Melanin is a natural skin pigment produced by specialized cells called melanocytes via a multistage biochemical pathway known as melanogenesis, involving the oxidation and polymerization of tyrosine. Melanogenesis is initiated upon exposure to ultraviolet (UV) radiation, causing the skin to darken, which protects skin cells from UVB radiation damage. However, the abnormal accumulation of melanin may lead to the development of certain skin diseases, including skin cancer. In this study, the antioxidant and antimelanogenic activities of the cell-free supernatant (CFS) of twenty strains were evaluated. Based on the results of 60% 2,2-diphenyl-1-picrylhydrazyl scavenging activity, 21% 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) scavenging capacity, and a 50% ascorbic acid equivalent ferric reducing antioxidant power value, Limosilactobacillus fermentum JNU532 was selected as the strain with the highest antioxidant potential. No cytotoxicity was observed in cells treated with the CFS of L. fermentum JNU532. Tyrosinase activity was reduced by 16.7% in CFS-treated B16F10 cells (but not in the cell-free system), with >23.2% reduction in melanin content upon treatment with the L. fermentum JNU532-derived CFS. The inhibitory effect of the L. fermentum JNU532-derived CFS on B16F10 cell melanogenesis pathways was investigated using quantitative reverse transcription polymerase chain reaction and western blotting. The inhibitory effects of the L. fermentum JNU532-derived CFS were mediated by inhibiting the transcription of TYR, TRP-1, TRP-2, and MITF and the protein expression of TYR, TRP-1, TRP-2, and MITF. Therefore, L. fermentum JNU532 may be considered a potentially useful, natural depigmentation agent.
Objectives: Poor complementary feeding practices have consistently contributed to the burden of child undernutrition in Indonesia. This study aimed to estimate the prevalence and predictors of the time of the introduction of solid, semi-solid, and soft foods (ISSSF), minimum dietary diversity (MDD), minimum meal frequency (MMF), and minimum acceptable diet (MAD). Methods: We analyzed 4804 last-born infants aged 6-23 months from the 2017 Indonesia Demographic and Health Survey, which employed multistage cluster random sampling. The outcomes were calculated based on the 2021 World Health Organization/United Nations Children's Fund guidelines. The predictors of the 4 complementary feeding indicators were assessed using multivariate Poisson regression with robust variance adjusting for potential confounders and study design. Results: The prevalence of ISSSF, MDD, MMF, and MAD was 86.1%, 54.3%, 71.8%, and 37.6%, respectively, with younger children less likely to meet 3 out of the 4 outcomes. Parental education, the presence of a birth attendant, and maternal media consumption were among the predictors of MDD and MAD. Children from families with higher income were more likely to meet MDD than those from low-income households (adjusted prevalence ratio [aPR], 1.16; 95% confidence interval [CI], 1.05 to 1.28). Living in an urban area was positively associated with MMF (aPR, 1.09; 95% CI, 1.04 to 1.15) and MAD (aPR, 1.12; 95% CI 1.02 to 1.24). In eastern regions, the prevalence of children achieving MDD and MAD was lower than in those living in Java and Bali. Conclusions: It is crucial that more attention and efforts are made to improve the recommended practices throughout Indonesia, since the prevalence of adequate complementary feeding practices remains low.
Purpose: The prevalence of osteoporosis in postmenopausal women is increasing, and diabetes patients have decreased bone density. Their health-related quality of life (HRQoL) is diminished by the resultant physical dysfunction and depression. The purpose of this study was to identify factors influencing HRQoL in postmenopausal women with diabetes and osteoporosis. Methods: This was a secondary data analysis of the Seventh Korea Health and Nutrition Examination Survey (2016-2018), which utilized a complex, multistage probability sample design. The participants in the study were 237 women with diabetes and osteoporosis. To evaluate the factors that influenced HRQoL, a complex-samples general linear model was constructed, and the Bonferroni correction was performed. Results: In this sample of women aged 45 to 80 years (mean±standard deviation, 71.12±7.21 years), the average HRQoL score was 0.83±0.18 out of 1.0. Factors influencing HRQoL were age (70s: t=-3.74, p<.001; 80s: t=-3.42, p=.001), walking for exercise more than 5 days a week (t=-2.83, p=.005), cerebrovascular disease (t=-8.33, p<.001), osteoarthritis (t=-2.04, p=.014), hypertension (t=2.03, p=.044), higher perceived stress (t=-2.17, p=.032), poor glycemic control (t=3.40, p=.001), waist circumference (t=-2.76, p=.007), sitting time per day (t=-2.10, p=.038), and a longer postmenopausal period (t=3.09, p=.002). Conclusion: In order to improve the HRQoL of postmenopausal women with osteoporosis and diabetes, it is necessary to implement intervention strategies that enable the effective management of chronic diseases, while preventing the complications of diabetes and minimizing stress through physical activity.
