• BMB Reports
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• v.51 no.1
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• pp.1-2
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• 2018

Positive selection on a new beneficial mutation generates a characteristic pattern of DNA sequence polymorphism when it reaches an intermediate allele frequency. On genome sequences of African Drosophila melanogaster, we detected such signatures of selection at 37 candidate loci and identified "sweeping haplotypes (SHs)" that are increasing or have increased rapidly in frequency due to hitchhiking. Based on geographic distribution of SH frequencies, we could infer whether selective sweeps occurred starting from de novo beneficial mutants under simple constant selective pressure. Single SHs were identified at more than half of loci. However, at many other loci, we observed multiple independent SHs, implying soft selective sweeps due to a high beneficial mutation rate or parallel evolution across space. Interestingly, SH frequencies were intermediate across multiple populations at about a quarter of the loci despite relatively low migration rates inferred between African populations. This invokes a certain form of frequency-dependent selection such as heterozygote advantage. At one locus, we observed a complex pattern of multiple independent that was compatible with recurrent frequency-dependent positive selection on new variants. In conclusion, genomic patterns of positive selection are very diverse, with equal contributions of hard and soft sweeps and a surprisingly large proportion of frequency-dependent selection in D. melanogaster populations.

• International Journal of Aeronautical and Space Sciences
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• v.2 no.1
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• pp.1-11
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• 2001

The time implicit point SGS scheme is applied to compute hypersonic viscous flows in thermochemical nonequilibrium. The performance of the point SGS scheme is then compared with those of the line SGS and the LU-SGS schemes. Comparison of convergence histories with the effect of multiple forward and backward sweeps are made for the flow over a 2D cylinder experimentally studied by Hornung and the flow over a hemisphere at conditions corresponding to the peak heating condition during the reentry flight of an SSTO vehicle. Results indicate that the point SGS scheme with multiple sweeps is as robust and efficient as the line SGS scheme. For the point SGS and the LU-SGS scheme, the rate of improvement in convergence is largest with two sweep cycles. However, for the line SGS scheme, it is found that more than one sweep cycle deteriorates the convergence rate.

• Proceedings of the Korea Contents Association Conference
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• 2009.05a
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• pp.648-651
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• 2009

Using a mode-matching technique, a waveguide structure with multiple stubs which is utilized as the component of various communication systems has frequency filtering characteristics. We define a proper fitness function to automatically design the pass and stop bands of a waveguide structure with multiple stubs for frequency filtering and the genetic algorithm can be implemented with the fitness function proposed in this paper. The frequency filtering characteristics are numerically computed and parametric sweeps are also performed.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.111.1-111.1
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• 2012

We examine the relationship between a type II radio burst that started from an unusually high frequency of 425 MHz (fundamental component) and an associated white-light coronal mass ejection on 2011 February 13. The radio burst had a drift rate of 2.5 MHz/sec, indicating a relatively high shock speed. From SDO AIA observations we find that a loop-like erupting front sweeps across high density coronal loops near the start time of the burst (17:34:15 UT). We find fragmented structures of the type II burst, which indicates the signature of the shock propagating through the multiple loops. The deduced distance of shock formation (0.06 Rs) from flare center and speed of the shock (1100 km $s^{-1}$) using the measured density from AIA/SDO observations are comparable to the height (0.05 Rs, from the solar surface) and speed (700 km $s^{-1}$) of the CME leading edge observed by STEREO/EUVI. We conclude that the type II burst could be onset even in the low corona (41 Mm or 0.06 Rs, above the solar surface) if a fast CME shock passes through the high density loops.