• 대한스포츠의학회지
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• 제36권4호
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• pp.197-206
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• 2018

Purpose: This study analyzed the muscle activity changes induced by motions of reaching forward and chest expansion that were examined from the bilateral muscles with rectus abdominis, external oblique, multifidus, and longissimus thoracic using Pilates cadillac instrument. Methods: Nine young adult women, who have no musculoskeletal disorder and any of chronic diseases, were participated. Surface electromyography system was used for recording of all signals produced by muscles, and then normalized as percentage of maximum voluntary isometric contraction (%MVIC). The paired t-test and repeated measures of analysis of variance was performed. Results: Reaching-forward motion showed a higher muscle activity from non-dominant external oblique muscle than that of the chest-expansion motion. During both reaching-forward motion and chest-expansion motion, MVIC values collected from dominant side of external oblique muscle were shown a significantly lower than the values obtained from non-dominant side (p<0.05). Conversely, %MVIC values in external oblique muscle collected from dominant side showed a significantly higher than the values obtained from non-dominant side of the same oblique muscle (p<0.05). Reaching-forward motion was caused a higher %MVIC on non-dominant external oblique muscle than that of the chest-expansion motion (p<0.05). Regardless of dominant or non-dominant sides, external oblique muscle was shown the highest activation rate of all the other muscles during reaching forward action, and longissimus thoracic muscle was shown the highest activation rate of all the other muscles during chest expansion action. Conclusion: Reaching-forward motion is suitable for activating an external oblique muscle, and chest-expansion motion is an effective enough in activating of longissimus thoracic muscle.

• 한국수산과학회지
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• 제5권2호
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• pp.57-62
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• 1972

잉어의 배육 골격근에서 actomyosin을 추출하여 몇 가지 생물물리화학적인 성질을 측정 검토한 결과는 다음과 같다. 즉, actamyosin의 침강 정수($s_{20},\;_\omega$)는 24.76s이고 그 점성은 단백 농도의 증가와 더불어 급상승하여 다른 actomyosin의 그것과 비숫한 경향을 보였다. 그리고, ATP-sensitivity는 $147\~176$이었고, PH영향하에서 ATPase activity는 산성측이 6,0부근, 알칼리성측이 9.5부근이었으므로 ATPase activating site가 산, 알칼리 양측에 있음을 알았다.

• 대한물리의학회지
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• 제10권1호
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• pp.1-7
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• 2015

PURPOSE: The aim of this study was to investigate the effects of distal movement on shoulder muscle activation during diagonal pattern of exercises. METHODS: Seventeen healthy male participants volunteered to participate. Five muscles of shoulder were investigated during standing performance of diagonal shoulder exercises with and without visual trace. Two patterns of the diagonal exercises were used as diagonal 1 flexion and extension (D1F-E), and diagonal 2 flexion and extension (D2F-E). Two way repeated measures analysis of variance was used, which the factor was the presence of distal movement and exercise variations. RESULTS: The average muscle activity values of the lower trapezius and anterior deltoid are higher with the D2F-E, compared to the D1F-E (p<.05). The distal movement effect was observed within included all muscles except the lower trapezius, which the values are significantly greater in exercise with distal movement (P<.05). All significant increase of the muscles during the exercise with distal movement condition showed over 0.9 for the observed power in present study. CONCLUSION: Present result suggested that the diagonal pattern of exercise with distal movement has additional advantages of activating the scapulothoracic muscle as well as glenohumeral muscles. In addition, the D2F-E exercise pattern is effective for activating lower trapezius and anterior deltoid muscles.

