• Toxicological Research
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• v.23 no.1
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• pp.1-9
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• 2007

Transporters are membrane proteins that mediate the transfer of substrate across the cellular membrane. In this overview, the characteristics and the toxicological relevance were discussed for various types of transporters. For drug transporters, the overview focused on ATP-binding cassette transporters and solute carrier family 21A/22A member transporters. Except for OCTN transporters and OATP transporters, drug transporters tend to have broad substrate specificity, suggesting drug-drug interaction at the level of transport processes (e.g., interaction between methotrexate and non-steroidal anti-inflammatory agents) is likely. For metal transporters, transporters for zinc, copper and multiple metals were discussed in this overview. These metal transporters have comparatively narrow substrate specificity, except for multiple metal transporters, suggesting that inter-substrate interaction at the level of transport is less likely. In contrast, the expressions of the transporters are often regulated by their substrates, suggesting cellular adaptation mechanism exists for these transporters. The drug-drug interactions in drug transporters and the cellular adaptation mechanisms for metal transporters are likely to lead to alterations in pharmacokinetics and cellular metal homeostasis, which may be linked to the development of toxicity. Therefore, the transporter-mediated alterations may have toxicological relevance.

• Journal of information and communication convergence engineering
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• v.14 no.3
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• pp.171-176
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• 2016

In this study, we investigate the physical layer secrecy performance of RF energy harvesting (EH) networks over Rayleigh fading channels. The RF-EH system considered here consists of one power transfer station, one source, one destination, and multiple passive eavesdroppers. The source harvests energy from the power transfer station and transmits the information to the destination by using a time switching-based relaying protocol. The eavesdroppers try to extract the transmitted information without an active attack. By using the statistical characteristics of the signal-to-noise ratio (SNR), the exact closed-form expressions of the existence probability of the secrecy capacity and the secrecy outage probability are derived. Further, we analyze the secrecy performance of the system with respect to various system parameters, such as the location of the system elements and the number of eavesdroppers. Finally, the equivalent Monte Carlo simulation results are provided to confirm the correctness of our calculations.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.11
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• pp.5370-5393
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• 2019

In this paper, we consider a two-way relay non-orthogonal multiple access (TWR-NOMA) system with residual hardware impairments (RHIs) and channel estimation errors (CEEs), where two group users exchange their information via the decode-and-forward (DF) relay by using NOMA protocol. To evaluate the performance of the considered system, exact analytical expressions for the outage probability of the two groups users are derived in closed-form. Moreover, the asymptotic outage behavior in the high signal-to-noise ratio (SNR) regime is examined and the diversity order is derived and discussed. Numerical simulation results verify the accuracy of theoretical analyses, and show that: i) RHIs and CEEs have a deleterious effects on the outage probabilities; ii) CEEs have significant effects on the performance of the near user; iii) Due to the RHIs, CEEs, inter-group interference and intra-group interference, there exists error floors for the outage probability.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.11
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• pp.5410-5426
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• 2019

With the advent of the fifth-generation (5G) era, Massive multiple-input multiple-output (MIMO) relay systems have experienced the rapid development. Recently, the performance analysis models of Massive MIMO relay systems have been proposed, which are mostly based on Rayleigh fading channels. In order to create a more suitable model for 5G Internet of Things scenarios, our study is based on the Rician fading channels, where line-of-sight (LOS) path exists in the channels. In this paper, we assume the channel state information (CSI) is perfect. In this case, we use statistical information to derive the analytical exact closed-form expression for the achievable sum rate of the uplink for the Massive MIMO two-hop relay system over Rician fading channels. Moreover, considering the different communication scenarios, we derive the analytical exact closed-form expression for the achievable sum rates of the uplink for other three scenarios. Finally, based on these expressions, we make simulations and analyze the performance under different transmit powers and Rician-factors, which provides a theoretical basis and reference for further research.

