• Archives of Pharmacal Research
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• 제27권7호
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• pp.806-810
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• 2004

Metformin is a biguanide antihyperglycemic agent often used for the treatment of non-insulin dependent diabetics (NIDDM). In this study, the pharmacokinetics and pharmacodynamics of metformin were investigated in Korean healthy volunteers during a fasting state for over 10 h. In order to evaluate the amount of glucose-lowering effect of metformin, the plasma concentrations of glucose were measured for a period of 10 h followed by the administration of metformin (oral 500 mg) or placebo. In addition, the concentration of metformin in blood samples was determined by HPLC assay for the drug. All volunteers were consumed with 12 g of white sugar 10 minutes after drug intake to maintain initial plasma glucose concentration. The time courses of the plasma concentration of metformin and the glucose-lowering effect were analyzed by nonlinear regression analysis. The estimated $C_{max}$, $T_{max}$, $CL_{t}$/F (apparent clearance), V/F(apparent volume of distribution), and half-life of metformin were 1.42$\{pm}$0.07 $\mu\textrm{g}$/mL, 2.59$\{pm}$0.18h, 66.12$\{pm}$4.6 L/h, 26.63 L, and 1.54 h respectively. Since a significant counterclock-wise hysteresis was found for the metformin concentration in the plasma-effect relationship, indirect response model was used to evaluate pharmacodynamic parameters for metformin. The mean concentration at half-maximum inhibition $IC_{50}$, $k_{in}$, $k_{out}$ were 2.26 $\mu\textrm{g}$/mL, 83.26 $H^{-1}$, and 0.68 $H^{-1}$, respectively. Therefore, the pharmacokinetic-pharmacodynamic model may be useful in the description for the relationship between plasma concentration of metformin and its glucose-lowering effect.

• Smart Structures and Systems
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• 제19권1호
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• pp.21-31
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• 2017

To control the stochastic vibration of a vibration-sensitive instrument supported on a beam, the beam is designed as a sandwich structure with magneto-rheological visco-elastomer (MRVE) core. The MRVE has dynamic properties such as stiffness and damping adjustable by applied magnetic fields. To achieve better vibration control effectiveness, the optimal bounded parametric control for the MRVE sandwich beam with supported mass under stochastic and deterministic support motion excitations is proposed, and the stochastic and shock vibration suppression capability of the optimally controlled beam with multi-mode coupling is studied. The dynamic behavior of MRVE core is described by the visco-elastic Kelvin-Voigt model with a controllable parameter dependent on applied magnetic fields, and the parameter is considered as an active bounded control. The partial differential equations for horizontal and vertical coupling motions of the sandwich beam are obtained and converted into the multi-mode coupling vibration equations with the bounded nonlinear parametric control according to the Galerkin method. The vibration equations and corresponding performance index construct the optimal bounded parametric control problem. Then the dynamical programming equation for the control problem is derived based on the dynamical programming principle. The optimal bounded parametric control law is obtained by solving the programming equation with the bounded control constraint. The controlled vibration responses of the MRVE sandwich beam under stochastic and shock excitations are obtained by substituting the optimal bounded control into the vibration equations and solving them. The further remarkable vibration suppression capability of the optimal bounded control compared with the passive control and the influence of the control parameters on the stochastic vibration suppression effectiveness are illustrated with numerical results. The proposed optimal bounded parametric control strategy is applicable to smart visco-elastic composite structures under deterministic and stochastic excitations for improving vibration control effectiveness.

• 한국해양공학회지
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• 제33권3호
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• pp.214-221
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• 2019

A series of model tests was performed to evaluate the survivability of an articulated tower-type buoy structure under harsh environmental conditions. The buoy structure consisted of three long pipes, a buoyancy module, and top equipment. The scale model was made of acrylic pipe and plastic with a scale ratio of 1/22. The experiments were carried out at the ocean engineering basin of KRISO. The performance of the buoy structure was investigated under waves only and under combined environmental conditions from sea state (SS) 5 to 7. A nonlinear time-domain numerical simulation was conducted using the mooring analysis program OrcaFlex. The survivability of the buoy was analyzed based on three factors: the pitch motion, submergence of the top structure, and anchor reaction force. The model test results were directly compared to the results of numerical simulations. The effects of the sea state and combined environment on the performance of the buoy structure were investigated.

