• 한국임상약학회지
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• 제18권2호
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• pp.75-83
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• 2008

Purpose: Currently lung cancer ranks second in cancer for incidence rate and is a disease that ranks first for a death rate by cancerous growth because it is already advanced at the time of diagnosis. The purpose of this paper was to analyze the factors that affect the effectiveness of and rash occurrence by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI) in patients with non-small cell lung cancer. Methods: A retrospective chart review of 100 patients, who took EGFR TKI (erlotinib, gefitinib) among patients who were diagnosed with non-small cell lung cancer in a Hospital in Korea between May 2005 and February 2008, was conducted. The drug effectiveness was evaluated by Response Evaluation Criteria In Solid Tumor. Results: EGFR mutation was the only factor associated with drug response (complete response and partial response). When stable disease was added to drug response as the evaluation parameter, ECOG and rash as well as EGFR mutation were found to be important factors. Survival, however, was not affected by EGFR mutation. The factors influenced on survival were older age (${\geq}65$), low ECOG ($1{\sim}2$), adenocarcinoma and rash. In the case of rash, group with EGFR mutation or low ECOG showed significantly higher chance of occurrence. There was no significant difference in rash occurrence between gefitinib and erlotinib groups. Conclusions: Based on the results, EGFR mutation positive and low ECOG ($1{\sim}2$) were significantly important factors for both effectiveness of EGFR TKI and rash occurrence. Also, rash itself was found to be an independently significant factor for the disease control and survival. Therefore, while administering EGFR TKI, patients who have the factors associated with rash occurrence should be closely monitored for effective and safe drug therapy.

• 대한치과기공학회지
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• 제34권4호
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• pp.447-455
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• 2012

Purpose: This study was to investigate oral hygiene knowledge and the actual condition of oral care for the students in the public health and non-public health Departments. Methods: The survey sample consisted of 262 randomly selected students. 197 of them are public health-related students and 65 are non-public health-related students. The questionnaires used in this study consisted of 4 items for general information, oral health status of 2 items, 5 items for Oral hygiene knowledge and actual condition of oral care of 5 items. Collected data were analyzed by Frequency Analysis t-test and Crosstabs using SPSS(Statistical Package for Social Sciences) Win 19.0 statistics program. Results: Regarding general characteristics of the subjects, there were 53.8% of first-year student, 26.0% of second-year student and 20.2% of third-year student among 52.3% of males and 47.7% of females. The subjects received less than "100,000" won(13.0%), "100,000-190,000" won (5.0%), "200,000-290,000" won(30.9%), "300,000-390,000" won (33.2%) and more than "400,000" won(17.9%) a month for an allowance. The subjects had 'none' (44.3%), '1'(6.5%), '2'(12.6%), '3'(5.0%), '4'(5.3%), 'more than' 5(0.8%) of dental caries and 'do not know' were 25.6%. The numbers of dental prosthetics were 'no' (35.5%), '1'(13.7%), '2'(17.2%), '3'(10.3%), '4'(11.5%), and 'more than 5'(11.8%). The public health students(84.8%) had a higher positive response rate than the non-public health students(66.2%). The public health students(80.2%) had a higher negative response rate than the non-public health students(78.5%) in the result of onset of gum disease pain awareness. The non-public health students(65.5%) had a higher negative response rate than the public health students(68.3%)) in the result of heredity of gum disease. The t-test showed that public health-related department students(M=8.264, SD=0.821) had more knowledge about oral hygiene than non-public health-related department students(M=8.015, SD=1.082). 'do not use' in the oral care products except toothpaste and toothbrush showed that public health-related department students(60.4%) use the products more than non-public health-related department students(66.2%). Conclusion: In this study, public health-related department students had higher oral hygiene knowledge and actual condition of oral care compared to non-public health-related students, but low in practical action. Due to the lower level of dental care products use in non-public health-related department, a continuous oral care education program is required.

• 한국작물학회지
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• 제40권6호
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• pp.738-746
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• 1995

인공안개처리에 따른 보리의 생장, 잡초경합양상 및 제초제반을을 검토코자 온실내에서 일련의 pot시험이 수행되었다. 안개조건에서 보리의 초장, 엽령, 엽폭 및 지상부 생체중은 증가하였으나 출수가 지연되고 출수율과 수량 구성요소인 수당영화수, 천립중 및 발아율은 감소하였다. 안개조건으로 초종수의 차이는 없으나 잡초발생량은 유의적으로 증가하였고, 주요한 발생초종은 둑새풀, 새포아풀, 벼룩나물, 점나도나물, 황새냉이 및 갈퀴덩쿨등이었다. 안개조건에서는잡초와의 경합기간이 길수록 초장의 감소가 인정되었으며 1,000립중은 초기경합에서만 감소하였으며 그밖의 보리의 생장은 경합의 영향을 받지 않았다. 안개조건에서 제초제처리에 따른 보리의 생체중은 공시 제초제 공히 증가되었으나 1,000립중은 오히려 감소되었으며, 그 중 Butachlor 및 Thiobencarb의 약해가 상대적으로 크게 나타났다. 처리 후 25일째 생체중에 의한 잡초방제가는 75∼90%로써 안개조건이 비안개조건보다 3∼15% 낮게 나타났으나 60일째는 96%이상으로 대등한 방제가를 보였다.

