• 제목/요약/키워드: non-particulate

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미세먼지 PM10에 노출된 RAW264.7 세포에 대한 해당화 추출물의 항염증 활성 (Anti-inflammatory effects of Rosa rugosa extracts in RAW264.7 cells exposed to particulate matter (PM10))

  • 안민아;현태경
    • Journal of Plant Biotechnology
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    • 제49권2호
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    • pp.145-149
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    • 2022
  • 직경이 10 ㎛ 미만의 미세먼지 입자(particulate matter 10, PM10)는 한국을 비롯한 동아시아 지역에서 해로운 대기오염의 주요한 원인 중 하나로 최근 주목받고 있으며, 호흡기와 피부에 유해한 영향을 미치는 주범이 되고 있다. FD는 대식세포에서 활성산소 종(ROS)의 생성과 염증반응을 과도하게 촉진시켜 세포 손상과 더불어 세포 사멸을 유도한다. 장미속의 낙엽관목인 해당화(Rosa rugosa)는 다양한 질병을 치료하는 목적으로 예부터 동아시아 지역에서 민간요법 치료제로써 사용되었다. 본 연구에서는 PM10으로 유도된 RAW 264.7 대식세포에서의 염증반응을 억제하는 해당화 각 기관별 추출물의 항염증 효과를 탐색하고자 한다. 미세먼지 입자가 처리되지 않은 RAW 264.7 대식세포와 비교했을 때, PM10을 100 ㎍/ml의 농도로 처리했을 경우 lipopolysaccharide 처리와 유사하게 nitric oxide (NO) 생성을 눈에 띄게 증가시켰다. 또한 100 ㎍/ml의 해당화 줄기 추출물은 미세먼지 입자 단독 처리군에 비해 NO 생성을 45% 이상 감소시켰고, PM10에 의해 유도된 interleukin(IL)-1β, IL-6, inducible nitric oxide synthase, and cyclooxygenase-2의 발현을 유의하게 감소시켰다. 이러한 결과는 해당화 줄기 추출물의 항염증 효과가 PM10으로 자극된 RAW 264.7 세포에서 염증 유발 매개체의 억제에 의해 매개됨을 나타내며, 해당화 줄기가 유해한 공기 중 미세먼지 입자에 의해 유발되는 염증반응에 대한 보호 효과가 있는 천연 자원으로서 가치가 있음을 시사한다.

비국부 이론을 이용한 입자 강화 복합재 이중후방응력 소성 구성방정식 모델 및 전단밴드 분석 (Non-Local Plasticity Constitutive Relation for Particulate Composite Material Using Combined Back-Stress Model and Shear Band Formation)

  • 윤수진;김신회;박재범;정규동
    • 대한기계학회논문집A
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    • 제38권10호
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    • pp.1057-1068
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    • 2014
  • 2개의 상으로 구성된 입자 강화 복합재에 대한 균질화와 내부 상태 변수에 대해 2차 미분항이 포함된 비구역적 이론을 적용하여 탄소성 구성 방정식을 제안하였다. 열역학과 소성 포텐셜을 통해 내부 상태 변수에 대한 전개식 또한 본 논문에 포함되었다. 연속체 결함 모델을 이용, 결함 인자에 따른 물성 저하 현상도 감안되었으며 이중 후방응력이 조합된 전개식 또한 제시하였다. 일부 예에 대한 수치해석 결과, 비구역적 변수의 영향이 증가할수록 전단밴드는 감소하나 반면 특정 후방응력 전개가 지배적일수록 소성변형 집중이 증가함이 관찰되었다. 더욱이 두 개의 강소성 상으로 이루어진 복합재의 경우 강성이 높은 게재물의 비중이 증가함에 따라 전단밴드 형성이 용이한 것으로 나타났다. 그 밖에 제어변수들의 변화에 따른 전단밴드 형성에 대한 분석 결과는 Rice 소성 불안정성 분석결과와 잘 일치함 또한 밝혀졌다.

