• Clinical and Experimental Pediatrics
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• v.45 no.8
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• pp.1048-1051
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• 2002

Toxic shock syndrome(TSS) is clinically similar to Kawasaki disease(KD) in that both of them are characterized by fever, desquamating rash and mucous membrane erythema. In contrast the main feature of TSS is hypotension, whereas the complication of KD is coronary vasculitis. We report an 8-year-old boy who fulfilled the crireria for TSS and KD. Initially he showed clinical features of TSS, so he was treated with intravenous antibiotics and supportive management. But the fever sustained, and the coronary aneurysm that is the main complication of Kawasaki disease was shown by echocardiogram on Day 14. He was treated with intravenous immunoglobulin twice and the fever subsided and general condition was improved.

• The Journal of Internal Korean Medicine
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• v.25 no.3
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• pp.518-528
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• 2004

This study was carried out to investigate the effects of Hyangsapyeongwisan(HP) on gastric mucosal lesions induced by indomethacin in mice. The control group consisted of gastro-inflammation elicited mice. The sample group consisted of mice given HP after onset of gastro-inflammation. In common morphological and histochemical change, various cell abnormalities were observed in the control group, such as mucous surface cell, peanut cell, surface epithelial cell, goblet cell abnormalities, all caused hemorrhagic erosion. The sample group was the same as the control group. In the immunohistochemical change, the distributions of COX-I, BrdU treated with HP were notably higher than those of the control group(p$NF-{\kappa}B$, COX-2, PKC, IL-12B in mice treated with HP were notably lower than those of the control group(p

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.16 no.1
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• pp.49-52
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• 2013

Antral web is a rare cause of gastric outlet obstruction in neonate. It is a 2-4 mm thin mucous membrane that can be found anywhere from 1 to 7 cm proximal to the pylorus. The baby was born at gestational age of $32^{+1}$ weeks with 1,880 g as 2nd baby of dizygotic twin. After birth, the baby had constant non-bilious vomiting without feeding while he didn't show abdominal distension or discoloration. The infantogram showed distended stomach with distal small bowel gas. Upper gastrointestinal series revealed that the antrum was abruptly narrowed at 1 cm proximal to pylorus. We performed laparotomy at the 10th day after birth and excised the 2 mm-thick web circumferentially. He began milk feeding after 6 days and discharged uneventfully at postoperative 35 days with corrected age of $38^{+4}$ weeks with body weight 2,420 g. The antral web should be considered in the case of non-bilious vomiting in neonate.

• The Journal of the Korean Society for Microbiology
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• v.10 no.1
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• pp.19-24
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• 1975

Anaerobic bacteria are the major residents of human skin and mucous membrane. The importance, as opportunistic pathogens, of anaerobic bacteria are well recognized because of more population. with decreased defense against bacterial invasion due to chemotherapy, rediation therapy, extensive surgical operation etc. are dealt at hospitals. An analysis of the anaerobe isolation results at Yonsei University Medical Center during the January 1974-May 1975 period was made and the following results were obtained. 1) From 118 patients 146 strains of anaerobes were isolated. Among these 81.3% were nonsporforming anaerobes. Most frequently isolated anaerobes were Pc. asaccharolyticus, Ps. anaerobius, Ps. intermedius, B. fragilis and Cl. perfringens. 2) Anaerobes were frequently isolated from wound, female genital, intraabdominal, and pleuropulmonary specimens. Fewer anaerobes were isolated from blood, spinal fluid and liver specimens. 3) The ratio of anaerobe isolation to total bacteria isolation were; liver 66.7%, intraabdominal 33.3%, pleuropulmonary 28.9%, spinal fluid 5.0% and blood 4.2%. 4) Among the 118 anaerobe isolated patients, 48.3% yielded anaerobes only and rest of them yielded anaerobes together with aerobes. 5) Most of the gram-positive anaerobes were susceptible to the antibiotics tested. Exception was to tetracycline to which appreciable number showed resistance. It was noteworthy that only 48% of B. fragilis was susceptible to tetracycline.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.115-115
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• 1995

