• Journal of Environmental Health Sciences
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• v.21 no.3
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• pp.1-15
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• 1995

Tolerance to toxic effects of cadmium(Cd), including lethality has been shown following pretreatment with cadmium and zinc. This study was designed to determine if tolerance also develops to Cd-induced hepatotoxicity and renal toxicity. Three groups of rats(A, B, C), each consisting of 52 rats, were studied and each group was divided into three subgroups(1,2,3), 28 rats for each subgroup. Rats were subcutaneously pretreated with saline(A), $CdCl_2$(0.5 mg/kg, B), and $ZnCl_2$(13.0 mg/kg, C) during time periods of 5 days. At the end of the period, rats were challenged with $CdCl_2$(3.0 and 6.0 mg/kg) by intraperitoneal injection. As for the cadmium levels in rat tissues after 1,3,5,6 days of pretreatments, it was highest in the liver. Then kidney, heart, blood and muscle followed it in that order. After 24, 48 and 96 hours of intraperitoneal injection by challenge doses the concentration of cadmium in liver and kidney increased proportionally to the increase of challenge dosage. However metallothioneins in liver and kidney were increased by the pretreatment of cadmium and zinc. These data indicate the liver is a major target-organ of acute Cd poisoning, and suggest that cadmium induced hepatic injury, via release of Cd-MT, may play an important role in the nephrotoxicity observed in response to short-term exposure to cadmium. This result suggest that increasing cadmium concentrations, gradually accumulating in liver and kidney as the result of the pretreatment, served to induce the synthesis of metallothionein, thus making them resistant to the challenge from cadmium.

• Physical Therapy Korea
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• v.13 no.3
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• pp.92-101
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• 2006

The purpose of this study was to investigate the characteristics and the current condition of musculoskeletal pain sufferers among fitness center users. The investigation used self-reporting questionnaire with the 797 subjects. On average, the subjects were 30.6 years old, 168.8 cm in height and 65.2 kg in weight. Among them, 423 were male (53.1%) and 374 were female (46.9%). Out of them, 276 suffered from pain, (35.2%). More men felt muscle aches than women (p<.05). In terms of pain, lower back area topped the list with 44.9%, followed by the lower extremities (30.1%), the neck (17.8%) and the upper part of the body (17.8%). Dieters suffered the most from pain (86.2%) while those exercising to build strength suffered the least with 26.8%. There was a significant relationship between the purpose for exercising and the amount of pain suffered (p<.05). By kind of exercise, pain stroke aerobic exercisers disproportionately with 42.4% while it almost steered clear of exercisers for strengthening with 26.9%. There was significant relationship between the kind of exercise and pain suffered (p<.05). The type of suffering differed by body shape. A significantly higher number of overweight people experienced pain than underweight people (p<.05). 32.8% of pain sufferers commented that the pain affects their workout, and on this issue there was no gender difference (p>.05). The pain caused more difficulties in doing activities of daily living for overweight or obese peoples than underweight peoples (p<.05). More than a third of health club and fitness center users are experiencing musculoskeletal pains. Measures such as professional training or information provision is required to prevent injury or disorder caused by improper exercise.

• Archives of Craniofacial Surgery
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• v.17 no.1
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• pp.39-42
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• 2016

Forehead osteomas are benign but can pose aesthetic and functional problems. These osteomas are resected via bicoronal or endoscopic approach. However, large osteomas cannot be removed via endoscopic approach, and bicoronal approach can result in damage to the supraorbital nerve with resultant numbness in the forehead. We present a new approach to resection of forehead osteomas, with access provided by an anterior hairline incision and subcutaneous dissection. Three patients underwent resection of the forehead osteoma through an anterior hairline incision. The dissection was carried in the subcutaneous plane, and the frontalis muscle and periosteum were divided parallel to the course of supraorbital nerve. The resulting bony defect was re-contoured using $Medpor^{(R)}$. All three patients recovered without any postoperative infection or complication and symptoms. Scalp sensory was preserved. Aesthetic outcomes were satisfactory. Patients remain free of recurrence for 12 months of follow up. The anterior hair line approach with subcutaneous dissection is an effective method for removal of forehead osteoma, since it offers broad visualization and hides the scar in the hairline. In addition, the dissection in the subcutaneous plane avoids inadvertent injury to the deep nerve branches and helps to maintains scalp sensation.