한반도 서부유입권역에서 대기 중 에어로졸 성분의 물리·화학적 특성 연구 III. 화학적 거동 및 장거리 이동 (Physico-chemical Characteristics of Submicron Aerosol at West Inflow Regions in the Korean Peninsula III. Physical-Chemical Behavior and Long-range Transport of PM1)

  • 박태현;안준영;최진수;임용재;박진수;김정호;오준;이용환;홍유덕;홍지형;최용주;이태형
    • 한국대기환경학회지
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    • 제33권2호
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    • pp.124-138
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    • 2017
  • Physico-chemical measurement of non-refractory submicron particles($NR-PM_1$) was conducted in Baengnyeong Island, Korea using Aerodyne High Resolution Time of Flight Aerosol Mass Spectrometer (HR-ToF-AMS) from 2012 to 2014. Organics and ammoniated sulfate were dominant species in $NR-PM_1$. The organics was found to have similar fractions(approximate 40%) of $NR-PM_1$ during the summer and winter, while the sulfate fractions of $NR-PM_1$ were calculated to be approximately 47% and 31% for the summer and winter, respectively, suggesting the possibility that particles provide non-acidic surfaces for condensation of nitric acid in the winter. The nitrate fractions of approximate 4% and 20% of $NR-PM_1$ were observed in August (summer) and November (winter), respectively, resulting that the relatively low concentration of sulfate in $NR-PM_1$ provided a non-acidic surface for nitric acid condensation and formation of particulate ammoniated nitrate is favored thermodynamically in winter. The new particle formation (NPF) event and particle growth rate were analyzed for each month in 2014 using Scanning Mobility Particle Sizer(SMPS). The Percent of NPF events was the highest in winter, but NPF event was not observed during summer due to relatively high temperature and frequent rainfall. The average particle growth rate was 3.5 nm/h and the highest particle growth rate was 5.5 nm/h in May. We observed the long-range transport of the anthropogenic sulfate from the East Asia during the intensive monitoring period of November between Qingdao and Baengnyeong Island in 2013. The relatively high concentrations of m/z 60 measured in HR-ToF-AMS was observed in May and June at Baengnyeong Island, suggesting the possibility of the influence of biomass burning from the East Asia to the Korean Peninsula.

분말사출재의 항복응력 측정법 개발 (Development of a Yield Stress Measuring Technique for Powder Injection Molding Feedstocks)

  • Rhee, Byung-Ohk;Lee, Jang-hoon
    • 유변학
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    • 제11권1호
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    • pp.57-65
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    • 1999
  • 분말사출재의 항복응력을 효과적이고 간단한 방법으로 측정하기 위해서 수차 장치를 사용한 항복응력 측정장치를 개발하였다. 수차 방식은 벽면 미끄러짐을 고려할 필요가 없는 장점이 있으나 전단률에 따른 점도 변화 측정에는 사용할 수 없는 단점도 있다. 수차 장치의 타당성 검토를 선형유체를 사용하여 검증하였으며, 수차 장치의 양단에서 나타나는 오차도 실험적으로 확인하였다. 분말 현탁액의 일반적인 특징이라고 여겨지는 항복 시 발생하는 순간 최대 토오크는 측정 장치의 제어기 특성에 따른 영향이 큰 것을 확인하고 안정 토오크 영역을 항복응력 계산의 기준으로 결정하였다. 측정되는 토오크에서 수차의 회전 저항에 따른 효과를 제거하기 위해 다양한 속도에서 측정된 토오크를 선형함수로 근사하여 회전 속도가 없을 때의 토오크를 얻었다. 측정 방법의 일반적인 검증을 위해 텅스텐 카바이드 분말과 왁스계 바인더를 이용한 분말사출재의 항복응력을 온도와 분말 충전률 변화에 따라서 측정하였다.

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The Effects of a Forceful Transforaminal Epidural Steroid Injection on Radicular Pain: A Preliminary Study

  • Byun, Jong Min;Park, Hahck Soo;Woo, Jae Hee;Kim, Jin
    • The Korean Journal of Pain
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    • 제27권4호
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    • pp.334-338
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    • 2014
  • Background: Lumbar transforaminal epidural steroid injections (TFESIs) are performed to provide symptom relief in patients with radicular pain. Recent articles suggested that injected volume itself have analgesic effects and higher volumes are associated with better outcomes. To date, few studies have been conducted to investigate the effects of volume. Therefore, well-designed controlled studies were necessary to confirm the effect of volume itself on pain relief. The purpose of this study was to examine the effectiveness of a forceful saline injection on lumbar TFESI using non-particulate steroids. Methods: Fifty consecutive patients with lumbar radicular pain were enrolled. The participants were allocated into one of two groups: dexamethasone with volume (Group DV) and dexamethasone alone (Group DO). The volume was delivered by a forceful injection of 5ml of normal saline. The primary end-point for this study was a VAS pain score and modified MacNab score indicating the rate of effectiveness at the four-week follow-up. Results: There were no significant post-procedural VAS differences between two groups (P = .252). The effectiveness rate among the patients was 47.8% in DV group, 34.8% in DO group, measured by modified MacNab score. The difference was not statistically significant (P = .117). Conclusions: A forceful saline injection did not have a significant effect during the treatment of radicular pain. Further studies with greater volumes and with additional techniques would offer a more conclusive perspective.

