• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2319-2324
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• 2012

Aim: To investigate the expression of three components of the Hedgehog (Hh) signaling pathway (SHH, SMO and GLI1) in human colorectal cancer (CRC) tissues and evaluate their association with clinicopathologic characteristics of the patients. Methods: Fresh tumor tissues and matched tissues adjacent to the tumor were collected from 43 CRC patients undergoing surgery. Normal colorectal tissues from 20 non-CRC cases were also sampled as normal controls. The expression of SHH, SMO, GLI1 mRNAs was assessed by RT-PCR and proteins were detected by immunohistochemical staining. Associations with clinicopathological characteristics of patients were analyzed. Results: SHH mRNA was expressed more frequently in tumor tissues than in normal tissues, but the difference did not reach significance in comparison to that in the adjacent tissues. SMO and GLI1 mRNAs were expressed more frequently in tumor tissues than in both adjacent andnormal tissues. The expression intensities of SHH, SMO, GLI1 mRNA in tumor tissues were significantly higher than those in adjacent tissues and normal tissues. Proteins were also detected more frequently in tumors than other tissues. No significant links were apparent with gender, age, location, degree of infiltration or Dukes stage. Conclusion: Positive rates and intensities of mRNA and protein expression of Hh signaling pathway related genes SHH, SMO, GLI1 were found to be significantly increased in CRC tissues. However, over-expression did not appear to be associated with particular clinicopathological characteristics.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.17 no.2
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• pp.11-17
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• 2011

Background: To evaluate the influences of Eye movement program applied to elderly people on static balance. Methods: The subjects consisted of fourteen elderly people. The subjects were divided into two group. The control group (n=7) received no exercise and/or stimulation. The Eye movement program training (E/P) group (n=7) performed balance training using word card and batom. E/P group were accomplished during 4weeks (5 day/week, 60 min/day). All tests were completed before and after experiment. The static balance ability was measured by normal standing when eye open and close on good balance system, respectively. For each case, the experimental data were obtained in 3 item; mean X speed, mean Y speed and velocity moment. Results: The result of this study were as follows: 1. In E/P group, the statistically significants were shown on only mean Y speed in the case of normal standing when eye open (p<.05), but the statistically significants were not shown on mean X, Y speed and velocity moment in the case of normal standing when eye close (p>.05). 2. In control group, the statistically significants were not shown on all posture (p>.05). 3. There was a statistically significant difference on the mean Y speed and velocity moment in the case of normal standing when eye open between control group and E/P group (p<.05). Conclusions: The above results revealed that balance training using Eye movement program were partly effective for improving the static balance ability.

• Journal of the Korean Society of Food Culture
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• v.17 no.3
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• pp.275-288
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• 2002

The purpose of this study was to investigate the cognitive differences among the aged who have different living conditions. 91 free-meal receivers and 86 people with stable lives were asked about their living conditions and cognitive function by using K-MMSE. All data were analyzed by SPSS 10.0 package. Free meal receivers had poorer socioeconomic status than the subjects who had stable lives. Cognitive function of free meal receivers was lower than the people with stable lives in the most cognitive factors. Especially age of 50 to 64, pre-aged group, who had been receiving free meals, showed lowest cognitive level than the other age groups. Among 7 cognitive factors, there was the greatest difference in attention and calculation between 2 groups. Percentage of 'conclusive dementia' among the free meal receivers was statistically higher than the people with stable lives and that of 'conclusively normal' was statistically lower in free meal receivers comparing with the people with stable lives. Moreover, socioeconomic factors like income, former job, marital status, housing and education, blood pressure and physical activity were significantly related to the subject's cognitive function.

• The Journal of Korean Academic Society of Nursing Education
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• v.20 no.2
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• pp.321-331
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• 2014

Purpose: The purpose of this study was to investigate the effects of case management service for hypertensive elderly patients through the customized visiting home health care program. Method: Non-equivalent control group pretest-posttest design was employed. Data were collected from April 2007 to January 2009. Among a total of fifty subjects, 25 subjects were belonged to the case management group and the others were belonged to the general management group. Results: 1) In experimental group, significant increasing rate of number of people within normal blood pressure by time, but no significant increasing rate of number of people within normal blood neutral fat, total cholesterol, HDL, & LDL. 2) In experimental group, the score of knowledge about disease and healthy life practice were increased on 8 week period but decreased on follow up period. Number of people within normal blood HDL and mean score of healthy life practice were significantly higher than control group on follow up period. Conclusion: Case management service was effective on controlling blood pressure but partly effective on blood lipid, knowledge about disease, and healthy life practice in hypertensive patients. Further study is needed to conduct a periodic re-evaluation of the effect of case management and to verify an optimal interval to provide the case management service.