• 한방재활의학과학회지
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• 제20권4호
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• pp.147-157
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• 2010

Objectives : The study is performed to investigate the influence of psychological stress on neck muscles tone and heart rate variability(HRV). Methods : This study was carried out with the data from stress response index score(SRI), surface electromyography(sEMG) and HRV. First subjects were divided into two group according to the SRI points. Subjects in group A had points of SRI in which lower than 30 points. Subjects in group B had points of SRI in which higher than 30 points. Then we investigated how to difference of the index of sEMG and HRV according to each groups. Results : In this study, the muscle contraction of both upper trapezius muscle in stress group were higher than non-stress group significantly. Complexity, root mean square of successive differences of R-R intervals(RMSSD), standard deviation difference between adjacent normal to normal intervals(SDSD), high frequency oscillation power(Ln(HF)), normalized HF(Norm HF) in stress group were lower than non-stress group significantly and normalized LF(Norm LF) was higher. Conclusions : This results show that the stress was associated with neck muscle condition and autonomic nervous system.

• 대한의용생체공학회:의공학회지
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• 제37권5호
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• pp.161-167
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• 2016

Recent technological advances in sensor fabrication and bio-signal processing enabled non-constraint and non-intrusive measurement of human bio-signals. Especially, non-constraint measurement of ECG makes it available to estimate various human health parameters such as heart rate. Additionally, non-constraint ECG measurement of wheelchair user provides real-time health parameter information for emergency response. For accurate emergency response with low false alarm rate, it is necessary to discriminate quality levels of ECG measured using non-constraint approach. Health parameters acquired from low quality ECG results in inaccurate information. Thus, in this study, a machine learning based approach for three-class classification of ECG quality level is suggested. Three sensors are embedded in the back seat, chest belt, and handle of automatic wheelchair. For the two sensors embedded in back seat and chest belt, capacitively coupled electrodes were used. The accuracy of quality level classification was estimated using Monte Carlo cross validation. The proposed approach demonstrated accuracy of 94.01%, 95.57%, and 96.94% for each channel of three sensors. Furthermore, the implemented algorithm enables classification of user posture by detection of contacted electrodes. The accuracy for posture estimation was 94.57%. The proposed algorithm will contribute to non-constraint and robust estimation of health parameter of wheelchair users.

• Radiation Oncology Journal
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• 제6권1호
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• pp.35-39
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• 1988

From Jan.1984 to Dec. 1986, 90 patients with lung cancer were treated at the Department of Radiation Therapy in Hanyang University Hospital. Histopathologically, 67 cases of them were the squamous cell carcinoma,7 cases were the adenocarcinoma, 4 cases were the large cell undiffe rentiated carcinoma and 12 cases were the small cell carcinoma. Among the 78 patients with non small cell carcinoma, 50 patients had received radiation dosage above 4000 cGy.40 patient had follow up from 17 months to 53 months. The complete response rate was $7.3\%$ and partial response rate was $68.3\%$. Overall survival at 1, 2 and 3 years were $47.5\%,\;23.5\%\;and\;6.3\%$ respectively. None was survived longer than 38 months. Median survival was 12.2 month for 40 patient and 9 month for stage III, M1 group and 9.5 month for stage III, MO group. In M1 patient no survival was seen after 2 years while in M0 patient $23.3\%$ survival was seen.

• Journal of Yeungnam Medical Science
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• 제38권4호
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• pp.308-317
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• 2021

Cancer is the leading cause of death and is on the rise worldwide. Until 2010, the development of targeted treatment was mainly focused on the growth mechanisms of cancer. Since then, drugs with mechanisms related to tumor immunity, especially immune checkpoint inhibitors, have proven effective, and most pharmaceutical companies are striving to develop related drugs. Programmed cell death-1 and programmed cell death ligand-1 inhibitors have shown great success in various cancer types. They showed durable and sustainable responses and were approved by the U.S. Food and Drug Administration. However, the response to inhibitors showed low percentages of cancer patients; 15% to 20%. Therefore, combination strategies with immunotherapy and conventional treatments were used to overcome the low response rate. Studies on combination therapy have typically reported improvements in the response rate and efficacy in several cancers, including non-small cell lung cancer, small cell lung cancer, breast cancer, and urogenital cancers. The combination of chemotherapy or targeted agents with immunotherapy is one of the leading pathways for cancer treatment.

