• Journal of Periodontal and Implant Science
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• 제44권5호
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• pp.222-226
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• 2014

Purpose: This study aimed to assess the interdental bone level in premolar bitewing radiographs while retracting the cheeks. Methods: Seventy-two horizontal bone defects were created on dried mandibles and maxillae. The distance from the bone level to the cement-enamel junction of premolars was detected by a modified digital caliper (considered the gold standard). The reliability of all radiographs was assessed by intraclass correlation coefficient (ICC), and the validity was compared to the gold standard using the analysis of variance test. P-values less than 0.05 were considered statistically significant. Results: This study showed that the reliability of radiographs without a cheek simulator and with 0.16 second exposure time was significantly higher than that of the two other groups (ICC=0.96 compared to 0.93 and 0.88, respectively). The results from the radiographs without a cheek simulator and with 0.16 second exposure time were more similar to the gold standard measures than those of the two other groups, although the difference was not statistically significant. Conclusions: Retracting the buccal soft tissue plays an important role in increasing the accuracy of radiographs in detecting the interdental alveolar bone level and produces more accurate results than increasing the exposure time, although it does not have a significant role in reliability of results.

• 대한기계학회논문집A
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• 제37권5호
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• pp.673-678
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• 2013

크립 그론 소음은 자동차 브레이크에서 제동압 제거 초기나 제동 말기에 발생하는 저주파 소음 현상이다. 이러한 현상은 브레이크 시스템에 국한되는 문제가 아니라 샤시의 진동특성에도 영향을 받는 것으로 예측되고 있기 때문에 그 특성 파악이 어려운 것으로 알려져 있다. 때문에 현재까지의 연구는 마찰재를 통한 개선이 대부분이었다. 그래서 실차를 이용한 실험은 여전히 어려운 과제로 남겨져 있다. 이번 연구는 환경에 민감한 크립 그론 소음의 특성과 샤시 진동특성의 영향을 실차와 NVH 전용 샤시 다이나모를 이용한 여러 가지 실험을 통해 알아 보았다. 이를 통해 실차에서의 새로운 크립 그론 소음 평가시 중요한 통제변수를 제시하고 차량 시스템 측면에서 소음 저감 대책 연구에 대한 가능성을 확인할 수 있었다.

• 비파괴검사학회지
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• 제32권1호
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• pp.41-46
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• 2012

MEMS/NEMS 구조체의 개발과 응용기술의 발달로 박판 및 박막의 기계적 물성 평가에 대한 요구가 점차 늘어나고 있다. 기계적 물성은 주로 인장시험이나 초음파의 속도 측정으로 평가되어 왔으나, 박판/박막 구조의 경우 기존의 기술로는 측정에 한계가 있어 나노압입시험법, 유도초음파법 등의 새로운 기술이 개발되고 있다. 본 연구에서는 박판 구조의 금속재료의 탄성계수를 평가하기 위하여 EMAT으로 송수신된 박판내에서의 유도초음파 진행 속도를 측정하였으며, 이론적으로 계산된 유도초음파 군속도와 실험적인 군속도의 최적화 과정을 통해 최종적으로 박판의 탄성계수를 평가하였다. 두께 $50{\mu}m$의 니켈 박판에서 측정된 영률은 201.6 GPa이었으며, 나노압입시험법으로 측정된 207 GPa, 참고문헌의 203.7 GPa과 비교하면 약 3% 내에서 일치하는 결과이다.

• 해양환경안전학회지
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• 제24권6호
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• pp.670-678
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• 2018

선박의 통행량이 많은 연안해역은 선박들 사이에 복잡한 조우상황이 자주 발생하기 때문에 충돌사고의 가능성이 높다. 따라서 해상에서 충돌사고를 줄이기 위해서는 항해사의 국제충돌예방규칙(COLREG) 준수에 더하여 정량적인 충돌위험평가가 요구된다. 본 연구에서는 선박의 계획항로에 대한 충돌위험을 평가하기 위한 새로운 충돌위험도 평가시스템이 개발되었다. 먼저 기존의 충돌위험 평가모델들을 검토함으로써 적절한 충돌위험 평가방법이 제시되었다. 시스템은 MATLAB을 사용하여 개발되었으며 해도, 범퍼 및 평가의 세 부분으로 구성된다. 개발된 시스템은 시험을 위해 간단한 계산조건으로 시험해역에 적용되었으며, 그리고 검증을 위해 실제 계산조건으로 실제해역에 적용되었다. 그 결과 충돌위험은 자선의 길이, 항해시간 및 항로 등에 의해 영향을 받는 것으로 나타났다. 개발된 시스템은 항해사가 출항전 최적안전항로를 선택하는데 도움을 줄 수 있을 것으로 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.4025-4029
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• 2015

