• Archives of Pharmacal Research
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• v.27 no.12
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• pp.1194-1201
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• 2004

Michael addition of certain nucleophiles on ${\alpha}$ , ${\beta}$-unsaturated ketones 1 led to the formation of adducts 2-7 as well as the reaction of arylidene derivatives with secondary amines afforded the amino compounds 9 and 11. Also, dialkylmalonates were treated with ${\alpha}$-cyano cinnamide to afford 13. On the other hand, double Michael cycloaddition of ethylcyanoacetate or tetrachlorophthalic anhydride to the suitable divinylketone were synthesized to produce 15-17. Selected compounds (13 and 6) were screened for muscle relaxant, anticonvulsant, and sedative activities using established pharmacological models. Their activities were compared with that of phenobarbital sodium taken as standard. Compound 6 was the most potent muscle relaxant while compounds 13a and 13c offered the highest anticonvulsant activity. Meanwhile compound 13c showed the highest potentiation of phenobarbital induced sleep in mice.

• Journal of Life Science
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• v.8 no.4
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• pp.395-399
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• 1998

Neurokinin A(NKA) and its derivatives ([Nle$^{7}$NKA,[Leu$^{7}$NKA] were synthesized by solid phase peptide synthesis method using Fmoc-TFA strategy and their smooth muscle contractile activities were measured to examine the structural effect of alkyl group at the 7th amino acid NKA on the smooth muscle contractile activity. The smooth muscle contractile activity. The smooth muscle contractile activities of [Nle$^{7}$]NKA and [Leu$^{7}$]NKA were only 5.64% and 1.55%, respectively when compared with NKA. This result suggested that the more three dimensional structure of th 7th amino acid as well as the whole message segment of NKA would be necessary to show the biological activity.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.10 no.1
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• pp.1-5
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• 2012

Purpose : In this study, stroke patients' limits of stability and functional reach test and tibialis anterior, gastrocnemius muscle of lower extremity muscle activities to evaluate the correlation. Methods : 30 adult stroke patients to participate in this study. Limits of stability were measured using biorescue, tibialis anterior and gastrocnemius muscle of muscles activities were measured with functional reach test when there was movement. Results : Limits of stability and functional reach test (r=0.753, p<0.01), RMS value of the limits of stability and tibialis anterior muscle (r=0.706, p<0.01), RMS value of the limits of stability and gastrocnemius muscle (r=0.766, p<0.01), RMS value of the functional reach test and tibialis anterior muscle (r=0.835, p<0.01), RMS value of the functional reach test and gastrocnemius muscle (r=0.663, p<0.01), RMS value of the tibialis anterior and gastrocnemius muscle (r=0.816, p<0.01) correlations are shown as statistically significant. Conclusion : The balance and lower extremity muscle activities of stroke patients were studied, and were positively correlated with the RMS value of the limits of stability and functional reach test, tibialis anterior muscle, and gastrocnemius muscle. This study has shown that stroke patients' ankle joint muscle activity can greatly.

• Physical Therapy Rehabilitation Science
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• v.11 no.4
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• pp.526-534
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• 2022

Objective: The purpose of this study was to compare muscle activities of stroke patients and healthy participants during bimanual tasks. Design: A cross sectional study. Methods: A total of 25 participants (13 hemiparetic stroke patients and 12 healthy participants) were recruited. The muscle activities using electromyogram (EMG) during bimanual tasks were collected from the following muscles: extensor carpi radialis longus (ECRL), biceps brachii (BB), and triceps brachii (TB). The bimanual tasks included eight tasks consisted of (1) raising the wrists up and down, (2) supinating and pronating the palms, (3) touching the shoulder with fingertips, (4) drawing vertical dot, (5) reaching for a cup and bring it in to drink, (6) drawing a circle outward and (7) inward, and (8) grasping the fingers. The EMG data collected from the muscles of paretic and non-paretic sides of stroke patients and the average from both sides of healthy subjects were normalized and compared after calculating the percentage of maximal isometric voluntary contraction. Results: The ECRL, BB and TB of the paretic side of the stroke patients showed relatively greater muscle activity compared to the non-paretic side as well asaverage of the healthy subject duringall tasks (p<0.05). In addition, the ECRL showed the highest muscle activity during most of the tasks. All of the non-paretic side musclesfrom stroke patients showed higher muscle activity compared to those of healthy subjects. Conclusions: The current study showed that muscle activities of upper extremity varied between paretic and non-paretic sides of stroke patients during bimanual tasks. Interestingly, the non-paretic side muscle activities were also different from those of normal participants.