Hyeonho Kim;Jung Hun Kim;Joohoe Kong;Ji Hoon Kyung
Journal of Korean Society of Industrial and Systems Engineering
/
v.45
no.4
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pp.42-52
/
2022
North Korea continues to upgrade and display its long-range rocket launchers to emphasize its military strength. Recently Republic of Korea kicked off the development of anti-artillery interception system similar to Israel's "Iron Dome", designed to protect against North Korea's arsenal of long-range rockets. The system may not work smoothly without the function assigning interceptors to incoming various-caliber artillery rockets. We view the assignment task as a dynamic weapon target assignment (DWTA) problem. DWTA is a multistage decision process in which decision in a stage affects decision processes and its results in the subsequent stages. We represent the DWTA problem as a Markov decision process (MDP). Distance from Seoul to North Korea's multiple rocket launchers positioned near the border, limits the processing time of the model solver within only a few second. It is impossible to compute the exact optimal solution within the allowed time interval due to the curse of dimensionality inherently in MDP model of practical DWTA problem. We apply two reinforcement-based algorithms to get the approximate solution of the MDP model within the time limit. To check the quality of the approximate solution, we adopt Shoot-Shoot-Look(SSL) policy as a baseline. Simulation results showed that both algorithms provide better solution than the solution from the baseline strategy.
Lijun Zhao;Ke Wang;Jinjing, Zhang;Jialong Zhang;Anhong Wang
KSII Transactions on Internet and Information Systems (TIIS)
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v.17
no.8
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pp.2068-2082
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2023
With the rapid development of deep learning, Depth Map Super-Resolution (DMSR) method has achieved more advanced performances. However, when the upsampling rate is very large, it is difficult to capture the structural consistency between color features and depth features by these DMSR methods. Therefore, we propose a color-image guided DMSR method based on iterative depth feature enhancement. Considering the feature difference between high-quality color features and low-quality depth features, we propose to decompose the depth features into High-Frequency (HF) and Low-Frequency (LF) components. Due to structural homogeneity of depth HF components and HF color features, only HF color features are used to enhance the depth HF features without using the LF color features. Before the HF and LF depth feature decomposition, the LF component of the previous depth decomposition and the updated HF component are combined together. After decomposing and reorganizing recursively-updated features, we combine all the depth LF features with the final updated depth HF features to obtain the enhanced-depth features. Next, the enhanced-depth features are input into the multistage depth map fusion reconstruction block, in which the cross enhancement module is introduced into the reconstruction block to fully mine the spatial correlation of depth map by interleaving various features between different convolution groups. Experimental results can show that the two objective assessments of root mean square error and mean absolute deviation of the proposed method are superior to those of many latest DMSR methods.
Sagr, Salem Giuma Ibrahim;Johari, M.A. Megat;Mijarsh, M.J.A.
