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Substantial Evidences Indicate That Inorganic Arsenic Is a Genotoxic Carcinogen: a Review

  • Roy, Jinia Sinha;Chatterjee, Debmita;Das, Nandana;Giri, Ashok K.
    • Toxicological Research
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    • v.34 no.4
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    • pp.311-324
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    • 2018
  • Arsenic is one of the most toxic environmental toxicants. More than 150 million people worldwide are exposed to arsenic through ground water contamination. It is an exclusive human carcinogen. Although the hallmarks of arsenic toxicity are skin lesions and skin cancers, arsenic can also induce cancers in the lung, liver, kidney, urinary bladder, and other internal organs. Arsenic is a non-mutagenic compound but can induce significant cytogenetic damage as measured by chromosomal aberrations, sister chromatid exchanges, and micronuclei formation in human systems. These genotoxic end points are extensively used to predict genotoxic potentials of different environmental chemicals, drugs, pesticides, and insecticides. These cytogenetic end points are also used for evaluating cancer risk. Here, by critically reviewing and analyzing the existing literature, we conclude that inorganic arsenic is a genotoxic carcinogen.

Effects of Material Modulus on Fracture Toughness of Human Enamel, a Natural Biocomposite

  • Mishra, Dhaneshwar;Yoo, Seung-Hyun
    • Journal of the Korean Society for Nondestructive Testing
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    • v.31 no.3
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    • pp.287-293
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    • 2011
  • The enamel, the upper layer of a tooth has remarkable capability of bearing severe loading on the tooth. The fracture behavior is important to understand the mechanism of load bearing and it could be very useful for developing new materials. Non-destructive evaluation of such materials will also benefit from this knowledge. The graded microstructures of enamel were modeled by finite element analysis software and the J-integrals and the stress intensity factors were evaluated as the fracture parameters. The results show that these parameters are location dependent. Those values increase when measured in the direction of dentine enamel junction. This finding matched well with experiments and implies many useful understanding of biomaterials and applications to new materials.

Risk Assessment of Airborne Volatile Organic Compounds in Ulsan Industrial Complex Area (울산공단지역의 대기중 휘발성 유기화합물에 대한 위해도 평가)

  • 남병현;윤미정;이진홍
    • Journal of the Korean Society of Safety
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    • v.14 no.2
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    • pp.103-108
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    • 1999
  • This study focused on risk assessment for inhalation of airborne volatile organic compounds (VOCs) in Ulsan industrial complex area. For non-carcinogenic risk, even the highest hazard index of toluene was estimated to be $4.8\times10^{-2}$, which was much lower than 1. The total hazard index of VOCs was estimated to be $5.8\times10^{-2}$. However, lifetime average cancer risk from the inhalation of airborne VOCs was estimated to be about $1.1\times10^{-3}/$, which was much higher than a risk standard of $10^{-5}$. The risk of $4.4\times10^{-5}$. came from benzene, the only human carcinogen among VOCs, while that of $1.05\times10^{-3}$ from probable human carcinogens including 1,3-butadiene and 1,2-dichloroethane. About 70% and 20% of total VOC cancer risk was due to the inhalation of 1,3-butadiene and 1,2-dichloroethane, respectively. Therefore, proper risk management of these 3 VOCs was required for the protection of health from cancer burden in Ulsan industrial complex area.

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Comparison of two diagnostic methods, allele-specific real-time PCR and 3'-tailed PCR to discriminate between Salmonella enterica serovars Gallinarum and S Pullorum (Salmonella enterica serovars Gallinarum과 S Pullorum의 감별을 위한 2가지 진단법: allele-specific real-time PCR과 3'-tailed PCR의 비교)

  • Lee, Se-Mi;Seo, Ja-Young;Lee, Jae-Il;Kim, Tae-Jung
    • Korean Journal of Veterinary Service
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    • v.31 no.4
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    • pp.485-492
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    • 2008
  • Salmonella enterica serovars Gallinarum(SG, causative agent of fowl typhoid) and S Pullorum(SP, causative agent of pullorum disease) are very important bacterial pathogens in poultry industry. They share some common antigenic properties though the characteristics of outbreaks are quite different. To discriminate between SG and SP, we developed two rapid diagnostic methods, allele-specific real-time PCR and 3'-tailed PCR over 2 single nucleotide polymorphisms ($237^{th}\;and\;598^{th}$). In both methods, $237^{th}$ allele was found to be a good target for differential diagnosis, while $598^{th}$ allele produced some non-specific reactions.

