• Journal of the Korean Institute of Telematics and Electronics A
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• v.32A no.9
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• pp.1184-1201
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• 1995

Two multiple access protocols are proposed for a multichannel WDM optical fibre local area network or metropolitan area network in which users are interconnected using a passive star topology. Each user has a single tunable transmitter and a single tunable receiver. A transmitter sends a control packet before its data packet transmission so that its intended receivers can tune to the proper data channel wavelength. The maximum throughput of the proposed protocols are independent of the effective normalized propagation delay which may include the transmitter and receiver tuning times and the processing delays. The maximum throughputs of the protocols are analyzed and compared with those of the existing ones by numerical examples. The message delay of the R- Aloha/synchronous N-server switch protocol which is suitable for the queued users is also analyzed.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.2 no.4
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• pp.209-221
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• 2008

In this paper, we propose a subcarrier allocation method and a composite linear minimum mean square error (LMMSE) channel estimator to increase spectrum efficiency in orthogonal frequency division multiplexing (OFDM) transmit diversity. The pilot symbols for OFDM transmit (Alamouti) diversity are exclusively allocated in two OFDM symbols in different antennas, which causes serious degradation of spectrum efficiency. To reduce the number of pilot symbols, our subcarrier allocation method uses repetition-coded data symbols, and the proposed channel estimator maintains good bit error rate (BER) performance.

• Journal of Korean Neurosurgical Society
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• v.67 no.5
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• pp.510-520
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• 2024

Objective : Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases, characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The treatment of PD aims to alleviate motor symptoms by replacing the reduced endogenous dopamine. Currently, there are no disease-modifying agents for the treatment of PD. Zebrafish (Danio rerio) have emerged as an effective tool for new drug discovery and screening in the age of translational research. The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is known to cause a similar loss of dopaminergic neurons in the human midbrain, with corresponding Parkinsonian symptoms. L-type calcium channels (LTCCs) have been implicated in the generation of mitochondrial oxidative stress, which underlies the pathogenesis of PD. Therefore, we investigated the neuro-restorative effect of LTCC inhibition in an MPTP-induced zebrafish PD model and suggested a possible drug candidate that might modify the progression of PD. Methods : All experiments were conducted using a line of transgenic zebrafish, Tg(dat:EGFP), in which green fluorescent protein (GFP) is expressed in dopaminergic neurons. The experimental groups were exposed to 500 μmol MPTP from 1 to 3 days post fertilization (dpf). The drug candidates : levodopa 1 mmol, nifedipine 10 μmol, nimodipine 3.5 μmol, diethylstilbestrol 0.3 μmol, luteolin 100 μmol, and calcitriol 0.25 μmol were exposed from 3 to 5 dpf. Locomotor activity was assessed by automated tracking and dopaminergic neurons were visualized in vivo by confocal microscopy. Results : Levodopa, nimodipine, diethylstilbestrol, and calcitriol had significant positive effects on the restoration of motor behavior, which was damaged by MPTP. Nimodipine and calcitriol have significant positive effects on the restoration of dopaminergic neurons, which were reduced by MPTP. Through locomotor analysis and dopaminergic neuron quantification, we identified the neuro-restorative effects of nimodipine and calcitriol in zebrafish MPTP-induced PD model. Conclusion : The present study identified the neuro-restorative effects of nimodipine and calcitriol in an MPTP-induced zebrafish model of PD. They restored dopaminergic neurons which were damaged due to the effects of MPTP and normalized the locomotor activity. LTCCs have potential pathological roles in neurodevelopmental and neurodegenerative disorders. Zebrafish are highly amenable to high-throughput drug screening and might, therefore, be a useful tool to work towards the identification of disease-modifying treatment for PD. Further studies including zebrafish genetic models to elucidate the mechanism of action of the disease-modifying candidate by investigating Ca2+ influx and mitochondrial function in dopaminergic neurons, are needed to reveal the pathogenesis of PD and develop disease-modifying treatments for PD.