• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.6967-6972
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• 2015

Background: Cigarette smoking and tobacco chewing are common modes of consuming tobacco all over the world. Parents need to be aware that germ cell integrity is vital for birth of healthy offspring as biological parenting begins much before birth of a child and even before conception. The present study was conducted to determine the etiology of non-familial sporadic heritable retinoblastoma (NFSHRb), by evaluating oxidative sperm DNA damage in fathers due to use of tobacco (smoking and chewing). Materials and Methods: We recruited 145 fathers of NFSHRb children and 53 fathers of healthy children (controls) in the study. Tobacco history was obtained by personal interview. Seminal reactive oxygen species (ROS) in semen, sperm DNA fragmentation index (DFI) and 8 hydroxy 2' deoxyguanosine (8-OHdG) levels in sperm were evaluated. The RB1 gene was screened in genomic blood DNA of parents of children with NFSHRb and controls. Odds ratios (ORs) derived from conditional logistic regression models. Results: There was significant difference in the levels of ROS (p<0.05), DFI (p<0.05) and 8-OHdG (p<0.05) between tobacco users and non-users. The OR of NFSHRb for smokers was 7.29 (95%CI 2.9-34.5, p<0.01), for tobacco chewers 4.75 (2.07-10.9, p<0.05) and for both 9.11 (3.79-39.2; p<0.01). Conclusions: This study emphasizes the adverse effect of tobacco on the paternal genome and how accumulation of oxidative damage in sperm DNA may contribute to the etiology of NFSHRb. In an ongoing parallel study in our laboratory, 11 of fathers who smoked underwent. Meditation and yoga interventions, showed significant decline in levels of highly mutagenic oxidised DNA adducts after 6 months. Thus our lifestyle and social habits impact sperm DNA integrity and simple interventions like yoga and meditation are therapeutic for oxidative damage to sperm DNA.

• 한국환경농학회지
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• 제19권2호
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• pp.147-153
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• 2000

흡연은 직접 또는 environmental tobacco smoke를 통하여 많은 위해성 물질을 인체에 유입시킨다. 이러한 위해 물질중 니코틴을 인체내의 대사에 따라서 암을 유발시키는 물질로 전이되기도 한다. 니코틴의 대사산물로 대표적인 발암물질인 nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK)가 있다. 많은 연구는 녹차의 추출물이 암을 예방하는데 탁월한 효능이 있음을 보고하고 있다. 그러나, 녹차의 암예방 효과에 대한 기작은 거의 알려져 있지 않다. 최근의 보고는 니코틴의 주요대사 산물인 코니틴이 안정한 물질임과 동시에 NNK의 활성 및 형성을 억제하는 것으로 알려져 있다. 본 연구는 세포내의 니코틴의 대사에 있어, 코티닌으로의 전이도에 녹차의 추출물이 미치는 영향에 대하여 연구하였다. 녹차의 추출물은 시험관에서 직접 혼합한 경우와 세포주를 이용한 실험에서, 니코틴이 코티닌으로 전이하는 데 긍정적 영향을 주었다. 이 결과는 녹차의 성분 중에 니코틴의 여러 대사경로중에서 코티닌의 대사를 촉진하는 물질이 함유되어 있음을 의미한다. 이 결과는 아울러, 녹차의 암 예방의 가능성에 대하여 설명할 수 있는 기전을 제시한다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.111-116
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• 2013