저자 등은 일련의 식물엑스에 대하여 항위염 및 항궤양효능에 관한 검색을 실시하여 오리나무수피의 MeOH엑스가 현저한 효과가 있음을 예지 하였으므로 그에 대하여 보다 구체적인 실험을 실시하였다. 즉 MeOH엑스를 Hexane, CMCl$_3$, BuOH로 계통적으로 추출하여 상기의 분획 및 잔사인 물분획을 제조하여 이에 대한 실험을 실시하였다. 소화성궤양이 공격인자와 방어인자의 불균형에 의해 형성됨을 Shay가 주장함으로써 공격인자의 억제를 알아보기 위한 Mizui 등의 방법인 HClㆍEtOH 유발 위손상 실험과 Guth 등의 Aspirin 위손상 실험 방법에 따라서 위 손상정표를 관찰하였다. Shay의 방법에 따라서 위궤양 모텔은 유문을 결찰하고 검체를 십이지장내에 투여하고 처치를 완료하고 12시간 후에 궤양정도와 또한 4시간의 유문결찰에 의한 위액분 비량, pH 및 산분비량에 미치는 영향을 관찰하였다. 또 염산과 pepsin 등에 의한 점막 손상에 대한 방어인자의 증강요인인 위 mucous membrane의 mucus분비를 알아보기 위한 absoluteㆍ에탄올 위손상에 대한 예방효과 시험을 시행하였다. 이 실험의 결과, 오리나무 MeOH엑스의 항위염 및 항위궤양효과는 BuOH 분획에서 강력한 작용이 있었으며 이 분획은 aspirin 유발 위손상 및 shay 궤양에 효과를 나타내었고 또한 mucin량의 증가를 보여주었다. 그러나 이 분획은 위액, pH 및 산분비량에 영향을 나타내지 아니하였다.

• Journal of Veterinary Clinics
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• v.35 no.3
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• pp.111-113
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• 2018

A three-month-old female African buffalo born at Seoul Zoo showed signs of abdominal distension, bulging of the perineal skin, and small stool volume compared to feed intake. Upon physical examination, atresia ani with rectovaginal fistula was diagnosed. This case was subjected to surgery under inhalation anesthesia after injecting a sedative. Surgery was performed in two steps: anal reconstruction and closing the rectovaginal fistula. First, a circular skin incision was made at the end of the rectal pouch to create an anus, and then the skin of the anus and the mucous membrane of the rectum were brought into apposition by simple interrupted sutures. Second, the rectovaginal fistula was ligated on both vulval and anal side. Antibiotics were administered on every alternate day and the sutures were removed at ten days surgery under sedation. The rectovaginal communication was closed and the calf was able to urinate and defecate normally. The animal grew to become a normal adult without any complications. This is the first case report of atresia ani with rectovaginal fistula in an African buffalo, that was successfully treated by surgical intervention.

• Korean Journal of Veterinary Research
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• v.18 no.1
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• pp.9-13
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• 1978

Nitrate poisoning was observed in Holstein calves raising for beef purpose in a dairy-farm of Gyeongbug province. The results observed were summarized as follows: 1. These calves had been fed mainly cornstalk, and a qualitative reaction by "dephenylamine blue test" for nitrate was positive in the serum of the affected calves and in the cornstalk provided. 2. In the clinical signs, the affected calves were suddenly recumbent without premonition and then dyspnea, followed by death. Death also occurred after inappetence, depression, dyspnea, cyanosis of mucous membrane, and terminal anoxic convulsions were observed. 3. In the macroscopical findings, the blood was dark brown (chocolate in color) and more or less poor coagulative. Petechiae of epicardium, severe cloudy swelling of liver, cloudy swelling and hemorrhage of kidney, congestion and hemorrhage of spleen, congestion and edema of lung, and congestion af abomasum and small intestine were observed in these cases. 4. Microscopical changes observed in these cases were peripheral congestion of lobules, centrilobular necrosis and sinusoidal dilatation in liver, hydropic degeneration of hepatic cells, hemorrhage and edema of kidney, necrosis of convoluted-tubular epithelium, and dilatation of Bowman's space and convoluted tubule. There were also congestion and hemorrhage of spleen, hemorrhage and edema of lung, cloudy swelling of myocardium, and congestion and hemorrhage of various organs.

