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BQ-123, $ET_{A}$ antagonist, decreases clinical sign and inflammatory region on EAE.

  • Kang, Bong-Su;Park, Young-Shim;In hoi Huh
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1996.04a
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    • pp.191-191
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    • 1996
  • BQ-123, a selective $ET_{A}$ receptor antagonist, reverses various responses induced by Endothelin-1 and it has been reported that BQ-123 ameliorates the cerebrovascular constriction, hypertension, and decrease of blood flow. Previously, we announced that the level of Endothelin-2 increase in the brain and spinal cord of EAE-induced lewis rat and showed the origin of ET-1 is activated macrophages. Intracisternal injection of $ET_{A}$ receptor antagonist, BQ-123(10nmol) was done for visualizing the role of endothelin-1 on the pathogenesis of EAE. BQ-123 apparently blocked the severity of clinical score of EAE and decreased the histologically observed inflammatory region. The blocking effect on the progression of EAE model following BQ-123, suggests that BQ-123 is a physiological antagonist in terms of development of the sign of multiple sclerosis.

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Optimal Design Method for an Actively Shielded MRI Superconducting Magnet (능동 차폐 MRI 초전도 자석에 대한 최적 설계 방법)

  • Lee, Kwang-Ho;Cho, Yun-Hyun
    • The Transactions of the Korean Institute of Electrical Engineers B
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    • v.49 no.6
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    • pp.421-430
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    • 2000
  • This paper describes an optimal design method which is applied a weighted least square (WLS) method for Magnetic Resonance Imaging (MRI) system. An optimal design approach is presented for a homogeneity superconducting magnet with the superconducting active shield especially for a magnetic resonance imaging system. The WLS is used to obtain the optimal configurations using the least amount and minimum volume of conductor, exhibiting the smallest level of field inhomogeneity and resulting in the least level of stray field. The proposed model is used to design a multiple-shield configuration for a 1.5 T MRI magnet. The field homogeneity is required less than 5 gauss stray field contour within 4m axially and 3m radially from origin. The designed magnet with the actively magnetic shielding coil out of main coils is analyzed by FEM and theoretical analysis method, investigated the field homogeneity.

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Synovial chondromatosis and osteochondroma in TMJ with CBCT images (측두하악관절에 발생한 활액연골종증과 골연골종의 CBCT 영상)

  • Seo, Yo-Seob;Lee, Gun-Sun;Kim, Jin-Soo;Kim, Jae-Duk
    • Imaging Science in Dentistry
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    • v.40 no.1
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    • pp.45-52
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    • 2010
  • Synovial chondromatosis is an uncommon disorder characterized by metaplastic formation of multiple cartilaginous and osteocartilaginous nodules within connective tissue of the synovial membrane of joints. Osteochondroma is a benign lesion of osseous and cartilagenous origin. It is frequently found in the general skeleton, but is rare in the mandibular condyle. We experienced 2 patients with abnormal appearance of temporomandibular joint. Histologic diagnoses were not obtained, because surgery was unwarranted in view of the lack of symptoms and the benign differential diagnosis. We describes 2 cases that show the characteristics of both disease simultaneously.

Origin of Direct Somatic Embryos from Cultureed Cotyledon Segments of korean Ginseng (Panax ginseng C.A. Meyer) (한국 인삼 (Panax ginseng C.A. Meyer)의 자엽절편 배양으로부터 형성되는 체세포배의 기원)

  • 최용의;소웅영
    • Korean Journal of Plant Tissue Culture
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    • v.21 no.3
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    • pp.177-182
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    • 1994
  • Cotyledon segments of korean ginseng produced somatic embryos when cultured on MS basal medium, whereas plumule or excised axis explants did not. histological examination revealed that the cells in proximal region of cotyledon turned meristematic and densely cytoplasmic was composed of smaller and more densely cytiplasmic cells than the subepidermal cells. however, in the case both epidermis and subepidermal cells were almost the same in size and cytoplasmic density, the embryo originated from multiple cells.

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Etiology and Mechanism of Neuropathic Pain (일반적인 신경병성 통증의 원인 및 기전)

  • Lim, Hyun-Dae
    • The Journal of the Korean dental association
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    • v.49 no.6
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    • pp.321-326
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    • 2011
  • Neuropathic pain is caused by functional abnonnalities of structural lesions in the peripheral or central nervous system, and occurs without peripheral nociceptor stimulation. Trigeminal neuropathy always pose differential location difficulties as multiple diseases are capablc of producing them: they can be the result of traumatism, tumors, or diseases of the connective tissue, infectious or demyelinating diseases, or may be of idiopathic origin. There are a number of mechanisms described as causing neuropathy. They can be described as ectopic nerve activity, neuroma, ephatic trasmission, change of sodium channel expression, sympathetic activity, central sensitization, and alteration in central inhibition systems. More than I mechanism may be active to create individual clinical presentations. In order to provide better pain control, the mechanism-based approach in treating neuropathic pain should be familiar to physicians.