Background: Cigarette smoking is the major risk factor for development of lung cancer. Identification of effects of tobacco on airway gene expression may provide insight into the causes. This research aimed to compare gene expression of large airway epithelium cells in normal smokers (n=13) and non-smokers (n=9) in order to find genes which discriminate the two groups and assess cigarette smoking effects on large airway epithelium cells.Materials and Methods: Genes discriminating smokers from non-smokers were identified by applying a neural network clustering method, growing self-organizing maps (GSOM), to microarray data according to class discrimination scores. An index was computed based on differentiation between each mean of gene expression in the two groups. This clustering approach provided the possibility of comparing thousands of genes simultaneously. Results: The applied approach compared the mean of 7,129 genes in smokers and non-smokers simultaneously and classified the genes of large airway epithelium cells which had differently expressed in smokers comparing with non-smokers. Seven genes were identified which had the highest different expression in smokers compared with the non-smokers group: NQO1, H19, ALDH3A1, AKR1C1, ABHD2, GPX2 and ADH7. Most (NQO1, ALDH3A1, AKR1C1, H19 and GPX2) are known to be clinically notable in lung cancer studies. Furthermore, statistical discriminate analysis showed that these genes could classify samples in smokers and non-smokers correctly with 100% accuracy. With the performed GSOM map, other nodes with high average discriminate scores included genes with alterations strongly related to the lung cancer such as AKR1C3, CYP1B1, UCHL1 and AKR1B10. Conclusions: This clustering by comparing expression of thousands of genes at the same time revealed alteration in normal smokers. Most of the identified genes were strongly relevant to lung cancer in the existing literature. The genes may be utilized to identify smokers with increased risk for lung cancer. A large sample study is now recommended to determine relations between the genes ABHD2 and ADH7 and smoking.

• 한국산학기술학회논문지
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• 제19권3호
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• pp.346-352
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• 2018

본 연구는 대학생들의 수면의 질에 영향을 미치는 흡연행태를 파악하여 대학생 및 20대 청년층을 대상으로 한 국가 흡연예방 및 금연 정책의 기초자료로 사용되고자 한다. 2017년 5월 29일에서 2017년 6월 2일까지 5일간 대학생 291명을 대상으로 흡연행태와 PSQI(Pittsburgh Sleep Quality Index) 설문지를 통해 수면의 질을 측정하였다. 다중 로지스틱 회귀분석을 Step-wise로 시행한 결과 학년이 증가할수록 OR=2.542-2.820배 수면의 질이 악화되었고, 비흡연자와 금연자에 비해 1갑 미만 흡연할 경우 OR=3.126배, 1갑 이상 흡연을 할 경우 OR=12.388배로 수면의 질이 악화되었다. 또한 일반담배 흡연자 중 수면의 질이 좋지 않은 대학생은 72.4%이나 전자담배 또는 가향담배 흡연자는 수면의 질이 좋지 않은 대학생이 82.6%로 일반담배보다 전자담배 또는 가향담배가 수면의 질을 더 악화시켰다. 수면의 질을 개선하기 위해서는 금연이 필수적이나 금연이 쉽지는 않으므로 국가차원에서 법적인 규제와 정책을 운영할 필요가 있고, 단계적 집중 금연관리를 해줄 수 있는 시스템 또는 서비스가 필요하다.

• Journal of Preventive Medicine and Public Health
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• 제52권6호
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• pp.427-432
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• 2019

Objectives: In Indonesia, 61 million adults smoked in 2018, and 59 million were exposed to secondhand smoke at offices or restaurants in 2011. The Presidential Decree 109/2012 encouraged local governments to implement a smoke-free policy (SFP), and the city of Jayapura enacted a local bill (1/2015) to that effect in 2015. This study aimed to evaluate compliance with this bill and to explore challenges in implementing it. Methods: We conducted a mixed-methods study. Quantitatively, we assessed compliance of facilities with 6 criteria (per the bill): the presence of signage, the lack of smoking activity, the lack of sale of tobacco, the lack of tobacco advertisements, the lack of cigarette smoke, and the lack of ashtrays. We surveyed 192 facilities, including health facilities, educational facilities, places of worship, government offices, and indoor and outdoor public facilities. Qualitatively, we explored challenges in implementation by interviewing 19 informants (government officers, students, and community members). Results: The rate of compliance with all 6 criteria was 17% overall, ranging from 0% at outdoor public facilities to 50% at health facilities. Spatial patterning was absent, as shown by similar compliance rates for SFP facilities within a 1-km boundary around the provincial and city health offices compared to those outside the boundary. Implementation challenges included (1) a limited budget for enforcement, (2) a lack of support from local non-governmental organizations and universities, (3) a lack of public awareness at the facilities themselves, and (4) a lack of examples set by local leaders. Conclusions: Overall compliance was low in Jayapura due to many challenges. This information provides lessons regarding tobacco control policy in underdeveloped areas far from the central government.

