• Title/Summary/Keyword: near-P.D-B

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Supplementary prenatal copper increases plasma triiodothyronine and brown adipose tissue uncoupling protein-1 gene expression but depresses thermogenesis in newborn lambs

  • Smith, Stephen B.;Sweatt, Craig R.;Carstens, Gordon E.
    • Asian-Australasian Journal of Animal Sciences
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    • v.33 no.3
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    • pp.506-514
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    • 2020
  • Objective: We tested the hypothesis that increasing dietary copper (Cu) to gravid ewes would enhance brown adipose tissue (BAT) thermogenesis in their offspring. Methods: Twin-bearing ewes were assigned on d 70 of gestation to diets containing 3, 10, or 20 ppm dietary Cu (n = 8 per group). Twin lambs were assigned at birth to a cold (6℃) or warm (28℃) environmental chamber for 48 h. Blood was collected from ewes and from lambs and perirenal BAT was collected after 48 h in the environmental chambers. Results: Prenatal Cu exposure increased ewe plasma triiodothyronine (T3) and thyroxine concentration (T4) (p<0.01) but prenatal Cu exposure had no effect on lamb plasma concentrations of T3, T4, glucose, or nonesterified fatty acid concentration (p≥0.08). The high level of prenatal Cu exposure depressed 48-h rectal temperature (p = 0.03). Cold exposure decreased BAT norepinephrine (NE) and increased BAT dopamine (p≤0.01), but prenatal Cu exposure had no effect on BAT cytochrome C oxidase activity or BAT NE or dopamine (p≥0.07). However, BAT of lambs from high-Cu ewes maintained higher uncoupling protein-1 (UCP1) gene expression than BAT of lambs from low- and medium-Cu ewes following warm or cold exposure in environmental chambers (p = 0.02). Cold exposure caused near depletion of BAT lipid by 48 h (p<0.001), increased BAT cytochrome c oxidase activity (p<0.01), and depressed plasma fatty acid concentrations (p<0.001). Conclusion: Although prenatal Cu exposure increased BAT UCP1 expression during warm and cold exposure, prenatal cold Cu exposure depressed 48-h rectal temperature. Cold exposure decreased BAT lipid content by over 80% and decreased lamb plasma fatty acid concentration by over 40%, indicating that fuel reserves for thermogenesis were nearly depleted by 48 h of cold exposure.

Hypoglycemic effect of Rehmannie Radix Preparata (Sookjihwang) extract in streptozotocin-induced diabetic rats

  • Kang, Shin-Jyung;Bao, Cun Liu;Park, Soo-Jin;Kim, Ae-Jung
    • Nutrition Research and Practice
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    • v.4 no.5
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    • pp.438-442
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    • 2010
  • Rhemannie Radix Preparata (RRP) has been previously employed in traditional oriental medicine as a treatment for diabetic thirst and improving blood flow. The aim of this study was to evaluate its hypoglycemic control by assaying the activities of key enzymes of carbohydrate metabolism in streptozotocin-(STZ)-induced diabetic rats. Further, RRP extracts were prepared in water (RRPW), in 50% ethanol (RRP50), and in 100% ethanol (RRP100), respectively, and compared for their actions in diabetic rats. The oral treatment of RRP (5 mg/kg b.w./d) to diabetic rats for 21 days resulted in a significant decline in blood glucose by 67% compared to diabetic control rats (P < 0.05). The altered activities of glucokinase, glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), and acetyl CoA carboxylase (ACC) in the livers of diabetic rats were reversed significantly to near-normal levels by the administration of RRP (P < 0.05). Among the three RRP extracts, RRP100 was the most effective in terms of hypoglycemic action. However, the administration of RRP to diabetic rats did not improve insulin production. The modulatory effects of RRP100 on the attenuation of carbohydrate enzyme activities appear to hold promise for widespread use for the treatment of diabetes in the future.