• Korean Journal of Applied Biomechanics
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• v.25 no.1
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• pp.103-111
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• 2015

Objective : The purpose of this study was to evaluate the effect for running shoes with resilience of midsole on biomechanical properties. Methods : 10 healthy males who had no history of injury in the lower extremity with an average age of 26.5 year(SD=1.84), height of 172.22 cm(SD=4.44) and weight of 67.51 kg(SD=6.17) participated in this study. All subjects ran on the treadmill wearing three different running shoes. Foot pressure data was collected using Pedar-X system(Novel Gmbh, Germany) operating at 100 Hz. Surface EMG signals for biceps femoris, rectus femoris, vastus lateralis, medial lateralis, tibialis anterior, medial gastrocnemius, soleus and peroneus longus were acquired at 1000 Hz using Bignoli 8 System(Delsys Inc., USA). To normalize the difference of the magnitude of muscle contractions, it was expressed as a percentage relative to the maximum voluntary contraction (MVC). The impact resilience of the midsole data was collected using Fastcam SA5 system(Photron Inc., USA). Collected data was analyzed using One-way ANOVA in order to investigate the effects of each running shoes. Results : TPU midsole was significantly wider in contact area than EVA, TPE midsole in midfoot and higher in EMG activity than EVA midsole at biceps femoris. TPE midsole was significantly wider in contact area than EVA midsole in rearfoot and higher in peak pressure than EVA midsole in forefoot. EVA midsole was significantly higher in EMG activity than TPU midsole at tibia anterior. In medial resilience of midsoles, TPE midsole was significantly higher than EVA, TPU midsole. Conclusion : TPU midsole can reduce the load on the midfoot effectively and activate tibialis anterior, biceps femoris to give help to running.

• Toxicological Research
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• v.33 no.1
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• pp.15-23
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• 2017

Acanthopanax divaricatus (Siebold & Zucc.) Seem. var. albeofructus (ADA), a traditional medical herb, has been used to treat arthritis and muscular injury, to strengthen muscle and bone, and to get vital energy. However, information regarding its toxicity is limited. ADA was administered by oral gavage to groups of rats at doses of 0 (control), 1,000, 1,500, 2,000, 2,500, and 3,000 mg/kg five times per week for 13 weeks. Mortality, clinical signs, body weights, food consumption, hematology, serum chemistry, urinalysis, organ weights, necropsy, histopathological finding, vaginal cytology, and sperm morphology were compared between control and ADA-treated groups. Salivation was intermittently observed in both sexes receiving 2,500 and 3,000 mg/kg directly after dosing. Absolute liver weights increased in females receiving 2,000, 2,500, and 3,000 mg/kg ADA (P < 0.05, P < 0.01, and P < 0.01, respectively) and so did the relative liver weights (P < 0.001). Salivation and increased liver weight were ADA-related changes but not considered to be adverse effects. Salivation was intermittent and transient, and the liver weight increase was minor and not accompanied by other changes such as hepatic morphological or functional alterations. The no-observed-adverse-effect-level was determined to be at least 3,000 mg/kg in both sexes of rats.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.36 no.6
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• pp.273-279
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• 2014

Purpose: This study assessed the association between eye symptoms (enophthalmos or diplopia) and site of damage, volume, deviated inferior rectus muscle (IRM) and type of fracture with computed tomography (CT). The intent is to anticipate the prognosis of orbital trauma at initial diagnosis. Methods: Forty-five patients were diagnosed with fractures of the inferior wall of one orbit. Fracture area, volume of displaced tissue, deviated IRM, and type of fracture were evaluated from coronal CT by one investigator. The association of those variables with the occurrence of eye symptoms (diplopia and enophthalmos) was assessed. Results: Of 45 patients, 27 were symptom-free (Group A) and 18 had symptoms (Group B) of enophthalmos and/or diplopia. In Group B, 12 had diplopia, one was enophthalmos, and five had both. By CT measurement, group A mean area was $192.6mm^2$ and the mean volume was $673.2mm^3$. Group B area was $316.2mm^2$ and volume was $1,710.6mm^3$. The volume was more influential on symptom occurrence. Each patient was categorized into four grades depending on the location of IRM. Symptom occurrence and higher grade were associated. Twenty-six patients had trap-door fracture (one side, attached to the fracture), and 19 had punched-out fracture (both sides detached). The punched-out fracture was more strongly associated with symptoms and had statistically significantly higher area and volume. Conclusion: In orbital trauma, measurement of fracture area and volume, evaluation of the deviated IRM and classification of the fracture type by coronal CT can effectively predict prognosis and surgical indication.