• Journal of the Ergonomics Society of Korea
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• v.30 no.5
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• pp.581-588
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• 2011

Objective: The objective of this study is to compare muscle activity levels of the lumbar and rectus femoris muscle when entering and exiting RV and passenger vehicles. Background: Three varieties of RVs and two varieties of passenger vehicles were selected for this study. Method: Twenty individual(10 male and 10 female) in their twenties and thirties with no chronic back pain or any other illness participated in this study. Participants performed entering and exiting the three models of RVs and two models of passenger cars. Appropriate rest time was given to participants between entering and exiting each vehicle in order to recover from muscle fatigue while performing their tasks. Results: Results from this study show that muscle activity levels were highest for entering RVs and exiting passenger vehicles. There were no significant differences in muscle activity levels for left and right side muscles in regards to entering and exiting vehicles. Application: These results can be used to provide baseline information for reduce muscle fatigue when getting in and out of vehicles.

• Journal of the Korean Applied Science and Technology
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• v.35 no.1
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• pp.36-42
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• 2018

This study was to investigate the difference of muscle activities in trunk, upper arm, and shoulder during push-up exercise based on 3 types of different arm position(posterior position, PP; normal position, NP; and anterior position, AP) and to provide effective push-up arm position for each muscle development. Fifteen healthy males(age, $21.5{\pm}0.5years$; height, $172.7{\pm}1.0cm$; body mass, $70.5{\pm}1.3kg$; shoulder width, $42.3{\pm}0.6cm$; and BMI, $23.6{\pm}0.5kg/m^2$) participated in this study. PP, NP, and AP of the arm were used to conduct push-up exercise and 8 muscles(deltoideus p. acromialis: DA; pectoralis minor: PMI; pectoralis major: PMA; serratus anterior: SA; biceps brachii: BB; triceps brachii: TB; latissimus dorsi: LD; and infraspinatus: IS) of right side were selected to measure muscle activities. Total 9 counts of push-up exercise were conducted and EMG data signals of 5-time(from $3^{th}$ to $7^{th}$) push-up movement were used for measuring muscle activities. PP push-up exercise showed that there was a significantly higher muscle activity of DA, PMI, PMA, SA, BB, LD, and IS(p<.05) and AP push-up exercise showed a significantly higher TB activity(p<.05). It would be suggested that different arm position evokes various muscle activities when conducting push-up exercise. PP would be the best push-up arm position for inducing various trunk, upper arm, and shoulder muscle activities compared to NP and AP.

• PNF and Movement
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• v.13 no.1
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• pp.1-7
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• 2015

Purpose: This study aimed to examine the activity of the shoulder flexor and extensor when hold-relax and contraction-relax techniques were applied with shoulder joint flexion. Methods: The subjects of this study were 15 healthy women. With the shoulder joint flexion at $0^{\circ}$ and $90^{\circ}$, hold-relax and contraction-relax techniques were applied for the same submaximal resistance to measure the activities of the deltoid muscle anterior fiber, deltoid muscle posterior fiber, pectoralis major fiber, and latissimus dorsi muscle with surface electromyography. An independent t-test was conducted in order to compare activities of each muscle according to the two techniques. Results: When the hold-relax and contraction-relax techniques were applied with the shoulder joint flexion at $0^{\circ}$, the activities of the shoulder flexor and extensor were not significantly different, but the activity of the flexor was higher when the contraction-relax technique was applied than when the hold-relax technique was applied. When the hold-relax and contraction-relax techniques were applied with the shoulder joint flexed at $90^{\circ}$, the activities of the shoulder flexor and extensor were not significantly different, but the activity of the extensor was relatively higher than when the flexor was at $0^{\circ}$ Conclusion: When the hold-relax and contraction-relax techniques were applied with the shoulder joint flexion at $0^{\circ}$, the activities of the shoulder flexor and extensor were not significantly different, but the activity of the flexor was higher when the contraction-relax technique was applied than when the hold-relax technique was applied. When the hold-relax and contraction-relax techniques were applied with the shoulder joint flexed at $90^{\circ}$, the activities of the shoulder flexor and extensor were not significantly different, but the activity of the extensor was relatively higher than when the flexor was at $0^{\circ}$.

