• The Journal of Korean Academy of Prosthodontics
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• v.32 no.1
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• pp.103-119
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• 1994

The purpose of this study was to evaluate the mandibular movements of TMD patients comparing to normal persons. Sirognathograph was used to measure five parameters of mandibular movements of twenty normal persons and eight TMD patients. Five parameters were (1) Maximum opening during maximum opening and closing, (2) Mean velocity during maximum opening and closing, (3) Maximum opening during unilateral chewing, (4) Mean velocity during unilateral chewing, (5) Consistency of mandibular movement during unilateral chewing. Based on above results, new Mandibular Movement Index(M.M.I.) was formulated and compared to Helkimo's Clinical Dysfunction Index by measuring two indices before treatment and 2 weeks, 4 weeks, 6 weeks, 8 weeks after treatment. The conclusions were as follows: 1, The amounts of maximum opening and mean velocity during maximum opening and closing of TMD patients were less than those of normal persons(p<0.01). 2. The amounts of maximum opening and mean velocity during unilateral chewing of TMD patients were less than those of normal persons(p<0.05) (P<0.01). 3. Although TMD patients showed limited mandibular movements during unilateral chewing, the consistency of mandibular movements was better than that of normal persons(p<0.05). 4. Both mandibular movement index and Helkimo's Clinical Dysfunction Index, were useful in diagnosing TMD patients.

• Speech Sciences
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• v.10 no.4
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• pp.189-200
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• 2003

The objective of this study was to examine two new parameters by which we could screen people with malignant vocal folds. The new parameters were the difference sums and Pearson correlation coefficients between adjacent pairs of intensity level matrices of narrow-band spectra. Audio files from the Korean Disordered Speech Database were analyzed by Praat, a speech analysis software, to obtain matrices of 400 intensity levels at 16 time points of each sustained vowel spectra. We limited our study to 12 normal subjects and 20 patients with malignant vocal folds who recorded at least three Korean vowels at a sound-proofed booth in Busan National University Hospital. Results indicated that the average coefficients of the abnormal subjects were much lower than those of the normal subjects while the average difference sums of the patients were much higher than those of the normal ones. Also, we found that the degree of the malignancy of the vocal folds was related to the coefficients and sums. However, some subjects at the initial stages of cancerous vocal folds yielded almost comparable coefficients and difference sums to those of the normal speakers. Further studies on larger databases will be desirable to set certain criteria or threshold levels for screening people with vocal fold diseases.

• Phonetics and Speech Sciences
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• v.2 no.4
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• pp.229-238
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• 2010

This study investigates the differences in acoustic parameters in vowel space across hearing loss, gender and vowels. The parameters include F1, F2, Euclidean Distance between vowels, and vowel triangular area comprised of /i/, /a/ and /u/. For this study, 20 hearing-impaired and normal hearing adults as a control group were asked to read 7 Korean vowels (/a, $\wedge$, o, u, w, i, $\varepsilon$/). Subjects' readings were recorded by NasalView and analyzed by Praat. Results showed that F1 were significantly higher in the hearing impaired group than in the normal hearing group, higher in the female group than in male group, and higher in low vowels than in high vowels. And the means of F2 was significantly higher in the hearing impaired group than in normal hearing group, higher in high vowels than in low vowels, and there was no difference between male and female group. Secondly, Euclidean distance between vowels was significantly shorter in the hearing-impaired group than in the normal group. Finally, acoustic vowel space area was significantly smaller in the hearing-impaired group than in the normal hearing group. The hearing-impaired group showed that front vowels tended to be backed and back vowels to be fronted.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.5 no.1
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• pp.38-43
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• 1994

Though normal vocal cords show regular vibration, pathologic vocal cords show irregularity between peaks. Jitter means fluctuation in the time interval between peaks, and Shimmer means cycle to cycle variation in the amplitude of the peaks. We investigated the vocal vibration of Korean normal persons objectively. The fundamental frequency, Jitter, Shimmer and SNR(signal to noise ratio) of normal persons were compared with that of vocal Polyp Patients with CSpeech Program for the possibility of distinguishing the pathologic vocal vibration from normal. The results were as follows ; Comparing the fundamental frequency of vocal Polyp Patients with normal persons, great change was noted only in female cases. But the Jitter and Shimmer of vocal polyp patients were greater than normal significantly in both male and female cases. SNR was lower than normal in vocal polyp patients. In the conclusion, fundamental frequency, Jitter, Shimmer and SNR might be meaningful parameters distinguisuing pathologic vibration from normal.

• Journal of Nutrition and Health
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• v.39 no.8
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• pp.721-727
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• 2006

This study was conducted to investigate the effects of Aralia elata, Acanthopanacis cortex and Ulmus davidiana water extracts on blood hemoglobin, $HbA_{1c}$, levels and biomarkers in the streptozotocin (STZ)-induced diabetic rats. Male Wistar rats divided into normal and diabetic groups. The diabetic groups subdivided into the control group (DM) and Araliaceae water extracts supplemented groups: Aralia elata (AE), Acanthopanacis cortex (AC) and Ulmus davidiana (UD). The extracts were supplemented in diet base on 11.42 g of raw Araliaceae/kg diet for 7 weeks. The diabetes was induced by injecting 572 (55 mg/kg B.W., i.p.) once 2 weeks before sacrifying. Relative weights of liver were significantly lowered in the DM group compared to the normal group, whereas those of kidney and heart were significantly increased in the DM group. Supplementation of the Araliaceae water extracts improved reduced liver weights in STZ-induced diabetic rats. Blood glucose level was significantly higher in the DM group than in the normal group, whereas insulin contents were significantly lowered in the DM groups. However, these parameters were normalized in the An, AC and UD supplemented groups, respectively. Blood hemoglobin and $HbA_{1c}$ levels were significantly higher in the DM group than in the normal group. When all of Araliaceae water extracts were supplemented to the diabetic rats lowered hemoglobin and $HbA_{1c}$ levels. Red blood cell, white blood cell and Lymphocyte were significantly higher in the DM group than in the normal group. The supplementation of Araliaceae family water extracts significantly lowered these parameters compared to the DM group. MCV, MCH contents were declined in the DM group, while the supplementation of Aralia elata, Acanthopanacis cortex and Ulmus davidiana water extracts elevated of these contents in STZ-induced diabetic rats. Accordingly, these results indicate that Aralia elata, Aeanthopanacis corex and Ulmus davidiana water extracts would seem to improve the blood biomarkers in STZ-induced diabetic rats.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.12 no.2
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• pp.140-144
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• 2001