Advances in materials Research
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v.11
no.2
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pp.121-146
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2022
In the recent years, the use of agricultural waste in green cement mortar and concrete production has attracted considerable attention because of potential saving in the large areas of landfills and potential enhancement on the performance of mortar. In this research, microparticles of palm oil fuel ash (POFA) obtained from a multistage thermal and mechanical treatment processes of raw POFA originating from palm oil mill was utilized as a pozzolanic material to produce high-performance cement mortar (HPCM). POFA was used as a partial replacement material to ordinary Portland cement (OPC) at replacement levels of 0, 5, 10, 15, 20, 25, 30, 35, 40% by volume. Sand with particle size smaller than 300 ㎛ was used to enhance the performance of the HPCM. The HPCM mixes were tested for workability, compressive strength, ultrasonic pulse velocity (UPV), porosity and absorption. The results portray that the incorporation of micro POFA in HPCMs led to a slight reduction in the compressive strength. At 40% replacement level, the compressive strength was 87.4 MPa at 28 days which is suitable for many high strength applications. Although adding POFA to the cement mixtures harmed the absorption and porosity, those properties were very low at 3.4% and 11.5% respectively at a 40% POFA replacement ratio and after 28 days of curing. The HPCM mixtures containing POFA exhibited greater increase in strength and UPV as well as greater reduction in absorption and porosity than the control OPC mortar from 7 to 28 days of curing age, as a result of the pozzolanic reaction of POFA. Micro POFA with finely graded sand resulted in a dense and high strength cement mortar due to the pozzolanic reaction and increased packing effect. Therefore, it is demonstrated that the POFA could be used with high replacement ratios as a pozzolanic material to produce HPCM.
KSCE Journal of Civil and Environmental Engineering Research
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v.29
no.3A
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pp.235-241
/
2009
PSC girder bridge is known to be more economical than other types of bridges and has been usually applied to a span range of 25 m to 35 m according to the standard shapes for highway bridges in Korea. The spans of the recently developed new types of PSC girders are also limited to 50 m at most. In this study, therefore, feasibility of the long-span PSC girder that reaches more than 50 m is investigated by applying several strategies from the perspectives of materials, design and construction. A systematic procedure is proposed that can be used to assess the effect of each strategy on the span. The proposed scheme adopts a graphical approach that represents a relationship between the number of prestressing tendons and the span, and is derived on a basis of safety assessment equations of the girder in each stage of fabrication and in service. In the companion paper, the amount of span extension is quantitatively evaluated by applying the proposed scheme into a sample PSC girder bridge.
Purpose: This study used a self-deterministic approach to explore the relationship between emotional intelligence (EI), academic motivation (AM), and achievement among health science students. Methods: A descriptive cross-sectional study was conducted in three cities of Saudi Arabia (Dammam, Riyadh, and Jeddah). A convenience sample of 450 students was incorporated using the multistage cluster sampling technique. The online survey contained three sections: students' basic data and academic achievement level, the modified Schutte self-report inventory, and the Academic Motivation Scale lowercase. Results: This study revealed moderate overall scores for EI (57.1%), AM (55.6%), and grade point average (GPA) (57.6%). The overall EI score, its domains, and GPA had significant positive correlations with overall AM and intrinsic and extrinsic motivation (p < .01). Amotivation had an insignificant correlation with GPA (p < .05), but it was negatively correlated with EI and its domains (p < .01). Multiple regression analysis proved that EI domains predicted 5.0% of GPA variance; emotions appraisal and expression (β = .02, p = .024), regulation (β = .11, p = .032), and utilization (β = .24, p < .01). EI domains also predicted 26.0% of AM variance; emotions appraisal and expression (β = .11, p = .04), regulation (β = .33, p < .01), and utilization (β = .23, p < .01). Moreover, AM predicted 4.0% of the variance in GPA; intrinsic (β = .25, p = .004) and extrinsic (β = .11, p = .022) motivation. AM also predicted 25.0% of the variance in EI: intrinsic (β = .34, p < .01) and extrinsic motivation (β = .26, p = .026). Conclusion: EI and AM have a bidirectional influence on each other, significantly shaping the GPA of health sciences students in Saudi Arabia, where intrinsic motivation has a predominant role. Thus, promoting students' AM and EI is recommended to foster their academic achievement.
