• 한국전기화학회:학술대회논문집
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• 1998.10a
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• pp.15-15
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• 1998

• Proceedings of the Korean Society of Life Science Conference
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• 2000.09a
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• pp.73-73
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• 2000

• Proceedings of the Korean Society of Life Science Conference
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• 2008.10a
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• pp.52.1-52.1
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• 2008

• Proceedings of the Zoological Society Korea Conference
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• 1997.10b
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• pp.314.1-314
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• 1997

No Abstract, See Full Text

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.600-601
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• 2005

• Journal of Ginseng Research
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• v.48 no.2
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• pp.202-210
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• 2024

Background: Panax ginseng Meyer polysaccharides exhibit various biological functions, like antagonizing galectin-3-mediated cell adhesion and migration. Galectin-8 (Gal-8), with its linker-joined N- and C-terminal carbohydrate recognition domains (CRDs), is also crucial to these biological processes, and thus plays a role in various pathological disorders. Yet the effect of ginseng-derived polysaccharides in modulating Gal-8 function has remained unclear. Methods: P. ginseng-derived pectin was chromatographically isolated and enzymatically digested to obtain a series of polysaccharides. Biolayer Interferometry (BLI) quantified their binding affinity to Gal-8, and their inhibitory effects on Gal-8 was assessed by hemagglutination, cell migration and T-cell apoptosis. Results: Our ginseng-derived pectin polysaccharides consist mostly of rhamnogalacturonan-I (RG-I) and homogalacturonan (HG). BLI shows that Gal-8 binding rests primarily in RG-I and its β-1,4-galactan side chains, with sub-micromolar K_D values. Both N- and C-terminal Gal-8 CRDs bind RG-I, with binding correlated with Gal-8-mediated function. Conclusion: P. ginseng RG-I pectin β-1,4-galactan side chains are crucial to binding Gal-8 and antagonizing its function. This study enhances our understanding of galectin-sugar interactions, information that may be used in the development of pharmaceutical agents targeting Gal-8.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.649-650
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• 2005

• Proceedings of the Korean Society of Life Science Conference
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• 2000.09a
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• pp.70-71
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• 2000

• Proceedings of the Korean Society of Life Science Conference
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• 2000.09a
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• pp.72-72
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• 2000

• Macromolecular Research
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• v.9 no.6
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• pp.339-344
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• 2001

In order to investigate the photoalignment mechanism of nematic liquid crystals on a polymer film, a new photoreactive polymer having chalcone groups as side chains was synthesized. Linearly polarized UV light causes preferential photoreactions of the chalcone unit along the polarization direction and thus induces the anisotrpy in the polymer alignment layer resulting in homogeneous LC alignment perpendicular to the polarization direction. The sequential investigations of photoalignment generated by the preferential E/Z isomerization and (2+2) cycloaddition reactions show that either photoreaction can solely induce the LC alignment in the direction perpendicular to UV polarization.