• Smart Structures and Systems
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• 제23권5호
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• pp.449-466
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• 2019

Cable-stayed bridges are attractive due to their beauty, reducing material consumption, less harm to the environment and so on, in comparison with other kinds of bridges. As a massive structure with long period and low damping (0.3 to 2%) under many dynamic loads, these bridges are susceptible to fatigue, serviceability disorder, damage or even collapse. Tuned Mass Damper (TMD) is a suitable controlling system to reduce the vibrations and prevent the threats in such bridges. In this paper, Multi Tuned Mass Damper (MTMD) system is added to the Ahvaz cable stayed Bridge in Iran, to reduce its seismic vibrations. First, the bridge is modeled in SAP2000 followed with result verification. Dead and live loads and the moving loads have been assigned to the bridge. Then the finite element model is developed in OpenSees, with the goal of running a nonlinear time-history analysis. Three far-field and three near-field earthquake records are imposed to the model after scaling to the PGA of 0.25 g, 0.4 g, 0.55 g and 0.7 g. Two MTMD systems, passive and active, with the number of TMDs from 1 to 8, are placed in specific points of the main span of bridge, adding a total mass ratio of 1 to 10% to the bridge. The parameters of the TMDs are optimized using Genetic Algorithm (GA). Also, the optimum force for active control is achieved by Fuzzy Logic Control (FLC). The results showed that the maximum displacement of the center of the bridge main span reduced 33% and 48% respectively by adding passive and active MTMD systems. The RMS of displacement reduced 37% and 47%, the velocity 36% and 42% and also the base shear in pylons, 27% and 47%, respectively by adding passive and active systems, in the best cases.

• Steel and Composite Structures
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• 제43권2호
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• pp.165-183
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• 2022

Most transportation departments have recognized and developed procedures to address the ever-increasing weights of trucks traveling on bridges in a service today. Transportation agencies also recognize the issues with overheight vehicles' collisions with bridges, but few stakeholders have definitive countermeasures. Bridges are becoming more vulnerable to collisions from overheight vehicles. The exact response under lateral impact force is difficult to predict. In this paper, nonlinear impact analysis shows that the degree of deformation recorded through the modeling of the unprotected vehicle-girder model provides realistic results compared to the observation from the US-61 bridge overheight vehicle impact. The predicted displacements are 0.229 m, 0.161 m, and 0.271 m in the girder bottom flange (lateral), bottom flange (vertical), and web (lateral) deformations, respectively, due to a truck traveling at 112.65 km/h. With such large deformations, the integrity of an impacted bridge becomes jeopardized, which in most cases requires closing the bridge for safety reasons and a need for rehabilitation. We proposed different sacrificial cushion systems to dissipate the energy of an overheight vehicle impact. The goal was to design and tune a suitable energy absorbing system that can protect the bridge and possibly reduce stresses in the overheight vehicle, minimizing the consequences of an impact. A material representing a Sorbothane high impact rubber was chosen and modeled in ANSYS. Out of three sacrificial schemes, a sandwich system is the best in protecting both the bridge and the overheight vehicle. The mitigation system reduced the lateral deflection in the bottom flange by 89%. The system decreased the stresses in the bridge girder and the top portion of the vehicle by 82% and 25%, respectively. The results reveal the capability of the proposed sacrificial system as an effective mitigation system.

