• Environmental Analysis Health and Toxicology
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• 제30권sup호
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• pp.7.1-7.10
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• 2015

Objectives For successful adoption of legislation controlling registration and assessment of chemical substances, it is important to obtain sufficient toxicological experimental evidence and other related information. It is also essential to obtain a sufficient number of predicted risk and toxicity results. Particularly, methods used in predicting toxicities of chemical substances during acquisition of required data, ultimately become an economic method for future dealings with new substances. Although the need for such methods is gradually increasing, the-required information about reliability and applicability range has not been systematically provided. Methods There are various representative environmental and human toxicity models based on quantitative structure-activity relationships (QSAR). Here, we secured the 10 representative QSAR-based prediction models and its information that can make predictions about substances that are expected to be regulated. We used models that predict and confirm usability of the information expected to be collected and submitted according to the legislation. After collecting and evaluating each predictive model and relevant data, we prepared methods quantifying the scientific validity and reliability, which are essential conditions for using predictive models. Results We calculated predicted values for the models. Furthermore, we deduced and compared adequacies of the models using the Alternative non-testing method assessed for Registration, Evaluation, Authorization, and Restriction of Chemicals Substances scoring system, and deduced the applicability domains for each model. Additionally, we calculated and compared inclusion rates of substances expected to be regulated, to confirm the applicability. Conclusions We evaluated and compared the data, adequacy, and applicability of our selected QSAR-based toxicity prediction models, and included them in a database. Based on this data, we aimed to construct a system that can be used with predicted toxicity results. Furthermore, by presenting the suitability of individual predicted results, we aimed to provide a foundation that could be used in actual assessments and regulations.

• 한국지반공학회논문집
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• 제22권12호
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• pp.15-24
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• 2006

공학적 물성치로서의 저변형율에서의 전단탄성계수의 결정은 다양한 토목분야에서 매우 중요하다. 이러한 지반의 전단 파탄성계수 주상도는 비파괴 탄성파 실험을 통하여 결정될 수 있다. 비파괴 탄성파 실험은 대상지반의 분산곡선을 결정하고, 결정된 분산곡선에 대한 역산을 수행하여 대상지반의 전단파탄성계수 주상도를 결정한다. 이러한 비파괴 탄성파 실험은 결정되는 분산곡선의 종류에 따라 크게 두가지로 구분할 수 있다. 첫번째는 겉보기 속도 분산곡선을 사용하는 방법과, 두번째는 모드 분산곡선을 사용하는 방법이다. 모드 분산곡선을 결정, 역산에 사용하는 방법의 경우, 계산 시간의 감소와 역산의 모호성을 감소시킬 수 있다. 모드 분산곡선을 결정하기 위해서는 다수의 감지기를 사용하는 다채널 표면파 실험을 통해서만 가능하다. 이러한 다수 감지기의 필요성은 현장에서의 실제 적용에 있어 실용성을 떨어뜨릴 수 있다. 본 논문에서는 HWAW방법을 표면파 모드 분해 및 모드 분산곡선 결정에 적용하였다. 제안된 방법은 $1{\sim}3m$의 감지기 간격을 가지는 2개의 감지기를 사용하는 짧은 실험구성을 사용하여 대상지반의 모드 분산곡선을 결정한다. 제안된 방법을 검증하기 위하여 수치 모의 실험과 현장실험을 수행하였으며, 이를 통하여 제안된 방법의 타당성을 확인할 수 있었다.

• 대한약침학회지
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• 제17권2호
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• pp.57-66
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• 2014

Objectives: This study was performed to analyze single dose toxicity and the lethal dose of Scolopendrid Pharmacopuncture in rats. Methods: All experiments were conducted at the Korea Testing & Research Institute (KTR), an institution authorized to perform non-clinical studies, under the regulations of Good Laboratory Practice (GLP). Sprague-Dawley rats were chosen for the pilot study. Doses of Scolopendrid pharmacopuncture, 0.1, 0.5, and 1.0 mL, were administered to the experimental group, and 1.0 mL doses of normal saline solution were administered to the control group. This study was conducted under the approval of the Institutional Animal Ethic Committee. Results: No deaths or abnormalities occurred in any of the groups. No significant changes in the weight, hematological parameters or clinical chemistry were noted between the control group and the experimental group. To check for abnormalities in organs and tissues, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs or tissues. Conclusion: The above findings suggest Scolopendrid Pharmacopuncture is a relatively safe to use for treatment. Further studies on the subject should be conducted to yield more concrete evidence.

