• Title/Summary/Keyword: multivariate classification

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Rapid discrimination system of Chinese cabbage (Brassica rapa) at metabolic level using Fourier transform infrared spectroscopy (FT-IR) based on multivariate analysis (배추 대사체 추출물의 FT-IR 스펙트럼 및 다변량 통계분석을 통한 계통 신속 식별 체계)

  • Ahn, Myung Suk;Lim, Chan Ju;Song, Seung Yeob;Min, Sung Ran;Lee, In Ho;Nou, Ill-Sup;Kim, Suk Weon
    • Journal of Plant Biotechnology
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    • v.43 no.3
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    • pp.383-390
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    • 2016
  • To determine whether FT-IR spectral analysis based on multivariate analysis could be used to discriminate Chinese cabbage breeding line at metabolic level, whole cell extracts of nine different breeding lines (three paternal, three maternal and three $F_1$ lines) were subjected to Fourier transform infrared spectroscopy (FT-IR). FT-IR spectral data of Chinese cabbage plants were analyzed by principal component analysis (PCA), partial least square discriminant analysis (PLS-DA), and hierarchical clustering analysis (HCA). The hierarchical dendrograms based on PLS-DA from two of three cross combinations showed that paternal, maternal, and their progeny $F_1$ lines samples were perfectly separated into three branches in breeding line dependent manner. However, a cross combination failed to fully discriminate them into three branches. Thus, hierarchical dendrograms based on PLS-DA of FT-IR spectral data of Chinese cabbage breeding lines could be used to represent the most probable chemotaxonomical relationship among maternal, paternal, and $F_1$ plants. Furthermore, these metabolic discrimination systems could be applied for rapid selection and classification of useful Chinese cabbage cultivars.

Characterization of Korean Archaeological Artifacts by Neutron Activation Analysis (I). Multivariate Classification of Korean Ancient Coins. (중성자 방사화분석에 의한 한국산 고고학적 유물의 특성화 연구 (I). 다변량 해석법에 의한 고전 (古錢) 의 분류 연구)

  • Chul Lee;Oh Cheun Kwun;Hyung Tae Kang;Ihn Chong Lee;Nak Bae Kim
    • Journal of the Korean Chemical Society
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    • v.31 no.6
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    • pp.555-566
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    • 1987
  • Fifty ancient Korean coins originated in Yi Dynasty have been determined for 9 elements such as Sn, Fe, As, Ag, Co, Sb, Ir, Ru and Ni by instrumental neutron activation analysis and for 3 elements such as Cu, Pb, and Zn by atomic absorption spectrometry. Bronze coins originated in early days of the dynasty contain as major constituents Cu, Pb and Sn approximately in the ratio 90 : 4 : 3, whereas, those in latter days contain in ratio 7 : 2 : 0. Brass coins which had begun in 17 century contain as major constituents Cu, Zn and Pb approximately in the ratio 7 : 1 : 1. The multivariate data have been analyzed for the relation among elemental contents through the variance-covariance matrix. The data have been further analyzed by a principal component mapping method. As the results training set of 8 class have been chosen, based on the spread of sample points in an eigen vector plot and archaeological data such as age and the office of minting. The training set and test set of samples have finally been analyzed for the assignment to certain classes or outliers through the statistical isolinear multiple component analysis (SIMCA).

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Oncological and functional outcomes following robot-assisted laparoscopic radical prostatectomy at a single institution: a minimum 5-year follow-up

