• Asian Pacific Journal of Cancer Prevention
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• v.16 no.14
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• pp.5963-5966
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• 2015

Background: This analysis was conducted to evaluate the efficacy and safety of a combination of gemcitabine and nedaplatin in treating patients with non-small cell lung cancer. Methods: Clinical studies evaluating the efficacy and safety of a combination of gemcitabine and nedaplatin with attention to response and safety for patients with non-small cell lung cancer were identified using a predefined search strategy. Pooled response rates for gemcitabine and nedaplatin were calculated. Results: In gemcitabine and nedaplatin based regimens, 4 clinical studies including 112 patients with non-small cell lung cancer were considered eligible for inclusion. The pooled analysis suggested that the pooled reponse rate was 40.2% (45/112). Main side effects included grade 3-4 neutropenia, thrombocytopenia, and anemia. Grade 3-4 nonhematological toxicity included nausea and vomiting, diarrhea, and hepatic dysfunction. There were no treatment-related deaths. Conclusion: This evidence based analysis suggests that the combination of gemcitabine and nedaplatin is associated with good response rate and accepted toxicity for treating patients with non-small cell lung cancer.

• Korean Journal of Psychosomatic Medicine
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• v.31 no.1
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• pp.19-24
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• 2023

Objectives : Biofeedback is a useful non-pharmacological treatment for panic disorder (PD), but no studies have identified physiological markers related to the treatment response. This study investigated predictors of the treatment response for biofeedback in patients with PD. Methods : A retrospective study based on the electronic medical records of 372 adult patients with PD was performed. Patients received biofeedback treatment at least once, and physiological markers including heart rate, heart rate variability, respiratory rate, skin conductance, skin temperature, and electromyography were collected before the treatment began. The patients were classified as responders or non-responders based on the change in Clinical Global Impression-Severity (CGI-S) score. Results : The response rate to biofeedback treatment was 30.4%. Multivariable logistic regression analysis revealed that a higher CGI-S score at baseline and fewer benzodiazepine prescriptions were associated with a better response to biofeedback treatment. According to subgroup analyses, the baseline CGI-S score, dose of benzodiazepines, and skin conductance are candidate predictors of the response to biofeedback treatment in men, while only baseline disease severity was associated with the treatment response in women. Conclusions : The present results suggest that skin conductance may be target marker and predictor for biofeedback in male patients with PD.

• The Korean Journal of Applied Statistics
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• v.33 no.4
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• pp.409-420
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• 2020

In business survey, modified cut-off sampling is commonly used to greatly increase the accuracy of the estimation while reducing the number of samples. However, non-response rate of take-all stratum has increased significantly and the sample substitution is not possible because the non-response in the take-all stratum affects the accuracy of the estimation. It is important to adjust the bias appropriately if non-response is affected by the variable of interest. In this study, a bias adjusted estimation is proposed as an appropriate method to deal with a non-response in the take-all stratum. In particular, the estimator proposed by Chung and Shin (2020) was applied to the bias adjustment for the take-all stratum; therefore, we suggest a new method to adjust properly for the take-all stratum. The superiority of the proposed estimator was examined through simulation studies and confirmed through actual data analysis.

• The Korean Journal of Applied Statistics
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• v.33 no.1
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• pp.11-23
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• 2020

Sampling design should provide statistics to meet a given accuracy while saving cost and time. However, a large number of non-responses are occurring due to the deterioration of survey circumstances, which significantly reduces the accuracy of the survey results. Non-responses occur for a variety of reasons. Chung and Shin (2017, 2019) and Min and Shin (2018) found that the accuracy of estimation is improved by removing the bias caused by non-response when the response rate is an exponential or linear function of variable of interests. For that case they assumed that the error of the super population model follows normal distribution. In this study, we proposed a non-response bias adjusted estimator in the case where the error of a super population model follows the gamma distribution or the log-normal distribution in a business survey. We confirmed the superiority of the proposed estimator through simulation studies.