A Model of the Operator Cognitive Behaviors During the Steam Generator Tube Rupture Accident at a Nuclear Power Plant

  • Mun, J.H.;Kang, C.S.
    • Nuclear Engineering and Technology
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    • v.28 no.5
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    • pp.467-481
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    • 1996
  • An integrated framework of modeling the human operator cognitive behavior during nuclear power plant accident scenarios is presented. It incorporates both plant and operator models. The basic structure of the operator model is similar to that of existing cognitive models, however, this model differs from those existing ones largely in too aspects. First, using frame and membership function, the pattern matching behavior, which is identified as the dominant cognitive process of operators responding to an accident sequence, is explicitly implemented in this model. Second, the non-task-related human cognitive activities like effect of stress and cognitive biases such as confirmation bias and availability bias, are also considered. A computer code, OPEC is assembled to simulate this framework and is actually applied to an SGTR sequence, and the resultant simulated behaviors of operator are obtained.

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Orientalism showed in Korean modern fashion (한국패션의 오리엔탈리즘)

  • Lee, Eun-Young;Park, Ha-Na
    • Korean Journal of Human Ecology
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    • v.13 no.5
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    • pp.811-819
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    • 2004
  • The purpose of this study is to examine orientalism in Korean modem fashion by Korean fashion designers. Orientalism in fashion has been widely known to people by the efforts of many researchers, but that in Korean fashion wasn't. We thus study the aesthetic meaning of Korean orientalism, and extend it to oriental fashion as well as meaning of modem orientalism shown in Korean fashion. For this study, we categorized the orientalism in Korean fashion as follows: 1) mix orientalism; 2) natural beauty with non technical skill; 3) humorous beauty; 4) color beauty.

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The Influence of Family Functioning on the Exposure of Domestic Violence in Children (가족기능이 자녀의 가정폭력 노출에 미치는 영향)

  • Kim, Kyeong-Shin;Kim, Jeong-Ran
    • Korean Journal of Human Ecology
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    • v.13 no.5
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    • pp.691-699
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    • 2004
  • The purpose of this study was to analyze the relationship between family functioning and family violence. The SPSS 10.0 for Windows was used to analyze data obtained through 1,044 children who live in Gwangju Chonnam area. Major findings are as follows: 1. Wife abuse and child abuse showed significant difference according to family cohesion, family flexibility, and family-system types. 2. In family violence non-experience group, 'balanced family' was found in 36.2% of the sample and 'extreme family' in 7.8%. In family violence experience group, 'balanced family' was found in 12.7% of the sample and 'extreme family' in 15.4%. 3. There were significant negative correlations between family functioning and family violence. Family cohesion and family flexibility had significant negative correlation with wife abuse and child abuse.

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Experiments in Information Retrieval (정보검색에서 실험연구 방법을 이용한 연구의 분석)

  • 곽철완
    • Journal of the Korean Society for information Management
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    • v.15 no.3
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    • pp.27-44
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    • 1998
  • The purpose of this study il to analyze the papers of experiments in information retrieval for systematic categorization. The result shows that broad categories are systems, units of analysis, variables. It found three subcategories in the units of analysis: search results, queries, user. Variables are divided into human variable and non-human variables and each variables are divided into independent and dependent variables as subcategories.

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Self-consciousness Improvement Effect of Nonstructured Developmental Art Therapy on a Developmental Disordered Child -A Study on the Single Case- (비구조적 발달 미술치료를 통한 발달장애아의 자아의식 향상 효과 -단일사례를 중심으로-)

  • Kang, Young-Ja;Kang, Soung-A
    • Korean Journal of Human Ecology
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    • v.11 no.4
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    • pp.321-334
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    • 2002
  • This study is a non-structured developmental art-therapy case study having done 134 times of total treatments for a 12 years old girl, having extremely poor verbal communication ability and sociality comparing to her ability in perception and motion. I presumed the cause of this gap between perceptibility and the communication ability was a problem related to self-consciousness. To cure the problem, I provided treatment programs designed to use material which can create a stable and reliable environment and can give body experiences such as painting and play-dough. As the treatment programs progressed, I found she had changed gradually to lead the game by herself and to express her favorite colors and shapes. Also she became to be able to express her experience as a simple word and to response short answers for questions.

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Parents' Cultural Beliefs about Children's Success in School (아동의 성공적인 학교생활에 대한 부모신념의 비교문화 연구)

  • Lee, Ju-Lie
    • Korean Journal of Human Ecology
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    • v.14 no.5
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    • pp.721-736
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    • 2005
  • Parents' beliefs about what child's qualities are associated with success in school were studied among Korean and Western society communities' parents. Parents from all groups agreed that four domains of a child's characteristics(cognitive qualities, social qualities, negative temperament, and dutifulness) had the major impact on school success, either positively or negatively. Parents from all groups indicated that non cognitive qualities were important or more important than cognitive factors. Cultural differences were found in the way the qualities clustered together and in the emphasis parents placed on specific qualities or domains of qualities.

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