• The Journal of Korean Physical Therapy
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• 제26권6호
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• pp.430-435
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• 2014

Purpose: The objective of this study was a virtual reality-based balance training program effective for improvement in physical function, examined the balance ability and fall efficacy of elderly women with experienced falls, intending to examine the program's usefulness as an exercise program to prevent the recurrence of a fall. Methods: The participants were 30 elderly women aged 65 or older who met the conditions. The participants were randomly assigned to either a balance training group (BT) or a virtual reality-based balance training group (VT) and received the training three times per week, 30 minutes per day, for six weeks. To measure static balance, the Tetrax Portable Multiple System (Tetrax Ltd, Israel) were used. To measure dynamic balance, the Berg Balance Scale (BBS) and functional reach test (FRT) was used, and regarding fall efficacy, the Korean Fall Efficacy Scale (K-FES) was used. Results: Tetrax significantly improved after the intervention in both the BT group and the VT group (p<0.05). The comparison between the two groups was not significantly. BBS and FRT result significantly improved after the intervention in both the BT and VT groups (p<0.001), while K-FES was significantly ameliorated in the VT group only (p<.05). Comparing the groups, there were more significant changes in the BBS (p<0.05) and FRT (p<0.01) result of the VT group than the BT group. Conclusion: A virtual reality-based balance training program is considered to be usable as an exercise program to prevent recurrence of falls in elderly women.

• 한국수자원학회논문집
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• 제32권6호
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• pp.711-720
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• 1999

서해안의 3개 실험유역을 선정, 강우-유출 현상 중 홍수수문곡선을 모의하기 위하여 선형저수지 모형을 적용하고 모형의 매개변수를 유역특성과 상관시켜 회귀분석을 실시하였다. 분석을 위하여 총 8개 모형이 이용되었으며 3개 유역, 5개 수위관측지점에서 시험·적용하였다. 선정된 모형의 매개변수 최적화는 선형계획기법의 일종인 Rosenbrock방법을 이용하였고 유도된 모형의 매개변수는 또 다른 강우-유출 사상에 모의하여 검정하였다. 그리고 검정된 모형 중 Nash모형은 저수지 수(N)와 저류상수(k), 그리고 선형저수지 모형의 경우 저류상수(k)를 유역특성치인 유역의 크기, 경사도 및 하천길이와 상관시켜 회귀분석을 실시하였으며 이 결과는 무계측 유역의 순간단위도(IUH)를 유도하는데 이용할 수 있을 것이다.

• Clinical and Experimental Reproductive Medicine
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• 제49권2호
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• pp.93-100
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• 2022

Objective: The impact of imatinib, a tyrosine kinase inhibitor, on ovarian follicles and several proteins related to follicular function and apoptosis was investigated in mice. Methods: Saline, cyclophosphamide (Cp; 50 or 75 mg/kg), or imatinib (7.5 or 15 mg/kg) was injected once intraperitoneally into female B6D2F1 mice (18 mice in each group). In multiple ovarian sections, the number of various types of follicles and the proportion of good-quality (G1) follicles were counted. The levels of six proteins (anti-Müllerian hormone [AMH], BCL-xL, BAX, acid sphingomyelinase [A-SMase], caspase-3, and α-smooth muscle actin [α-SMA]) within the whole ovaries were quantified using Western blots. Results: Compared to the saline group, a significant reduction of the primordial follicle count was observed in the group treated with imatinib 7.5 and 15 mg/kg, as well as in the group treated with Cp 75 mg/kg. Administration of Cp significantly decreased the proportion of G1 primordial follicles, but administration of imatinib did not. No differences in the AMH, anti-apoptotic BCLX-L, pro-apoptotic BAX, and A-SMase levels in the ovarian tissues were observed among the five groups. However, caspase-3 and α-SMA levels were significantly higher in the imatinib and Cp groups than in the saline group. Conclusion: The administration of imatinib to mice significantly reduced the primordial follicle count and increased the protein levels of caspase-3 and α-SMA. Our findings suggest that imatinib potentially exerts ovarian toxicity via apoptotic processes, similarly to Cp.

• Steel and Composite Structures
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• 제44권2호
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• pp.155-169
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• 2022

