• ETRI Journal
• /
• v.28 no.6
• /
• pp.770-776
• /
• 2006

This paper presents a hyperspectral imaging technique based on laser-induced fluorescence for non-invasive detection of tumorous tissue on mouse skin. Hyperspectral imaging sensors collect image data in a number of narrow, adjacent spectral bands. Such high-resolution measurement of spectral information reveals contiguous emission spectra at each image pixel useful for the characterization of constituent materials. The hyperspectral image data used in this study are fluorescence images of mouse skin consisting of 21 spectral bands in the visible spectrum of the wavelengths ranging from 440 nm to 640 nm. Fluorescence signal is measured with the use of laser excitation at 337 nm. An acousto-optic tunable filter (AOTF) is used to capture images at 10 nm intervals. All spectral band images are spatially registered with the reference band image at 490 nm to obtain exact pixel correspondences by compensating the spatial offsets caused by the refraction differences in AOTF at different wavelengths during the image capture procedure. The unique fluorescence spectral signatures demonstrate a good separation to differentiate malignant tumors from normal tissues for rapid detection of skin cancers without biopsy.

• 제어로봇시스템학회:학술대회논문집
• /
• 2005.06a
• /
• pp.805-808
• /
• 2005

We constructed an eddy current tester as education programs of electronics and computers. The tester is designed based on frequency counting of square-waves digitally, where information of phase is lost, but which is very compact. Main controller of the tester is PIC16HC84A. Other parts, detection-coils, oscillators, and stabilizers are made by us. The tester is able to detect change of order(-5) in waves of 1MHz, whose function is kept in several minutes. The measurement period is 10-20 msec in the several minutes. Using the tester, we observed narrow gaps of copper/aluminum wires, and detected resistivity difference of 1.7 or 2.7 [$10^{-8}$ $ohm^{\ast}m$].

• Tuberculosis and Respiratory Diseases
• /
• v.86 no.3
• /
• pp.176-182
• /
• 2023

Since the introduction of low-dose computed tomography (CT) screening for patients at high risk of lung cancer, the detection rate of suspicious lung cancer has increased. In addition, there have been many advances in therapeutics targeting oncogenic drivers in non-small cell lung cancer. Therefore, accurate pathological diagnosis of lung cancer, including molecular diagnosis, is increasingly important. This review examines the problems in the pathological diagnosis of suspected lung cancer. For successful pathological diagnosis of lung cancer, clinicians should determine the appropriate modality of the diagnostic procedure, considering individual patient characteristics, CT findings, and the possibility of complications. Furthermore, clinicians should make efforts to obtain a sufficient amount of tissue sample using non- or less-invasive procedures for pathological diagnosis and biomarker analysis.

• Journal of the Institute of Convergence Signal Processing
• /
• v.19 no.1
• /
• pp.28-34
• /
• 2018

This paper is composed of a passenger management system using a temperature sensing module, a PIR sensor module for detecting movement inside a room, and a smart breath sensing module for determining a sleeping state. An embedded sensor module and a communication system integrated the sensing part and the algorithm driving part. As the aging society is accelerating and becoming more upgraded, the social cost of Silver Care increases, and in order to protect privacy, it is necessary to reduce costs by developing efficient smart silver care devices. The proposed non - image human body detection IOT sensor system is implemented by hardware and software and has superior performance compared with conventional image monitoring method.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.4
• /
• pp.1631-1635
• /
• 2016

Helicobacter pylori infection plays an important role in the pathogenesis of chronic gastritis, peptic ulcer disease and gastric malignancy. A diagnosis of infection is thus an important part of a treatment strategy of many gastrointestinal tract diseases. Many diagnostic tests are available but all have some limitations in different clinical situations and laboratory settings. A single gold standard cannot available, but be used for diagnosis of Helicobacter pylori infection in daily clinical practice in all areas, so several techniques have been developed to give reliable results, especially focusing on real time endoscopic features. The narrow band imaging system (NBI) and high resolution endoscopy are imaging techniques for enhanced visualization of infected mucosa and premalignant gastric lesions. The aim of this article is to review the current diagnostic options and possible future developments detection of Helicobacter pylori infection.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2008.06a
• /
• pp.473-474
• /
• 2008

This paper proposes that the relative transmittance and emission intensity measured via optical emission spectroscopy (OES) is a useful for fault detection of reactive ion etch process. With the increased requests for non-invasive as well as real-time plasma process monitoring for fault detection and classification (FDC), OES is suggested as a useful diagnostic tool that satisfies both of the requirements. Relative optical transmittance and emission intensity of oxygen plasma acquired from various process conditions are directly compared with the process variables, such as RF power, oxygen flow and chamber pressure. The changes of RF power and Pressure are linearly proportional to the emission intensity while the change of gas flow can be detected with the relative transmittance.