• 대한두개안면성형외과학회지
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• 제25권2호
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• pp.51-61
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• 2024

Background: The influence of smoking on nonsyndromic clefts has been a topic of research for many years. However, few studies have investigated the effect of smoking on causing clefts in different gene pools. Methods: A meta-analysis was conducted of case-control studies related to smoking. Keywords such as "clefts," "cleft lip," "cleft palate," "orofacial cleft," and "smoking" were used to search the MEDLINE, Embase, and Cochrane databases. Results: In total, 51 articles were reviewed. The RevMan software was utilized for the analysis, and the Mantel-Haenszel method was employed to pool the odds ratios (ORs) and 95% confidence intervals. Although the overall OR, a measure of the association between exposure and outcome, was higher for smokers than for non-smokers, this association was significantly stronger in individuals from Asia and South America (1.73), and lowest in Europe (1.31). Among active and passive smokers in Asia, the OR was approximately 0.93, indicating an equivalent impact from both types of smoking. Conclusion: This analysis indirectly suggests that restriction measures targeting both active and passive smoking are crucial in Asia.

• 한국산학기술학회논문지
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• 제19권12호
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• pp.451-461
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• 2018

본 연구에서는 2015년 담배가격 인상정책 전후 청소년 흡연율 변화, 금연시도율 변화 등에 대해 살펴보고자 하였다. 이에 본 연구는 총 800개교의 중학생 및 고등학생을 대상으로 조사를 실시한 제9차(2013년), 제10차(2014년), 제11차(2015년) 청소년건강행태온라인 조사 원시자료를 이용하여 청소년들의 일반적 특성, 정신건강 및 주관적 학업성적, 음주 및 흡연관련 특성에 따른 담배가격 인상 전후 흡연율 변화 및 금연시도율, 금연시도이유 중 '담배값이 너무 비싸서' 선택률, 흡연량 변화를 분석하였다. 본 연구에서 전체 청소년의 현재 흡연율은 2013년 9.7%에서 2014년 9.2%로 감소하는 모습을 보였고, 담배가격 인상 후인 2015년 흡연율은 7.8%로 전년대비 15.2% 감소율을 보여 담배가격 인상 전보다 큰 폭으로 감소한 것으로 나타났다. 이러한 결과들을 통해 담배가격 인상정책이 청소년 흡연율을 감소시키는데 매우 효과적일 뿐만 아니라 금연동기 및 흡연 예방에도 매우 효과적이라는 것을 확인할 수 있었다. 청소년기 흡연자의 대다수가 성인기 흡연자로 이어진다는 점에서 청소년기의 흡연 예방 및 금연 유도는 매우 중요하다. 향후 흡연실을 허용하지 않는 완전 금연구역의 확대와 담배 광고, 판촉, 후원에 대한 포괄적 금지는 시급히 추진되어야 하며 이미 근거를 바탕으로 작성된 WHO FCTC의 각조약을 충실히 이행할때 금연효과를 극대화 할 수 있을 것이라 사료된다.

• 한국작물학회지
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• 제41권2호
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• pp.200-206
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• 1996