In the present paper an analytical model was developed to study the non-linear vibrations of Functionally Graded Carbon Nanotube (FG-CNT) reinforced doubly-curved shallow shells using the Multiple Scales Method (MSM). The nonlinear partial differential equations of motion are based on the FGM shallow shell hypothesis, the non-linear geometric Von-Karman relationships, and the Galerkin method to reduce the partial differential equations associated with simply supported boundary conditions. The novelty of the present model is the simultaneous prediction of the natural frequencies and their mode shapes versus different curvatures (cylindrical, spherical, conical, and plate) and the different types of FG-CNTs. In addition to combining the vibration analysis with optimization algorithms based on the genetic algorithm, a design optimization methode was developed to maximize the natural frequencies. By considering the expression of the non-dimensional frequency as an objective optimization function, a genetic algorithm program was developed by valuing the mechanical properties, the geometric properties and the FG-CNT configuration of shallow double curvature shells. The results obtained show that the curvature, the volume fraction and the types of NTC distribution have considerable effects on the variation of the Dimensionless Fundamental Linear Frequency (DFLF). The frequency response of the shallow shells of the FG-CNTRC showed two types of nonlinear hardening and softening which are strongly influenced by the change in the fundamental vibration mode. In GA optimization, the mechanical properties and geometric properties in the transverse direction, the volume fraction, and types of distribution of CNTs have a considerable effect on the fundamental frequencies of shallow double-curvature shells. Where the difference between optimized and not optimized DFLF can reach 13.26%.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권2호
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• pp.391-411
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• 2023

Aggregates play the skeleton and supporting role in the construction field, high-precision measurement and high-efficiency analysis of aggregates are frequently employed to evaluate the project quality. Aiming at the unbalanced operation time and segmentation accuracy for multi-class segmentation algorithms of aggregate images, a Chaotic Sparrow Search Algorithm (CSSA) is put forward to optimize it. In this algorithm, the chaotic map is combined with the sinusoidal dynamic weight and the elite mutation strategies; and it is firstly proposed to promote the SSA's optimization accuracy and stability without reducing the SSA's speed. The CSSA is utilized to optimize the popular multi-class segmentation algorithm-Multiple Entropy Thresholding (MET). By taking three METs as objective functions, i.e., Kapur Entropy, Minimum-cross Entropy and Renyi Entropy, the CSSA is implemented to quickly and automatically calculate the extreme value of the function and get the corresponding correct thresholds. The image adaptive multi-class segmentation model is called CSSA-MET. In order to comprehensively evaluate it, a new parameter I based on the segmentation accuracy and processing speed is constructed. The results reveal that the CSSA outperforms the other seven methods of optimization performance, as well as the quality evaluation of aggregate images segmented by the CSSA-MET, and the speed and accuracy are balanced. In particular, the highest I value can be obtained when the CSSA is applied to optimize the Renyi Entropy, which indicates that this combination is more suitable for segmenting the aggregate images.

• Korean Journal of Radiology
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• 제23권1호
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• pp.101-111
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• 2022

Objective: Familial intracranial aneurysms (FIAs) are found in approximately 6%-20% of patients with intracranial aneurysms (IAs), suggesting that genetic predisposition likely plays a role in its pathogenesis. The aim of this study was to identify possible IA-associated variants using whole exome sequencing (WES) in selected Korean families with FIA. Materials and Methods: Among the 26 families in our institutional database with two or more IA-affected first-degree relatives, three families that were genetically enriched (multiple, early onset, or common site involvement within the families) for IA were selected for WES. Filtering strategies, including a family-based approach and knowledge-based prioritization, were applied to derive possible IA-associated variants from the families. A chromosomal microarray was performed to detect relatively large chromosomal abnormalities. Results: Thirteen individuals from the three families were sequenced, of whom seven had IAs. We noted three rare, potentially deleterious variants (PLOD3 c.1315G>A, NTM c.968C>T, and CHST14 c.58C>T), which are the most promising candidates among the 11 potential IA-associated variants considering gene-phenotype relationships, gene function, co-segregation, and variant pathogenicity. Microarray analysis did not reveal any significant copy number variants in the families. Conclusion: Using WES, we found that rare, potentially deleterious variants in PLOD3, NTM, and CHST14 genes are likely responsible for the subsets of FIAs in a cohort of Korean families.

• Archives of Plastic Surgery
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• 제51권5호
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• pp.495-503
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• 2024

Anterior mandible defects result in loss of support for the tongue, floor of the mouth and lower lip, resulting in impairment of airway, feeding, and speech. We treated four patients with these "Andy Gump" deformities. Reconstruction was performed with two free flaps: a fibula osteocutaneous flap for the anterior mandible and floor of the mouth, and a soft tissue free flap for the lip, chin, and anterior neck. The lower lip was suspended cranially with fascia or tendon grafts±mini-temporalis turndown flaps. All flaps survived completely. All patients were tube feed-dependent before surgery; they all resumed an oral diet. All tracheostomies were decannulated. Lip competence was restored as evidenced by cessation of drooling. Speech improved from unintelligible to intelligible with frequent repetitions. Objective assessment was performed with the functional intraoral Glasgow scale; the mean FIGS score improved from 3.25 (range 3-4) to 11 (range 9-13). We conclude that composite anterior mandible and tongue defects have large tissue requirements that require multiple free flaps. Reconstruction leads to significant improvement in function.

