• Title/Summary/Keyword: nm23-M5

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Characterization and Localization of the Murine nm23-M5 in Mouse Testis

  • Kang, Sung-Jo;Park, Yun-Jung;Kim, Jin-Hoi
    • Proceedings of the KSAR Conference
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    • 2004.06a
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    • pp.223-223
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    • 2004
  • Nucleoside diphosphate kinases(NDPKs) are ubiquitous enzymes involved in numerous regulatory processes associated with transcriptional regulation, cell proliferation, development, and differentiation. In this study, we was examined characterization and localization of the nm23-M5 in mouse testis by Western blotting, immunohistochemical and conforcal imaging study using specific antibodies raised against nm23-M5. (omitted)

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Cell- and Stage-Specific Expression of the Murine nm23-M5 Gene during Late Spermatogenesis and Spermiogenesis

  • Hwang Gyu-Chan;Ok Do-Won;Lee Mi-Suk;Kim Jin-Hoe
    • Proceedings of the KSAR Conference
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    • 2002.06a
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    • pp.5-5
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    • 2002
  • Nucleoside diphosphate kinases (NDPKs) are conserved through evolution and have been shown to be involved in various biological phenomena. By functional screening in yeast, we identified a new member of the NDPK family, ㎚23-M5, which encodes a 211-amino acid protein with 86% identify to the human homolog, ㎚23-H5. Northern blot analysis reveals that ㎚23-M5 encodes two transcripts of 0.8 and 0.7 kb, which are highly and specifically expressed in adult testis. Reverse transcriptase polymerase chain reaction analysis shows that nm23-M5 first appears in pachytene spermatocytes and increase chain reaction in abundance through subsequent stages. (omitted)

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Targeting Tumor Metastasis by Regulating Nm23 Gene Expression

  • Prabhu, V. Vinod;Siddikuzzaman, Siddikuzzaman;Grace, V.M. Berlin;Guruvayoorappan, C.
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.8
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    • pp.3539-3548
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    • 2012
  • The Nm23 gene is a metastatic suppressor identified in a melanoma cell line and expressed in different tumors where their levels of expression are associated with reduced or increased metastatic potential. Nm23 is one of the over 20 metastasis suppressor genes (MSGs) confirmed in vivo. It is highly conserved from yeast to human, implying a critical developmental function. Tumors with alteration of the p53 gene and reduced expression of the Nm23 gene are more prone to metastasis. Nm23-H1 has 3'-5' exonuclease activity. This review focuses on the role of Nm23 in cancer progression and also a potential novel target for cancer therapy.

Effects of Emission Layer Thickness on the Efficiency of Blue Phosphorescent Organic Light Emitting Diodes with Triple Layer Structure (발광층 두께가 삼층 구조 청색 인광 OLED의 효율 특성에 미치는 영향)

  • Seo, Yu-Seok;Moon, Dae-Gyu
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.23 no.2
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    • pp.143-147
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    • 2010
  • We have fabricated simple triple-layer blue-emitting phosphorescent organic light emitting diodes (OLEDs) using different thicknesses of N,N'-dicarbazolyl-3,5-benzene (mCP) host layers doped with bis[(4,6-di-fluorophenyl)-pyridinate-N,$C^{2'}$]picolmate (FIrpic) guest materials. The thicknesses of mCP:FIrpic layers were 5, 10, and 30 nm. Driving voltage, current and power efficiencies were investigated. The current efficiency was higher in the 10 nm thick mCP:FIrpic device, resulting from the better electron-hole balance. The device with 10 nm mCP:FIrpic layer exhibited the maximum current efficiency of 22.5 cd/A and power efficiency of 7.4 lm/W at a luminance of 1000 cd/$m^2$.

Optical Properties of Sea Water in Tokyo Bay (동경만에서의 해수의 광학적 성질)

