• 대한화장품학회지
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• 제41권3호
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• pp.279-285
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• 2015

여성의 얼굴에 과색소침착이 발생하는 것은 불안감, 특히 미적인 요소에 있어서 많은 고민을 유발한다. 피부의 흑화는 자외선(UV)에 대하여 이를 방어하기 위한 기작으로 멜라닌의 양과 밀접한 관계가 있다. 이러한 피부의 구성성분을 관찰하기 위해, confocal scanning laser microscope (CSLM)은 피부에 직접 현미경 검사를 실시하여 어떠한 조직의 변화 없이 피부를 실시간으로 관찰할 수 있는 비침습적 이미지 장치이다. 본 연구에서는 자외선 조사를 통해 유도된 하박 내측 피부의 과색소침착을 유도하여, 다른 피부색을 평가하는 측정기기와 상관성을 분석하여, CSLM을 이용한 새로운 미백 평가방법을 제시하였다. CSLM을 활용한 미백 효능 평가법은 소비자가 보다 이해하기 쉽도록 미백 제품을 평가하는데 유용할 것으로 생각된다.

• 한국전문물리치료학회지
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• 제22권3호
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• pp.98-105
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• 2015

Muscular dystrophy is a hereditary musculoskeletal disorder caused by a mutation in the dystrophin gene. Duchenne muscular dystrophy (DMD) is one of the most common, and progresses relatively faster than other muscular dystrophies. It is characterized by progressive myofiber degeneration, muscle weakness and ultimately ambulatory loss. Since it is an X-linked recessive inheritance, DMD is mostly expressed in males and rarely expressed or less severe in females. The most effective measurement tool for DMD is magnetic resonance imaging (MRI), which allows non-invasive examination of longitudinal measurement. It can detect progressive decline of skeletal muscle size by measuring a maximal cross-sectional area of skeletal muscle. Additionally, other techniques in MRI, like $T_2$-weighted imaging, assess muscle damage, including inflammation, by detecting changes in $T_2$ relaxation time. Current MRI techniques even allow quantification of metabolic differences between affected and non-affected muscles in DMD. There is no current cure, but physical therapist can improve their quality of life by maintaining muscle strength and function, especially if treatment (and other forms of medical intervention) begins in the early stages of the disease.

• 대한방사선기술학회지:방사선기술과학
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• 제31권2호
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• pp.123-127
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• 2008

목 적: 임상에서 인버터식 X선장치의 사용이 보편화됨에 따라 이에 대한 보다 정확하고 간편한 성능평가 방법이 요구되고 있다. 따라서 최근 국내에 소개되어 사용되고 있는 X-Ray Multi-Function Test Device (model : Xi (unfors)-prestige)를 이용한 성능평가의 유용성을 확인하고자 한다. 방 법: 인버터식 X선장치의 성능 평가시 접속형 측정장비로 널리 활용되고 있는 Dynalyzer III를 이용한 성능평가를 기준으로 하여 비접속형 측정장비인 X-Ray Multi-Function Test Device (model: Xi (unfors)-prestige)의 성능평가를 비교 분석하여 그 유용성을 검토하였다. 결 과: 두 측정기에 대한 X선 출력선량은 큰 차이 없이 측정되었으며 촬영조건 등의 변화에 따라서 접속형인 Dynalyzer III가 약간 증가된 값으로 측정되었으며 출력의 재현성은 두 측정기 모두 성능평가 합격 기준 0.05 이하인 0.002 이하로, 직선성은 합격기준인 0.1 이하로 평가되었다. 촬영조건의 정확도에서는 관전압은 1.8과 2, 관전류는 2.01과 2.3, 촬영시간은 T > 0.01 sec에서 ${\pm}10%$ 이하로 나타났다. 모두 성능평가 기준의 허용범위에 있는 것으로 나타났다. 결 론: X-Ray Multi-Function Test Device (model: Xi (unfors)-prestige) 측정기를 이용한 인버터식 X선장치의 X선 출력의 재현성, 직선성과 촬영조건의 정확도에 대한 성능평가의 유용성을 확인하였다.

• 대한핵의학회지
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• 제36권1호
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• pp.64-73
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• 2002

FDG-PET has potential as an effective, non-invasive tool to measure tumor response to anticancer therapy. The changes in tumor FDG uptake may provide an early, sensitive guide to the clinical and subclinical response of tumors to cancer treatment, as well as functional assessment of residual viable tumor. This may allow the evaluation of subclinical response to anticancer drugs in early clinical trials and improvements in patients management. However, monitoring tumor responses with FDG-PET is still in its infancy. The methods of measurement of FDG uptake are currently diverse and timing with respect to anti cancer therapy variable. Therefore, there is a need for larger-scale trials along with standardized methodology and a collection of reproducibility data. The recent guideline from the European group seems to be the most comprehensive. In future, the combination of morphological and metabolic images may improve the quantitative nature of these measurements by relating tumor viability to total tumor mass. More data on sensitivity and specificity of FDG-PET technique are needed along with continued advancement of PET methodology.