• Korean Journal of Veterinary Research
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• v.41 no.2
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• pp.227-231
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• 2001

A 8-year-old, intact male Yorkshire Terrier Dog was presented with dark-black mass on the third digits of the left forelimb. Three months earlier, the dog had experienced an episode of digit amputation because of growing mass with ulcerated nodule of the same area. According to the owner, the recurrence of the mass appeared suddenly and was growing rapidly from the amputation site. The mass was more infiltrative than the first one and measured 1.5 cm in diameter. The clinical signs were anorexia, coughing, respiratory distress, exercise intolerance, cardiac murmurs, and cyanosis on the oral mucous membrane. Plain radiographic findings revealed multiple, various-sized(0.5 to 7 cm in diameter), slightly firm-nodules on the thoracic region but digital bone lysis was not seen. These lesions on the thoracic cavity were considered likely to be metastatic from the digit and the dog was naturally died after 3 weeks from the time. Histologically, the digital mass confirmed the diagnosis of metastatic malignant melanoma that was composed of round melanocytic neoplastic, anaplastic, and melanin-containing cells. This report records clinical information and gross and light microscopic features of metastatic malignant melanoma in a dog.

• Environmental Analysis Health and Toxicology
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• v.12 no.3_4
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• pp.55-59
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• 1997

Furfural, an organic solvent, is widely used as synthetic component material in producing chemical products. However, furfural has been reported that it shows strong toxicities to human being showing intense stimulus to skin, eyes, mucous membrane and nerve system. It is also known to cause anemia, liver cirrhosis, kidney failure and genetic toxicity in the human being working in the exposed area. LD$_{50}$ of furfural for peritoneal injected mouse has been known around 20mg/kg, but the acute toxicity on aquatic organisms such as fish, daphnid or algae are not well known, compared to those on rodents. In this experiment, we studied on the fish toxicity of furfural using Japanese Medaka (Orvzias latipes) and Common Carp (Cvprinus carpio). We also observed histological changes in the fish organs. The LC$_{50}$ were 12. Smg/L in Japanese Medaka and 21.8 mg/L in Common Carp, respectively. When Common Carps were exposed to 120mg/L of furfural concentration for 30 minutes, blood congestion in gills and lysis of secondary lamella were shown. Though the muscle of caudal fin was not completely eroded, its epidermic cells were shown to be necrotic in various parts. Tissue atrophy and cell necrosis were also shown in the liver of Common Carps exposed to furfural. From these results, furfural seems to cause histological damages on liver, an internal organ as well as on external organs such as gills and fins eventhough the fish were exposed for a short-term.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.3 no.1
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• pp.7-18
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• 1970

The present paper deals with mortality and pathogenetic investigation of the oysters Crassostrea gigas cultured by tile coventional bamboo and hanging method in Kimhae and Koje-Do in 1969. The results of the investigation may be summarized as follows: 1. Mortality of the oysters by the bamboo method in Kimhae was $9.5\%$ in June, $10.2\%$ In July, $12.3\%$ in August and $12.1\%$ in September, respectively, 2. Mortality of the oysters cultured by the hanging method in Koje-Do was $2.4\%$ in June, $2.9\%$ in July, $30.7\%$ in October, $37.3\%$ in November and $30.0\%$ in December, respectively 3. The diseased oysters had severe inflammation, necrosis and multiple abscess in the epithelia of stomach, mid-gut, digestive tubules, blood vessels and gonads, mucous membrane and surrounding tissue. 4. From August gram negative bacteria were found in the nodules of connective tissue and multiple abscess of the diseased oysters. Particularly the connective tissue of the diseased oysters contained more bacteria than epithelia. 5. Since the bacteria are less abundant in the region of digenerated tissue, mortality of the oysters is not caused only by the infectious bacteria but seems that is also caused by other environmental factors such as extreme temperatures and salinities.