• Advances in Computational Design
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• v.1 no.3
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• pp.275-296
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• 2016

This article presents an adaptive directional differential evolution (ADDE) algorithm and its application in solving discrete sizing truss optimization problems. The algorithm is featured by a new self-adaptation approach and a simple directional strategy. In the adaptation approach, the mutation operator is adjusted in accordance with the change of population diversity, which can well balance between global exploration and local exploitation as well as locate the promising solutions. The directional strategy is based on the order relation between two difference solutions chosen for mutation and can bias the search direction for increasing the possibility of finding improved solutions. In addition, a new scaling factor is introduced as a vector of uniform random variables to maintain the diversity without crossover operation. Numerical results show that the optimal solutions of ADDE are as good as or better than those from some modern metaheuristics in the literature, while ADDE often uses fewer structural analyses.

• YAKHAK HOEJI
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• v.43 no.5
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• pp.614-622
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• 1999

The standard operation procedure of mouse lymphoma L5178Y $tk^{+/-}-3.7.2C$ gene mutation assay (MOLY) has been regarded as a sensitive in vitro mammalian cell gene mutation assay that is capable of detecting clastogens as well as mutagens. Using MOLY, one of natural sweetner, stevioside (5mg/ml) and its aglycon, steviol ($340{\;}\mu\textrm{g}/ml$) were evaluated the mutagenicity. Stevioside and steviol did not induce mutagenicity in MOLY. On the other hand, stevioside (250mg/kg, B.W.) and steviol (200mg/kg, B.W.) were also evaluated their ability to induce micronuclei in regenerating hepatocytes and bone marrow cells of ddY mice. From these results, stevioside and steviol did not induce any mutagenic effect both MOLY and in vivo micronucleus test.

• Annals of Pediatric Endocrinology and Metabolism
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• v.23 no.4
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• pp.235-239
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• 2018

Most cases of congenital hyperthyroidism are autoimmune forms caused by maternal thyroid stimulating antibodies. Nonautoimmune forms of congenital hyperthyroidism caused by activating mutations of the thyrotropin receptor (TSHR) gene are rare. A woman gave birth to a boy during an emergency cesarean section at 33 weeks of gestation due to fetal tachycardia. On the 24th day of life, thyroid function tests were performed due to persistent tachycardia, and hyperthyroidism was confirmed. Auto-antibodies to TSHR, thyroid peroxidase, and thyroglobulin were not found. The patient was treated with propylthiouracil and propranolol, but hyperthyroidism was not well controlled. At 3 months of age, the patient had craniosynostosis and hydrocephalus, and underwent a ventriculoperitoneal shunt operation. Direct sequencing of the TSHR gene showed a heterozygous mutation of c.1899C>A (p.Asp633Glu) in exon 10. No mutations were discovered in any of the parents in a familial genetic study. We have reported a case of sporadic nonautoimmune congenital hyperthyroidism, by a missense mutation of the TSHR gene, for the first time in South Korea.

• Journal of the Korea Society of Computer and Information
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• v.16 no.12
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• pp.23-31
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• 2011

The simple bacteria cooperative optimization (sBCO) algorithm that we developed as one of optimization algorithms has shown relatively good performances, but their performances were limited by step-by-step movement of individuals at a time. In order to solve this problem, we proposed a new method that assigned a speed to each individual according to its rank and it was confirmed that it improved the performances of sBCO in some degree. In addition to the assigning of speed to the individuals, we employed a new mutation operation that most existing evolutionary algorithms used in order to enhance the performances of sBCO in this paper. A specific percent of bad individuals are mutated within an area that is proportion to the rank of the individual in the mutation operation. That is, Gaussian noise of large standard deviation is added as the fitness of individuals is low. From this, the probability that the individuals with lower ranks can be located far from its parent will be increased. This causes that the probability of falling into local optimum areas is decreased and the probability of fast escaping the local optimum areas is increased. From experimental results with four function optimization problems, we showed that the performances of sBCO with mutation operation and individual speed were increased. If the optimization function is quite complex, however, the performances are not always better. We should devise a new method for solving this problem as a further work.

• Proceedings of the IEEK Conference
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• 2002.07a
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• pp.666-669
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• 2002

A microprocessor with genetic instructions such as crossover, mutation and inversion is proposed. The processor is modeled using VHDL, synthesized to a schematic and implemented on a FPGA. The control path is implemented with a microprogram consisting of about 15032-bit microwords, and the operation of each instruction is checked through simulation.

• Childhood Kidney Diseases
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• v.13 no.1
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• pp.84-91
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• 2009

We experienced a female neonate with congenital nephrotic syndrome (CNS) associated with congenital diaphragmatic hernia (CDH). Because of the rare combination of two conditions, we report this case with literature review. CDH was found immediately after birth and emergency operation was done for hernia repair. But on the next day, generalized edema and oliguria(0.59 mL/kg/hour) was found and her blood chemistry showed hypoalbuminemia (1.6 g/dL), increased BUN (27.7 mg/dL) and serum creatinine( 1.8 mg/dL) along with heavy proteinuria (4+). We started albumin infusion with a bolus of intravenous furosemide. We suspected the neonate had congenital nephrotic syndrome and her 24hr urine protein was 1,816 mg/day. In spite of immunosuppressive therapy, the nephrotic syndrome and renal failure progressed. We started peritoneal dialysis on the day of life 22 but it was not satisfactory. She was complicated by intracranial hemorrhage and multi-organ failure and expired at 34 days of age. Kidney necropsy was performed which showed diffuse mesangial sclerosis (DMS). Her chromosome study revealed 46, XX and her gene study revealed a heterozygous missense mutation, Arg366His, in Wilms tumor suppressor gene (WT1). This case deserves attention on account of the 4th case of CNS with CDH revealing the Arg366His mutation in the WT1 gene and G the 1st case of early onset renal failure without male pseudohermaphroditism and Wilms tumor with CNS, CDH and the Arg366His mutation in the WT1 gene. So, this report gives support to the hypothesis that Arg366His mutation in the WT1 gene can result in CNS and CDH.