  • YANG Yong-Rhim;MORINAGA Tsutomu
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.19 no.3
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    • pp.234-240
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    • 1986
  • Optical properties of sea vater were studied in Tokyo Bay, Japan, based on the data obtained from six oceanographic station in April, 1985. The observation of surface and underwater irradiances of sea water for eight kinds of wavelength (378, 422, 481, 513, 570, 621, 653, and 677 mm) of sun light was conducted using the underwater irradiameter (Isigawa ${\sharp}SR-8$). The mean attenuation coefficient of the sea water appeared to be 0.335($0.081{\sim}0.862$) and the attenuation coefficient of the sea water for each wavelength appeared as 0.268 for 378nm, 0.354 for 422nm, 0.274 for 481nm, 0.256 for 513nm, 0.284 for 570nm, 0.356 for 621nm, 0.425 for 653nm, and 0.464 for 677nm. The transparency was 5.0m ($2.5{\sim}6.5m$), water color was 10.2 ($8{\sim}14.0$) in the study area and the sun altitude was $53.62^{\circ}$ ($38.54^{\circ}{\sim}66.23^{\circ}$). The relationship between attenuation coefficient (K) and transparency (D) was K= 2.22/D ($1.30/D{\sim}3.54/D$). The rates of light penetration for eight kinds of wavelength (378, 422, 481, 513, 570, 621, 653, and 677 nm) were computed with reference to the surface light intensity each. The mean rates of light penetration in proportion to depths were $62.72\%$ ($42.23{\sim}78.43\%$) in 1 m layer, $11.91\%$ ($1.34{\sim}29.67\%$) in 5m layer, $2.64\%$ ($0.023{\sim}8.80\%$) in 10m layer, and $0.50\%$ ($0.02{\sim}3.99\%$) in 20 m layer. The rate of light penetration at the transparency layer with reference to the surface light intensity was shown as $12.51\%$ ($2.91{\sim}27.25\%$).

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Dynamics of Transverse Magnetic Domain Walls in Rectangular-shape Thin-film Nanowires Studied by Micromagnetic Simulations

  • Lee, Jun-Young;Choi, Sang-Kook;Kim, Sang-Koog
    • Journal of Magnetics
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    • v.11 no.2
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    • pp.74-76
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    • 2006
  • Dynamic behaviors of transverse domain walls (TDWs) in rectangular shaped thin-film magnetic nanowires with different widths under applied magnetic fields less than the Walker field were studied by micromagnetic simulations. It was found that the velocity of stable TDWs in the viscous region increases from 147 to 419 m/s and their mass decreases from $6.24{\times}10^{-23}\;to\;2.70{\times}10^{-23}kg$ with increasing strength of the applied magnetic field ranging from 5 to 20 Oe for the nanowire with a dimension of 10 nm in thickness and $5{\mu}m$ in length, and 50 nm in width. With increasing the width of nanowires from 50 to 125 nm at a specific field strength of 5 Oe, the TDW's velocity also increases from 147 to 246 m/s and its mass decreases from $6.24{\times}10^{-23}\;to\;5.91{\times}10^{-23}kg$.

Optical Properties of Sea Water in the Northwestern Waters of Jeju Island (제주도 북서해역에서의 해수의 광학적 성질)

  • 양용림
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.17 no.2
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    • pp.53-58
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    • 1981
  • Optical properties of sea water were studied in the northwestern water of Jeju Island, based on seven oceanographic stations in July, 1980. Submarine daylight intensity was measured at intervals of 5m depth in the upper 70m layer by using the underwater irradiameter(Kahlsico #268 WA360). The mean absorption coefficients of the sea water were appeared as 0.106(0.084-0.152), 0.135(0.106-0.184), 0.089(0.069-0.130) for clear, red, green, and blue color respectively. The transparency ranged from 11 to 19 meters(mean 16.1m). The mean water color in this area was 4.3(3-5) in Forel scales. The relation between absorption coefficient(k) and transparency(D) was k=1.66/D, k=2.12/D, k=1.38/D, and k=1.51/D for clear, red green, and blue color respectively. The rates of light penetration for clear, red, green, and blue color in four different depths were computed with reference to the surface light intensity respectively. The mean rates of light penetration in proportion to depths were as follows; clear : 56.57%(5m), 20.54%(15m), 4.60%(30m), 0.68%(50m). red : 50.14%(5m), 2.37%(30m), 0.23%(50m). green : 62.29%(5m), 26.43%(15m), 7.74%(30m), 1.56%(50m). blue : 59.29%(5m), 23.43%(15m), 6.10%(30m), 1.08%(50m).