• 비파괴검사학회지
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• 제36권4호
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• pp.300-307
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• 2016

차량 부품의 고장은 운용 중단과 탈선 결과로 나타날 수 있으며 차량 주요부품의 이상상태를 진단하는 것은 중요하다. 온도를 이용한 진단 방법은 철도차량 회전기기의 -예를 들면, 베어링, 감속기, 견인전동기, 디스크- 비정상 상태를 진단하는 기본적인 방법이다. 본 연구에서는 적외선열화상과 패턴 이미지법을 이용하여 차량 하부의 회전기기의 이상 진단시스템을 구축하여 현장시험을 수행하였다. 그 이상상태 진단시스템은 차량 하부 회전기기의 이상발열 상태를 진단할 수 있었으며 비정상 상태를 평가할 수 있었다.

• The Journal of Advanced Prosthodontics
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• 제8권2호
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• pp.101-109
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• 2016

PURPOSE. To investigate the void parameters within the resin cements used for fiber post cementation by micro-CT (${\mu}CT$) and regional push-out bonding strength. MATERIALS AND METHODS. Twenty-one, single and round shaped roots were enlarged with a low-speed drill following by endodontic treatment. The roots were divided into three groups (n=7) and fiber posts were cemented with Maxcem Elite, Multilink N and Superbond C&B resin cements. Specimens were scanned using ${\mu}CT$ scanner at resolution of $13.7{\mu}m$. The number, area, and volume of voids between dentin and post were evaluated. A method of analysis based on the post segmentation was used, and coronal, middle and apical thirds considered separately. After the ${\mu}CT$ analysis, roots were embedded in epoxy resin and sectioned into 2 mm thick slices (63 sections in total). Push-out testing was performed with universal testing device at 0.5 mm/min cross-head speed. Data were analyzed with Kruskal-Wallis and Mann-Whitney U tests (${\alpha}=.05$). RESULTS. Overall, significant differences between the resin cements and the post level were observed in the void number, area, and volume (P<.05). Super-Bond C&B showed the most void formation ($44.86{\pm}22.71$). Multilink N showed the least void surface ($3.51{\pm}2.24mm^2$) and volume ($0.01{\pm}0.01mm^3$). Regional push-out bond strength of the cements was not different (P>.05). CONCLUSION. ${\mu}CT$ proved to be a powerful non-destructive 3D analysis tool for visualizing the void parameters. Multilink N had the lowest void parameters. When efficiency of all cements was evaluated, direct relationship between the post region and push-out bonding strength was not observed.

• 한국의학물리학회지:의학물리
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• 제28권4호
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• pp.197-206
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• 2017

We develop guidelines for the quality assurance of radiation treatment planning systems (TPS) by comparing and reviewing recommendations from major countries and organizations, as well as by analyzing the AAPM, ESTRO, and IAEA TPS quality assurance guidelines. We establish quality assurance items for acceptance testing, commissioning, periodic testing, system management, and security, and propose methods to perform each item within acceptable standards. Acceptance includes tests of hardware and network environments, data transmission, software, and benchmarking as specified by the system supplier, and apply the IAEA classification criteria. Commissioning includes dosimetric and non-dosimetric items for assessing TPS performance by applying the AAPM classification criteria and the latest technical items from the IAEA. Periodic quality assurance tests include daily, weekly, monthly, yearly, and occasional items by applying the AAPM classification criteria. System management and security items include the state and network connectivity of TPS, periodic data backup, and data access security. The guidelines for TPS quality assurance proposed in this study will help to improve the safety and quality of radiotherapy by preventing incidents related to radiotherapy.

• 비파괴검사학회지
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• 제29권2호
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• pp.108-113
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• 2009

자기 누설 탐상 검사법은 지하에 매설된 가스 배관을 검사하기 위해 가장 널리 사용되고 있는 비파괴검사 방법 중의 하나이다. 자기 누설 탐상 시스템이 지하에 매설된 배관을 통과하게 되면 배관은 영구자석에 의해 착자된다. 배관의 부식이나 결함이 있는 경우 배관의 단면적이 변화하기 때문에 이 부분에서 누설자속이 변화한다. 홀 센서에 의해 검출되는 누설자속 신호로부터 결함의 길이, 폭, 깊이 등과 같은 결함의 형상을 판별하게 된다. 본 논문에서는 홀 센서를 통해 검출된 축 방향과 반경 방향 신호를 이용하여 결함의 길이를 추정하는 여러 알고리즘을 제시하고, KOGAS 모의 시험배관에 만든 실제 결함에 대해 결함의 길이 추정성능을 비교 분석하였다. 실제 데이터에 대한 추정 성능 비교를 위해 한국가스공사의 모의시험배관에 인공결함을 제작하여 사용하였다. 축 방향 및 반경 방향 신호에 대해 각각 최소값 혹은 첨두값의 80%와 90%를 기준으로 길이를 추정하였을 경우 가장 좋은 성능을 보임을 확인하였다.