• Archives of Craniofacial Surgery
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• v.11 no.2
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• pp.107-110
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• 2010

Purpose: Chondroid syringoma is a rare mixed tumor of the skin that was first described by Hirsch and Helwig (1961). Characteristically, it is composed of the proliferation of epithelial cells in a myxoid and chondroid matrix. Most lesions occur on the head and neck region, and their size may range from 0.5~3 cm. Since a chondroid syringoma presents similar characteristics to other masses on the head and neck region, it is significantly important to distinguish with other masses by a surgical biopsy. Methods: A 51-year old woman presented with a painless nodular mass ($0.5{\times}0.5{\times}0.5cm$) on the philtrum, which appeared during the previous year. The mass was treated with a laser without a surgical biopsy. However, the size of the mass showed no changes. Surgical excision under local anesthesia was performed and sent for histopathology. Results: Gross examination showed a mass surrounded by a well developed capsule within the dermal layer. After complete excision without injury to the orbicularis oris muscle, the wound was covered with a local flap. The histology examination revealed numerous cuboid epithelial cells with tuboalveolar structures and keratinous cysts within a chondroid stroma. No recurrence or metastasis was observed at the follow-up visits. Conclusion: Chondroid syringoma is a rare mass on the face. An accurate diagnosis is essential for optimal treatment. This paper reports a case of a chondroid syringoma on the philtrum with a brief review of the relevant literature.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.21 no.2
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• pp.39-46
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• 2015

Background: The purpose of this study was to investigate the influence of short-term treadmill walking with high-heeled shoes on electromyography activities of the medial gastrocnemius, lateral gastrocnemius and tibialis anterior in healthy young females. Methods: Fifteen healthy females were recruited for this study. To measure muscle activation, the subjects were asked in random order to walk on a treadmill using either high-heeled shoes or barefoot conditions. The shoe heel height for high-heeled walking was 7 cm. The walking speed on the treadmill was 4 km/h, and the inclination rate of the treadmill was 10%. The subjects performed treadmill walking in the barefoot and high-heeled walking conditions for 5 minutes. Electromyography data were collected from the tibialis anterior, medial gastrocnemius, lateral gastrocnemius, and soleus on both firm and foam surfaces and during eyes-open and-closed conditions while standing. Results: Tibialis anterior activity was significantly different before and after the walking task while standing on a foam surface with eyes closed (p<.05). Conclusion: This finding suggests that the activity of the tibialis anterior may be lowered after high-heeled walking. Therefore, high-heeled shoes contribute to harmful effects at the ankle joints, increasing the risks of falling and musculoskeletal injury.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.41 no.3
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• pp.153-160
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• 2017

Gait analysis has been conducted in various environments, but the biomechanics during the transition from uphill walking to downhill walking have not been reported. The purpose of this study is to investigate the knee and ankle joint kinematics and kinetics during walking on a triangle-shaped slope compared with those during level walking. Kinematic and kinetic data of eighteen participants were obtained using a force plate and motion capture system. The greater peak ankle dorsiflexion angle and moment and the peak knee extension moment were observed (p<0.05) during both uphill and downhill walking on the triangle-shaped slope. In summary, uphill walking on a triangle-shaped slope, which showed a peak knee flexion of more than $50^{\circ}$ with greater peak knee extension moment, could increase the risk of patellofemoral pain syndrome. Downhill walking on a triangle-shaped slope, which involved greater ankle dorsiflexion excursion and peak ankle dorsiflexion, could cause gastrocnemius muscle strain and Achilles tendon overuse injury.

• Archives of Reconstructive Microsurgery
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• v.10 no.1
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• pp.34-37
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• 2001

The injury on the dorsum of foot is usually manifested in the defect of bone and soft tissue, so its reconstruction requires composite tissue. Free flap satisfies this defect but its indication is determined by the defect size, recipient status and so on. Iliac crest bone and fibular bone are useful bone flap but in more than 8cm defect, fibular flap is more useful. The drawback of fibular free flap is the absence of soft-tissue coverage, so another local flap and myocutaneous flap must be added. Fibula-hemisoleus ostemusculocutaneous free flap has been used for the reconstruction of upper and lower extremity. Its advantages are one stage operation, one donor site and the flexibility of the reconstruction with the use of muscle, bone, and skin. This flap has never been reported for the reconstruction of dorsum of foot. In our case, 20-year-old woman was referred with the 17 cm defect of 1st metatarsal bone and $16{\times}8cm$ sized soft tissue loss on the dorsum of the right foot. We reconstructed successfully the dorsum of foot with fibula-hemisoleus osteomusculocutaneous free flap and the patient can walk without crutches after 6 monthes.