  • Kang, Jun-Koo;Chung, Jae-Wook;Chun, So Young;Ha, Yun-Sok;Choi, Seock Hwan;Lee, Jun Nyung;Kim, Bum Soo;Yoon, Ghil Suk;Kim, Hyun Tae;Kim, Tae-Hwan;Kwon, Tae Gyun
    • Journal of Yeungnam Medical Science
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    • v.35 no.2
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    • pp.171-178
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    • 2018
  • Background: To evaluate mid-term oncological and functional outcomes in patients with prostate cancer treated by robot-assisted laparoscopic radical prostatectomy (RALP) at our institution. Methods: We retrospectively reviewed the medical records of 128 patients with prostate cancer who underwent RALP at our institution between February 2008 and April 2010. All patients enrolled in this study were followed up for at least 5 years. We analyzed biochemical recurrence (BCR)-free survival using a Kaplan-Meier survival curve analysis and predictive factors for BCR using multivariate Cox regression analysis. Continence recovery rate, defined as no use of urinary pads, was also evaluated. Results: Based on the D'Amico risk classification, there were 30 low-risk patients (23.4%), 47 intermediaterisk patients (38.8%), and 51 high-risk patients (39.8%), preoperatively. Based on pathological findings, 50.0% of patients (64/128) showed non-organ confined disease (${\geq}T3a$) and 26.6% (34/128) had high grade disease (Gleason score ${\geq}8$). During a median follow-up period of 71 months (range, 66-78 months), the frequency of BCR was 33.6% (43/128) and the median BCR-free survival was 65.9 (0.4-88.0) months. Multivariate Cox regression analysis revealed that high grade disease (Gleason score ${\geq}8$) was an independent predictor for BCR (hazard ratio=4.180, 95% confidence interval=1.02-17.12, p=0.047). In addition, a majority of patients remained continent following the RALP procedure, without the need for additional intervention for post-prostatectomy incontinence. Conclusion: Our study demonstrated acceptable outcomes following an initial RALP procedure, despite 50% of the patients investigated demonstrating high-risk features associated with non-organ confined disease.

A Study on the Prediction Model of Stock Price Index Trend based on GA-MSVM that Simultaneously Optimizes Feature and Instance Selection (입력변수 및 학습사례 선정을 동시에 최적화하는 GA-MSVM 기반 주가지수 추세 예측 모형에 관한 연구)

  • Lee, Jong-sik;Ahn, Hyunchul
    • Journal of Intelligence and Information Systems
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    • v.23 no.4
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    • pp.147-168
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    • 2017
  • There have been many studies on accurate stock market forecasting in academia for a long time, and now there are also various forecasting models using various techniques. Recently, many attempts have been made to predict the stock index using various machine learning methods including Deep Learning. Although the fundamental analysis and the technical analysis method are used for the analysis of the traditional stock investment transaction, the technical analysis method is more useful for the application of the short-term transaction prediction or statistical and mathematical techniques. Most of the studies that have been conducted using these technical indicators have studied the model of predicting stock prices by binary classification - rising or falling - of stock market fluctuations in the future market (usually next trading day). However, it is also true that this binary classification has many unfavorable aspects in predicting trends, identifying trading signals, or signaling portfolio rebalancing. In this study, we try to predict the stock index by expanding the stock index trend (upward trend, boxed, downward trend) to the multiple classification system in the existing binary index method. In order to solve this multi-classification problem, a technique such as Multinomial Logistic Regression Analysis (MLOGIT), Multiple Discriminant Analysis (MDA) or Artificial Neural Networks (ANN) we propose an optimization model using Genetic Algorithm as a wrapper for improving the performance of this model using Multi-classification Support Vector Machines (MSVM), which has proved to be superior in prediction performance. In particular, the proposed model named GA-MSVM is designed to maximize model performance by optimizing not only the kernel function parameters of MSVM, but also the optimal selection of input variables (feature selection) as well as instance selection. In order to verify the performance of the proposed model, we applied the proposed method to the real data. The results show that the proposed method is more effective than the conventional multivariate SVM, which has been known to show the best prediction performance up to now, as well as existing artificial intelligence / data mining techniques such as MDA, MLOGIT, CBR, and it is confirmed that the prediction performance is better than this. Especially, it has been confirmed that the 'instance selection' plays a very important role in predicting the stock index trend, and it is confirmed that the improvement effect of the model is more important than other factors. To verify the usefulness of GA-MSVM, we applied it to Korea's real KOSPI200 stock index trend forecast. Our research is primarily aimed at predicting trend segments to capture signal acquisition or short-term trend transition points. The experimental data set includes technical indicators such as the price and volatility index (2004 ~ 2017) and macroeconomic data (interest rate, exchange rate, S&P 500, etc.) of KOSPI200 stock index in Korea. Using a variety of statistical methods including one-way ANOVA and stepwise MDA, 15 indicators were selected as candidate independent variables. The dependent variable, trend classification, was classified into three states: 1 (upward trend), 0 (boxed), and -1 (downward trend). 70% of the total data for each class was used for training and the remaining 30% was used for verifying. To verify the performance of the proposed model, several comparative model experiments such as MDA, MLOGIT, CBR, ANN and MSVM were conducted. MSVM has adopted the One-Against-One (OAO) approach, which is known as the most accurate approach among the various MSVM approaches. Although there are some limitations, the final experimental results demonstrate that the proposed model, GA-MSVM, performs at a significantly higher level than all comparative models.