• 비파괴검사학회지
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• 제34권3호
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• pp.233-240
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• 2014

나노/마이크로 소자의 개발이 활발해짐에 따라 나노/마이크로 박막의 기계적 물성의 정밀 측정에 대한 필요성이 점차 커지고 있다. 기존의 파괴적인 방법의 한계를 극복하기 위한 방법으로, 유도초음파를 이용한 비파괴적인 박막 물성 방법에 대한 관심이 늘어나고 있다. 유도초음파를 이용하여 박막의 물성을 측정하는 실험을 설계하거나, 물성 측정에 대한 실험 결과를 이해하는데 있어 박막의 분산선도를 이해하는 것은 필수적이라 할 수 있다. 본 연구에서는, 전달 행렬법을 이용하여 박막의 분산선도를 계산하는 방법을 제시하고, 이를 금속 박막에 적용하여 그 특성을 관찰하였다. 전달 행렬법을 이용하여 다층판에서의 주파수에 따라 유도초음파가 전파하는 속도를 계산하여 상용 프로그램과 비교하여 그 타당성을 확인하였다. 이러한 방법을 Si 기판 위에 증착된 Al 금속 박막에 적용하여 얻은 분산곡선의 분석을 통해, 박막의 두께 조건에 따른 모드와 분산 및 비분산 특성이 나타나는 구간을 관찰할 수 있었다.

• 대한간호학회지
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• 제47권4호
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• pp.526-539
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• 2017

Purpose: This study was undertaken to develop and test a mastery learning program of nursing skills for undergraduate nursing students. Methods: In this methodological study, first, the preliminary draft of a mastery learning program to provide training for nursing skills was developed based on Bloom's framework for mastery learning. Second, to test the developed program, a single-blinded, nonequivalent control group nonsynchronized study was conducted on 50 senior nursing students in a University selected by convenient sampling. Thirteen students were assigned to a control group; 13, 12, and 13 of them were assigned to intravenous therapy, transfusion, and patient transfer groups, respectively. The achievement levels and performance scores of the selected nursing skills were measured before and after the completion of the program in all the groups. Lastly, the final program was confirmed based on the results of the program testing. Results: Intravenous therapy, transfusion, and patient transfer were selected as essential nursing skills for the program based on the priorities rated by clinical instructors and staff nurses. The achievement levels of selected nursing skills were determined by Angoff scores. After participating in the program, the proportion of passers and performance scores of the nursing skills in the experimental groups were significantly higher than those in the control group. The final program was confirmed which included a diagnostic test, enrichment activities for the passers and three repetitions of corrective activities and formative assessments for non-passers. Conclusion: The results suggest that a mastery learning program for undergraduate students can lead to better improvement and performance of essential nursing skills.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7885-7889
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• 2014

Background: Activating mutations of epidermal growth factor receptor (EGFR) could predict response to tyrosine kinase inhibitor (TKI) treatment in patients with non-small cell lung cancer (NSCLC). However, the detection of EGFR mutation is frequently challenging in clinical practice for the lack of tumor tissue. The aim of this study was to investigate the feasibility of performing EGFR mutation testing on various types of liquid-based cytology (LBC) samples. Materials and Methods: A total of 434 liquid-based cytology samples were collected from March 2010 and November 2013. Among them, 101 with diagnosis of lung adenocarcinoma had paired surgically resected specimens. The ADx Amplification Refractory Mutation System (ADx-ARMS) was used to determine EGFR mutation status both in LBC and resected samples. Results: All liquid-based cytology samples were adequate for EGFR mutation analysis. The mutation rate was 50.5% in the 434 NSCLC patients with LBC samples and the incidence rates of EGFR mutation were consistent among different specimens. We also detected EGFR positives in 52.5% (53/101) patients with paired histologic specimens. The concordance rate of EGFR mutation between LBC samples and paired histologic specimens was 92.1%. Conclusions: Our results suggest that liquid-based cytology samples are highly reliable for EGFR mutation testing in patients with NSCLC.