• Journal of Korean Academy of Nursing
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• v.29 no.3
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• pp.688-699
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• 1999

This study was to find out the perceptions of toward death and caring behavior of lay persons in one community : One Island in Puan County, Chonbuk. The methodology of this study was ethnography. For this study, the fieldwork was conducted from October 1997 to July 1998. Data collected by in-depth interview and participant observations. The participants consisted fo were 17 persons of both sexes. The key informants were four specific people. The result of this study is as follows ; The people perceived two different kinds of death. Normal death, which means death from old age. The person was respected as an ancestor God and was believed to exist forever with their offspring. Abnormal death was regarded as negative, many had fears toward this kind of death. The causes of abnormal death were supernatural phenomena and had absolute holy meanings. Whether death was good or bad, the death was not personal, but collective events as family or community affairs and was interpreted as death and birth for their offsprings. Funeral rites were family-centered and/or com munity-centered. They did normal procedures for normal deaths for abnormal deaths, there were many protective ceremonies(BuJungMagi : the prevention of the taboo of uncleanliness) for the remaining people. These ceremonies combined confucism and shamanism. Caring behavior for dying persons was ruled as community-centered, reciprocal and reality-centered principles.

• Phonetics and Speech Sciences
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• v.10 no.2
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• pp.69-76
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• 2018

The elderly are at increased risk of developing dysphagia due to aging and illnesses. The aim of the current study was to analyze, via an acoustic study, the change in the voice quality of normal elderly people after a 3oz water-swallow test. Subjects included a group of 60 normal elderly people (age: $mean{\pm}SD=76.9{\pm}6.66$) and 60 healthy young adults (age: $mean{\pm}SD=25.1{\pm}2.36$). Every participant produced a five-second /a/ phonation pre- and post-swallowing, and the fractioned two-second sections were analyzed using the MDVP (multi dimensional voice program) analysis. The elderly group demonstrated a post-swallowing increase in the following related acoustic parameters: fundamental frequency, fundamental frequency variation, amplitude-variation, and noise in both two-second sections. However, the younger group showed an increase only in frequency related acoustic parameters (i.e., STD ) in the first two-second section. The significant changes in values in the post-swallowing parameters might indicate temporary irregularities in pitch and amplitude along with higher amounts of noise in the voice. The results could be attributed to water residues in the vocal fold and vocal tract, as well as a deterioration of the motor and sensory functions caused by anatomical and physiological changes that result from aging.

• Biomedical Science Letters
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• v.14 no.2
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• pp.123-126
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• 2008

Long QT Syndrome (LQT) is a congenital disease due to the failure of electrical system of the heart. We have analyzed KCNE1 gene which is known to be the cause of Type V LQT in Korean genome. Although SNPs of KCNE1 have been reported for Chinese and Malaysians no data are available for Korean people yet. PCR primers were prepared to investigate the sequences for normal and SNP at G30A, G112A, C162T. They were different only by 3' ends. Genomic DNAs were extracted from the people who were known to be normal clinically (35) or patients (20) with metabolic disease. As results, we were able to recognize several SNPs in these Korean samples. Some people were homozygous or heterozygous depending upon the type of SNP. This study should facilitate the research on the cause of Type VLQTs and to develop the further therapy at genetic level.

• Journal of Korean Physical Therapy Science
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• v.5 no.4
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• pp.845-850
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• 1998

The purpose of those study is to estimate grip and hand activity of RA patients and find that the evaluation is very a valuable to the RA patients. The term of the evaluation was from June 25. 1998.. to July 30. 1998 and researched at Hanyang university Rheumatic Hospital. This study researched 100 normal people and 85 RA patients and analyzed the results and averaged those with t-test by Excel data. The results of those study are as follows. 1. The highest percent of those results of the dynamometer, pinch research was the people who are on 40s. 2. The results of all RA patients marked lower than those of normal people. 3. It's difficult to do hard work such as washing, opening can, transferring boxes to the patients. 4. The above research is effective to RA patients.

• Journal of Institute of Control, Robotics and Systems
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• v.20 no.6
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• pp.663-668
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• 2014

This paper presents a hook-type finger force measuring system with force sensors. The system is composed of a body, two three-axis force sensors, a hook, and so on. The two three-axis force sensors system was specially designed using FEM(Finite Element Method) and fabricated using strain-gages. The sensors measure the finger forces of both normal people and handicapped people in the system, and the forces are combined. The developed hook-type finger force measuring system can measure the pulling finger force of both normal and handicapped people. The pulling force tests of men and women were performed using the developed the system. It is thought that the developed system can be used to measure the pulling force of fingers.

• Speech Sciences
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• v.10 no.4
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• pp.189-200
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• 2003

The objective of this study was to examine two new parameters by which we could screen people with malignant vocal folds. The new parameters were the difference sums and Pearson correlation coefficients between adjacent pairs of intensity level matrices of narrow-band spectra. Audio files from the Korean Disordered Speech Database were analyzed by Praat, a speech analysis software, to obtain matrices of 400 intensity levels at 16 time points of each sustained vowel spectra. We limited our study to 12 normal subjects and 20 patients with malignant vocal folds who recorded at least three Korean vowels at a sound-proofed booth in Busan National University Hospital. Results indicated that the average coefficients of the abnormal subjects were much lower than those of the normal subjects while the average difference sums of the patients were much higher than those of the normal ones. Also, we found that the degree of the malignancy of the vocal folds was related to the coefficients and sums. However, some subjects at the initial stages of cancerous vocal folds yielded almost comparable coefficients and difference sums to those of the normal speakers. Further studies on larger databases will be desirable to set certain criteria or threshold levels for screening people with vocal fold diseases.