• 한국지반공학회논문집
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• 제23권3호
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• pp.141-147
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• 2007

말뚝의 동적 응답 해석을 위한 다양한 방법들이 개발되어 있으며, 이 중에서 비선형 스프링, p-y 곡선을 이용하여 지반-말뚝 상호작용을 고려하는 방법이 널리 사용되고 있다. 그러나, 현재 사용되는 동적 p-y 곡선은 정적 또는 주기 하중에 의한 횡방향 재하 시험에 의해 개발되었다. 또한, p-y 곡선에 scaling factor를 도입하여 액상화에 의한 지반-말뚝 상호작용의 영향을 모사하고자 하는 시도가 이루어져 왔으나, 지금까지 정확한 scaling factor를 산정하지 못하고 있는 실정이다. 이에 본 연구에서는 Ig 진동대 실험으로부터 구한 말뚝 주변 지반의 과잉간극수압과 지반-말뚝 시스템의 고유진동수 관계 및 수치해석으로부터 구한 말뚝 주변 지반의 탄성계수의 변화와 지반-말뚝 시스템의 고유진동수 관계로부터, 말뚝 주변 지반의 탄성계수의 변화로 표현되는 p-y 곡선의 scaling factor를 구하였다. 그 결과, scaling factor는 과잉간극수압비에 따른 지수 함수의 형태로 나타났다.

• Earthquakes and Structures
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• 제22권5호
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• pp.503-515
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• 2022

This paper presents the development of seismic fragility curves for a precast reinforced concrete bridge instrumented with a structural health monitoring (SHM) system. The bridge is located near an active seismic fault in the Dominican Republic (DR) and provides the only access to several local communities in the aftermath of a potential damaging earthquake; moreover, the sample bridge was designed with outdated building codes and uses structural detailing not adequate for structures in seismic regions. The bridge was instrumented with an SHM system to extract information about its state of structural integrity and estimate its seismic performance. The data obtained from the SHM system is integrated with structural models to develop a set of fragility curves to be used as a quantitative measure of the expected damage; the fragility curves provide an estimate of the probability that the structure will exceed different damage limit states as a function of an earthquake intensity measure. To obtain the fragility curves a digital twin of the bridge is developed combining a computational finite element model and the information extracted from the SHM system. The digital twin is used as a response prediction tool that minimizes modeling uncertainty, significantly improving the predicting capability of the model and the accuracy of the fragility curves. The digital twin was used to perform a nonlinear incremental dynamic analysis (IDA) with selected ground motions that are consistent with the seismic fault and site characteristics. The fragility curves show that for the maximum expected acceleration (with a 2% probability of exceedance in 50 years) the structure has a 62% probability of undergoing extensive damage. This is the first study presenting fragility curves for civil infrastructure in the DR and the proposed methodology can be extended to other structures to support disaster mitigation and post-disaster decision-making strategies.

• Structural Engineering and Mechanics
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• 제87권2호
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• pp.151-164
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• 2023

The latest earthquake's costly repairs and economic disruption were brought on by excessive residual drift. Self-centering systems are one of the most efficient ways in the current generation of seismic resistance system to get rid of and reduce residual drift. The mechanics and behavior of the self-centering system in response to seismic forces were impacted by a number of important factors. The amount of post-tensioning (PT) force, which is often employed for the standing posture after an earthquake, is the first important component. The energy dissipater element is another one that has a significant impact on how the self-centering system behaves. Using the damper as a replaceable and affordable tool and fuse in self-centering frames has been recommended to boost energy absorption and dampening of structural systems during earthquakes. In this research, the self-centering steel moment frame connections are equipped with cushion flexural dampers (CFDs) as an energy dissipator system to increase energy absorption, post-yielding stiffness, and ease replacement after an earthquake. Also, it has been carefully considered how to reduce permanent deformations in the self-centering steel moment frames exposed to seismic loads while maintaining adequate stiffness, strength, and ductility. After confirming the FE model's findings with an earlier experimental PT connection, the behavior of the self-centering connection using CFD has been surveyed in this study. The FE modeling takes into account strands preloading as well as geometric and material nonlinearities. In addition to contact and sliding phenomena, gap opening and closing actions are included in the models. According to the findings, self-centering moment-resisting frames (SF-MRF) combined with CFD enhance post-yielding stiffness and energy absorption with the least amount of permeant deformation in a certain CFD thickness. The obtained findings demonstrate that the effective energy dissipation ratio (β), is increased to 0.25% while also lowering the residual drift to less than 0.5%. Also, this enhancement in the self-centering connection with CFD's seismic performance was attained with a respectable moment capacity to beam plastic moment capacity ratio.