Factor Analysis of Genetic Evaluations For Type Traits of Canadian Holstein Sires and Cows

  • Ali, A.K.;Koots, K.R.;Burnside, E.B.
    • Asian-Australasian Journal of Animal Sciences
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    • v.11 no.5
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    • pp.463-469
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    • 1998
  • Factor analysis was applied as a multivariate statistical technique to official genetic evaluations of type classification traits for 1,265,785 Holstein cows and 10,321 sires computed from data collected between August 1982 and June 1994 in Canada. Type traits included eighteen linear descriptive traits and eight major score card traits. Principal components of the factor analysis showed that only five factors explain the information of the genetic value of linear descriptive traits for both cows and sires. Factor 1 included traits related to mammary system, like texture, median suspensory, fore attachment, fore teat placement and rear attachment height and width. Factor 2 described stature, size, chest width and pin width. These two factors had a similar pattern for both cows and sires. In constrast, Factor 3 for cows involved only bone-quality, while in addition for sires, Factor 3 included foot angle, rear legs desirability and legs set. Factor 4 for cows related to foot angle, set of rear leg and leg desirability, while Factor 4 related to loin strenth and pin setting for sires. Finally, Factor 5 included loin strength and pin setting for cows and described only pin setting for sires. Two factors only were required to describe score card traits of cows and sires. Factor 1 related to final score, feet and legs, udder traits, mammary system and dairy character, while frame/capacity and rump were described by Factor 2. Communality estimates which determine the proportion of variance of a type trait that is shared with other type traits via the common factor variant were high, the highest ${\geq}$ 80% for final score, stature, size and chest width. Pin width and pin desirability had the lowest communality, 56% and 37%. Results indicated shifts in emphasis over the twelve-year period away from udder traits and dairy character, and towards size, scale and width traits. A new system that computes fmal score from type components has been initiated.

Risk factors affecting amputation in diabetic foot

  • Lee, Jun Ho;Yoon, Ji Sung;Lee, Hyoung Woo;Won, Kyu Chang;Moon, Jun Sung;Chung, Seung Min;Lee, Yin Young
    • Journal of Yeungnam Medical Science
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    • v.37 no.4
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    • pp.314-320
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    • 2020
  • Background: A diabetic foot is the most common cause of non-traumatic lower extremity amputations (LEA). The study seeks to assess the risk factors of amputation in patients with diabetic foot ulcers (DFU). Methods: The study was conducted on 351 patients with DFUs from January 2010 to December 2018. Their demographic characteristics, disease history, laboratory data, ankle-brachial index, Wagner classification, osteomyelitis, sarcopenia index, and ulcer sizes were considered as variables to predict outcome. A chi-square test and multivariate logistic regression analysis were performed to test the relationship of the data gathered. Additionally, the subjects were divided into two groups based on their amputation surgery. Results: Out of the 351 subjects, 170 required LEA. The mean age of the subjects was 61 years and the mean duration of diabetes was 15 years; there was no significant difference between the two groups in terms of these averages. Osteomyelitis (hazard ratio [HR], 6.164; 95% confidence interval [CI], 3.561-10.671), lesion on percutaneous transluminal angioplasty (HR, 2.494; 95% CI, 1.087-5.721), estimated glomerular filtration rate (eGFR; HR, 0.99; 95% CI, 0.981-0.999), ulcer size (HR, 1.247; 95% CI, 1.107-1.405), and forefoot ulcer location (HR, 2.475; 95% CI, 0.224-0.73) were associated with risk of amputation. Conclusion: Osteomyelitis, peripheral artery disease, chronic kidney disease, ulcer size, and forefoot ulcer location were risk factors for amputation in diabetic foot patients. Further investigation would contribute to the establishment of a diabetic foot risk stratification system for Koreans, allowing for optimal individualized treatment.