• 한국의학물리학회지:의학물리
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• 제12권1호
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• pp.9-17
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• 2001

본 논문의 목적은 조직(Tissue)에서의 광학적 특성(Optical Properties)을 이용한 광학적 생검(Optical Biopsy)방법을 소개하고, 방사선 치료에서 치료 반응 결과를 확인하는데 적당한 도구인가를 확인하고자 한다 본 연구는 구강(Oral Cavity) 내부조직을 샘플로, 건강한 사람 4명과 구강 암환자 4명의 자원을 받았다. 연구실에서 제작한 FastEEM(Excitation Emission Matrix) 장비를 이용하여 생체 내(in vivo)상태에서 측정하였다. 건강한 구강의 정상조직(Normal Tissue)과 병이 있는 구강의 비정상조직에서 기존의 생검과 동시에 새로운 광학적 생검을 하였다. 광학적 생검 결과와 기존의 생검 결과를 비교 확인하고, 암 조직으로 진단 받은 환자들에게 2차 광학적 생검을 실시하였다. 암 조직에 대한 1차 광학적 생검과 2차 측정 결과에 대한 형광스펙트럼을 비교 분석하였고, 자료분석은 Gillenwater가 개발한 337nm에 근거한 진단 알고리즘을 이용하였다. 광학적 생검 방법은 암 조직을 정상조직과 확실하게 구분시키는 장비임을 확인하였다. 건강한 구강조직과 악성 종양 조직의 측정 형광세기를 비교하면 정상조직인 경우 암 조직의 형광세기보다 모든 환자에 대해서 크게 나타났다. 암 조직의 구성이 시간에 따라 변하였을 때(7일) 광학적 생검을 하면 측정된 4명의 환자의 형광의 세기에 변화가 있었다. 7일간 시간이 지난 암 조직이 형광세기가 더 작은 값을 갖는다. 광학적 생검은 조직을 인체에서 분리하지 않는 생체 내, 실시간, 비침습성(noninvasive)생검 방법이다. 본 연구에서는 구강의 정상조직과, 암 조직, 그리고 암 조직의 진화에 따른 구성의 변화를 형광스펙트럼으로 확인하였다. 형광분광법을 이용한 FastEEM장치는 암 조직의 변화를 확인함으로 방사선 치료 후 발생하는 암 조직 구성의 화학적, 생물학적, 형태학적 변화를 실시간으로 정확하게 측정이 가능한 장치임을 확인하였다.

• Near Infrared Analysis
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• 제2권1호
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• pp.43-53
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• 2001

A non-invasive spectroscopic method is presented for the measurement of pulmonary edema. Both early diagnosis and quantitative edema estimates were investigated. The spectroscopic determination of pulmonary edema involved the acquisition of diffuse reflectance spectra in the near-infrared (NIR) region with change in water concentration - water is the main constituent of edema fluid. Pulmonary edema was induced into the excised perfused lungs of seven animals by elevating the hydrostatic pressure. Estimates of edema were ascertained from a partial least squares regression of the measured spectral response. Actual edema was determined from the change (increase) in total lung weight. Estimates in relative lung weight increases due to in vitro edema were made with the near infrared spectra. The results revealed that fluid accumulation produced spectral changes in the O-H and C-H absorptions as well as scattering changes in the spectra. Histology of the lung was used to verify the presence or absence of interstitial and alveolar edema. Results demonstrated that near infrared spectroscopy might provide a new tool for clinical assessment of pulmonary edema.

• 전기학회논문지
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• 제60권4호
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• pp.877-879
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• 2011

Bowel sounds (BS) are produced by the movement of the intestinal contents in the lumen of the gastro-intestinal tract during peristalsis and thus, it can be used clinically as useful indicators of bowel motility. We devised an estimation algorithm of bowel motility based on the regression modeling of the jitter and shimmer of BS signals measured by auscultation. Ten healthy males ($23.5\pm2.1$ years) were examined. Consequently, the correlation coefficient, coefficient of determination and standard error between the colon transit times (CTT) measured by a conventional radiograph and the values estimated by our algorithm were 0.98, 0.96 and 2.86, respectively. Also, through k-fold cross validation, the average value of the absolute differences between them was $5.0\pm2.5$ hours. This method could be used as a complementary tool for the non-invasive measurement of bowel motility.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1667-1670
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• 2014