Simulation of Performance in Compressed Still Image Transmission System over Wireless CDMA Channel (CDMA무선채널에서 압축된 정지영상 전송 시스템의 성능 시뮬레이션)

  • 황태욱;김영철;노재성;조성준
    • Proceedings of the IEEK Conference
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    • 2001.06a
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    • pp.93-96
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    • 2001
  • In this paper, the performance of DS/CDMA-BPSK system for image transmission is simulated by computer, and received image is compared with the origin image. In order to transmit standard image 'Lena', the image is discrete-cosine- transformed and quantized. Then image transmission data is made through assigning 8 bits to the image and high frequency data part of the image is compressed for reducing the size of data. The source-coded image is transmitted and received by the DS/CDMA-BPSK system. The BER, PSNR, and source Quality are changed according to the number of multiple access users, processing gain of the system, and SMR.

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Giant Ganglioneuroma of Thoracic Spine : A Case Report and Review of Literature

  • Huang, Yong;Liu, Lidi;Li, Qiao;Zhang, Shaokun
    • Journal of Korean Neurosurgical Society
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    • v.60 no.3
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    • pp.371-374
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    • 2017
  • Ganglioneuroma (GN) is a rare benign tumor of neural crest origin usually found in the abdomen, but may occasionally present at uncommon sites including the cervical, lumbar, or sacral spine. However, GNs of thoracic spine are extremely rare. In this report, we describe a 12-year-old girl with giant GN in the thoracic spine, who underwent successful resection (T1-4 level) of the tumor. Histopathological examination confirmed the diagnosis. GN should be considered in the differential diagnosis of any paraspinal mass. A high index of suspicion and correlation of clinico-radiological findings is necessary in differentiating a large benign tumor from a malignant growth. Complete surgical excision is the treatment of choice; however tumor size and location need to be considered for the surgical approach (one-step or multiple surgeries). Close follow-up after surgery is mandatory.

Determination of temperature and flux variations during ultra-thin InGaN quantum well growth on a 2" wafer for GaN Green LED

  • Kim, Hyo-Jeong;Kim, Min-Ho;Jeong, Hun-Yeong;Lee, Hyeon-Hwi
    • Proceedings of the Korean Vacuum Society Conference
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    • 2010.08a
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    • pp.149-149
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    • 2010
  • The origin of the inhomogeneous distribution of photoluminescence (PL) peak wavelength on a commercial 2" GaN wafer for green light emitting diode has been investigated by wide momentum transfer (Q) range x-ray diffraction (XRD) profile of InGaN/GaN multiple quantum wells. Near the GaN (0004) Bragg peak, wide-Q range XRD (${\Delta}Q$ > $1.4{\AA}-1$) was measured along the growth direction. Wide-Q XRD gives precise and direct information of ultra-thin InGaN quantum well structure. Based on the QW structural information, the variation of PL spectra can be explained by the combined effect of temperature gradient and slightly uneven flow of atomic sources during the QW growth. In narrow variations of indium composition and thickness of QW, an effective indium composition can be a good character to match structural data to PL spectra.

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Fungicide Resistance and Genetic Diversity of Botrytis cinerea of Citrus (감귤 잿빛곰팡이병균의 살균제에 대한 저항성 및 유전적 다양성)

  • 고영진;이재군;서정규;문두길;한해룡
    • Korean Journal Plant Pathology
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    • v.14 no.6
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    • pp.682-688
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    • 1998
  • Fungicide resistance of 48 isolates of Botrytis cinerea collected from citrus in Cheju was investigated and genetic diversity was analyzed with random amplified polymorphic DNA(RAPD). High levels of resistance to benzimidazole fungicides benomyl and thiophanate-methyl and N-phenylcarbamate fungicide diethofencarb were observed. Negative cross resistance was clear between benzimidazole and N-phenylcarbamate fungicides, and multiple resistance to the fungicides was also observed. There was cross resistance among the dicarboximide fungicides procymidione, vinclozolin and iprodione as it was observed between the benzimidazole fungicides benomyl and thiophanate-methyl. The lowest levels of resistance were to the dicarboximide fungicides, but no sensitive isolate to polyoxin B was observed. The isolates showed genetically diverse RAPD profiles according to the geographic origin collected, but there was no significant correaltion between RAPD profiles of genomic DNA and the levels of fungicide resistance of the isolates. The isolates showed genetically diverse RAPD profiles, indicating that genetic differentiation had already occurred in the populations of B. cinerea distributed in Cheju.

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A Network Capacity Model for Multimodal Freight Transportation Systems

  • Park, Min-Young;Kim, Yong-Jin
    • Journal of Korea Port Economic Association
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    • v.22 no.1
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    • pp.175-198
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    • 2006
  • This paper presents a network capacity model that can be used as an analytical tool for strategic planning and resource allocation for multimodal transportation systems. In the context of freight transportation, the multimodal network capacity problem (MNCP) is formulated as a mathematical model of nonlinear bi-level optimization problem. Given network configuration and freight demand for multiple origin-destination pairs, the MNCP model is designed to determine the maximum flow that the network can accommodate. To solve the MNCP, a heuristic solution algorithm is developed on the basis of a linear approximation method. A hypothetical exercise shows that the MNCP model and solution algorithm can be successfully implemented and applied to not only estimate the capacity of multimodal network, but also to identify the capacity gaps over all individual facilities in the network, including intermodal facilities. Transportation agencies and planners would benefit from the MNCP model in identifying investment priorities and thus developing sustainable transportation systems in a manner that considers all feasible modes as well as low-cost capacity improvements.

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