• Journal of Korean Society of Archives and Records Management
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• v.18 no.1
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• pp.129-154
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• 2018

It is time to prepare for the imminent development from the field of records management through decentralization to the records management of the new age in accordance with the flow of decentralization. To overcome a centralized record management system, more archives should be established to realize autonomous and decentralized records management. In accordance with the shift to a full-scale electronic record management environment, the appropriateness and effectiveness of the three-phase system of processing-archival-permanent record management based on physical transfer should be reviewed in terms of transfer cost and work efficiency. The archives should function as institutional archives to carry out the continuous volume record management and the autonomous record management at the institution level. This study examined the possibilities and implications of the archives to expand their functions as archives of institutions for the decentralization of record management and information governance orientation. In addition, the study diversified the types of records management institutions as a way to accomplish this and determined a way to design the functions of archives that integrate the current-end-end-end records management. At each level, institutions should set up archives based on their circumstances and aim at information governance at the level of each archive. Moreover, each archive level should establish a horizontal network to govern record information management.

• Journal of the Korean Association of Geographic Information Studies
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• v.7 no.4
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• pp.34-45
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• 2004

Existing Semangeum's water balance analysis simplifies whole basin to single basin and achieved volume of effluence that produce by Kajiyama way to foundation. But Semangeum is complicated and various rice-wine strainer supply system. And there is difficulty to apply as elastic when water balance element is changed at free point. Divided to unit possession station for suitable water balance analysis model application to Semangeum in this study. And developed basin water balance model of GIS base that can do details analysis is bite about development and transfer of an appropriation in the budget of basin water resources. Achieved study including abstraction and concept design that use UML (unified modeling language) diagram for details analysis, stream network composition for rice-wine strainer supply system application, preprocessing of GIS base and postprocessing module development, model revision and verification etc. Support of this water balance analysis model is available to establish efficient water resources administration plan through outward flow process analysis of water resources. And support is considered to be possible in more convenient and, reasonable water resources administration way establishment by minimizing manual processing in systematic water resources government official to user and support diversified analysis system.

• IMMUNE NETWORK
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• v.11 no.1
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• pp.79-94
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• 2011

Background: Dendritic cell (DC)-based vaccines are currently being evaluated as a novel strategy for tumor vaccination and immunotherapy. However, inducing long-term regression in established tumor-implanted mice is difficult. Here, we show that deoxypohophyllotoxin (DPT) induces maturation and activation of bone marrow-derived DCs via Toll-like receptor (TLR) 4 activation of MAPK and NF-${\kappa}B$. Methods: The phenotypic and functional maturation of DPT-treated DCs was assessed by flow cytometric analysis and cytokine production, respectively. DPT-treated DCs was also used for mixed leukocyte reaction to evaluate T cell-priming capacity and for tumor regression against melanoma. Results: DPT promoted the activation of $CD8^+$ T cells and the Th1 immune response by inducing IL-12 production in DCs. In a B16F10 melanoma-implanted mouse model, we demonstrated that DPT-treated DCs (DPT-DCs) enhance immune priming and regression of an established tumor in vivo. Furthermore, migration of DPT-DCs to the draining lymph nodes was induced via CCR7 upregulation. Mice that received DPT-DCs displayed enhanced antitumor therapeutic efficacy, which was associated with increased IFN-${\gamma}$ production and induction of cytotoxic T lymphocyte activity. Conclusion: These findings strongly suggest that the adjuvant effect of DPT in DC vaccination is associated with the polarization of T effector cells toward a Th1 phenotype and provides a potential therapeutic antitumor immunity.

