• Korean Journal of Radiology
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• 제23권1호
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• pp.13-29
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• 2022

Nonalcoholic fatty liver disease, characterized by excessive accumulation of fat in the liver, is the most common chronic liver disease worldwide. The current standard for the detection of hepatic steatosis is liver biopsy; however, it is limited by invasiveness and sampling errors. Accordingly, MR spectroscopy and proton density fat fraction obtained with MRI have been accepted as non-invasive modalities for quantifying hepatic steatosis. Recently, various quantitative ultrasonography techniques have been developed and validated for the quantification of hepatic steatosis. These techniques measure various acoustic parameters, including attenuation coefficient, backscatter coefficient and speckle statistics, speed of sound, and shear wave elastography metrics. In this article, we introduce several representative quantitative ultrasonography techniques and their diagnostic value for the detection of hepatic steatosis.

• ETRI Journal
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• 제28권6호
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• pp.770-776
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• 2006

This paper presents a hyperspectral imaging technique based on laser-induced fluorescence for non-invasive detection of tumorous tissue on mouse skin. Hyperspectral imaging sensors collect image data in a number of narrow, adjacent spectral bands. Such high-resolution measurement of spectral information reveals contiguous emission spectra at each image pixel useful for the characterization of constituent materials. The hyperspectral image data used in this study are fluorescence images of mouse skin consisting of 21 spectral bands in the visible spectrum of the wavelengths ranging from 440 nm to 640 nm. Fluorescence signal is measured with the use of laser excitation at 337 nm. An acousto-optic tunable filter (AOTF) is used to capture images at 10 nm intervals. All spectral band images are spatially registered with the reference band image at 490 nm to obtain exact pixel correspondences by compensating the spatial offsets caused by the refraction differences in AOTF at different wavelengths during the image capture procedure. The unique fluorescence spectral signatures demonstrate a good separation to differentiate malignant tumors from normal tissues for rapid detection of skin cancers without biopsy.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.805-808
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• 2005

We constructed an eddy current tester as education programs of electronics and computers. The tester is designed based on frequency counting of square-waves digitally, where information of phase is lost, but which is very compact. Main controller of the tester is PIC16HC84A. Other parts, detection-coils, oscillators, and stabilizers are made by us. The tester is able to detect change of order(-5) in waves of 1MHz, whose function is kept in several minutes. The measurement period is 10-20 msec in the several minutes. Using the tester, we observed narrow gaps of copper/aluminum wires, and detected resistivity difference of 1.7 or 2.7 [$10^{-8}$ $ohm^{\ast}m$].

• Tuberculosis and Respiratory Diseases
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• 제86권3호
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• pp.176-182
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• 2023

Since the introduction of low-dose computed tomography (CT) screening for patients at high risk of lung cancer, the detection rate of suspicious lung cancer has increased. In addition, there have been many advances in therapeutics targeting oncogenic drivers in non-small cell lung cancer. Therefore, accurate pathological diagnosis of lung cancer, including molecular diagnosis, is increasingly important. This review examines the problems in the pathological diagnosis of suspected lung cancer. For successful pathological diagnosis of lung cancer, clinicians should determine the appropriate modality of the diagnostic procedure, considering individual patient characteristics, CT findings, and the possibility of complications. Furthermore, clinicians should make efforts to obtain a sufficient amount of tissue sample using non- or less-invasive procedures for pathological diagnosis and biomarker analysis.

• 융합신호처리학회논문지
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• 제19권1호
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• pp.28-34
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• 2018

본 논문은 적외선 온도센서를 이용한 재실인원 측정을 통한 출입자 관리 시스템, 방 내부의 움직임 파악하기 위한 PIR센서 모듈, 그리고 취침 상태를 판별하기 위한 스마트 호흡감지 모듈로 구성된다. 센싱부와 알고리즘 구동 부를 일체화 한 임베디드 형태의 센서 모듈과 통신 시스템으로 구성하였다. 고령화 사회가 가속화, 고급화됨에 따라 실버케어에 대한 사회적 비용이 증가하고 프라이버시를 보호하기 위해선 효율적인 실버케어기기 개발을 통하여 비용 감소가 필요하다. 제안된 비 영상 인체감지 IOT 센서 시스템은 하드웨어와 소프트웨어로 구현하였고 기존의 영상에 의한 감시 방법과 비교하여 우수한 성능을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1631-1635
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• 2016

Helicobacter pylori infection plays an important role in the pathogenesis of chronic gastritis, peptic ulcer disease and gastric malignancy. A diagnosis of infection is thus an important part of a treatment strategy of many gastrointestinal tract diseases. Many diagnostic tests are available but all have some limitations in different clinical situations and laboratory settings. A single gold standard cannot available, but be used for diagnosis of Helicobacter pylori infection in daily clinical practice in all areas, so several techniques have been developed to give reliable results, especially focusing on real time endoscopic features. The narrow band imaging system (NBI) and high resolution endoscopy are imaging techniques for enhanced visualization of infected mucosa and premalignant gastric lesions. The aim of this article is to review the current diagnostic options and possible future developments detection of Helicobacter pylori infection.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2008년도 하계학술대회 논문집 Vol.9
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• pp.473-474
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• 2008

This paper proposes that the relative transmittance and emission intensity measured via optical emission spectroscopy (OES) is a useful for fault detection of reactive ion etch process. With the increased requests for non-invasive as well as real-time plasma process monitoring for fault detection and classification (FDC), OES is suggested as a useful diagnostic tool that satisfies both of the requirements. Relative optical transmittance and emission intensity of oxygen plasma acquired from various process conditions are directly compared with the process variables, such as RF power, oxygen flow and chamber pressure. The changes of RF power and Pressure are linearly proportional to the emission intensity while the change of gas flow can be detected with the relative transmittance.

