• 대한두개안면성형외과학회지
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• 제11권2호
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• pp.107-110
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• 2010

Purpose: Chondroid syringoma is a rare mixed tumor of the skin that was first described by Hirsch and Helwig (1961). Characteristically, it is composed of the proliferation of epithelial cells in a myxoid and chondroid matrix. Most lesions occur on the head and neck region, and their size may range from 0.5~3 cm. Since a chondroid syringoma presents similar characteristics to other masses on the head and neck region, it is significantly important to distinguish with other masses by a surgical biopsy. Methods: A 51-year old woman presented with a painless nodular mass ($0.5{\times}0.5{\times}0.5cm$) on the philtrum, which appeared during the previous year. The mass was treated with a laser without a surgical biopsy. However, the size of the mass showed no changes. Surgical excision under local anesthesia was performed and sent for histopathology. Results: Gross examination showed a mass surrounded by a well developed capsule within the dermal layer. After complete excision without injury to the orbicularis oris muscle, the wound was covered with a local flap. The histology examination revealed numerous cuboid epithelial cells with tuboalveolar structures and keratinous cysts within a chondroid stroma. No recurrence or metastasis was observed at the follow-up visits. Conclusion: Chondroid syringoma is a rare mass on the face. An accurate diagnosis is essential for optimal treatment. This paper reports a case of a chondroid syringoma on the philtrum with a brief review of the relevant literature.

• 대한정형도수물리치료학회지
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• 제21권2호
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• pp.39-46
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• 2015

Background: The purpose of this study was to investigate the influence of short-term treadmill walking with high-heeled shoes on electromyography activities of the medial gastrocnemius, lateral gastrocnemius and tibialis anterior in healthy young females. Methods: Fifteen healthy females were recruited for this study. To measure muscle activation, the subjects were asked in random order to walk on a treadmill using either high-heeled shoes or barefoot conditions. The shoe heel height for high-heeled walking was 7 cm. The walking speed on the treadmill was 4 km/h, and the inclination rate of the treadmill was 10%. The subjects performed treadmill walking in the barefoot and high-heeled walking conditions for 5 minutes. Electromyography data were collected from the tibialis anterior, medial gastrocnemius, lateral gastrocnemius, and soleus on both firm and foam surfaces and during eyes-open and-closed conditions while standing. Results: Tibialis anterior activity was significantly different before and after the walking task while standing on a foam surface with eyes closed (p<.05). Conclusion: This finding suggests that the activity of the tibialis anterior may be lowered after high-heeled walking. Therefore, high-heeled shoes contribute to harmful effects at the ankle joints, increasing the risks of falling and musculoskeletal injury.

• 대한기계학회논문집B
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• 제41권3호
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• pp.153-160
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• 2017

보행 분석은 다양한 지형에서 수행되고 있으나 지형이 변화되는 시점에서의 보행 분석 연구는 보고된 바 없다. 본 연구의 목적은 삼각경사 보행 시 지형이 변화되는 시점에서 발목 및 무릎 관절의 운동학과 운동역학을 평지 보행과 비교 분석하는 것이다. 3차원 동작분석 시스템과 지면 반력기를 사용하여 성인 남성 18명의 하지 운동학 및 운동역학 자료를 획득하였다. 삼각경사 보행에서 최대 발목 배측굴곡각 및 모멘트와 최대 무릎 신전 모멘트가 평지보행과 비교하였을 때 증가하였다(p<0.05). 삼각경사의 상승경사 보행 시 $50^{\circ}$가 넘는 무릎 굽힘각과 그 시기에 발생하는 큰 무릎 신전 모멘트는 슬개대퇴증후군의 위험을 높일 수 있을 것으로 보인다. 또한 삼각경사의 하강경사 보행에서 증가된 발목 배측굴곡 운동범위는 비복근과 아킬레스건 부상 위험을 높일 수 있을 것으로 보인다.