A number of auriferous veins occur in the Precambrian metamorphic terrain from Chungju to Mugeug district. These gold (-silver) deposits consist mainly of the fissure-filling quartz veins intruding the Precambrian gneiss or schist and Jurassic or Cretaceous granite. These gold (-silver) deposits can be 'divided into two mineralization epochs, (a) gold-rich veins related to Daebo igneous activity, and (b) gold-silver veins related to Bulgugsa igneous activity. These two groups of ore deposits with different generation can be characterized by the mode of occurrence of ore vein and the ore mineral associations. The auriferous quartz veins of Taechang and Boryeon mines associated with late Jurassic igneous activity are massive in character, and show the simple mineral assemblages and low Ag/Au ratio in the ores, representing a single mineralization system. The ore minerals are predominantly quartz containing minor or trace amonts of pyrrhotite, sphalerite, galena, pyrite, chalcopyrite and electrum. Electrum is closely associated with pyrrhotite and has chemical compositions from 61.4 to 78.5 atomic % Au. Fluid inclusion data suggest that ore minerals were deposited at temperatures between 238 and $390^{\circ}C$ from $CO_2$-rich fluids. The gold and/or silver-bearing quartz veins of Geumwang mine related to middle Cretaceous igneous activity are characterized by the multistage history, diverse mineral assemblages with high Ag/Au ratio in the ores. The ores of Geumwang mine have two contrasting mineral assemblages (1) pyrite+galena+sphalerite+arsenopyrite+electrum+argentite, representing the higher gold mineralization, and (2) pyrite+chalcopyrite+ galena +sphalerite+ arsenopyrite+silver sulfosalts+ electrum+ native silver+argentite, representing the higher silver mineralization. Electrum is closely associated with pyrite and has chemical compositions from 11.2 to 49.9 atomic % Au. The depositional environment during the higher gold mineralization can be estimated as the range of both temperature and sulfur fugacity, T= $200{\sim}300^{\circ}C$, log f ($S_2$) = $10^{-10}{\sim}10^{-15}$. The higher silver mineralization may be interpreted to have formed a range of falling temperature ($150{\sim}200^{\circ}C$) and low sulfur fugacity($10^{-10}{\sim}10^{-15}$). These temperature data are consistent with homogenization temperatures of fluId inclusions in quartz. Thus, the gold veins related to the Daebo igneous activity may be formed by the environment of higher temperature and pressure than the gold-silver veins associated with the Bulgugsa igneous activity.
This study included the analysis of mushroom data collected from Mt. Chiak in Gangwon-do using various methods. Former studies of Korean mushrooms are limited by regional characters and there is less species diversity among the regions. This study tried to find a way for the forecast of mushroom distribution and appearance by indexes of species diversity. The indexes used in this study include the number of fungi (N), the number of species (S), similarity index (C), richness index (R1, R2), variety index (V1, V2), evenness index (E1, E2, E3, E4, E5), and dominance index (D1) to analyze variety of species diversity. Analyses of data of fungi using a multistage cluster sampling indicate that the average value of C for years was higher than the average value of C for areas. The mushrooms consisted of 208 species in 686 individuals in limited fungal collection from 2002 to 2003. One hundred thirty nine species in 393 individuals were collected in 2002, and 122 species 293 individuals were collected in 2003. The individuals collected in 2003 were smaller than 2002's individuals. Similarity, richness, and variety indexes' values of 2003 were reduced than 2002's values but dominance index of 2003 was increased than 2002's value. Generally the species diversity of the environment to evaluate the index of similarity, richness, and variety was a higher index; dominance index was lower than that of the surrounding environment, suggesting a good diversity. As a result, the occurrence of mushrooms in the surrounding environment and the various factors seem fell in 2002 compared to 2003. The majority genus of the limited fungal collection was Mycena genus in 63 individuals; the majority species was Laccaria laccata in 34 individuals. Ninety three species in 106 individuals were collected by the extended collection and the majority genus of the extended collection was Amanita genus in 17 individuals; the majority species was Amanita citrina (Schaeff.) Pers. which was found in 5 individuals. This demonstrates that periodical similarity's value was 0.159 is higher than special similarity's 0.119. This indicates that the probability of the appearance of same mushrooms in the same area in following year is higher than the probability of the appearance of same mushrooms in the surrounding area in same year. The value of coefficient of variation (CV), in which the amount of change is much or less by N is higher than the CV value by S. CV value of dominance index(D) was the highest r point among other indexes, and evenness index (E) was the lowest point among other indexes. The correlation matrix with 66 combinations between the indexes, the combinations with correlations was 46 combinations. These results revealed that indexes of R1, V2, and E1 were proper to represent species diversity of fungi based on the correlation matrix and the theory of statistical independence which means there is no or less mutual association. This research would contribute to the study about variable living creature by measuring method and in the future this would be used to figure out regulation about fungi with their correlation, values in ecosystem, develop improving new models about agricultural fungi species and numbers by investigating agricultural variable species.
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