• Title/Summary/Keyword: nested radical

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DECOMPOSITIONS OF GRADED MAXIMAL SUBMODULES

  • Moh'd, Fida
    • Communications of the Korean Mathematical Society
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    • v.37 no.1
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    • pp.1-15
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    • 2022
  • In this paper, we present different decompositions of graded maximal submodules of a graded module. From these decompositions, we derive decompositions of the graded Jacobson radical of a graded module. Using these decompositions, we prove new theorems about graded maximal submodules, improve old theorems, and give other proofs for old theorems.

Therapeutic Assessment of Primaquine for Radical Cure of Plasmodium vivax Malaria at Primary and Tertiary Care Centres in Southwestern India

  • Kumar, Rishikesh;Guddattu, Vasudeva;Saravu, Kavitha
    • Parasites, Hosts and Diseases
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    • v.54 no.6
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    • pp.733-742
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    • 2016
  • Acquaintance is scanty on primaquine (PQ) efficacy and Plasmodium vivax recurrence in Udupi district, Karnataka, India. We assessed the efficacy of 14 days PQ regimen (0.25 mg/kg/day) to prevent P. vivax recurrence. Microscopically, aparasitemic adults (${\geq}18years$) after acute vivax malaria on day 28 were re-enrolled into 15 months' long follow-up study. A peripheral blood smear examination was performed with participants at every 1-2 month interval. A nested PCR test was performed to confirm the mono-infection with P. vivax. Of 114 participants, 28 (24.6%) recurred subsequently. The median (IQR) duration of the first recurrence was 3.1 (2.2-5.8) months which ranged from 1.2 to 15.1 months, including initial 28 days. Participants with history of vivax malaria had significantly higher risk of recurrence, with hazard ratio (HR) (95% CI) of 2.62 (1.24-5.54) (P=0.012). Severity of disease (11.4%, 13/114) was not associated (P=1.00) with recurrence. Of 28 recurrence cases, the nPCR proved that P. vivax mono-infection recurrence rate was at least 72.7% (16/22) at first recurrence. In Udupi district, PQ dose of 0.25 mg/kg/day over 14 days seems inadequate to prevent recurrence in substantial proportion of vivax malaria. Patients with a history of vivax malaria are at high risk of recurrences.