Background: Calprotectin in feces seems to be a more sensitive marker for gastrointestinal (GI) cancers than fecal occult blood, but its specificity may be too low for screening average risk populations. This study aims at evaluating the diagnostic value of fecal calprotectin as a screening biomarker for GI malignancies. Materials and Methods: In a case-control study, 100 patients with GI malignancies (50 patients with colorectal cancer and 50 patients with gastric cancer) and 50 controls were recruited in Tabriz Imam Reza and Sina hospitals during a 24-month period. One to two weeks after the last endoscopy/colonoscopy, fecal specimens were collected by the patients and examined by ELISA method for quantitative measurement of calprotectin content. The results were compared between the three groups. Results: The mean fecal calprotectin level was $109.1{\pm}105.3$ (2.3-454.3, median:74), $241.1{\pm}205.2$ (3.4-610.0, median:19.3) and $45.9{\pm}55.1{\mu}g/g$ (1.3-257.1, median:19.3) in gastric cancer, colorectal cancer and control group, respectively, the differences being significant (p<0.001) and remaining after adjustment for age. The optimal cut-off point for fecal calprotectin was ${\geq}75.8{\mu}g/g$ for distinguishing colorectal cancer from normal cases (sensitivity and specificity of 80% and 84%, respectively). This value was ${\geq}41.9{\mu}g/g$ for distinguishing gastric cancer from normal cases (sensitivity and specificity of 62%). Conclusions: Our results revealed that fecal calprotectin might be a useful and non-invasive biomarker for distinguishing colorectal cancer from non-malignant GI conditions. However, due to low sensitivity and specificity, this biomarker may not help physicians distinguishing gastric cancer cases from healthy subjects.

• Progress in Superconductivity
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• 제10권1호
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• pp.1-5
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• 2008

Magnetocardiography (MCG) is a non-contact, non-invasive, and harmless diagnostic tool to detect the abnormal electrical conductivities of the heart caused by the various coronary artery disease or cardiac muscular disease. The purpose of this study is to identify whether MCG signals and MCG parameter values vary depending on the location of sensor assembly. It will be an important reference for the standard measurement. Four healthy male subjects (33.3$\pm$6.3 years) participated in this study. Basal recording was made at 20 mm apart from the chest surface. All subjects were requested to take a regular breathe while MCG was taken. The gap between the chest surface and the bottom of the sensor assembly was 20, 40, 60, and 80 mm. Recording was made using 64 channel MCG system (Axial type, first order gradiometer) developed by Korea Research Institute of Standards and Science (KRISS). After resting for two minutes in a supine position on the bed in magnetically shielded room, MCG were recorded for 30 s. As the sensor location is getting away from the chest surface signal, the amplitude of R and T wave peak decreases to 70% (at 40 mm gap), 50% (at 60 mm), and 37% (at 80 mm) of the reference strength measured (y = $1.3903e^{-0.0169x}$, $R^2$ = 0.99; where y=amplitude remained after reduction, x=distance between chest surface and sensor location). The regression equations may be used as a good reference to calculate how much strength will be decreased by the distance. In MCG parameters, most values of parameters were decreased as the gap was increased. As an example, the current moment at T-wave peak reduced to 52% (at 40 mm gap), 33% (at 60 mm), and 19% (at 80 mm). However, the difference caused by the gap could be reduced by considering the distance when the MCG parameters were calculated. The study results can be used as a useful reference to design the baseline and the sensor location.

• 대한의용생체공학회:의공학회지
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• 제35권4호
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• pp.95-98
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• 2014

The baroreflex is one kind of homeostatic mechanisms to regulate acute blood pressure (BP) changes by controlling heartbeat interval (HBI). To quantify the effect of baroreflex, we suggested a new approach of analyzing Granger causality between systolic BP (SBP) and HBI. The index defined as baroreflex effectiveness (BRE) was generated by the hypothesis that more effectual baroreflex would be related to more effective Granger causal influence of SBP on HBI. Six obstructive sleep apnea (OSA) patients (apnea-hypopnea index, AHI ${\geq}5$ events/hr) and six normal subjects participated in the study. Their SBP and HBI during nocturnal sleep were obtained from a non-invasive continuous BP measurement device. While the BRE ($mean{\pm}SD$) of normal subjects was $47.0{\pm}4.0%$, OSA patients exhibited the BRE of $34.0{\pm}3.8%$. The impaired baroreflex function of OSA patients can be explained by the physiological mechanism associated with recurrent hypoxic episodes during sleep. Thus, the significantly lower BRE in OSA patients verified the availability of Granger causality analysis to evaluate baroreflex during sleep. Furthermore, the range of BRE obtained from normal subjects was not overlapped with that obtained from OSA patients. It suggests the potential of BRE as a new helpful tool for diagnosing OSA.