• PNF and Movement
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• v.22 no.1
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• pp.31-41
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• 2024

Purpose: The purpose of this study is to compare lower extremity muscle activities and ankle joint angles between different foot strike patterns (forefoot strike, heelfoot strike) during stair ascent walking. Methods: The subjects of this study were 22 males who walked in each foot strike pattern on ascent stairs at a speed of 85 beats/min. During stair walking with the two types of foot strike patterns, the muscle activities of the rectus femoris, tibialis anterior, medial gastrocnemius, hamstring, and gluteus medius were measured. Additionally, ankle joint angles for inversion, eversion, dorsi flexion, and plantar flexion were recorded. Each participant underwent the experiment three times, with the foot strike pattern randomized. Results were averaged according to the foot strike pattern. Results: Significant differences in ankle angles were observed across all phases according to foot strike pattern. Muscle activities in the lower extremities showed significant differences in all phases except the swing 1 phase. Moreover, differences in foot movement trajectory were noted depending on the foot strike pattern. Conclusion: Walking on ascent stairs elicited differences in lower extremity muscle activities and ankle joint angles based on foot strike pattern. These findings can serve as foundational data for selecting a suitable foot strike pattern tailored to individual patient conditions when training patients in walking on ascent stairs.

• Journal of the Ergonomics Society of Korea
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• v.33 no.6
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• pp.533-541
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• 2014

Objective: The aim of this study is to evaluate the differences in electromyographic activities of upper extremity muscle between repeated taping and to compare the effects of each taping method in stroke patients. Background: Taping studies for functional improvement and pain relief of the UE have been conducted using various methods. Despite being an important factor when you treatment to a patient in a clinical attachment numbers situation quantitative research is that there is not at all to the taping at the time of application. Method: Twenty patients volunteered in this study and were tested under four taping conditions as follows, in random order: (1) no taping, (2) taping applied once, (3) taping applied twice, and (4) taping applied thrice. The muscle activity and maximum peak of the extensor carpi radialis muscle in electromyographic activities were measured, respectively. Results: The muscle activity and maximum peak of the extensor carpi radialis muscle showed significant differences among the four conditions (p<.05). In the post hoc test, the extensor muscle showed significant differences in muscle activity and maximum peak in electromyographic activities, except between taping applied twice and thrice. Conclusion: These findings demonstrate that repeated taping up to two times may be useful in improving the muscle activity and maximum peak of the extensor muscle. Application: This study provides useful information to future researchers regarding the effects of repeated taping applications on muscle activity and maximum peak of the muscles of the human body.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.13 no.1
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• pp.44-57
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• 2007

Purpose: The objective of this study is to analyze the activities of muscles importantly functioning when walking with different inclinations and speeds of a treadmill, in order to provide basic data on walking exercise using a treadmill. Method: The selected subjects of this study were 16 men and women who had lower extremity injury. A treadmill was used to provide the activation of muscle, and the electromyography was used to analyze the muscle activity variables. The Biodex was used to measure the value of maximum isometric contraction. The inclinations of the treadmill were 0%, 5% and 10%, respectively, and its speeds were 2Km/h. 3Km/h, 4Km/h, 5Km/h, and 6Km/h, respectively. Result: For quadriceps femoris muscle and trunk muscle, there were significant differences in muscle activity when different speeds were applied at 0%, 5% and 10% inclinations.(p<0.05) The activity of vastus medialis muscle was 9.78% at 0% inclination and 2km/h speed, whereas it was 9.32% at 0% inclination and 3km/h, which was slightly lower. The activity of erector spinae muscle was 24.93% at 0% inclination and 2km/h speed, whereas it was 24.84% at 0% inclination and 3km/h, whereas it was 23.99% at 0% inclination and 4km/h, which was slightly lower. The activity of vastus medialis muscle was 11.89% at 10% inclination and 2km/h speed, whereas it was 10.65% at 10% inclination and 3km/h, which was slightly lower. The activity of rectus femoris muscle was 10.26% at 10% inclination and 2km/h speed, whereas it was 9.77% at 10% inclination and 3km/h, which was slightly lower. Conclusion: It was found that the activities of trunk muscle and quadriceps femoris muscle increase as the inclination and the speed of a treadmill increase during treadmill walking.