Background: Gastrointestinal tract cancers are among the most common cancers in Iran and comprise approximately 38% of all the reported cases of cancer. This study aimed to describe the epidemiology and to investigate spatial clustering of common cancers of the gastrointestinal tract across the counties of Iran using full Bayesian smoothing and Moran I Index statistics. Materials and Methods: The data of the national registry cancer were used in this study. Besides, indirect standardized rates were calculated for 371 counties of Iranand smoothed using Winbug 1.4 software with a full Bayesian method. Global Moran I and local Moran I were also used to investigate clustering. Results: According to the results, 75,644 new cases of cancer were nationally registered in Iran among which 18,019 cases (23.8%) were esophagus, gastric, colorectal, and liver cancers. The results of Global Moran's I test were 0.60 (P=0.001), 0.47 (P=0.001), 0.29 (P=0.001), and 0.40 (P=0.001) for esophagus, gastric, colorectal, and liver cancers, respectively. This shows clustering of the four studied cancers in Iran at the national level. Conclusions: High level clustering of the cases was seen in northern, northwestern, western, and northeastern areas for esophagus, gastric, and colorectal cancers. Considering liver cancer, high clustering was observed in some counties in central, northeastern, and southern areas.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7695-7700
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• 2015

Background: HER2/neu overexpression on cell membranes of breast cancer cells is due to HER2/neu gene amplification and it is important to identify potential candidates for anti HER2 therapy with trastuzumab. IHC, FISH and CISH are standard FDA approved assays currently used to determine HER2 status in routine practice. The aim of this study was to determine HER2 gene amplification, using the CISH method in breast carcinoma samples which had IHC +2 reactions. Materials and Methods: This study was conducted from 2008-2010 using 334 consecutive breast carcinoma samples referred from local laboratories to Mehr Hospital. CISH assays were performed for all cases, and IHC tests were also done for determining efficacy and accuracy of local labs. HER2 status in local IHC tests was compared with central IHC and CISH results. Results: Of 334 breast cancer patients, 16 were negative for HER2 IHC (0, +1), 201 cases were equivocal (+2), and 31 positive (+3). Of 334 referral cases, 88 were CISH positive (26.3%) and 246 were CISH negative (73.7%). Of 201 IHC +2 cases, HER2 gene amplification was observed in 42 cases (kappa: 0.42). A 29.9% concordance was found between local IHC and central IHC. Sensitivity and specificity of local IHC were 90% and 53.8%, respectively. Conclusions: Low accuracy of IHC results in local labs was associated with the following factors: using former FDA-approved criteria for HER2 interpretation, utilizing non-validated kits, and lack of any quality assurance program. Therefore, following the new 2014 ASCO/CAP guideline and comprehensive quality assurance should be implemented to ensure accuracy of HER2 testing.

• 한국분무공학회지
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• 제22권3호
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• pp.122-128
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• 2017

Currently, the proportion of diesel vehicles in all automobile has grown significantly over the past few years. Air pollutant also grew up and became a social problem. In particular, the issue of NOx emissions caused by NOx high emission in real driving has become a global issue. Despite the fact that the regulatory and reduction project of the new vehicle is actively carried out, there are no existence regulations of In-use diesel vehicle's NOx emission. Therefore, the emission characteristics of the in-use diesel vehicles were investigated to seek ways to reduce NOx emissions in this study. The test targets were used in 237 close inspection of exhaust gases and model year varied from 1996 to 2011. However, the classification of emissions by emission standards differed considerably from NOx emissions. This means that the selection method for early retirement targets should be converted from model year to amount of emissions. If the current early retirement program was applied to the existing system, pre-Euro 3 was 22.530 g/km and Euro 4 was 21.810 g/km to NOx reduction. However, when the vehicle was changed to high emission target vehicle, NOx reduction increase maximum 84.705 kg/yr. According to the study results, an effective reduction in NOx emissions can be achieved if an earlier target in expanded to Euro 4 vehicles.