Keratinization of Lung Squamous Cell Carcinoma Is Associated with Poor Clinical Outcome

  • Park, Hye Jung;Cha, Yoon-Jin;Kim, Seong Han;Kim, Arum;Kim, Eun Young;Chang, Yoon Soo
    • Tuberculosis and Respiratory Diseases
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    • v.80 no.2
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    • pp.179-186
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    • 2017
  • Background: Although the World Health Organization (WHO) classification of lung squamous cell carcinoma (SCC) was revised in 2015, its clinical implications for lung SCC subsets remain unclear. We investigated whether the morphologic characteristics of lung SCC, including keratinization, were associated with clinical parameters and clinical outcome of patients. Methods: A total of 81 patients who underwent curative surgical resection of diagnosed lung SCC, were enrolled in this study. Attributes such as keratinization, tumor budding, single cell invasion, and nuclear size within the tumor, as well as immunohistochemistry of Bcl-xL and pS6 expressions, were evaluated. Results: The keratinizing and nonkeratinizing subtypes did not differ with respect to age, sex, TNM stage, and morphologic parameters such as nuclear diameter, tumor budding, and single cell invasion at the tumor edge. Most patients with the keratinizing subtype (98.0%) had a history of smoking, whereas the nonkeratinizing group had a relatively higher proportion of never-smokers relative to the keratinizing group (24.0% vs. 2.0%; p=0.008, chi-square test). Expression of pS6 (a surrogate marker of mammalian target of rapamycin complex 1 [mTORC1] signaling that regulates keratinocyte differentiation), and Bcl-xL (a key anti-apoptotic molecule that may inhibit keratinization), did not correlate significantly with the presence of keratinization. Patients with the keratinizing subtype had a significantly shorter overall survival (85.2 months vs. 135.7 months, p=0.010, log-rank test), and a multivariate analysis showed that keratinization was an independent, poor prognostic factor (hazard ratio, 2.389; 95% confidence interval, 1.090-5.233; p=0.030). Conclusion: In lung SCC, keratinization is associated with a poor prognosis, and might be associated with smoking.

Postoperative survival According to the Glasgow Prognostic Score in Patients with Resected Lung Adenocarcinoma

  • Machida, Yuichiro;Sagawa, Motoyasu;Tanaka, Makoto;Motono, Nozomu;Matsui, Takuma;Usuda, Katsuo;Uramoto, Hidetaka
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.10
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    • pp.4677-4680
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    • 2016
  • Background: The Glasgow Prognostic Score (GPS) is calculated from measured CRP and albumin levels. We here evaluated the significance of the GPS in patients with resected pulmonary adenocarcinoma. Materials and Methods: The present study included 156 patients with lung adenocarcinoma who underwent lobectomy at Kanazawa Medical University between 2002 and 2012. Classification was into three groups: those with normal albumin (>=3.5 g/dl) and C-reactive protein (CRP) (<=1.0 mg/dl) levels were classified as GPS 0 (n =136), those with low albumin (<3.5 g/dl) or elevated CRP (>1.0 mg/dl) levels as GPS 1 (n = 16), and those with low albumin (<3.5 g/dl) and elevated CRP (>1.0 mg/dl) levels as GPS 2 (n = 4). We retrospectively investigated relationships between the patient characteristics including the GPS, and disease-free survival and cancer-specific survival. Results: The pathological stages of the patients were as follows: IA (n=78, 50%), IB (n=31, 19.9%), IIA (n=20.0, 12.8%), IIB (n=9.0, 5.7%), and IIIA (n=18.0, 11.5%). Lobectomy was performed in all cases. The average GPS was 0.15 (0-2) and showed significant relationships with stage and tumor size. The 2-year survival rates in patients with GPS0, 1 and 2 were 81.4%, 38.4%, and 25.0%, respectively. Clear correlations were noted with both cancer-specific survival and disease-free survival. Furthermore, multivariate analysis revealed that GPS was a significant prognostic factor. Conclusions: The GPS could be a prognostic factor for patients with resected pulmonary adenocarcinoma.

