• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2297-2301
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• 2015

Background: Despite widely adopted standard methods for follow-up including cystoscopy plus cytology, recurrence rates of non muscle-invasive bladder cancer (NMIBC) have not improved over the past decades, still ranging from 60% through 70%. Hence, widely acceptable surveillance strategies with excellent sensitivity are needed. Early recurrence has led to the development of a novel cystoscopy technique utilizing photodynamic diagnosis (PDD). Although, no studies have evaluated the efficacy of PDD for patients of MIBC, BCG failure or 2nd-transurethelial resection (TUR). Materials and Methods: The present study was performed from October 2012 through May 2013. IRB approved 25 patients initially underwent a cystoscopy examination of white light and blue light followed by the resection of tumors identified. Resections were performed from bladder mucosa areas considered suspicious at PDD, along with PDD negative normal bladder mucosa area resected by random biopsy. Specimens were divided into two groups, PDD positive and negative. Primary endpoints were sensitivity and specificity. Results: A total of 147 specimens extracted from 25 patients were included in the analysis. Some 45 out of 92 PDD-positive specimens were confirmed to have bladder cancer, and 51 out of PDD-negative 55 specimens were confirmed to be cancer negative. The sensitivity of PDD was 91.8% (45/49) and specificity was 52.0% (51/98). The sensitivity:specificity was 89.5% (17/19) : 47.6% (30/63) in 12 2nd-TUR patients, 90.5% (19/21) : 61.1% (11/18) in seven MIBC patients, and 95.0% (19/20) : 48.5% (16/33) in eight failed BCG cases. Conclusions: PDD-TURBT has high sensitivity to diagnose BC even for 2nd-TUR, MIBC or BCG failure cases.

• Korean Journal of Acupuncture
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• 제28권3호
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• pp.13-23
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• 2011

Objectives : The aim of this study was to develop the combined medical stimulus system consisted of the PEMFs (Pulsed electromagnetic fields) and LED which are able to stimulate local point such as acupoints and trigger points. Methods : To evaluate the therapeutic effect on the musculoskeletal disorders and the possibility of alternative method on manual acupuncture, we compared the fatigue recovery of two groups by analyzing the EMG and peak torque (non-stimulation and, stimulation group) after strenuous knee exercise. We chose the LR9 as a stimulation point. Results : The median frequency (MF) and fatigue index (F.I) of the stimulation group were recovered faster than those of the non-stimulation group. Also the peak torques of both groups were not restored until after 20 minutes. However, the peak torque of the stimulation group was regained higher than that of the non-stimulation group. Conclusions : We confirmed that the proposed combined stimulus system had useful effects as treatment instrument of musculoskeletal disorder using non-invasive method of PEMFs and LED.

• 대한통합의학회지
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• 제10권2호
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• pp.105-113
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• 2022

Purpose: The purpose of this study is to investigate the effect of non-invasive transcranial direct current stimulation (tDCS) on muscle activity, including 10 m WT, TUG, and BBS, in hemiplegic stroke patients. Methods: This study was conducted on 42 inpatients diagnosed with hemiplegia due to stroke at hospital B in Daejeon for more than 6 months. Walking training was conducted for six weeks, five times a week for 30 minutes, with a general walking group (14 people), tDCS walking group (14 people), and tDCS (sham) walking group (14 people). Results: As a result of the study, the change in the muscle activity before and after tDCS intervention was significantly increased in the tibialis anterior muscle in the CG group. In the EG group, the erector spine (lumbar), rectus femoris, and tibialis anterior muscles significantly increased. In the SEG group, significant increases were observed in the rectus femoris and tibialis anterior muscles. Significant differences were found in the rectus femoris and tibialis anterior muscles in the comparison between groups after intervention according to tDCS application. Also, 10 m WT, TUG, and BBS were significantly increased in the CG, EG, and SEG groups after intervention, and there were significant differences in 10 m WT, TUG, and BBS in comparison between groups after intervention according to tDCS application. Conclusion: As a result, tDCS is an effective in improving the walking ability of stroke patients, and in particular, it effectively increases the muscle activity of the rectus femoris and tibialis anterior muscles, which act directly on walking, and also improves the speed and stability of walking. It is considered being an effective method to increase the gait of stroke patients by combining it with the existing gait training.

• 한국지능시스템학회논문지
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• 제12권4호
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• pp.366-372
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• 2002

뇌파(Electroencephalogram, EEG)는 뇌 신경세포가 정보를 처리하는 과정에서 발생하는 전기적인 신호를 두피 표면에서 측정한 것이다. 이러한 뇌파는 비침습적인 방법으로 전기적인 신호를 측정하며 측정시 여러가지 형태의 잡파(artifact)가 섞이기 쉽다. 이러한 잡파는 뇌의 정보처리과정에 대한 유용한 정보를 담고 있는 뇌파를 분석하는데 방해가 되므로 이를 제거하기 위한 노력이 계속되어 왔다. 그러나 본 연구에서는 보다 적극적인 방향으로 잡파가 섞인 뇌파의 특성을 분석하여 이를 통해 제어 시스템 등과 같은 시스템에 적용할 수 있는 가능성을 알아보았다. 대표적인 잡파인 eye_blinking, eye_rolling, muscle 둥이 각각 포함된 뇌파에 대해서 선형 및 비선형 분석을 실시함으로써 유의미한 특성 차이를 나타내었다.