• Journal of KIISE:Information Networking
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• v.27 no.1
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• pp.22-29
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• 2000

In this paper, we analyzed the performance of EY-NPMA(Elimination Yield-Non-preemptive Priority Multiple Access) protocol-channel access control protocol of HIPERLAN(HIgh PErformance Radio Local Area Network) type 1 specification, adopted as european high speed wireless LAN standard by ETSI(European Telecommunication Standards Institute). We established a system model for EY-NPMA protocol analysis, analyzed success probability in a channel access cycle, and derived expressions for the average length of contention phase. Using a M/G/1 model, we approximated the normalized delay, and throughput, and we evaluated these results by simulations.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.7 no.6
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• pp.1153-1160
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• 2003

In this paper, the performance of the UWB communication systems is analyzed in the presence of the Narrow Band Interference(NBI). UWB communication systems are modeled as using the Pulse Position Modulation(PPM). In this system, a Gaussian monocycle is used as the received pulses. The NBI is considered as a zero-mean random process with a constant spectral power density over its whole bandwidth. We obtain the mathematical expressions for describing the effect of the NBI on the UWB system. And it can be shown that the suppression of the effect of NBI on the UWB systems is available by adjusting the PPM related parameter.

• Journal of the Korean Institute of Telematics and Electronics
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• v.27 no.3
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• pp.31-39
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• 1990

An optimization problem of AND-EXOR PLA's with input decoders can be regarded as a minimization problem of Exclusive-Or Sum-Of-Products expressions (ESOP's) for multiple-valued input two-valued output functions. In this paper, We propose a minimization algorithm for ESOP's. The algorithm is based on an iterative improvement. Five rules are used to replace a pair of products with another one. We minimized many ESOP's for arithmetic circuits. In most cases, ESOP's required fewer products than SOP's to realized same functions.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.2
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• pp.628-649
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• 2017

Security and resource-saving are both demands of the fifth generation (5G) wireless networks. In this paper, we study the secrecy spectrum efficiency (SSE) and secrecy energy efficiency (SEE) of a K-tier massive multiple-input multiple-output (MIMO) enabled heterogeneous cellular network (HetNet), in which artificial noise (AN) are employed for secrecy enhancement. Assuming (i) independent Poisson point process model for the locations of base stations (BSs) of each tier as well as that of eavesdroppers, (ii) zero-forcing precoding at the macrocell BSs (MBSs), and (iii) maximum average received power-based cell selection, the tractable lower bound expressions for SSE and SEE of massive MIMO enabled HetNets are derived. Then, the influences on secrecy oriented spectrum and energy efficiency performance caused by the power allocation for AN, transmit antenna number, number of users served by each MBS, and eavesdropper density are analyzed respectively. Moreover, the analysis accuracy is verified by Monte Carlo simulations.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.9
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• pp.4242-4263
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• 2017

Multi-User Multiple-Input Multiple-Output (MU-MIMO) technology has recently attracted significant attention from academia and industry because of it is increasingly important role in improving networks' capacity and data rate. Moreover, MU-MIMO systems for the Fifth Generation (5G) have already been researched. High Quality of Service (QoS) and efficient operations at the Medium Access Control (MAC) layer have become key requirements. In this paper, we propose a downlink MU-MIMO MAC protocol based on adaptive Channel State Information (CSI) feedback (called MMM-A) for Wireless Local Area Networks (WLANs). A modified CSMA/CA mechanism using new frame formats is adopted in the proposed protocol. Specifically, the CSI is exchanged between stations (STAs) in an adaptive way, and a packet selection strategy which can guarantee a fairer QoS for scenarios with differentiated traffic is also included in the MMM-A protocol. We then derive the expressions of the throughput and access delay, and analyze the performance of the protocol. It is easy to find that the MMM-A protocol outperforms the commonly used protocols in terms of the saturated throughput and access delay through simulation and analysis results.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.5
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• pp.1682-1701
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• 2015

In this paper, we propose an intergraded unified imperfect CSI model and investigate the joined effects of feedback delay and channel estimation errors (CEE) for two-hop relaying systems with transmit beamforming and relay selection. We derived closed-form expressions for important performance measures including the exact analysis and lower bounds of outage probability as well as error performance. The ergodic capacity is also included with closed-form results. Furthermore, diversity and coding gains based on the asymptotic analysis at high SNRs are also presented, which are simple and concise and provide new analytical insights into the corresponding power allocation scheme. The analysis indicates that delay effect results in the coding gain loss and the diversity order loss, while CEE will merely cause the coding gain loss. Numerical results verify the theoretical analysis and illustrate the system is more sensitive to transmit beamforming delay compared with relay selection delay and also verify the superiority of optimum power allocation. We further investigate the outage loss due to the CEE and feedback delays, which indicates that the effect of the CEE is more influential at low-to-medium SNR, and then it will hand over the dominate role to the feedback delay.