• 전자공학회논문지S
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• 제35S권8호
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• pp.47-54
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• 1998

여러 가지 응용 분야에서 대용량 영상 데이터 베이스가 폭넓게 사용 되면서 전체 데이터베이스를 효율적이고 빠르게 검색하는 것이 절실하다. 가변 블록 크기와 블록 매칭 알고리즘에 의한 내용기반 화상의 검색을 위한 새로운 방법을 보인다. 제안한 방법에는 영상의 색상이나 공간 배치와 같은 가시적인 단서를 찾아서 영상의 특색을 나타내고 있다. 그리고 원하는 유사도에 함당한 검색 횟수에 자동으로 수렴되어 빠른 검색이 이루어진다. 구현된 방식은 약 150개의 영상 데이터 베이스로서 시험했다. 시험 결과 임의 지정한 검색효율 0.65에서 J & V 알고리즘 대비 1.9배 그리고 지정한 고정 블록 크기에 대비하여 1.83배 빠른 검색 시간을 달성함을 보인다.

• 대한화장품학회지
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• 제25권4호
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• pp.111-121
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• 1999

Acne vulgaris, the most common skin disease. can be formed as only a few comedons or severe inflammatory lesions. The pathogenesis of acne involves various factors; excessive androgen, excessive sebum production, abnormal alteration of follicular epithelium, proliferation of Propionibacterium acnes, and inflammation. We investigated acne therapy using oriental herbs described in the Korean traditional medical book(Dong-ui-bo-gam). Oriental herbs(Angelica daurica, Arctium lappa, Coptidis rhizoma, and Glycyrrhiza glabra) were chosen based on their respective property of sebum control, anti-inflammatory activity, and anti-bacterial activity. We examined the effect of acne treatment, in terms of chemotactic inhibition, lipogenesis inhibition, and anti-bacterial activity for P. acnes. 1. Neutrophil chemotaxis assay; P. acnes secrete chemotactic factors and other pro-inflammatory extracellular products. Neutrophil chemotactic activity of P. acnes was measured by 48-well chemotaxis method. Angelica daurica clearly suppressed chemotactic activity of P. acnes. 2. Using sebaceous gland of hamster ear lipogenesis assay; Sebaceous lipogenesis was measured using ear biopsies by incubation or $C^{14}$-acetate in culture media. The $C^{14}$-labeled lipids were extracted and determined by liquid scintilation counting. Coptidis rhizoma markedly inhibited sebum production. 3. Anti-bacterial assay for P. acnes(MIC test); Glycyrrhiza glabra showed anti-bacterial activity. P. acnes did not develop resistance against Glycyrrhiza glabra. Retinoids are effectively to inhibit sebum production and regulate follicular keratinization process, with little anti-inflammatory activity. Angelica daurica suppressed neutrophil chemotaxis, Coptidis rhizoma inhibited sebum production, and Glycyrrhiza glabra showed anti-bacterial activity against P. acnes. A combined formulation of Angelica daurica, Coptidis rhizoma. and Glycyrrhiza glabra is expected to provide effective acne treatment.

• Nuclear Engineering and Technology
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• 제44권8호
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• pp.919-928
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• 2012

The applications of computers and communication system and network technologies in nuclear power plants have expanded recently. This application of digital technologies to the instrumentation and control systems of nuclear power plants brings with it the cyber security concerns similar to other critical infrastructures. Cyber security risk assessments for digital instrumentation and control systems have become more crucial in the development of new systems and in the operation of existing systems. Although the instrumentation and control systems of nuclear power plants are similar to industrial control systems, the former have specifications that differ from the latter in terms of architecture and function, in order to satisfy nuclear safety requirements, which need different methods for the application of cyber security risk assessment. In this paper, the characteristics of nuclear power plant instrumentation and control systems are described, and the considerations needed when conducting cyber security risk assessments in accordance with the lifecycle process of instrumentation and control systems are discussed. For cyber security risk assessments of instrumentation and control systems, the activities and considerations necessary for assessments during the system design phase or component design and equipment supply phase are presented in the following 6 steps: 1) System Identification and Cyber Security Modeling, 2) Asset and Impact Analysis, 3) Threat Analysis, 4) Vulnerability Analysis, 5) Security Control Design, and 6) Penetration test. The results from an application of the method to a digital reactor protection system are described.