• 한국도로학회논문집
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• 제9권1호
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• pp.1-15
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• 2007

본 연구에서는 시험도로 계측 자료와 유한요소해석 기법을 사용한 구조해석 결과를 비교하여 포장 전반에 걸친 거동을 분석할 수 있는 기반을 마련하는데 목적이 있다. 시험도로와 같이 다양한 하중 재하시험을 통하여 얻은 계측 결과와 유한요소 해석 결과를 비교하여 타당성을 입증할 경우, 향후 포장의 구조해석 및 설계 과정에서 유한요소해석 기법의 다양한 응용이 가능하다. 본 연구에서는 슬래브, 린, 보조기층, 길어깨, 다웰 및 타이바가 모두 포함된 3차원 콘크리트 해석 모형을 개발하여 동일 조건의 시험도로 계측값과 비교분석을 실시하였다. 또한, 다양한 온도 조건에서 구조해석을 수행하여 컬링에 의한 슬래브 거동을 파악하였다. 콘크리트포장에서 얻어진 변형률계의 계측 결과들과 유한요소해석에서 얻어진 예측 변형률사이의 오차를 줄이기 위하여 분석 방식은 실제 상황과 유사하게 모사하도록 구현하였으며, 가능하면 변수들을 실제 상황과 일치하도록 변화시켰다. 온도 변화 등 여러 가지 상황을 현장과 동일하게 만든 결과, 유한요소해석에서 예측한 값들이 현장에서 얻은 계측값에 유사하게 접근하는 것을 확인할 수 있었다. 그러나 린층에서는 해석값이 다소 과다하게 발생하여 추가 연구가 필요할 것으로 판단된다. 또한 실제 컬링을 모사한 구조해석 결과 계측값과 거의 동일하게 나타났으며 영구컬링의 존재도 확인할 수 있었다.

• 한국강구조학회 논문집
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• 제9권4호통권33호
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• pp.659-672
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• 1997

합성 박스형 교량의 비선형 온도분포로부터 유발되는 열응답(thermal response)은 여러 변수들의 영향을 받는다( 기상조건, 재료상수, 교량의 위치 및 방향, 단면형상 등). 본 논문에서는 계절, 교량의 위치 및 방향, 단면형상 그리고 몇 가지 재료특성치의 변화가 합성 박스형 교량의 축변형 곡률 및 응력에 미치는 영향 파악을 위해 매개변수해석을 수행하였으며, 이 해석을 수행하기 위한 2차원 시간 종속적 유한요소모델에 대해 간략히 언급하였다. 먼저, 매개변수들이 하루동안의 곡률 변화에 미치는 영향에 대해 고려하고, 최대 곡률을 나타내는 시간의 합성 박스형 단면의 은도 및 응력분포에 미치는 영향에 대해 고려하였다. 최종적으로, 이 매개변수들의 변화가 온도에의한 축변형, 곡률 및 응력의 일최대값에 미치는 영향에 대해 고려하였다. 온도에의한 영향은 경우에따라서는 사하중이나 활하중이 구조물에 주는 영향만큼 클 수 있고 또한 강합성교의 설계시 바닥판 콘크리트 슬래브와 강재들보와의 온도차를 $10^{\circ}C$로 가정하고, 동시에 온도의 분포가 콘크리트 슬래브단면과 강재들보단면에서 일정하다고 가정하고 구한 온도응력은 실제 온도하중의 영향을 과소평가할 수 있다.