Convergence performance comparison using combination of ML-SVM, PCA, VBM and GMM for detection of AD (알츠하이머 병의 검출을 위한 ML-SVM, PCA, VBM, GMM을 결합한 융합적 성능 비교)

  • Alam, Saurar;Kwon, Goo-Rak
    • Journal of the Korea Convergence Society
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    • v.7 no.4
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    • pp.1-7
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    • 2016
  • Structural MRI(sMRI) imaging is used to extract morphometric features after Grey Matter (GM), White Matter (WM) for several univariate and multivariate method, and Cerebro-spinal Fluid (CSF) segmentation. A new approach is applied for the diagnosis of very mild to mild AD. We propose the classification method of Alzheimer disease patients from normal controls by combining morphometric features and Gaussian Mixture Models parameters along with MMSE (Mini Mental State Examination) score. The combined features are fed into Multi-kernel SVM classifier after getting rid of curse of dimensionality using principal component analysis. The experimenral results of the proposed diagnosis method yield up to 96% stratification accuracy with Multi-kernel SVM along with high sensitivity and specificity above 90%.

A Study on Classification of Bodytype of Elderly Males for Upper Garments Construction (상의 구성을 위한 노년기 남성의 체형 분류)

  • 이선명
    • The Research Journal of the Costume Culture
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    • v.1 no.2
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    • pp.159-179
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    • 1993
  • The purpose of this study is to collect data for he improvement of the accuracy of upper garments construction of the old whose bodies have been changed due to their age. In this study the body measurements with 61 items were taken from 226 men(aged fro m 60 to 80) living in Seoul by the R. Martin's method in 1992. The data were calculate by computer and analyzed by the multivariate method, especially factor and cluster analysis. The results of the study were as follows; 1. The average stature of elderly males was 163.6cm, chest circumference 91.6cm, waist circumference 9\\85.5cm. hip circumference 92.8cm, neck circumference 37cm, arm length 55.4 cm, back length 42.6cm, shoulder breadth 42.9cm and the Roher's Index 1.39, which was a standard body shape. 2. The items of factor analysis were explained to seven, namely, the degree of fatness of the upper body, the size of the frame of body, the length of the upper body, the degree of curve of the front body, the size of shoulder, the shape of the back, and the slope of shoulder. 3. The body types of subjects were classified into four types. The majority was type 4, which was 67% of subjects and considered as balanced body type. The distinctive features of those types are as follows; Type 1. The subjects of this type had a slight skeletal structure and were the thinnest of all the subjects with thin and forward-bent arm. Type 2. The subjects of this type were the tallest of all the subjects. they had the straightest side of body and a well-developed upper arm. The thigh length of this type was longer than the length of trunk. Type. 3. The subjects of this type was only one, so ti could be excluded. Type 4. The subjects of this type had a long trunk, well-developed shoulder, and a crook in their neck and back. The arm length and thigh of this type were short and those circumferences were thick. Type 5. The subjects of this type were the shortest of all, but had the highest degree of fatness in the waist and abdominal. They had well-developed front muscles of body and projected hip.

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