• Korean Journal of Clinical Laboratory Science
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• v.40 no.1
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• pp.41-47
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• 2008

Colorectal carcinoma is occurred frequently to Korean and so ranked the fourth from various cancers. Due to western dietary life, this cancer has been increased continually. Therefore, the study will be needed to find a candidate gene involved in the development and progression of colorectal carcinoma and to diagnose and treatment helpfully. The striking feature from cancer suppressor genes is known for LOH (loss of heterozygosity), which is the method to find allele genetic loss or mutation of cancer cell. The purpose of this study was designed to find a carcinogenic gene from colon cancer using microsatellite marker on 17th and 18th chromosome from 30 subjects. The LOH was investigated in order of D18S59 57% (17/30), TP53CA 50% (15/30), D18S68 47% (14/30), D18S69 43% (13/30). The genetic mutation depends on loci of colorectal carcinoma was shown higher with 2.44 from colon cancer than with 1.25 from right colorectal carcinoma (p<0.032). The genetic mutation with lymph nodes was investigated higher with 2.69 at mutated group than with 1.14 at non-mutated group (p<0.003). At genetic mutated pattern depends on disease stage, there was higher significant difference at III-IV stage 2.50 than that of I-II stage 1.17, respectively (p=0.015). There was no difference at comparison between histological classification and serological CEA increase. The loss on 18q21 found in this study is highly recurrence loci and was observed 43% for Korean with high recurrence. Therefore, LOH is a very useful tool to detect 18q21 loci in clinical application, prior to the treatment of colorectal carcinoma. After the operation of colorectol carcinoma, the efficient application using LOH at operated part tissue which is designed to protect the recurrence as well as its cure will be needed.

• Journal of Microbiology and Biotechnology
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• v.31 no.2
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• pp.290-297
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• 2021

Leptolyngbya sp. KIOST-1 (LK1) is a newly isolated cyanobacterium that shows no obvious cytotoxicity and contains high protein content for both human and animal diets. However, only limited information is available on its toxic effects. The purpose of this study was to validate the safety of LK1 powder. Following Organisation for Economic Co-operation and Development (OECD) guidelines, a single-dose oral toxicity test in Sprague Dawley rats was performed. Genotoxicity was assessed using a bacterial reverse mutation test with Salmonella typhimurium (strains TA98, TA100, TA1535, and TA1537) and Escherichia coli WP2 uvrA, an in vitro mammalian chromosome aberration test using Chinese hamster lung cells, and an in vivo mammalian erythrocyte micronucleus test using Hsd:ICR (CD-1) SPF mouse bone marrow. After LK1 administration (2,500 mg/kg), there were no LK1-related body weight changes or necropsy findings. The reverse mutation test showed no increased reverse mutation upon exposure to 5,000 ㎍/plate of the LK1 powder, the maximum tested amount. The chromosome aberration test and micronucleus assay demonstrated no chromosomal abnormalities and genotoxicity, respectively, in the presence of the LK1 powder. The absence of physiological findings and genetic abnormalities suggests that LK1 powder is appropriate as a candidate biomass to be used as a safe food ingredient.

• Proceedings of the KIEE Conference
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• 1999.07c
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• pp.1123-1125
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• 1999

This paper proposes an optimization technique using Genetic Algorithm(GA) for service restoration in the distribution system. Restoration planning problem can be treated as a combinatorial optimization problem. So GA is appropriate to solve the service restoration problem in the distribution network. But searching capabilities of the GA can be enhanced by developing relevant repairing operation and modifying GA operations. In this paper, we aimed at finding appropriate open sectionalizing switch position for the restoration of distribution networks after disturbances using enhanced GA with repairing operation and modified mutation. Simulation results show that proposed method found the open sectionalizing switches with less out of service area and minimize transmission line losses and voltage drop.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2003.09a
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• pp.187-190
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• 2003

Many manufacturing companies consider the integrated and concurrent scheduling because they need the global optimization technology that could manufacture various products more responsive to customer needs. In this paper, we propose an advanced scheduling model to generate the schedules considering resource constraints and precedence constraints in make-to-order (MTO) manufacturing environments. Precedence of work- in-process(WIP) and resources constraints have recently emerged as one of the main constraints in advanced scheduling problems. The advanced scheduling problems is formulated as a multiobjective mathematical model for generating operation schedules which are obeyed resources constraints, alternative workstations of operations and the precedence constraints of WIP in MTO manufacturing. For effectively solving the advanced scheduling problem, the multi-objective hybrid genetic algorithm (m-hGA) is proposed in this paper. The m-hGA is to minimize the makespan, total flow time of order, and maximum tardiness for each order, simultaneously. The m-hGA approach with local search-based mutation through swap mutation is developed to solve the advanced scheduling problem. Numerical example is tested and presented for advanced scheduling problems with various orders to describe the performance of the proposed m-hGA.