• The Korean Journal of Physiology and Pharmacology
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• 제26권5호
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• pp.347-355
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• 2022

Abdominal aortic aneurysm (AAA) is a life-threatening disorder worldwide. Fibroblast growth factor 21 (FGF21) was shown to display a high level in the plasma of patients with AAA; however, its detailed functions underlying AAA pathogenesis are unclear. An in vitro AAA model was established in human aortic vascular smooth muscle cells (HASMCs) by angiotensin II (Ang-II) stimulation. Cell counting kit-8, wound healing, and Transwell assays were utilized for measuring cell proliferation and migration. RT-qPCR was used for detecting mRNA expression of FGF21 and activating transcription factor 4 (ATF4). Western blotting was utilized for assessing protein levels of FGF21, ATF4, and markers for the contractile phenotype of HASMCs. ChIP and luciferase reporter assays were implemented for identifying the binding relation between AFT4 and FGF21 promoters. FGF21 and ATF4 were both upregulated in Ang-II-treated HASMCs. Knocking down FGF21 attenuated Ang-II-induced proliferation, migration, and phenotype switch of HASMCs. ATF4 activated FGF21 transcription by binding to its promoter. FGF21 overexpression reversed AFT4 silencing-mediated inhibition of cell proliferation, migration, and phenotype switch. ATF4 transcriptionally upregulates FGF21 to promote the proliferation, migration, and phenotype switch of Ang-II-treated HASMCs.

• The Journal of Korean Physical Therapy
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• 제24권5호
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• pp.319-324
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• 2012

Purpose: This study examined the muscle activities of the erector spinae (ES) and gluteus maximus (GM) during bridging exercises with and without abdominal-hollowing. Methods: Nineteen healthy subjects with no medical history of low back pain or hip flexion contracture were enrolled in this study. The subjects performed bridging exercises with and without abdominal hollowing or with and without a one-leg lift. The muscle activities of the ES and GM were measured by surface electromyography during bridging exercises under each condition. A 2 (abdominal hollowing)X2 (one-leg lift) repeated ANOVA was used to compare the normalized muscle activities of the ES and GM. Results: The muscle activity of the ES during bridging exercise with abdominal-hollowing was significantly smaller than that without abdominal-hollowing (p=0.00). The muscle activities of the GM during bridging exercise with abdominal-hollowing were significantly greater than those without abdominal-hollowing (p=0.00). In addition, the muscle activities of the GM during bridging exercise with one-leg lifting was significantly greater than that without one-leg lifting (p=0.00). Conclusion: Bridging exercise with abdominal-hollowing appears to be more effective on activating the GM muscle than that without abdominal-hollowing minimizing the activation of the ES muscle.

• 대한물리치료과학회지
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• 제19권4호
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• pp.41-46
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• 2012

Background : The purpose of this study was to investigate the electromyographic(EMG) amplitude of the gluteus medius muscle bilaterally at various hip angles and motions(flexion, extension and abduction). Methods : Thirty young with a mean(SD) age of 21.03(1.69) years performed hip motions(flexion, extension and abduction) while the surface EMG activity of the gluteus medius muscles was recorded bilaterally. Subjects were instructed to use the right lower limb during moving 3 different direction. Differences in EMG amplitudes in according with movement direction and angle were assessed by use of paired t-test analyses of variance for the right and left lower extremities. The alpha level was set at .05. Results : Gluteus medius muscle EMG activities in the both side were significantly greater for abduction at angles of 30 degrees than those for other motions at other angles. Conclusion : Hip abduction at angles of 30 degrees on the standing position may be effective in activating the gluteus medius muscle.

• 대한물리치료과학회지
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• 제22권1호
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• pp.43-48
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• 2015

Background : The purpose of this study was find out more effective method for improving muscle strengthening in lower extremities according squatting exercise method among knee joint angle 45, 60, 90 degree and between gym ball behind back and wall. Methods : Participants were 21 university students(males 10, females 11) who didn't have any problem with orthopedic surgery. We divided participants to two groups with gym ball group and wall group. Gym ball group were performance squatting exercise with gym ball behind back. Each group had performance squatting exercise according knee joint angle 45, 60, 90 degree. We collected data from E.M.G of Biceps femoris, Gastrocnemius, Vastus medialis and lateralis, Tibialis anterior in lower extremity according knee joint angle 45, 60, 90 degree of each groups. We analyzed data using by ANOVA and ANCOVA of SPSS PC ver. 12.0 in order to determine more effective method according various squatting exercise. Results : Each groups show significantly difference value of biceps femoris, vastus lateralis and medialis, tibialis anterior, gastrocnemius lateralis and medialis among knee joint angle 45, 60, 90 degree. But there was no significantly difference value between gym ball group and wall group according knee joint angle. Conclusions : We suggested that squatting exercise with gym ball was more effective method improving lower extremity muscle strengthening, and changing knee joint angle was more effective compared than continued knee joint angle.