• Progress in Medical Physics
• /
• v.21 no.1
• /
• pp.22-28
• /
• 2010

To evaluate the potential value of $^1H$ Magnetic resonance spectroscopy (MRS) for detecting and characterizing invasive ductal carcinoma of breast. We conducted $^1H$ Magnetic resonance spectroscopy (MRS), using a 3.0T MR scanner, on 40 patients who were histologically diagnosed to have invasive ductal carcinoma (IDC); tumor areas of the patients were designated as experimental samples, and non-tumor areas as control samples. The peak at 3.2 ppm is characteristically intense and observed in 34 cases of the total 40 invasive ductal carcinoma (sensitivity 86.2%; specificity 100%; positive predictive value 100%; negative predictive value 60%). In constrast peak at 1.3 ppm is characteristically intense and observed in normal breast (sensitivity 86.2%; specificity 100%; positive predictive value 100%; negative predictive value 60%). The study shows that $^1H$ MRS can effectively discriminate invasive ductal carcinoma from normal breast in most cases. It also demonstrates the feasibility of localized in vivo $^1H$ MRS technique as a new diagnostic modality in the detection of breast tumor.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.22
• /
• pp.9927-9931
• /
• 2014

The objectives of this study were to examine serum periplakin expression in patients with urothelial carcinoma of the urinary bladder and in normal controls, and to examine relationships with clinicopathological findings. Detection of serum periplakin was performed in 50 patients and 30 normal controls with anti-periplakin antibodies using the automatic dot blot system, and a micro-dot blot array with a 256 solid-pin system. Levels in patients with urothelial carcinoma of the urinary bladder were significantly lower than those in normal controls (0.31 and 5.68, respectively; p<0.0001). The area under the receiver-operator curve level for urothelial carcinoma of the urinary bladder was 0.845. The sensitivity and specificity, using a cut-off point of 4.045, were 83.7% and 73.3%, respectively. In addition, serum periplakin levels were significantly higher in patients with muscle-invasive cancer than in those with nonmuscle-invasive cancer (P = 0.03). In multivariate Cox proportional hazards regression analysis, none of the clinicopathological factors was associated with an increased risk for progression and cancer-specific survival. Examination of the serum periplakin level may play a role as a non-invasive diagnostic modality to aid urine cytology and cystoscopy.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.7
• /
• pp.151-157
• /
• 2019

Recently, monitoring respiration of people has been of interest using non-invasive method. Among the vital signals usually used for indicating health status, non-invasive and portable device based monitoring respiratory status is practically useful and enable one to promptly deal with abnormal physical status. This paper proposes the approach to real-time detection of apnea signal based on Short-Time-Fourier-Transform(STFT). Contrary to the analysis of a signal in frequency domain using Fast-Fourier Transform, this paper employs Short-time-Fourier-Transform so that frequency response can be analyzed in short time interval. The respiratory signal is acquired using UWB radar sensor that enables one to obtain respiration signal in contactless way. Detection of respiratory status is carried out by analyzing frequency response, and classification of respiratory status can be provided. In particular, STFT is employed to analyze respiratory signal in real-time, leading to effective analysis of the respiratory status in practice. In the case of existence of noise in the signal, appropriate filtering process is employed as well. The proposed method is straightforward and is workable in practice to analyze the respiratory status of people. To evaluate the proposed method, experimental results are provided.

• Advances in pediatric surgery
• /
• v.20 no.2
• /
• pp.33-37
• /
• 2014

Purpose: The purpose of this study was to compare the diagnostic accuracy of the non-invasive diagnostic methods and rectal suction biopsy for the detection of Hirschsprung disease (HD). Methods: We reviewed diagnostic methods and results retrospectively in patients who underwent anorectal manometry, barium enema and rectal suction biopsy for the diagnosis of HD at Asan Medical Center from January 2000 to December 2012. Results: There were 97 patients (59 neonates and 38 infants) in the study period. The overall accuracy of anorectal manometry for the diagnosis of HD was 71.1% and its sensitivity was 51.4% (48.1% in neonate and 62.5% in infant, respectively) and its overall specificity was 82.3% (81.3% in neonate and 83.3% in infant, respectively). The Overall accuracy of barium enema was 66.0% (72.8% in neonate and 55.3% in infant, respectively) and specificity of barium enema was 53.2% (56.3% in neonate and 50.0% in infant, respectively). These results were lower than those of anorectal manometry. The overall sensitivity of barium enema was 88.6% (92.6% in neonate and 75.0% in infant, respectively) and it was higher than the sensitivity of anorectal manometry. Histological studies confirmed HD in 35 patients, in one of whom the suction biopsy showed negative finding. Conclusion: Accuracy of non-invasive methods for diagnosis of HD in our study is lower than those in previous study, so we need to improve the quality of diagnostic tools in our hospital. We conclude that the rectal suction biopsy is the most accurate test for diagnosing HD, so the biopsy to confirm the diagnosis of the HD is very important.