• Archives of Reconstructive Microsurgery
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• 제10권1호
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• pp.34-37
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• 2001

The injury on the dorsum of foot is usually manifested in the defect of bone and soft tissue, so its reconstruction requires composite tissue. Free flap satisfies this defect but its indication is determined by the defect size, recipient status and so on. Iliac crest bone and fibular bone are useful bone flap but in more than 8cm defect, fibular flap is more useful. The drawback of fibular free flap is the absence of soft-tissue coverage, so another local flap and myocutaneous flap must be added. Fibula-hemisoleus ostemusculocutaneous free flap has been used for the reconstruction of upper and lower extremity. Its advantages are one stage operation, one donor site and the flexibility of the reconstruction with the use of muscle, bone, and skin. This flap has never been reported for the reconstruction of dorsum of foot. In our case, 20-year-old woman was referred with the 17 cm defect of 1st metatarsal bone and $16{\times}8cm$ sized soft tissue loss on the dorsum of the right foot. We reconstructed successfully the dorsum of foot with fibula-hemisoleus osteomusculocutaneous free flap and the patient can walk without crutches after 6 monthes.

• 한국운동역학회지
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• 제21권2호
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• pp.173-179
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• 2011

This study aims to analyse difference in biomechanical factors between dominant legs and recessive ones according to muscular imbalance during drop landing targeting talented children in sports. The subjects of the study were ten primary students who are attending to Sports Program for Talented Children organized by C university (age: $12.28{\pm}0.70$ year, height: $1.52{\pm}0.11$ m, and weight: $45.2{\pm}4.9$ kg). Strength legs were classified into dominant side and strengthless legs were classified into non-dominant legs. For three-dimensional analyses of the data collected, 6 video cameras(MotionMaster200, Visol, Korea) were used. To analyse ground reaction force, two force platforms(AMTI ORG-6, MA) were used and to analyse electromyograghy a 8-channeled wireless Noraxon Myoresearch made in USA was used at 1000 Hz for sampling. As a result, it was discovered that the dominants legs controlled knee bending motions more stably than strengthless legs as the maximum vertical ground reaction force was significantly high in dominant legs(p<.05), and joint moment of knee joints of the dominant legs was high(p<.05). Therefore, this study suggested that injury prevention program focusing on muscular balance as well as the existing sports programs for talented children should be developed based on results of the study and it is expected that the results will be useful for improvement of sports programs for talented children.

• Journal of Korean Neurosurgical Society
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• 제52권3호
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• pp.267-269
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• 2012

Traumatic brachial plexus injuries can be devastating, causing partial to total denervation of the muscles of the upper extremities. Surgical reconstruction can restore motor and/or sensory function following nerve injuries. Direct nerve-to-nerve transfers can provide a closer nerve source to the target muscle, thereby enhancing the quality and rate of recovery. Restoration of elbow flexion is the primary goal for patients with brachial plexus injuries. A 4-year-old right-hand-dominant male sustained a fracture of the left scapula in a car accident. He was treated conservatively. After the accident, he presented with motor weakness of the left upper extremity. Shoulder abduction was grade 3 and elbow flexor was grade 0. Hand function was intact. Nerve conduction studies and an electromyogram were performed, which revealed left lateral and posterior cord brachial plexopathy with axonotmesis. He was admitted to Rehabilitation Medicine and treated. However, marked neurological dysfunction in the left upper extremity was still observed. Six months after trauma, under general anesthesia with the patient in the supine position, the brachial plexus was explored through infraclavicular and supraclavicular incisions. Each terminal branch was confirmed by electrophysiology. Avulsion of the C5 roots and absence of usable stump proximally were confirmed intraoperatively. Under a microscope, neurotization from the musculocutaneous nerve to two medial pectoral nerves was performed with nylon 8-0. Physical treatment and electrostimulation started 2 weeks postoperatively. At a 3-month postoperative visit, evidence of reinnervation of the elbow flexors was observed. At his last follow-up, 2 years following trauma, the patient had recovered Medical Research Council (MRC) grade 4+ elbow flexors. We propose that neurotization from medial pectoral nerves to musculocutaneous nerve can be used successfully to restore elbow flexion in patients with brachial plexus injuries.