The effect of small embankments on wind speeds

  • Quinn, A.D.;Robertson, A.P.;Hoxey, R.P.;Short, J.L.;Burgess, L.R.;Smith, B.W.
    • Wind and Structures
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    • v.1 no.4
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    • pp.303-315
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    • 1998
  • Full-scale measurements have been made to determine the increase in wind speed over two exposed embankments, one of $23^{\circ}$ slope and 4.7 m in height, the other of $24^{\circ}$ slope and 7.3 m in height. Measurements were made at heights of 5, 10 and 15 m above the upper edge of each embankment and at the same heights approximately 100 m upwind in the lower-level approach fetch. Despite the modest sizes of the embankments, the maximum recorded increase in mean wind speed was 28% and the minimum was 13%; these increase relate to increases in wind loads on structures erected at the top of the embankments of 64% and 28% respectively. The associated increases in gust speeds are estimated at 33% and 18%, which imply increases in gust loading of 77% and 39% respectively. These experimental results are compared with predictions obtained from a computational fluid dynamics (CFD) analysis, using three high Reynolds number eddy-viscosity models and estimates from the UK wind loading code, BS 6399: Part 2. The CFD results are generally in agreement with the experimental data, although near-ground effects on the embankment crest are poorly reproduced.

Modeling of Hanlim's gas turbine generator & qualitative analysis of PSS operation (한림가스터빈 발전기/제어계의 모델링 및 PSS 동작의 정성적 분석)

  • Choi, K.S.;Moon, Y.H.;Kim, D.J.;Choo, J.B.;Lyu, S.H.
    • Proceedings of the KIEE Conference
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    • 1996.11a
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    • pp.95-98
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    • 1996
  • Response speed of generator/control system kas increased with the aid of the development of power electronics. Even though it is desirable to enhance response speed for the control system(AVR/Gov) of generator itself, in case a certain generator/control system with high response excitation system is connected with bulk power system, terminal voltage and active power of some generators can oscillate with adjoining generators or near area when even a little of disturbance take place. PSS(Power System Stabilizer) is used to damp rotor swing by adding the supplementary signal in phase with speed. As the stable AVR response is very important before PSS is installed, modeling and analysis of generator/control system was performed. Next we have analysed PSS response of Hanlim's gas turbine by transmission line open/close test.

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A Study on Knowledge, Attitudes, and Practice of Health Care of Housewives in Rural Area (with Established Viliage Voluntary Health Worker System) (일부(一部) 농촌지역(農村地域) 주부(主婦)의 보건의료(保健醫療)에 대한 지식(知識).태도(態度) 및 실천도(實踐度)에 관한 조사(調査) -마을보건임원조직(保健任員組織) 활용지역(活用地域) 중심(中心)-)

  • Chung, Hae-Kyung;Choi, Sam-Sop
    • Journal of Preventive Medicine and Public Health
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    • v.12 no.1
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    • pp.107-120
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    • 1979
  • In order to determine the knowledge of, attitudes to, and practice of housewives toward health care in a rural area, a survey with questionnaire was carried out with 87 housewives who were sampled randomly from 6 villages in Sudong Myun, from April 16th to 21st, 1979. The following results were obtained. 1. Of the housewives studied, 61.5% knew that B.C.G. is a vaccine for T.B prevention and 12.3% knew that D.P.T. is a vaccine for diphtheria, pertussis, and tetanus. 2. The vaccination rate of the children under six-year of the housewives studied was: polio 83.1%, B.C.G. 75.4%, D.P.T. 66.2%, and measles 55.4% respectively. 3. The vaccination rate was higher in children in the area near from the health subcenter than in there of the area further away. 4. Out of 87 respondants, 87.5% knew one or more methods of contraception for spacing children. These were: loop 69.0%, oral pill 66.7% and condom 14.9% respectively. 5. Out of 87 respondants, 82.2% knew the methods of contraception for sterilization. These were: laparascopy 87.5% and vasectomy 16.9%. 6. Out of 87 respondants those who had experience using contraceptive methods were 70.1% and present users were 47.1%. 7. Contraception practice rate was higher in the group of housewives having middle school education or above than those having primary school education or less. 8. Functions of the health subcenter listed by respondants were: patients care 72.4%, family planning 31.0%, vaccination 23.0%, T.B. control 3.4%, health education 3.4%, infant birth delivery assistance 1.1% respectively. 9. Housewives who knew that there is a village health voluntary worker in their own village were 63.2%(55), and 58.2% of those who knew appreciated her activities. 10. Purposes of expenditure of Myun community health development funds listed by respondants were: aid for patient care 34.5%, aid for health subcenter operation 16.1%, and aid for Myun health development 6.9% respectively. 11. It seems that both of the distance from the health subcenter and the utility rate level of the village health voluntary worker are co-related to the B.C.G. vaccination rate of children. 12. It seems that both of the distance from the health subcenter and the utility rate level of the village health voluntary worker are not co-related to the rate of contraception practice.