• 한국수자원학회논문집
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• 제53권5호
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• pp.383-393
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• 2020

본 연구에서는 소양강댐 유역에서의 실측 단일사상 강우-유출 자료를 활용하여 Clark 단위도 방법의 매개변수를 최적화 하였으며, 그 결과를 제시하였다. 일반적으로 국내에서는 유역특성인자 최적화 분석시 미육군공병단의 HEC-1, HEC-HMS 등의 모형을 사용하고 있다. 그러나 해당 모형의 경우 유출수문곡선의 형상, 크기 등의 재현에만 초점이 맞춰져 있으며, 산정된 매개변수들의 평균을 사용하고 있어 실제 강우-유출 관계를 묘사하는데 어려움이 존재하고 있다. 이러한 점에서 본 연구에서는 기존 Clark 합성단위도법과 계층적 Bayesian 기법을 결합하여 수집된 강우-유출 자료를 동시에 활용하여 매개변수를 산정할 수 있는 모형을 개발하였다. 본 연구에서 개발된 모형을 적용한 결과 개별 단일사상 기반의 최적화 기법에 비해 다중 강우-유출 자료를 Pooling하여 매개변수를 산정하는 계층적 Bayesian 모형에서 BIC 결과 및 다수의 통계적 지표를 통해 모형의 우수성을 확인할 수 있었다. 더불어 홍수량에 따른 유역특성인자 매개변수 반응에 대한 관계규명을 기반으로 향후 댐 설계 또는 PMF 산정시 본 연구의 결과가 활용이 가능할 것으로 판단된다.

• 대한한의진단학회지
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• 제15권2호
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• pp.175-190
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• 2011

Objectives: Even though there has been no consensus on the concept of viscera organ between the oriental and western medicine, we tried to investigate the correlation between clinical biomarkers of five Jang and chronological age and develop the models for predicting five Jang biological ages by statistical analysis. Methods: We obtained data from about 120,000 subjects who visited health promotion centers for health promotion and disease prevention from January 2004 to June 2009. Participants were included if they were over 20 years old, and excluded if reported to have cardiovascular disease or other serious medical illness such as cancer, malignant hypertension, uncontrolled diabetes, cardiopulmonary insufficiency, liver disease, pancreatic disease or renal disease. Among the clinical biomarkers obtained, we selected the biomarkers which were associated with the function of 5 Jang in previous studies, or showed statistically significant correlation with age. Multiple regression models were used for building prediction models of biological age after adjusting for potential confounders for men and women, respectively. Pearson correlation coefficient was calculated to examine the linear relationship between age and various biomarkers, and multiple regression analysis was used for building the prediction models of five Jang biological ages for men and women, respectively. All statistical data analysis was performed by using SPSS Version 12.0 software and statistical significance was obtained if p<0.05. Results: For males, the best models were developed using 12, 2, 8, 3, and 4 biomarkers for predicting biological ages of heart, lung, liver, pancreas, and kidney, respectively (R2 = 0.57, 0.43, 0.11, 0.24, and 0.93, respectively). Similar to males, for the females, 10, 2, 8, 3, and 4 biomarkers were selected as the models respectively (R2 = 0.76, 0.44, 0.14, 0.38, and 0.89, respectively). Conclusions: As we have developed for the first time the models for predicting five Jang biological ages with common clinical biomarkers, it is expected that these models may be used as clinical supplementary tools in the evaluation of aging status and functional decline of five Jang according to age in health promotion centers and private clinics. At the same time, it is considered that the use as objective tools to evaluate aging status and functional decline of each Jang.

• 한국정보과학회논문지:시스템및이론
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• 제36권3호
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• pp.135-139
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• 2009

여러 문자열들을 비교하여 유사성 또는 거리(오차)를 계산하는 문제는 패턴매칭, 웹검색 바이오인포매틱스, 컴퓨터 보안 등 다양한 응용 분야와의 연관성으로 인해 활발히 연구되어 왔다. 주어진 문자열 집합 내의 여러 문자열들의 거리를 비교하기 위해 주어진 집합 내의 모든 문자열들을 대표하는 한 문자열(대표문자열)을 찾는 방법이 있다. 대표문자열 방법은 주어진 문자열 집합과 가장 유사한 한 문자열을 찾는 방법으로 주로 이용되는 목적함수는 거리반경과 거리합이 있다. 거리반경은 집합 내의 문자열들과 특정 문자열과의 거리들의 최대값으로 정의되며, 모든 문자열들 중에서 최소의 거리반경을 만드는 문자열을 주어진 문자열 집합에 대한 거리반경기반 대표문자열이라 한다. 거리합은 집합 내의 문자열들과 특정 문자열과의 거리들의 합으로 정의되며, 모든 문자열들 중에서 최소의 거리합을 만드는 문자열을 주어진 문자열집합에 대한 거리합기반 대표문자열이라 한다. 본 논문에서는 메트릭 거리함수에 대해 거리반경기반 대표문자열 문제가 NP-완전임을 증명한다.