• Journal of Ginseng Research
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• 제48권1호
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• pp.12-19
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• 2024

Skeletal muscle (SM) is the largest organ of the body and is largely responsible for the metabolism required to maintain body functions. Furthermore, the maintenance of SM is dependent on the activation of muscle satellite (stem) cells (MSCs) and the subsequent proliferation and fusion of differentiating myoblasts into mature myofibers (myogenesis). Natural compounds are being used as therapeutic options to promote SM regeneration during aging, muscle atrophy, sarcopenia, cachexia, or obesity. In particular, ginseng-derived compounds have been utilized in these contexts, though ginsenoside Rg1 is mostly used for SM mass management. These compounds primarily function by activating the Akt/mTOR signaling pathway, upregulating myogenin and MyoD to induce muscle hypertrophy, downregulating atrophic factors (atrogin1, muscle ring-finger protein-1, myostatin, and mitochondrial reactive oxygen species production), and suppressing the expressions of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in cachexia. Ginsenoside compounds are also used for obesity management, and their anti-obesity effects are attributed to peroxisome proliferator activated receptor gamma (PPARγ) inhibition, AMPK activation, glucose transporter type 4 (GLUT4) translocation, and increased phosphorylations of insulin resistance (IR), insulin receptor substrate-1 (IRS-1), and Akt. This review was undertaken to provide an overview of the use of ginseng-related compounds for the management of SM-related disorders.

• Molecules and Cells
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• 제22권2호
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• pp.239-245
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• 2006

This study examined whether adult bovine muscle satellite cells from 30-month-old Hanwoo cattle are multipotential. The satellite cells were found to have the potential to proliferate and differentiate into myoblasts with the formation of multinucleated cells. In addition, treatment with the peroxisome proliferator activating receptor-${\gamma}$ ($PPAR{\gamma}$) agonist, rosiglitazone, promoted their trans-differentiation into adipocytes with significant increases in glycerol accumulation and glycerol-3-phosphate dehydrogenase activity. Western blot analysis revealed that increased levels of the adipocyte fatty acid-binding protein, $PPAR{\gamma}$ and of CCAAT/enhancerbinding protein were closely related to rosiglitazoneinduced differentiation of the cells. These findings demonstrate that satellite cells from adult Hanwoo cattle are multipotent, and that their trans-differentiation into adipocytes can be induced by rosiglitazone.

• Natural Product Sciences
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• 제23권3호
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• pp.169-174
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• 2017

The aim of this study was to investigate the effect and action mechanism of quercetin on penile corpus cavernosum smooth muscle (PCCSM). PCCSM precontracted with phenylephrine (Phe) was treated with four different concentrations of quercetin ($10^{-7}$, $10^{-6}$, $10^{-5}$ and $10^{-4}M$). PCCSM were preincubated with N-Nitro-L-arginine methyl ester hydrochloride (L-NAME) and 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) to block nitric oxide synthase and guanylate cyclase, respectively. The changes in PCCSM tension were recorded, and cyclic nucleotides in the perfusate were measured by radioimmunoassay. The interactions of quercetin with phosphodiesterase type 5 inhibitors (PDE5-Is) such as sildenafil, udenafil and mirodenafil, were also evaluated. PCCSM relaxation induced by quercetin occurred in a concentrationdependent manner. The application of quercetin to PCCSM pre-treated with L-NAME and ODQ significantly inhibited the relaxation. Quercetin significantly increased cGMP in the perfusate. Furthermore, quercetin enhanced PDE5-Is-induced relaxation of PCCSM. Quercetin relaxed the PCCSM by activating the NO-cGMP signaling pathway, and it may be a therapeutic candidate or an alternative treatment for patients with erectile dysfunction who do not completely respond to PDE5-Is.