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T Lymphocyte Subsets and Cytokines in Rats Transplanted with Adipose-Derived Mesenchymal Stem Cells and Acellular Nerve for Repairing the Nerve Defects

  • Jiang, Liang-fu;Chen, Ou;Chu, Ting-gang;Ding, Jian;Yu, Qing
    • Journal of Korean Neurosurgical Society
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    • v.58 no.2
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    • pp.101-106
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    • 2015
  • Objective : The aim of this study was to explore the immunity in rats transplanted with adipose-derived mesenchymal stem cells (ADSCs) and acellular nerve (ACN) for repairing sciatic nerve defects. Methods : ADSCs were isolated from the adipose tissues of Wistar rats. Sprague-Dawley rats were used to establish a sciatic nerve defect model and then divided into four groups, according to the following methods : Group A, allogenic nerve graft; Group B, allograft with ACN; Group C, allograft ADSCs+ACN, and Group D, nerve autograft. Results : At the day before transplantation and 3, 7, 14, and 28 days after transplantation, orbital venous blood of the Sprague-Dawley rats in each group was collected to detect the proportion of $CD3^+$, $CD4^+$, and $CD8^+$ subsets using flow cytometry and to determine the serum concentration of interleukin-2 (IL-2), tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) and $interferon-{\gamma}$ ($IFN-{\gamma}$) using enzyme-linked immunosorbent assay (ELISA). At each postoperative time point, the proportion of $CD3^+$, $CD4^+$, and $CD8^+$ subsets and the serum concentration of IL-2, $TNF-{\alpha}$, and $IFN-{\gamma}$ in group C were all near to those in group B and group D, in which no statistically significant difference was observed. As compared with group A, the proportion of $CD3^+$, $CD4^+$, and $CD8^+$ subsets and the serum concentration of IL-2, $TNF-{\alpha}$, and $IFN-{\gamma}$ were significantly reduced in group C (p<0.05). Conclusion : The artificial nerve established with ADSCs and ACN has no obvious allograft rejection for repairing rat nerve defects.

Effects of Rotation Speed on Heat Transfer and Flow in a Coolant Passage with Turning Region ( I ) - Cross Ribbed Duct - (곡관부를 가지는 내부 냉각유로에서 회전수 변화에 따른 열전달 및 유동 특성 ( I ) - 엇갈린 요철배열 덕트 -)

  • Kim Kyung Min;Kim Yun Young;Rhee Dong Ho;Cho Hyung Hee
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.29 no.6 s.237
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    • pp.737-746
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    • 2005
  • The present study investigates heat/mass transfer and flow characteristics in a ribbed rotating passage with turning region. The duct has an aspect ratio (W/H) of 0.5 and a hydraulic diameter ($D_h$) of 26.67 mm. Rib turbulators are attached in the cross arrangement on the leading and trailing surfaces of the passage. The ribs have a rectangular cross section of $2\;mm\;(e){\times}\;mm\;(w)$ and an attack angle of $70^{\circ}$. The pitch-to-rib height ratio (p/e) is 7.5, and the rib height-to-hydraulic diameter ratio ($e/D_h$) is 0.075. The rotation number ranges from 0.0 to 0.20 while the Reynolds number is constant at 10,000. To verify the heat/mass transfer augmentation, internal flow structures are calculated for the same conditions using a commercial code FLUENT 6.1. The heat transfer data of the smooth duct for various Ro numbers agree well with not only the McAdams correlation but also the previous studies. The cross-rib turbulators significantly enhance heat/mass transfer in the passage by disturbing the main flow near the surfaces and generating one asymmetric cell of secondary flow skewing along the ribs. Because the secondary flow is induced in the first-pass and turning region, heat/mass transfer discrepancy is observed in the second-pass even for the stationary case. When the passage rotates, heat/mass transfer and flow phenomena change. Especially, the effect of rotation is more dominant than the effect of the ribs at the higher rotation number in the upstream of the second-pass.