신재생에너지의 확산이 대기오염 배출 저감에 미치는 영향 분석 (Analysis on Impacts of Renewable Energy Promotion on Mitigation of Air Pollution)

  • 배정환;정서림
    • 신재생에너지
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    • 제16권3호
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    • pp.13-26
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    • 2020
  • This study analyzed whether the diffusion of new and renewable energy contributed to mitigating emissions of various air pollutants, including particulate matter, using panel econometric models. The theoretical foundation of such econometric models is based on the Environmental Kuznets Curve (EKC) hypothesis, which assumes an inverted U-shaped relation between national income and environmental pollution, as originally proposed by Grossman and Krueger. We examined whether there are inverted U-, U-shaped, or N-shaped relations between national income and air pollution. We demonstrate that increases in new and renewable energy significantly mitigated emissions of CO, NOX, and PM2.5. Additionally, we included NOX, SOX, PM10, and VOCs as secondary emission sources of PM2.5 and found that emission of PM10 resulted in the highest PM2.5 emissions, followed by NOX and SOX emissions. The impact of new and renewable energy on air pollution varied across regions. Increase of new and renewable energy in the Honam region significantly mitigated CO, NOX, and TSP emissions, while that in the Youngnam and metropolitan areas did not significantly mitigate air pollution overall. There was a U-shaped relationship between air pollution and national income for CO, NOX, PM2.5, and SOX, while an inverted N-shape was observed for PM10.

A study of improving filtration efficiency through SiC whisker synthesis on carbon felt by CVD VS method

  • 김광주;최두진
    • 한국진공학회:학술대회논문집
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    • 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
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    • pp.150-150
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    • 2016
  • Mankind is enjoying a great convenience of their life by the rapid growth of secondary industry since the Industrial Revolution and it is possible due to the invention of huge power such as engine. The automobile which plays the important role of industrial development and human movement is powered by the Engine Module, and especially Diesel engine is widely used because of mechanical durability and energy efficiency. The main work mechanism of the Diesel engine is composed of inhalation of the organic material (coal, oil, etc.), combustion, explosion and exhaust Cycle process then the carbon compound emissions during the last exhaust process are essential which is known as the major causes of air pollution issues in recent years. In particular, COx, called carbon oxide compound which is composed of a very small size of the particles from several ten to hundred nano meter and they exist as a suspension in the atmosphere. These Diesel particles can be accumulated at the respiratory organs and cause many serious diseases. In order to compensate for the weak point of such a Diesel Engine, the DPF(Diesel Particulate Filter) post-cleaning equipment has been used and it mainly consists of ceramic materials(SiC, Cordierite etc) because of the necessity for the engine system durability on the exposure of high temperature, high pressure and chemical harsh environmental. Ceramic Material filter, but it remains a lot of problems yet, such as limitations of collecting very small particles below micro size, high cost due to difficulties of manufacturing process and low fuel consumption efficiency due to back pressure increase by the small pore structure. This study is to test the possibility of new structure by direct infiltration of SiC Whisker on Carbon felt as the next generation filter and this new filter is expected to improve the above various problems of the Ceramic DPF currently in use and reduction of the cost simultaneously. In this experiment, non-catalytic VS CVD (Vapor-Solid Chemical Vaporized Deposition) system was adopted to keep high mechanical properties of SiC and MTS (Methyl-Trichloro-Silane) gas used as source and H2 gas used as dilute gas. From this, the suitable whisker growth for high performance filter was observed depending on each deposition conditions change (input gas ratio, temperature, mass flow rate etc.).