• Biomedical Science Letters
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• v.23 no.3
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• pp.215-222
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• 2017

Obesity has been directly associated with the development of hypertension and cardiovascular disease. The purpose of this study was to investigate the blood pressure response during graded exercise test in obese adults. 189 subjects (age: $47.96{\pm}10.23$) were assigned to two groups: non-obese group (N=105, BMI: $22.05{\pm}1.57$, waist circumference: $76.90{\pm}6.17$) and obese group (N=84, BMI: $26.96{\pm}2.51$, waist circumference: $88.29{\pm}6.41$). The subjects underwent health screening and exercise treadmill test from January 2012 to December 2014. Graded exercise test was performed according to the Bruce protocol. Exercise duration (P=0.046) and METs (P=0.015) were significantly lower in obese group than non-obese group. There was no difference in the rate of change in blood pressure response between obese group and non-obese group during exercise, and the recovery rate of systolic blood pressure was delayed in the obese group compared to non-obese group in the first recovery period (P=0.020). The significant factors of increasing rate of change in maximum systolic blood pressure was waist (P=0.046) and hip circumference (P=0.008). In conclusion, these results demonstrate that, for hypertension prevention in obese adults, waist and hip circumference levels should be managed within normal range.

• The Korean Journal of Applied Statistics
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• v.32 no.4
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• pp.631-642
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• 2019

Many methods have been developed to solve problems found in sample surveys involving a large number of item non-responses that cause inaccuracies in estimation. However, the non-response adjustment method used under the assumption of random non-response generates a bias in cases where the response rate is affected by the variable of interest. Chung and Shin (2017) and Min and Shin (2018) proposed a method to improve the accuracy of estimation by appropriately adjusting a bias generated when the response rate is a function of the variables of interest. In this study, we studied a case where the response rate function is linear and the error of the super population model follows normal distribution. We also examined the effect of the number of stratum population on bias adjustment. The performance of the proposed estimator was examined through simulation studies and confirmed through actual data analysis.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.11
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• pp.4797-4800
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• 2015

Background: This analysis was conducted to evaluate the efficacy and safety of crizotinib based regimens in treating Chinese patients with EML4-ALK positive non-small-cell lung cancer. Materials and Methods: Clinical studies evaluating the efficacy and safety of crizotinib based regimens on response and safety for Chinese patients with EML4-ALK positive non-small-cell lung cancer were identified by using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: In crizotinib based regimens, 3 clinical studies which including 128 Chinese patients with EML4-ALK positive non-small-cell lung cancer and treated with crizotinib based regimen were considered eligible for inclusion. Pooled analysis suggested that, in all patients, the pooled RR was 59.3% (76/128) in crizotinib based regimens. ALT/AST mild visual disturbances, nausea, and vomiting were the main side effects. No treatment related death occurred in these crizotinib based treatments. Conclusions: This pooled analysis suggests that crizotinib based regimens are associated with good response rate and accepted toxicities in treating Chinese patients with EML4-ALK positive non-small-cell lung cancer.

• The Korean Journal of Applied Statistics
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• v.34 no.6
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• pp.923-936
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• 2021

A large number of non-responses are occurring in the sample survey, and various methods have been developed to deal with them appropriately. In particular, the bias caused by non-ignorable non-response greatly reduces the accuracy of estimation and makes non-response processing difficult. Recently, Chung and Shin (2017, 2020) proposed an estimator that improves the accuracy of estimation using parametric super-population model and response rate model. In this study, we suggested a bias corrected non-response mean estimator using a nonparametric function generalizing the form of a parametric super-population model. We confirmed the superiority of the proposed estimator through simulation studies.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5521-5524
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• 2015

Purpose: This analysis was conducted to evaluate the efficacy and safety of icotinib based regimens in treating patients with non-small cell lung cancer (NSCLC). Methods: Clinical studies evaluating the efficacy and safety of icotinib-based regimens with regard to response and safety for patients with NSCLC were identified using a predefined search strategy. Pooled response rates of treatment were calculated. Results: With icotinib-based regimens, 7 clinical studies which including 5,985 Chinese patients with NSCLC were considered eligible for inclusion. The pooled analysis suggested that, in all patients, the positive reponse rate was 30.1% (1,803/5,985) with icotinib-based regimens. Mild skin itching, rashes and diarrhea were the main side effects. No grade III or IV renal or liver toxicity was observed. No treatment-related death occurred in patients treated with icotinib-based regimens. Conclusions: This evidence based analysis suggests that icotinib based regimens are associated with mild response rate and acceptable toxicity for treating Chinese patients with NSCLC.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.174-176
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• 2002

A total of 134 patients with stage 1 of non-small cell lung cancer treated by carbon ion beam of HIMAC NIRS were investigated for control rate and delivered dose. The delivered dose of every patient was converted to biological effective dose (BED) of LQ model using fraction number, dose per fraction and alpha beta ratio which shows the maximum correlation between BED and tumor control. The BED of every patient was classified to establish a BED response curve for control. Assuming fraction numbers, dose response curves were introduced from BED response curve. The total doses to realize several control rates were obtained for the treatment of small fraction number.