• IMMUNE NETWORK
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• v.11 no.2
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• pp.114-122
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• 2011

Background: The leukocyte common antigen (CD45) is a transmembrane-type protein tyrosine phosphatase that has five isoforms. Methods: We generated seven murine mAbs against human CD45 by injecting cells from different origins, such as human thymocytes, PBMCs, and leukemic cell lines. By using various immunological methods including flow cytometry, immunohistochemistry, and immunoprecipitation, we evaluated the reactivity of those mAbs to CD45 of thymus as well as tonsil lysates. Furthermore, we transiently transfected COS-7 cells with each of gene constructs that express five human CD45 isoforms respectively, and examined the specificities of the mAbs against the transfected isoforms. Results: In case of thymocytes, lymphocytes, and monocytes, all the seven mAbs demonstrated positive reactivities whereas none was reactive to erythrocytes and platelets. The majority of immune cells in formalin-fixed paraffin-embedded thymus and tonsil tissues displayed strong membranous immunoreactivity, and the main antigen was detected near 220 kDa in all cases. Among the mAbs, four mAbs (AP4, DN11, SHL-1, and P6) recognized a region commonly present in all the five isoforms. One mAb, YG27, recognized four isoforms (ABC, AB, BC, and O). Two mAbs, P1 and P14, recognized the isoforms that contain exon A encoded regions (ABC and AB). Conclusion: In this study, we confirmed that AP4, DN11, SHL-1, YG27 and P6, are mAbs reactive with the CD45 antigen whereas P1 and P14 are reactive with the CD45RA antigen.

• Journal of the Korean Geographical Society
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• v.46 no.6
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• pp.673-692
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• 2011

Advances in computer technology have enabled us to develop and use numerical landscape evolution models (NLEMs) for exploring the dynamics of geomorphic system from a variety of viewpoints which previously could have not been taken. However, as of yet there have been no trials using or developing NLEMs in Korea. The purpose of this research is to develop a 2 dimensional NLEM on a geological time scale and evaluate its usefulness. The newly developed NLEM (ND-NLEM) treats bedrock weathering as one of the major geomorphic processes and attempts to simulate the thickness of soil. As such it is possible to model the weathering-limited as well as the transport-limited environment on hillslopes. Moreover the ND-NLEM includes not only slow and continuous mass transport like soil creep, but also rapid and discrete mass transport like landslides. Bedrock incision is simulated in the ND-NLEM where fluvial transport capacity is large enough to move all channel bed loads, such that ND-NLEM can model the detachment-limited environment. Furthermore the ND-NLEM adopts the D-infinity algorithm when routing flows in the model domain, so it reduces distortion due to the use of the steepest descent slope flow direction algorithm. In the experiments to evaluate the usefulness of the ND-NLEM, characteristics of the channel network observed from the model results were similar to those of the case study area for comparison, and the hypsometry curve log during the experiment showed rational evidence of landscape evolution. Therefore, the ND-NLEM is shown to be useful for simulating landscape evolution on a geological time scale.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.2
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• pp.507-519
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• 2013

This study is to evaluate agricultural water supply capacity in Geum river basin (9,865 $km^2$), one of the 5 big river basin of South Korea using MODSIM-DSS (MODified SIMyld-Decision Support System) model. The model is a generalized river basin decision support system and network flow model developed at Colorado State University designed specifically to meet the growing demands and pressures on river basin management. The model was established by dividing the basin into 14 subbasins and the irrigation facilities viz. agricultural reservoirs, pumping stations, diversions, culverts and groundwater wells were grouped and networked within each subbasin and networked between subbasins including municipal and industrial water supplies. To prepare the inflows to agricultural reservoirs and multipurpose dams, the Soil and Water Assessment Tool (SWAT) was calibrated using 6 years (2005-2010) observed dam inflow and storage data. By MODSIM run for 8 years from 2004 to 2011, the agricultural water shortage had occurred during the drought years of 2006, 2008, and 2009. The agricultural water shortage could be calculated as 282 $10^6m^3$, 286 $10^6m^3$, and 329 $10^6m^3$ respectively.

• Journal of Advanced Marine Engineering and Technology
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• v.40 no.9
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• pp.799-804
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• 2016

Broadband powerline communication (BPLC) uses distribution lines as a medium for achieving effective bidirectional data communication along with electric current flow. As the material characteristics of power lines are not good at the communication channel, the development of power line communication (PLC) systems for internet, voice, and data services requires measurement-based models of the transfer characteristics of the network suitable for performance analysis by simulation. In this paper, an analytic model describing a complex transfer function is presented to obtain the attenuation and path parameters for a multipath power line model. The calculated results demonstrated frequency-selective fading in multipath channels and signal attenuation with frequency, and were in good agreement with the experimental results. Inductive coupling units are used as couplers for coupling the signal to the power line to avoid physical connections to the distribution line. The inductance of the ferrite core, which depends on the frequency, determines the cut-off frequency of the inductive coupler. Coupling loss can be minimized by increasing the number of windings around the coupler. Coupling efficiency was improved by more than 6 dB with three windings compared to the results obtained with one winding.