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A longitudinal study of the relation of lead in blood to lead in air concentrations among battery workers

  • Hodgkins Douglas G.;Robins Thomas G.;Hinkamp David L.;Schork M. Anthony;Krebs William H.
    • 대한예방의학회:학술대회논문집
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    • 대한예방의학회 1994년도 교수 연수회(환경)
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    • pp.577-584
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    • 1994
  • The relation between lead in air (PbA) and lead in blood (PbB), concentrations was investigated among 44 workers in five major operations in a United States high volume, lead acid battery plant. The study covered a 30 month period in which workers received frequent PbA and PbB determinations, workers remained in a single job, and PbA concentrations averaged below the US Occupational Safety and Health Administration (OSHA) permissible exposure limit of $50{\mu}g/m^{3}$. In both univariate and multivariable linear regressions, longitudinal analyses averaging PbA concentrations over the 30 month study period appeared superior to cross sectional analyses using only six month PbA averages .to model PbB concentrations. The covariate adjusted coefficient ($\alpha$ value) for PbA($\mu/m^{3}$) in models of PbB (${\mu}g/100\;g$) was 1-14. This figure is strikingly higher than that reported in previous studies in the lead acid battery industry in all of which PbA concentrations were substantially higher than in the current study. Plausible explanations for the differences in a: values include non-linearity of the PbA-PbB curve, a higher fraction of large size particulate associated with higher PbA concentrations, survivor bias among workers exposed to higher PbA concentrations, and the cross sectional designs of most previous studies. Despite previously reported problems with the model used by OSHA to predict PbA-PbB relations, the findings of this study are in good agreement with the predictions of that model.

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축산단지 비점오염물질 저감을 위한 자유수면형 인공습지 적용 (Application of Free Water Surface Constructed Wetland for NPS Control in Livestock Watershed Area)

  • 이정용;강창국;이소영;김이형
    • 한국습지학회지
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    • 제13권3호
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    • pp.481-488
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    • 2011
  • 금강수계의 논산 양지리에 위치한 인공습지는 축산폐수처리시설에서 방류되는 처리수의 추가처리와 함께 강우시 유역에서 유출되는 비점오염물질을 처리하기 위하여 설치되었다. 본 시설은 2008년 설치된 이후부터 시설검증을 위한 모니터링을 수행중에 있으며 본 연구결과는 시설의 설치 직후로부터 1년간의 모니터링 결과를 정리한 것이다. 모니터링 결과, 평균 오염물질 저감효율은 TSS가 86%, BOD가 60%, TN은 45%, TP의 경우 70%로 산정되었다. 대부분의 모니터링에서 입자상 물질과 인의 평균 저감효율이 60% 이상의 높은 저감효율을 보이는 반면 질소의 경우 축산폐수의 높은 질소농도에 비해 낮은 유기물 농도에 의하여 낮은 저감효율을 나타내는 것으로 분석되었다. 따라서 유출수내 질소제거능 향상을 위해서는 긴 수리학적 체류시간 및 추가적 DO공급이 필요한 것으로 평가되었다.

자전연소합성법에 의한 여러 가지 섬유상 및 입상 탄화물의 제조 (Fabrication of Various Carbides with Fibrous and Particulate Shapes by Self-Propagating High Temperature Synthesis Method)

  • 방환철;윤존도
    • 한국재료학회지
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    • 제10권5호
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    • pp.343-349
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    • 2000
  • 자전연소합성(SHS)법을 이용하여 탄소섬유와 티타늄, 지르코늄, 니오븀, 규소, 붕소, 중석, 몰리브덴의 분말로부터 여러 가지 섬유상 탄화물의 합성을 시도하였다. 티타늄과 지르코늄은 예열없이, 그 이외의 경우는 전기로 또는 화학로를 사용하여 예열하여 반응을일으킨 결과, TiC, ZrC, NbC, SiC, $B_4$C, WC,$ Mo_2$C 의 순수한 탄화물의 형성되었다. TiC, ZrC, NbC 및 $B_4$C 탄화물의 형상은 속의 빈 섬유상이었고, SiC는 보다 작은 입자와 미세 휘스커로 이루어진 섬유상을 하고 있었고 WC와 $Mo_2$C 는 비섬유상을 하고 있었다. 여러 가지 형상의 원인에 대하여 합리적 설명을 시도하였으며 정성적 메카니즘을 제안하였다.

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