• 한국의학물리학회지:의학물리
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• 제21권1호
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• pp.22-28
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• 2010

유방암 중에서 가장 발생율이 높은 침윤성 관상피암을 대상으로 생체 국소 수소핵 자기공명분광법(localized in vivo $^1H$ MRS)을 시행하여 조직학적 형태에 따른 자기공명 분광상(MR spectroscopy)의 특성을 분석하고자 본 연구를 실시하였다. 조직학적으로 침윤성 관상피암으로 진단 받은 환자 40명을 대상으로 하여 종양이 있는 부위를 실험군으로 정하였고 종양이 없는 반대쪽 부위를 대조군으로 정하여 3.0T MR scanner를 이용한 수소핵 자기공명분광영상으로 검사를 시행하여 영상 및 분광 정보를 얻었다. 유방암 환자 40명 중 34명(85%)에서 3.2 ppm 분광정점을 확인할 수 있었고 MRS상 3.2 ppm에서의 분광정점 발현여부를 유방암의 진단 기준으로 선택하는 경우 민감도는 85% (34/40), 특이도는 92.5% (37/40), 양성예측율은 100% (34/34), 음성 예측율은 86% (37/43)이었다. 정상 조직의 1.3 ppm에서의 분광정점을 진단 기준으로 정할때 민감도는 92.5% (37/40), 특이도는 85% (34/40), 양성 예측율은 100% (37/37), 음성 예측율은 91.8% (34/37)이었다. $^1H$ MRS방법이 유방암의 진단에 이용될 수 있는 가능성을 제시하였고 추후 지속적인 연구를 통해 임상적으로 진단 및 치료 판정에 널리 이용될 수 있을 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9927-9931
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• 2014

The objectives of this study were to examine serum periplakin expression in patients with urothelial carcinoma of the urinary bladder and in normal controls, and to examine relationships with clinicopathological findings. Detection of serum periplakin was performed in 50 patients and 30 normal controls with anti-periplakin antibodies using the automatic dot blot system, and a micro-dot blot array with a 256 solid-pin system. Levels in patients with urothelial carcinoma of the urinary bladder were significantly lower than those in normal controls (0.31 and 5.68, respectively; p<0.0001). The area under the receiver-operator curve level for urothelial carcinoma of the urinary bladder was 0.845. The sensitivity and specificity, using a cut-off point of 4.045, were 83.7% and 73.3%, respectively. In addition, serum periplakin levels were significantly higher in patients with muscle-invasive cancer than in those with nonmuscle-invasive cancer (P = 0.03). In multivariate Cox proportional hazards regression analysis, none of the clinicopathological factors was associated with an increased risk for progression and cancer-specific survival. Examination of the serum periplakin level may play a role as a non-invasive diagnostic modality to aid urine cytology and cystoscopy.

• 한국산학기술학회논문지
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• 제20권7호
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• pp.151-157
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• 2019

최근 비침투 또는 비접촉 방식을 활용한 호흡상태 관찰에 대한 관심이 높아지고 있다. 여러 가지 많은 생체신호들 중 호흡신호를 활용하여 건강상태를 점검하는 것은 비정상적인 건강 상태에 대한 신속한 대응을 가능하게 해 준다. 본 논문에서는 국소 퓨리에 변환을 활용한 실시간 무호흡 상태 검출에 대한 방법을 제시한다. 기존의 고속 퓨리에 변환을 활용한 신호해석과 달리, 본 논문에서는 국소 퓨리에 변환을 사용하여 짧은 신호 구간에서의 주파수 응답을 분석한다. 본 연구에서 호흡 신호는 비접촉 방식을 활용하였으며, 초광대역 레이더 모듈을 활용하여 신호를 획득하였다. 국소 퓨리에 변환을 활용하여 호흡 상태를 검출한 후, 검출 결과에 따라 호흡 상태에 대한 분류가 가능하다. 특히 국소 퓨리에 변환은 실시간으로 호흡 상태에 대한 주파수 분석이 가능하도록 하였다. 호흡신호에 잡음이 존재할 경우를 대비하여 적절한 필터링 알고리즘이 적용되었다. 본 논문에서 제안하는 방법은 직관적으로 구현이 가능하고, 실질적으로 사람의 호흡상태에 대한 분석이 가능하도록 해준다. 제안한 방법을 검증하기 위해 호흡신호를 활용한 실험결과를 제시한다.