AN ANALYSIS OF INFRARED IMAGES OF JUPITER IMPACTED BY P/SHOEMAKER-LEVY 9

  • KIM YONG HA;SUNG KIYUN;KIM SANG JOON;COCHRAN W. D.;LESTER D. F.;TRAFTON L.;CLARK B. E.
    • Journal of The Korean Astronomical Society
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    • v.29 no.2
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    • pp.245-253
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    • 1996
  • We have analyzed infrared (IR) images of Jupiter which was observed at the McDonald Observatory, Texas, U.S.A., during the P/SHoemaker-LEvy 9 (SL9) impact period and about one week after the last impact. The IR images were obtained on the 2.7m telescope using a NICMOS array with filters to isolate the $1.5{\mu}m\;NH_3\; band,\;the\;2.3{\mu}m\;CH_4\;band,\;the\;2.12{\mu}m\;H_2\;S(0)$ pressure-induced absorption, and the continua at $1.58{\mu}m\;and\;2.0{\mu}m$ (short K-band). All images except those with the $1.58{\mu}m$ continuum filter show bright impact sites against the relatively dark Jovian disk near the impact latitude of about $45^{\circ}$ S. This implies that dusts originated from the impacts reflect the solar radiation at high altitudes before absorbed by stratospheric $CH_4,\;NH_3 \;or\;H_2$. The impact sites observed with the $2.3{\mu}m$ filter are conspicuously bright against a very dark background. The morphology of impact sites, G, L, and H at 2.3 and $2.12{\mu}m$ filters shows clearly an asymmetric structure toward the incident direction of the comet fragments, in agreement with the studies of visible impact images obtained with the Hubble Space Telescope. Comparisons of reflectances of G, L, and H sites with simple radiative transfer models suggest that optically thick dust layers were formed at high altitudes at which methane absorption attenuates incoming sunlight only by about $1\%$. The dust layers in these sites seem to form at about the same altitude regardless of the magnitude of the impacts, but they appear to descend gradually after the impacts. The dust layers have optical depths of 2-5, according to the models.

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Genetic Differentiation among Sheep Populations from Near-sea Mainland in East Asia

  • Lu, S.X.;Chang, H.;Du, L.;Tsunoda, K.;Ji, D.J.;Sun, W.;Yang, Z.P.;Chang, G.B.;Mao, Y.J.;Wang, Q.H.;Xu, M.
    • Asian-Australasian Journal of Animal Sciences
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    • v.17 no.10
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    • pp.1360-1365
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    • 2004
  • Using the method of 'random sampling in typical colonies of the central area of the habitat', 60 Small-tailed Han sheep were obtained in Jining city, Shangdong province. The variations of Small-tailed Han sheep at 12 structural loci encoding blood proteins were detected by several electrophoresis techniques and their gene frequencies were then estimated. The same data of four other sheep populations from Near-sea Mainland in East Asia were cited for the analysis of genetic differentiation. The average heterozygosities of five populations, namely Kharkhorin sheep, Ulaanbaatar sheep, Small-tailed Han sheep, Hu sheep and Cham Tribe sheep were 0.3447, 0.3285, 0.3157, 0.3884 and 0.2300, respectively. The coefficient of gene differentiation among four populations, Kharkhorin sheep, Ulaanbaatar sheep, Small-tailed Han sheep and Hu sheep, was 0.045557, and that between these four breeds and Cham Tribe sheep was 0.088005, indicating that the level of gene differentiation among the former four sheep populations of Mongolian group was comparatively lower than that between Cham Tribe sheep and other four sheep populations. The origin of Cham Tribe sheep deserve further research. The documentary research on the evolution of Small-tailed Han sheep and Hu sheep from Mongolian sheep was further verified by the biochemical experiments in the study. It was reasonably deduced that Hu sheep, Small Tailed Han sheep and Cham Tribe sheep were decreasingly influenced by the bloodline of Mongolian sheep.

Triangular Ring Resonator Without Direct Coupling Between Two Access Waveguides of Multimode Interference Coupler (다중모드 결합기의 입출력 광도파로 사이에 광결합이 없는 삼각형 링 공진기)

  • Kim, Doo-Gun;Kim, Hyo-Jin;Kim, Seon-Hoon;Ki, Hyun-Chul;Kim, Hwe-Jong;Oh, Geum-Yoon;Choi, Young-Wan
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.59 no.1
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    • pp.123-128
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    • 2010
  • We have investigated the properties of the novel triangular ring resonator with the total internal reflection mirrors and the semiconductor optical amplifier for photonic integrated circuits (PIC). A novel triangular resonators containing active and passive sections are fabricated and characterized with various multimode interference (MMI) lengths. The optimum MMI length and width turn out to be 108 and 9 ${\mu}m$, respectively. A free spectral range of approximately 228 GHz is observed near 1558 nm along with an on-off ratio of 9 dB. The proposed triangular resonator has a good advantage to remove the direct coupling between the two access waveguides of the MMI coupler. Hence, such resonators can be directly integrated with other devices making compact and highly functional PIC possible.