• BMB Reports
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• 제45권6호
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• pp.348-353
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• 2012

L-2-Oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrug that maintains glutathione in tissues. The present study was designed to investigate anti-fibrotic and anti-oxidative effects of OTC via modulation of nuclear factor erythroid 2-related factor 2 (Nrf2) in an in vivo thioacetamide (TAA)-induced hepatic fibrosis model. Treatment with OTC (80 or 160 mg/kg) improved serum liver function parameters and significantly ameliorated liver fibrosis. The OTC treatment groups exhibited significantly lower expression of ${\alpha}$-smooth muscle actin, transforming growth factor-${\beta}1$, and collagen ${\alpha}1$ mRNA than that in the TAA model group. Furthermore, the OTC treatment groups showed a significant decrease in hepatic malondialdehyde level compared to that in the TAA model group. Nrf2 and heme oxygenase-1 expression increased significantly in the OTC treatment groups compared with that in the TAA model group. Taken together, these results suggest that OTC restores the anti-oxidative system by upregulating Nrf2; thus, ameliorating liver injury and a fibrotic reaction.

• 동의생리병리학회지
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• 제29권4호
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• pp.337-346
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• 2015

Sprain is the injury of meridian-muscle, and is caused by qi and blood obstruction or regional stagnation of qi and blood. So we take the channel points where pain flows. If we take the locations that feel pain, those locations are treatments points and ashi points. So we searched over the ashi points appearing on the patients with wrist sprain. Ashi points appeared on LI5, TE4, SI5 around wrist joints, LI10, LI11, LU6 around elbow joints, LI14, LU3, LU4, PC2 around upper arm. Also, ashi points appeared much on ST17, KI23, PC1, SP18, ST18 around thoracic region, and, on BL15, BL44, BL13 around anterior and thoracodorsal region, in order stated. Ashi points of the highest frequency appeared on LI14 around upper arm, and on LI5, TE4 around wrist joint, and SI5, ST17, KI12, PC1, SP18 appeared with second highest frequency. And ashi points on elbow points and thoracodorsal region appeared with the same frequency. Therefore, it is possible for us to know that the pain location appears in order of upper arm, anterior thoracic region, elbow joint region, and, thoracodorsal region, in treating wrist joints. There was a tendency that pain and movement disturbance recovered more quickly, depending on the pain reduction, as we found out the ashi points closely from stagnated qi and blood caused by wrist arthritis, and relaxed the stiff location. Rubbing treatments in treating pain ashi points is considered to play an important role to reduce pain effectively, so it is necessary to make a further study.

• Clinics in Shoulder and Elbow
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• 제10권1호
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• pp.131-135
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• 2007

23세 남환에서 발생한 요골 두 급성 전방 탈구를 경험하였기에 이를 보고하고자 한다. 수상 당시 전완부는 회내전, 주관절은 약간 굴곡되어 있었고, 손이 지면에 닿아 체중이 실리면서 주관절의 갑작스런 과도한 회내전이 발생하였다. 요골 두는 상완근의 외측 근육 다발에 의해 감돈 되었고, 윤상인대가 척골의 후방 부착부에서 견열되어 요골 두와 소두 사이에 끼어 정복을 방해하였다. 관혈적 정복을 시행하였다. 12개월간 추시 관찰을 하였으며 요골 두의 정복은 잘 유지되고 있었고 주관절의 운동제한은 없었다.

• The Korean Journal of Physiology and Pharmacology
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• 제20권6호
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• pp.657-667
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• 2016

Critical limb ischemia (CLI) is one of the most severe forms of peripheral artery diseases, but current treatment strategies do not guarantee complete recovery of vascular blood flow or reduce the risk of mortality. Recently, human bone marrow derived mesenchymal stem cells (MSCs) have been reported to have a paracrine influence on angiogenesis in several ischemic diseases. However, little evidence is available regarding optimal cell doses and injection frequencies. Thus, the authors undertook this study to investigate the effects of cell dose and injection frequency on cell survival and paracrine effects. MSCs were injected at $10^6$ or $10^5$ per injection (high and low doses) either once (single injection) or once in two consecutive weeks (double injection) into ischemic legs. Mice were sacrificed 4 weeks after first injection. Angiogenic effects were confirmed in vitro and in vivo, and M2 macrophage infiltration into ischemic tissues and rates of limb salvage were documented. MSCs were found to induce angiogenesis through a paracrine effect in vitro, and were found to survive in ischemic muscle for up to 4 weeks dependent on cell dose and injection frequency. In addition, double high dose and low dose of MSC injections increased vessel formation, and decreased fibrosis volumes and apoptotic cell numbers, whereas a single high dose did not. Our results showed MSCs protect against ischemic injury in a paracrine manner, and suggest that increasing injection frequency is more important than MSC dosage for the treatment CLI.