• Genomics & Informatics
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• v.20 no.4
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• pp.49.1-49.7
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• 2022

Many packages for a meta-analysis of genome-wide association studies (GWAS) have been developed to discover genetic variants. Although variations across studies must be considered, there are not many currently-accessible packages that estimate between-study heterogeneity. Thus, we propose a python based application called Beta-Meta which can easily process a meta-analysis by automatically selecting between a fixed effects and a random effects model based on heterogeneity. Beta-Meta implements flexible input data manipulation to allow multiple meta-analyses of different genotype-phenotype associations in a single process. It provides a step-by-step meta-analysis of GWAS for each association in the following order: heterogeneity test, two different calculations of an effect size and a p-value based on heterogeneity, and the Benjamini-Hochberg p-value adjustment. These methods enable users to validate the results of individual studies with greater statistical power and better estimation precision. We elaborate on these and illustrate them with examples from several studies of infertility-related disorders.

• Clinical and Experimental Reproductive Medicine
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• v.29 no.4
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• pp.251-258
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• 2002

Objective : The aim of this study was to evaluate the outcomes of the GnRH antagonist (Cetrotide) minimal stimulation protocol comparing with GnRH agonist combined long step down stimulation protocol in PCOS patients. Materials and Method: From Apr 2001 to May 2002, 22 patients (22 cycles) were performed in controlled ovarian hyperstimulation using by GnRH antagonist and GnRH agonist for PCOS patients. GnRH antagonist (Cetrotide) combined minimal stimulation protocol was administered in 10 patients (10 cycles, Study Group) and GnRH agonist long step down stimulation protocol was administered in 12 patients (12 cycles, Control Group). We compared the pregnancy rate/cycle, total FSH (A)/cycle, Retrieved oocyte/cycle, the incidence of ovarian hyperstimulation syndrome, multiple pregnancy rate between the two groups. Student-t test were used to determine statistical significance. Statistical significance was defined as p<0.05. Results: Group of GnRH antagonist (Cetrorelix) minimal stimulation protocol produced fewer oocytes (6.4 versus 16.3 oocytes/cycle) using a lower dose of FSH (22.2 versus 36.1 Ample/cycle) and none developed OHSS and multiple pregnancy. Although the trends were in favour of the GnRH antagonist (Cetrorelix) protocol, the differences did not reach statistical significance. This was probably due to small sample size. Conclusion: The use of GnRH antagonist reduce the risk of ovarian hyperstimulation and multiple pregnancy. We suggest that GnRH antagonist might be alternative controlled ovarian hyperstimulation method, especially in PCOS patients who will be ovarian high response.

• IEIE Transactions on Smart Processing and Computing
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• v.1 no.1
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• pp.8-16
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• 2012

An image obtained from a low light environment results in a low-exposure problem caused by non-ideal camera settings, i.e. aperture size and shutter speed. Of particular note, the multiple color-filter aperture (MCA) system inherently suffers from low-exposure problems and performance degradation in its image classification and registration processes due to its finite size of the apertures. In this context, this paper presents a novel method for the color enhancement of low-exposure images and its application to color shift model-based MCA system for image refocusing. Although various histogram equalization (HE) approaches have been proposed, they tend to distort the color information of the processed image due to the range limits of the histogram. The proposed color enhancement algorithm enhances the global brightness by analyzing the basic cause of the low-exposure phenomenon, and then compensates for the contrast degradation artifacts by using an adaptive histogram specification. We also apply the proposed algorithm to the preprocessing step of the refocusing technique in the MCA system to enhance the color image. The experimental results confirm that the proposed method can enhance the contrast of any low-exposure color image acquired by a conventional camera, and is suitable for commercial low-cost, high-quality imaging devices, such as consumer-grade camcorders, real-time 3D reconstruction systems, digital, and computational cameras.

• Korea journal of population studies
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• v.2 no.1
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• pp.5-16
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• 1978

The main purpose of this study is to examine the recent level of fertility and potentiality of the Korean population in Japan and to investigate some forces which influence the fertility of them using survey data. Some estimates of the level of fertility for the Korean population in Japan in 1974 are presented in Table 1. Comparing the some estimates for 1974 with those for 1969, the level of fertility in 1974 was realistically declined. It also indicated that potentiality of Koreans in Japan showed decreasing population. For investigating some factors affecting fertility, total births is selected which regressed on some variables believed in general to be influential in determiaing fertility. It was used a step-wise multiple regression to determine the independent as well as the combined effects of each of the variables. The SPSS computer program was used to perform the anlysis. Result from this data reveals that wife's family size preference as relevant predictor does influence the fertility of Koreans in Japan at this point considering that the age group of 20-29 is very much related. By employing multiple classification analysis, the analysis is concluded by nothing that the wi 3 family size preference has an even stronger relationship with economic factors than any other facto 3.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.3
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• pp.1140-1154
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• 2015

Multiple Description (MD) coding is a promising alternative for the robust transmission of information over error-prone channels. Lattice vector quantization (LVQ) is a significant version of MD techniques to design an MD image coder. However, different from the traditional 2D texture image, the 3D depth image has its own special characteristics, which should be taken into account for efficient compression. In this paper, an optimized MDLVQ scheme is proposed in view of the characteristics of 3D depth image. First, due to the sparsity of depth image, the image blocks can be classified into edge blocks and smooth blocks, which are encoded by different modes. Furthermore, according to the boundary contents in edge blocks, the step size of LVQ can be regulated adaptively for each block. Experimental results validate the effectiveness of the proposed scheme, which show better rate distortion performance compared with the conventional MDLVQ.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.11
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• pp.5392-5395
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• 2013