Backgrounds & Objectives : Prolonged hearing loss was considered as one of the factors which have the potential to cause vocal changes. However, the analysis of quality of phonation in hearing loss patients has not been achieved enough. The purpose of the study was to evaluate the difference in objective acoustic parameters between long-term hearing impaired patients and normal control group. Material & Methods : The material of this investigation comprised a group of 20 patients (M : F=10 : 10) with moderate or profound hearing loss(over 50dB). The duration of all hearing loss was over 1 year. All of them underwent the acoustic examinations comprising electroglottography, multidimensional voice program and formant analysis during phonation of the bowels /a/ with free confortable tone and /i/ with voluntary high tone. The results of the acoustic examinations were compared with those of a control group, composed of 20 sex- and age-matched normal hearing subjects. Results : In the male hearing loss subjects, the significant increase was detected in pitch and shimmer during phonation of /a/ and in pitch during phonation of /i/. In addition, this group was characterized by decreased fundamental frequency during phonation of /i/. In female, there was no difference between hearing loss group and normal control group except a decreased formant 1 frequency. Conclusion : Long-term moderate and profound sensorineural hearing loss could affect the objective voice parameters.

• Applied Biological Chemistry
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• v.51 no.4
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• pp.294-298
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• 2008

Effects of endosulfan (EN), an insecticide, and bleomycin (BL), an antibiotic, on the body weight in the normal mice, and the in vivo cell growth, tumor weight, and hematological parameters of the Ehrlich ascites carcinoma (EAC) cell-bearing Swiss albino mice Mus musculus were evaluated. EN and BL were respectively administered orally and intraperitoneally to the experimental mice; the control group consisted of EAC cell-bearing untreated mice only. EN reduced the body weight in normal mice, whereas BL resulted in a steady body weight compared to the control. EN increased the EAC cell count significantly by reducing the growth of normal viable cells. In contrast, BL reduced the cell count by increasing the proportion of viable cells in the body. The tumor weights induced by EN were significantly higher than those of the EAC control and the BL-treated animals. In comparisons with the control and the BL mice, hematological parameters such as hemoglobin (%) and the number of RBC and lymphocytes were lowered, while counts of WBC, neutrophils, and monocytes were elevated after EN treatments. These results show that BL is capable of reducing the EN-induced neoplastic and haematological alterations in the mice under laboratory conditions.

• Phonetics and Speech Sciences
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• v.10 no.2
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• pp.69-76
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• 2018

The elderly are at increased risk of developing dysphagia due to aging and illnesses. The aim of the current study was to analyze, via an acoustic study, the change in the voice quality of normal elderly people after a 3oz water-swallow test. Subjects included a group of 60 normal elderly people (age: $mean{\pm}SD=76.9{\pm}6.66$) and 60 healthy young adults (age: $mean{\pm}SD=25.1{\pm}2.36$). Every participant produced a five-second /a/ phonation pre- and post-swallowing, and the fractioned two-second sections were analyzed using the MDVP (multi dimensional voice program) analysis. The elderly group demonstrated a post-swallowing increase in the following related acoustic parameters: fundamental frequency, fundamental frequency variation, amplitude-variation, and noise in both two-second sections. However, the younger group showed an increase only in frequency related acoustic parameters (i.e., STD ) in the first two-second section. The significant changes in values in the post-swallowing parameters might indicate temporary irregularities in pitch and amplitude along with higher amounts of noise in the voice. The results could be attributed to water residues in the vocal fold and vocal tract, as well as a deterioration of the motor and sensory functions caused by anatomical and physiological changes that result from aging.

• Preventive Nutrition and Food Science
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• v.12 no.1
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• pp.23-28
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• 2007

The purpose of this study was to investigate the relationships of obesity, serum antioxidant mineral concentrations and blood lipid parameters in middle school students. Subjects were assigned to two groups, obese (BMI$\geq$25, 32 boys, 24 girls) and normal group (18.5

• Journal of the Korea Academia-Industrial cooperation Society
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• v.7 no.6
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• pp.1116-1121
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• 2006

We studied on some techniques which are able to discriminate the difference between normal and infarcted myocardium by consecutive image analysis in B-mode echocardiogram. In order to analyze two-dimensional echocardiogram, we presented inter-frame and intra-frame analysis method throughout the complete heart cycle in closed-chest human and proposed new analysis parameters which are named HGE and LT. The analysis technique using the proposed parameters revealed quantitatively dominant features between normal and infarcted regions. The infarcted areas yield regions of higher intensity throughout the entire cardiac cycle, but normal tissue demonstrates greater variability throughout the entire cardiac cycle. Hence, we could verify that these parameters varying over the entire cardiac cycle are good indicators for the state of myocardium.