In females, the three most common cancers were liver and bile duct, oral cavity, and cervix. Cancers with the highest percentages of increase were thyroid, prostate, and colorectal. Conclusions: Elderly cancer cases are increasing. Treatment modalities and palliative care for older populations are urgently needed.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10367-10374
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• 2015

Background: Cancer and non-communicable diseases are a major issue not only for the developed but also developing countries. Public health and primary care nursing offer great potential for primary and secondary prevention of these diseases through community and family-based approaches. Within Thailand there are related established educational curricula but less is known about how graduate practitioners enact ideas in practice and how these can influence policy at local levels. Aim: The aim of this inquiry was to develop family nursing practice in primary care settings in the Isaan region or Northeastern Thailand and to distill what worked well into a nursing model to guide practice. Materials and Methods: An appreciative inquiry approach involving analysis of written reports, focus group discussions and individual interviews was used to synthesize what worked well for fourteen family nurses involved in primary care delivery and to build the related model. Results: Three main strategies were seen to offer a basis for optimal care delivery, namely: enacting a participatory action approach mobilizing families' social capital; using family nursing process; and implementing action strategies within communities. These were distilled into a new conceptual model. Conclusions: The model has some features in common with related community partnership models and the World Health Organization Europe Family Health Nurse model, but highlights practical strategies for family nursing enactment. The model offers a basis not only for planning and implementing family care to help prevent cancer and other diseases but also for education of nurses and health care providers working in communities. This articulation of what works in this culture also offers possible transference to different contexts internationally, with related potential to inform health and social care policies, and international development of care models.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2785-2791
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• 2014

Aims: To analyze time-dependent changes in female breast cancer (BC) mortality in China, forecast the trend in the ensuing 5 years, and provide recommendations for prevention and management. Materials and Methods: Mortality data of breast cancer in China from 1991 to 2011 was used to describe characteristics and distribution, such as the changes of the standardized mortality rate, urban-rural differences and age differences. Trend-surface analysis was used to study the geographical distribution of mortality. In addition, curve estimation, time series modeling, Gray modeling (GM) and joinpoint regression were performed to estimate and predict future trends. Results: In China, the mortality rate of breast cancer has increased yearly since 1991. In addition, our data predicted that the trend will continue to increase in the ensuing 5 years. Rates in urban areas are higher than those in rural areas. Over the past decade, all peak ages for death by breast cancer have been delayed, with the first death peak occurring at 55 to 65 years of age in urban and rural areas. Geographical analysis indicated that mortality rates increased from Southwest to Northeast and from West to East. Conclusions: The standardized mortality rate of breast cancer in China is rising and the upward trend is predicted to continue for the next 5 years. Since this can cause an enormous health impact in China, much better prevention and management of breast cancer is needed. Consequently, disease control centers in China should place more focus on the northeastern, eastern and southeastern parts of China for breast cancer prevention and management, and the key population should be among women between ages 55 to 65, especially those in urban communities.