• The Journal of Natural Sciences
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• v.18 no.1
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• pp.1-8
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• 2007

An efficient sampling method of computer simulation is reviewed. Using the method, several thermodynamic states can be investigated at a time in a single simulation. It is due to the ability of the method to explore the relevant parts of configuration space equally for every state being investigated. The method can be used in simulations of complex systems such as biopolymers which are still greatly hampered by the multi-minima problem. In this article I present a brief theoretical review of the method and illustrate how to realize it in the simulations.