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Three White Organic Light-emitting Diodes with Blue-green Fluorescent and Red Phosphorescent Dyes

  • Galbadrakha, Ragchaa;Bang, Hwan-Seok;Baek, Heume-Il;Lee, Chang-Hee
    • Journal of Information Display
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    • v.9 no.3
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    • pp.23-27
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    • 2008
  • This paper reports that well-balanced white emission with three primary colors can be achieved with a simple white organic light-emitting diode (WOLED) structure of ITO / $\alpha$-NPD (50 nm) / $\alpha$-NPD: Btp2Ir(acac) (8 wt%, 6 nm) / $\alpha$-NPD (5 nm) / BCP (3 nm) / $Alq_3$: C545T (0.5 wt%, 10 nm) / $Alq_3$ (40 nm) / LiF (0.5 nm) / Al (100 nm). The external quantum efficiency of the device reached 3.8% at a current density (luminance) of 4.6 mA/$cm^2$ (310 cd/$m^2$), and the maximal luminance of the device reached 19,000 cd/$m^2$ at 11.5 V. The insignificant blue shift of the emitting color with an increasing current density can be attributed to the narrowing of the exciton formation zone width.

Optical Properties of Sea Water in Sagami Bay, Japan (일본 상모만에서의 해수의 광학적 성질)

  • YANG Yong-Rhim
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.20 no.2
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    • pp.119-125
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    • 1987
  • Optical properties of sea water were studied in the Sagami Bay, Japan, based on the data obtained from six oceanographic stations in June, 1985. The observation of surface irradiance and underwater irradiance of sea water for eight kind of wavelengths (378, 422, 481, 513, 570, 621, 653, 677 nm) of sun light was conducted using the underwater irradiameter $(Isigawa\;\#\;SR-8)$. The mean attenuation coefficient of the sea water was appeared to be 0.166 $(0.061\~0.644)$ and the attenuation coefficient of the sea water for wavelength appeared such as 0.121 for 378 nm, 0.105 for 422 nm, 0.097 for 481 nm, 0.099 for 513 nm, 0.138 for 570 nm, 0.253 for 621 nm, 0.258 for 653 nm, 0.253 for 677 nm. The transparency was 12.9 m $(7.2\~18m)$, water color was $(5\~10m)$ in the study area and the sun altitude was $70.79^{\circ}\;(57.44^{\circ}\~78.42^{\circ}C)$ The relationship between attenuation coefficient (K) ana transparency (D) was $K=2.87/D(1.06/D\~5.48/D)$. The rates of light penetration for eight kind of wavelenths (378, 422, 481, 513, 570, 621, 653, 677 nm) were computed with reference to the surface light intensity respectively, The mean rate of light penetration in proportion to depths were $77.93\%\;(52.52\~94.06\%)$ in 1 m layer, $35.46\%\;(4.00\~73.64\%)$ in 5m layer, $18.71\%\;(0.24\~54.23\%)$ in 10m layer and $7.00\%\;(0.007\~27.58\%)$in 20m layer. The rate of light penetration at the transparency layer with reference to the surface light intensity was shown as $13.02\%\;(0.42\~34.78\%)$.

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Silicon Fabry-Perot Tunable Thermo-Optic Filter (실리콘 파브리-페로 파장가변 열광학 필터)

  • Park, Su-Yeon;Kang, Dong-Heon;Kim, Young-Ho;Gil, Sang-Keun
    • Journal of IKEEE
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    • v.12 no.3
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    • pp.131-137
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    • 2008
  • A silicon Fabry-Perot tunable thermo-optic filter for WDM using the thin film silicon coating is proposed and experimented. The filter is implemented by using the CMP process and polishing both sides of the commercial silicon wafer with normal thickness of 100${\mu}m{\pm}$1%. The filter also has 2-layer or 3-layer dielectrics thin film coating mirror which are alternated ${\lambda}$/4 layers of $SiO_2$($n_{low}$=1.44) and a-Si($n_{high}$=3.48) for the central wavelength of 1550nm by RF sputtering. The experiment shows that FSR is 3.61nm and FWHM is 0.56nm and the finesse is 6.4 for 2-layer mirror with the reflection of 61%, and that FSR is 3.36nm and FWHM is 0.13nm and the finesse is 25.5 for 3-layer mirror with the reflection of 89%. According to thermo-optic effect, the transmitted central wavelength of 1549.73nm at $23^{\circ}C$ is shifted to 1550.91nm at $30^{\circ}C$ and 1553.46nm at $60^{\circ}C$ for 2-layer mirror, and the transmitted central wavelength of 1549.83nm at $23^{\circ}C$ is shifted to 1550.92nm at $30^{\circ}C$ and 1553.07nm at $60^{\circ}C$ for 3-layer mirror.

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