• IMMUNE NETWORK
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• v.7 no.3
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• pp.133-140
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• 2007

Background: It is well established that cross talk between natural killer (NK) cells and myeloid dendritic cells (DC) leads to NK cell activation and DC maturation. In the present study, we investigated whether type 1-polarized DC (DC1) matured in the presence of IFN-${\gamma}$ and type 2-polarized DC (DC2) matured in the presence of PGE2 can differentially activate NK cells. Methods: In order to generate DC, plastic adherent monocytes were cultured in RPMI 1640 containing GM-CSF and IL-4. At day 6, maturation was induced by culturing the cells for 2 days with cytokines or PGE2 in the presence or absence of LPS. Each population of DC was cocultured with NK cells for 24 h. The antigen expression on DC was analyzed by flow cytometry and cytokine production in culture supernatant was measured by ELISA or a bioassay for TNF-${\alpha}$ determination. NK cell-mediated lysis was determined using a standard 4h chromium release assay. Results: DC2, unlike DC1, had weak, if any, ability to induce NK cell activation as measured by IFN-${\gamma}$ production and cytolytic activity. DC2 were weakly stimulated by activated NK cells compared to DC1. In addition, IFN-${\gamma}$-primed mature DC appeared to be most resistant to active NK cell-mediated lysis even at a high NK cell/DC ratio. On the other hand, PGE2-primed DC were less resistant to feedback regulation by NK cells than IFN-${\gamma}$-primed mature DC. Finally, we showed that the differential effect of two types of DC population on NK cell activity is not due to differences in their ability to form conjugates with NK cells. Conclusion: These results suggest that different combinations of inflammatory mediators differentially affect the effector function of DC and, as a result, the function of NK cells, eventually leading to distinct levels of activation in adaptive immunity.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.16 no.6
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• pp.182-194
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• 2017

Most of the drone (Unmanned Aerial Vehicle) research in terms of traffic management involves detecting and tracking roads or vehicles. The purpose of analyzing image footage in the transportation sector is to overcome the limitations of the existing traffic data collection system (vehicle detectors, DSRC, etc.). With regards to this, drones are the good alternatives. However, due to limitation in their maximum flight time, they are appropriate to use as a complementary rather than replacing the existing collection system. Therefore, further research is needed for utilizing drones for transportation analysis purpose. Traffic problems often arise from one particular section or a point that expands to the whole road network and drones can be fully utilized to analyze these particular sections. Based on the study on the uses of traffic survey analysis, this study is conducted by extracting traffic flow parameters from video images(range 800~1000m) of highway unit segments that were taken by drones. In addition, video images were taken at a high altitude with the development of imaging technologies.

• Journal of Wetlands Research
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• v.17 no.4
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• pp.348-358
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• 2015

Impacts of climate change are being observed in the globe as well as the Korean peninsula. In the past 100 years, the average temperature of the earth rose about 0.75 degree in celsius, while that of Korean peninsula rose about 1.5 degree in celsius. The fifth Assessment Report of IPCC(Intergovermental Panel on Climate Change) predicts that the water pollution will be aggravated by change of hydrologic extremes such as floods and droughts and increase of water temperature (KMA and MOLIT, 2009). In this study, future runoff was calculated by applying climate change scenario to analyze the future water quality for each targe period (Obs : 2001 ~ 2010, Target I : 2011 ~ 2040, Target II : 2041 ~ 2070, Target III : 2071 ~ 2100) in Hongcheon river basin, Korea. In addition, The future water quality was analyzed by using multiple linear regression analysis and artificial neural networks after flow-duration curve analysis. As the results of future water quality prediction in Hongcheon river basin, we have known that BOD, COD and SS will be increased at the end of 21 century. Therefore, we need consider long-term water and water quality management planning and monitoring for the improvement of water quality in the future. For the prediction of more reliable future water quality, we may need consider various social factors with climate components.