답전전환지 잎담배 수확엽의 적정숙도 판단기준 확립을 위한 기본자료로 이용하기 위하여 수확기를 달리하였을 때의 성숙정도별 엽중 이화학성 변화와 밭담배와의 성분함량 차이를 조사 분석한 결과는 다음과 같다. 1. 엽장과 엽폭의 수축률은 착엽위치에 관계없이 과숙>미숙>적숙>완숙엽 순으로 높았고 논담배 완숙엽은 밭 완숙엽에 비하여 수축률이 상대적으로 높았다. 2. 엽중 내용성분에서 니코틴과 전실소는 성숙이 진전될수록 낮았으나 환원당 함량은 반대로 나타났고 동일숙도의 논, 밭담배 간에는 밭담배가 높았다. 3. 건조엽의 부풀성은 성숙이 진전될수록 낮았고, 논, 밭담배 간에는 차이가 없었으며, 부스러짐성은 미숙>과숙>적숙>완숙엽 순으로 높아 조기 및 만기수확으로 부스러짐성은 증가하였다. 4. 궐련의 화학성분에서 끽연시의 유해인자로 작용하는 CO, TPM, tar성분등이 논담배가 밭담배에 비하여 다소 높았고 연소성도 상대적으로 불량하였다. 5. 비택발성 유기산 함량에서 oxalic, succinic acid 함량은 성숙이 진전될수록 낮아지고, malonic acid는 높아지나 malic, citric acid는 일정한 경향이 없었으며, 논담배는 밭담배에 비해 oxalic, malonic acid 함량에서 다소 낮았다. 6. 지방산 함량은 성숙정도간 차이는 적었고, 성분간에는 linolenic>palmitic>oleic>lnoleic>stearic acid 함량순이었으며, 논, 밭담배 간에도 거의 대등한 함량을 보여 토양조건이나 성숙정도간 반응차는 적었다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.775-780
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• 2013

Background: In the year 2010, it is estimated that nearly 0.36 million new cases and 0.19 million deaths with Non-Hodgkin lymphoma occurred. In India, among males, NHL incidence rates vary across the country which has encouraged us to conduct a case-control study to study risk factors. Materials and Methods: The present unmatched hospital-based case-control study conducted at Tata Memorial Hospital included subjects registered between the years 1997-99. There were 390 'lymphoma cases' and 1,383 'normal controls. Results: Data on age, tobacco habits, occupational history, dietary factors, tea, coffee were collected by the social investigators. Univariate and multivariate methods were applied for obtaining the odds ratios for risk factors. Conclusions: In the study, cigarette smoking (OR=2.0) and bidi smoking (OR=2.8), were associated with excess risk of lymphoma. Among the dietary items, only consumption of mutton showed 7.3-fold significant excess risk for lymphoma. Consumption of milk showed a 6-fold excess risk (OR=1.5); while coffee showed a 50% reduction in risk for lymphoma. Among occupational exposure, exposure to use of pesticides showed 3-fold excess risk for lymphoma.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3533-3540
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• 2016

Background: Cigarette smoking is one of the leading global causes of premature and preventable death. In Brunei Darussalam, smoking-related diseases have been a primary cause of mortality for the past three decades. Despite the increasing efforts that have been made in recent years to reduce the consumption of tobacco products in Brunei, the prevalence of adolescent smoking cigarette, however has risen alarmingly, from 8.9% in 2013 to 11.4% in 2014, with a higher prevalence found in males (17.8%) than in females (4.8%). In response to the need for more effective smoking prevention programmes in Brunei, this study sought to explore factors that influence Bruneian male adolescents to start and continue smoking. Materials and Methods: A qualitative study using focus group discussions (FGDs) as the data collection method was conducted from October to November 2015. A total of 43 studentss, comprising 31 smokers and 12 non-smokers, aged 13-17 years, from two government secondary schools in Bandar Seri Begawan, participated in six FGDs. Discussions were recorded and translated. Transcripts were entered into NVivo10, before thematic analysis was conducted. Results: We identified three themes under the core construct of 'factors influencing smoking initiation' ('family as teachers', 'overt pressure from peers' and 'perceived smoking has many advantages') and three themes under the core construct of 'factors influencing smoking continuation' ('craving and addiction', 'smoking as a 'social activity' and 'easy accessibility of cigarettes'). Conclusions: Based on the findings, it is recommended that future prevention activities should be embedded in a comprehensive approach, involving all stakeholders within a community, and should be focused towards bringing a change in smoking and parenting behavior of parents, social norms within the culture towards all population levels, and at strengthening the existing non-smoking policies in schools and other public places where young people congregate.