• Physical Therapy Rehabilitation Science
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• 제2권1호
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• pp.27-30
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• 2013

Objective: Low back pain is a primary of source of dysfunction and economic costs. Gluteus medius muscle co-activation and activity pattern change caused the low back pain. Active release technique (ART) is a patented, non-invasive, soft tissue treatment process that both locates and breaks down the scar tissue and adhesions. The purpose of this study was to assess the effects on chronic low back pain using ART on gluteus medius so that suggest usable treatment method for treating chronic low back pain. Design: One group pretest-posttest design. Methods: Twelve patients with chronic low back pain were participated in this study. Subjects in ART group were received 2 times a week for 3 weeks treatments with either ART on gluteus medius muscle trigger points. Outcome measures were conducted by pain intensity with a pain visual analogue scale and pressure pain threshold on gluteus medius. Results: Completion of the intervention, the visual analogue scale was decreased in ART group (p<0.05). Also pressure pain threshold was decreased in ART group (p<0.05). Conclusions: Our results suggest that the response to ART may be usable to treat low back pain. ART was presented to reduce pain level of low back in people with chronic low back pain. Further study is required to management for low back pain due to gluteus medius and more ART study.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9927-9931
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• 2014

The objectives of this study were to examine serum periplakin expression in patients with urothelial carcinoma of the urinary bladder and in normal controls, and to examine relationships with clinicopathological findings. Detection of serum periplakin was performed in 50 patients and 30 normal controls with anti-periplakin antibodies using the automatic dot blot system, and a micro-dot blot array with a 256 solid-pin system. Levels in patients with urothelial carcinoma of the urinary bladder were significantly lower than those in normal controls (0.31 and 5.68, respectively; p<0.0001). The area under the receiver-operator curve level for urothelial carcinoma of the urinary bladder was 0.845. The sensitivity and specificity, using a cut-off point of 4.045, were 83.7% and 73.3%, respectively. In addition, serum periplakin levels were significantly higher in patients with muscle-invasive cancer than in those with nonmuscle-invasive cancer (P = 0.03). In multivariate Cox proportional hazards regression analysis, none of the clinicopathological factors was associated with an increased risk for progression and cancer-specific survival. Examination of the serum periplakin level may play a role as a non-invasive diagnostic modality to aid urine cytology and cystoscopy.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4357-4361
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• 2012

Objective: The guidelines on indications for prophylactic use of Bacille Calmette-Gu$\acute{e}$rin (BCG) against non-muscle-invasive bladder cancer (NMIBC) have changed over the years. In order to assess the impact on outcome, the present retrospective comparison of BCG efficacy by time period with Japanese patients was conducted. Patients and Methods: A total of 146 cases of NMIBC treated with BCG since February 1985 were retrospectively evaluated. All patients received 80 mg of BCG (Tokyo 172 strain) six to eight times a week for prophylactic use. Comparison was made among three historical groups (Group A: 1980's, 39 cases; Group B: 1990's, 61 cases; Group C: 2000's, 46 cases). Results: In total, recurrence was seen in 55 of the 146 cases (37.7%), and progression in 14 (9.6%), 1 patient dying of cancer. These overall results were similar to those outlined in previous reports. However, the outcomes of this time-period-based analysis indicated a tendency for a shorter time to recurrence in patients after 2000, although a log-rank test showed no significance (P=0.229). Seven of the cases featuring progression (i.e., half of all such cases) were among the 46 Group C patients (15.2%). Excluding these progressive cases, there was no significant difference among the remaining 132 patients in the three groups. Conclusion: This study results revealed a tendency for a lower non-recurrence rate after 2000 in our series. This could stem from a number of factors, including changes in BCG indication criteria and the evolution of histopathological diagnostic criteria.

• 한국한의학연구원논문집
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• 제1권1호
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• pp.273-287
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• 1995

Moire topography, a simple technique for three-dimensional quantitation, was used to provide interference fringe photographs of the human back with sufficient accuracy to be used for detecting patient with asymmetry due to scoliosis, the disease of cervix and lumbar, muscle dysfunction. Contour lines are a suitable and widely accepted method of describing a three-dimensional surface. In the moire technique, contour lines of an object are produced as interference fringes while the object is illuminated by a spotlight through a special grating. The fringe pattern is produced by the interference of the grating and its shadow on the object. A photograph of a moire pattern on the human back will permit an assessment of the overall body shape and the symmetry of the back. This study uses shadow moire topography. Moire topography provides a non-invasive technique for quantifying the shape of the human body. In the use of moire topography for the Oriental Medicine Diagnosis, the strength of moire lies in the ablility to detect change due to deformity of human body.

• Journal of Electrical Engineering and Technology
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• 제7권5호
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• pp.759-764
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• 2012

In this paper, we propose a microwave hyperthermic lipolysis method to reduce subcutaneous fat without skin burn using external RF antenna. Since skin is closer to the antenna and has higher conductivity compared to the fat beneath, the temperature of the skin rises higher than that of the fat when the external antenna illuminates EM energy into a body, which may cause skin burn. In order to avoid the damages on skin, a skin cooling system is employed to the external antenna. The operating frequency is set at 5.8 GHz which is one of the ISM bands, to concentrate EM power efficiently on fat and not to heat up the muscle behind the fat. The operation time and RF power level has been determined based on experimental results with pork. The feasibility of the proposed method was shown by applying the method to the rat.

• 대한후두음성언어의학회지
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• 제10권1호
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• pp.24-29
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• 1999

Extrinsic laryngeal muscles are well known to be important for the classical singers. We tried to elucidate any differences in the function of above muscles between trained and untrained singers by non-invasive surface electromyography(EMG). Four trained sopranos and four untrained singers sang vowel /i/ at different pitch(E3, G3, C4, E4, G4, C5, E5, G5, C6). The EMG activities of the suprahyoid, infrahyoid and omohyoid muscles were measured using surface electrodes. In trained singers, infrahyoid muscle activities increased more than those of suprahyoid in most of pitch. To the contrary, in untrained singers, the pattern of EMG activities were variable among each subjects and the EMG activities of suprahyoid muscles were relatively greater than those of infrahyoid.