Application of electric wheelchair, sort of wheelchair which is playing important role in transporting patients and old people, has been increasing. In this study, we designed the electric wheelchairs' driving system. Using the multi-step gear, the driving system can get great power, even though the small capacity of motors. First, we designed the multi-step gear, test its bending strength and contact strength, as well as verified its performance. We installed 'B-type electric brake(Multiple plate clutch, Anti-magnetization) in same axle of the driving system, so it is possible to stop under huge torque and small size. Using this driving system of the multi-step gear which we designed, it's possible to improve driving gear efficiency 30% up and create the high-competitive electric wheelchair. And, it is easy to repair and control.

• Progress in Superconductivity and Cryogenics
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• v.21 no.3
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• pp.27-31
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• 2019

Large grain YBCO bulk superconductors are fabricated by the top-seeded melt growth (TSMG) or top-seeded infiltration growth (TSIG) method. Both growth methods use at least one of $YBa_2Cu_3O_{7-{\delta}}$, $Y_2BaCuO_5$, $BaCuO_3$ pre-reacted precursor powders. However, the synthesis of the pre-reacted powders includes multiple calcination runs which are cost-bearing and time-consuming. In this work, we report the successful growth of single-domain YBCO bulk superconductors directly by using the powder compact that has been pressed from the mixture of $Y_2O_3$, $BaCuO_3$ and CuO powders without any intermediate grinding step. Single-domain YBCO bulk superconductor has been also prepared by using $Y_2O_3$, $BaO_2$ and CuO powders without intermediate grinding step. Investigations on the trapped magnetic field and microstructure of the melt-processed specimen show that the elimination of the repeated processes of calcinations and pulverization has hardly affected on the crystal growth and the magnetic properties of the grown YBCO bulk superconductors. However, it is thought that the presence of residual carbon affects on the size of Y211 particles in melt-processed YBCO bulk superconductor.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.4
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• pp.726-747
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• 2013

In order to support a large number of mobile stations (MSs) with statistical multiplexing in cellular networks, a random access scheme is widely used for uplink (UL) bandwidth request (BR). In the design of a random access based BR scheme, there are two important requirements: short connection delay and diverse Quality of Services (QoSs) support. Such requirements are crucial for IMT-Advanced systems like IEEE 802.16m to provide various types of fourth generation (4G) data services. IEEE 802.16m provides advanced UL BR schemes for non-real time polling service (nrtPS) and best-effort (BE) service to meet the requirements of short connection time and multiple QoS level support. In order to provide short connection time and multiple QoS support, three-step and differentiated BR procedures are adopted. In this paper, a novel modelling of IEEE 802.16m contention based BR scheme is proposed that uses a 2-dimensional discrete time Markov chain. Both the short access delay three-step BR procedures and normal five-step BR procedure are considered in the model. Our proposed model also incorporates the IEEE 802.16m differentiated BR procedure. With the proposed model, we extensively evaluate the performance of IEEE 802.16m BR for two different service classes by changing QoS parameters, such as backoff window size and BR timer. Computer simulations are performed to corroborate the accuracy of the proposed model for various operation scenarios. With the proposed model, accurate QoS parameter values can be derived for the IEEE 802.16m contention-based BR scheme.

• Proceedings of the Microbiological Society of Korea Conference
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• 2002.10a
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• pp.175-179
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• 2002

The assemblies of our partial genomic sequence data of Sphingomonas chungbukensis DJ77, with the total size of 877,928 bp, was done by TIGR Assembler. The total size of our current obtained contigs was about 0.73 Mb. A comparative genome analysis between our uncompleted genome and the other completed genomes was performed by taking advantage of the availability of multiple complete genomes in COGs database (Clusters of Orthologous Groups of proteins) to produce the genomic prediction of our S. chungbukensis DJ77. This analysis based on homologues search among completed genomes provides good initial step to our better assigning putative function to predicted coding sequences.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.07b
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• pp.976-979
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• 2002

A focusing grating coupler (FGC) was not fabricated by the 'Continuous Path Control' writing strategy but by an electron-beam lithography system of more general exposure mode, which matches not only the address grid with the grating period but also an integer multiple of the address grid resolution (5 nm), To more simplify the fabrication, we are able to reduce a process step without large decrease of pattern quality by excluding a conducting material or layer such as metal (Al, Cr, Au), which are deposited on top or bottom of an e-beam resist to prevent charge build-up during e-beam exposure. A grating pitch period and an aperture feature size of the FGC designed and fabricated by e-beam lithography and reactive ion etching were ranged over 384.3 nm to 448.2 nm, and $0.5{\times}0.5mm^2$ area, respectively, This fabrication method presented will reduce processing time and improve the grating quality by means of a consideration of the address grid resolpution, grating direction, pitch size and shapes when exposing. Here our investigations concentrate on the design and efficient fabrication results of the FGC for coupling from slab waveguide to a spot in free space.