• Tuberculosis and Respiratory Diseases
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• 제40권4호
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• pp.367-377
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• 1993

연구배경 : 절제가 불가능한 비소세포 폐암 환자에 대한 복합화학요법의 유용성은 아직도 분명치 않다. 그러나, cisplatin을 주축으로하는 복합화학요법의 반응율은 항암제 단독 투여시의 반응율 보다, 또한 high-dose cisplatin군의 반응율이 low-dose cisplatin군의 반응율보다 높은 것으로 최근 보고되고 있다. 복합화학요법(high VPP), 복합화학요법과 방사선 치료의 병행요법이 진행된 비소세포 폐암에서 생존율을 증가시키는지 알아보기 위해 본 연구를 시작하였다. 방법 : 조직학적으로 비소세포 폐암으로 진단된 stage III이상의 환자 35명을 대상으로 하였다. 이들중, 19명은 VP-16과 high-dose cisplatin(100 $mg/m^2$)으로 구성되는 복합화학요법 그리고 복합화학요법과 방사선 치료를 시행받았으며, 나머지 16명은 치료를 받지 않았다. 두군간의 생존율과 반응율의 차이 및 치료에 다른 부작용을 알아보기 위해 환자의 병록 일지를 검토하였다. 결과: 1) 전체적인 객관적 반응율은 한명의 완전관해를 포함하여 47%(9/19) 였다. 2) 복합화학요법과 방사선 치료를 병행하여 받은 환자군에서의 반응율은 한명의 완전관해를 포함하여 60%(6/10) 였으며, 3개월, 6개월 및 127개월 생존율은 각각 100%, 70% 및 40% 였다. 3) 복합화학요법을 받은 환자군에서의 반응율은 완전관해 없이 33%(3/9) 였으며, 3개월, 6개월 및 12개월 생존율은 각각 78%, 67% 및 33% 였다. 4) 전체적으로 치료군에서 비치료군에 비해 통계적으로 유의하게 (p<0.05) 생존기간이 연장되었다(중앙생간 307일과 95일). 5) 여러 예후인자에 따른 분석에서 운동능력이 좋을수록, stage III에서 그리고 편평상피암에서 좋은 반응율을 보였다. 6) 부작용으로서는 오성과 구토(100%), 탈모증(90%), 빈혈(79%), 백혈구 감소증 (69%), 혈소판 감소증(2%), creatinine의 증가(16%) 그리고 신경독성(5%) 등이 있었다. 결론 : 이상의 결과로 진행된 비소세포 폐암 환자에 대한 hign VPP 복합화학요법은 비치료군에 비해 치료군에서 생존율을 높이는 비교적 좋은 효과가 있으므로 좋은 적응증을 가진 환자들을 선택하여 효과적인 항암치료 및 방사선 치료를 시행하여야 할 것으로 사료된다. 그러나, hign VPP 복합화학요법에 따른 효과 개선은 본 연구 결과에선 뚜렷하지 않으므로 보다 많은 증례에서 추구 연구가 필요하리라 생각된다.

• Journal of the Korean Data Analysis Society
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• 제20권6호
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• pp.2953-2966
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• 2018

주택가격은 거시경제상황을 나타내는 다양한 변수들과 밀접한 관계를 지니고 있다. 다수의 선행연구에서는 경제상황 변화 하에서의 주택가격 행태나 여러 변수들과의 관계성에 초점을 맞추고 있다. 본 논문에서는 선행연구를 참고하되 데이터에 근거한 새로운 시각의 실증분석을 실시하고자 하였다. 주택가격에 미치는 잠재적 영향요인들 중 정책금리에 초점을 맞추고 금리충격에 대한 여타 주요 변수들의 비선형적 반응 행태를 분석하였다. 데이터마이닝 기법 중 하나인 랜덤 포레스트 알고리즘을 이용하여 선행연구에서 제시되었던 거시경제변수들의 변수 중요도 점수를 산출하였다. 이 과정을 통해 변수를 선택한 뒤, 비선형성을 포착할 수 있는 모형을 사용하여 충격반응을 산출하였다. 동 모형에 따르면 주택가격의 경우에 있어서 금리 인상 시에만 충격반응이 유의미하게 나타났다. 특히 기존 전통적 VAR(vector autoregression) 방법론에서 포착하지 못한 비선형적 특징에 기인하여 금리 인상 충격의 크기가 커질 경우 그 효과가 정률적으로만 증가하는 것이 아니라 그 이상 증폭될 수 있다는 분석 결과를 얻었다. 이러한 파급효과의 비선형성, 비대칭성은 정책 수단으로서의 금리를 보다 신중한 시각에서 접근해야 함을 의미한다고 하겠다.

• 대한기계학회논문집B
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• 제37권11호
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• pp.1031-1036
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• 2013

종래의 모터 펌프를 이용한 매트용 온수보일러는 큰 유량을 공급할 수 있지만 모터 펌프의 진동과 소음이 큰 단점이 있다. 모터 펌프를 사용하지 않는 매트용 온수보일러의 경우 소음과 진동이 억제되는 장점이 있지만 감소된 유량으로 인해 매트의 온도 편차가 큰 단점이 있다. 본 연구에서는 기존 펌프 없는 온수보일러가 가지고 있는 문제점을 개선하여 순환유량을 증가시킨 새로운 온수 보일러 방식을 제안하고 실험을 통해 그 성능을 입증하였다. 성능 실험 결과 순환 유량의 증가로 매트 온도 상승시간이 대폭 줄어들었으며 유입 온수와 유출 온수의 온도 편차도 많이 줄어들어 종래의 펌프 없는 온수보일러와 비교하여 성능 개선을 입증하였다.