• Structural Engineering and Mechanics
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• 제88권4호
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• pp.311-322
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• 2023

Riverine flood is one of the critical natural threats to river-crossing bridges. As floods are the most-occurred natural hazard worldwide, survival probability of bridges due to floods must be assessed in a speedy but precise manner. In this regard, the paper presents a reliability-based approach for a rapid assessment of failure probability of vulnerable bridge components under floods. This robust method is generic in nature and can be applied to both concrete and steel girder bridges. The developed methodology essentially utilizes limit state performance functions, expressed in terms of capacity and flood demand, for probable failure modes of various vulnerable components of bridges. Advanced First Order Reliability Method (AFORM), Monte Carlo Simulation (MCS), and Latin Hypercube Simulation (LHS) techniques are applied for the purpose of reliability assessment and developing flood fragility curves of bridges in which flow velocity and water height are taken as flood intensity measures. Upon validating the proposed method, it is applied to a case study bridge that experiences the flood scenario of a river in Gujarat, India. Research outcome portrays how effectively and efficiently the proposed reliability-based method can be applied for a quick assessment of flood vulnerability of bridges in any flood-prone region of interest.

• 한국결정성장학회지
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• 제7권1호
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• pp.143-150
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• 1997

본 연구는 수소로 희석된 $B_2H_6$를 도판트 소스 가스로 사용하여 이온 질량 주입(ion mass doping)을 하였을 때 다결정 박막의 전기적 특성과 도판트의 활성화시 방사 손상(radiation damage)의 효과에 대하여 고찰하였다. 다결정 박막에서 보론(boron)의 SIMS 분석과 컴퓨터 시뮬레이션인 TRIM92를 비교해서 가장 주입 확률이 높은 이온의 종류는 $B_2H_x\;^+$(x=1, 2, 3‥‥) 형태의 분자 이온임을 알았다. 높은 에너지의 질량 이온 주입 결과 시간에 따라 변화하는 비정질화된 층의 분율이 다결정 박막 내에 연속적인 비정질 충으로 존재하였다. 주입 이온의 질량 분리가 일어나지 않는 이온 질량 주입법(ion mass doping technique)에 의해 비정질화는 유발된다. 손상된 시편의 중간 열처리 온도 범위에서 도판트 활성화 거동과 역 열처리(reverse annealing) 효과가 관찰되었다. 이와 같은 연구의 결과 p-채널 다결정 박막 트랜지스터의 오프 스테이트(off-state) 전류는 방사 손상(radiation damage)에 의존한다.

• Bulletin of the Korean Chemical Society
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• 제15권5호
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• pp.394-399
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• 1994

The catalytic mechanism of malonyl-CoA synthetase from Rhizobium trifolii was investigated by the steady state kinetics and intermediate identification. Initial velocity studies and the product inhibition studies with AMP and PPi strongly suggested ordered Bi Uni Uni Bi Ping-Pong Ter Ter system as the most probable steady state kinetic mechanism of malonyl-CoA synthetase. Michaelis constants were $0.17{\pm}0.04 {\mu}M,\;0.24{\pm}0.18 {\mu}M\;and\;0.045{\pm}0.26 {\mu}$M for ATP, malonate and CoA, respectively. The TLC analysis of the $^{32}P-labelled$ products in reaction mixture containing $[{\gamma}-^{32}P]$ ATP in the absence of CoA showed that PPi was produced after the sequential addition of ATP and malonate. Formation of malonyl-AMP, suggested as an intermediate in the kinetically deduced mechanism, was confirmed by the analysis of $^{31}P-NMR$ spectra of AMP product isolated from the $^{18}O$ transfer experiment using $[^{18}O]$malonate. Two resonances were observed, corresponding to AMP labelled with zero and one atom of $^{18}O$, indicating that one atom of $^{18}O$ transferred from $[^{18}O]$malonate to AMP through the formation of malonyl-AMP. Formation of malonyl-AMP was also confirmed through the TLC analysis of reaction mixture containing $[{\alpha}-^{32}P]$ATP. These results strongly support the ordered Bi Uni Uni Bi Ping-Pong Ter Ter mechanism deduced from the initial velocity and product inhibition studies.

• 상하수도학회지
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• 제22권1호
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• pp.121-129
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• 2008

하천의 수질은 하천 흐름, 오염원 유입 그리고 하천내부의 수질변화 기작에 따라 변화한다. 일반적으로 하천의 수질모의는 시간의 흐름에 영향을 받지 않는 정상상태에 대하여 실시하나, 실제로 이러한 상황은 존재하지 않는 것이 현실이다. 따라서 하천의 수질상태에 대한 각종 정보가 정확하다고 하여도 수질모델에서 가정하는 근본적인 조건이 다른 경우 오차의 발생은 필연적인 사실이 된다. 본 연구는 하천의 수질모델링에 자주 사용되는 QUAL2E와 미국환경부에서 새로 개발하고 있는 QUAL2K 그리고 저자들이 개발한 CAP 수질모델을 금강의 대청댐 하류 약 30 km 구간에 대한 집중적인 현장 실측을 통해 확보한 자료를 이용하여 적용하여 모델링 결과를 비교하고 해당 지역의 수질모델링에 나타나는 오차의 원인을 밝혀내고자 수행되었다. 전체적으로 BOD5 및 COD의 경우 실측치보다 약간씩 낮게 모의되는 경향을 나타내었으며 TN과 TP의 경우 상대적으로 양호한 모의결과를 보이고 있다. 모델별로는 $BOD_5$와 TP의 경우 QUAL2E모델이, TN의 경우 QUAL2K모델이 가장 작은 오차를 나타내었으나 모델별로 오차정도의 차이가 유의성이 있다고 판단하기는 어렵다고 본다. 본 연구에서 모델링 오차의 가장 큰 원인에는 첫째, 정상상태 수질 모형이 하천의 수리동역학적 유동특성을 잘 반영하기 어렵다는 것과, 둘째, 현장에는 육안으로는 발견되지 않는 수많은 오염원이 존재하며 아직까지는 이를 체계적으로 추적하지 못하고 있다는 것, 셋째, 수질분석을 위해 하안에서 시료채취를 유입지천 또는 오염원이 완전하게 혼합되지 못한 상태에서 시행할 수 있는데 이에 대한 고려가 충분하지 못한 것을 들 수 있다.

• 인터넷정보학회지
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• 제14권3호
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• pp.78-85
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• 2013

The revelations made possible by Edward Snowden, a contractor of the US intelligence service NSA, are a sobering reminder that the Internet is not an 'anonymous' means of communication. In fact, the Internet has never been conceived with anonymity in mind. If anything, the Internet and networking technologies provide far more detailed and traceable information about where, when, with whom we communicate. The content of the communication can also be made available to third parties who obtain encryption keys or have the means of exploiting vulnerabilities (either by design or by oversight) of encryption software. Irrebuttable evidence has emerged that the US and the UK intelligence services have had an indiscriminate access to the meta-data of communications and, in some cases, the content of the communications in the name of security and protection of the public. The conventional means of judicial scrutiny of such an access turned out to be ineffectual. The most alarming attitude of the public and some politicians is "If you have nothing to hide, you need not be concerned." Where individuals have nothing to hide, intelligence services have no business in the first place to have a peek. If the public espouses the groundless assumption that State organs are benevolent "( they will have a look only to find out whether there are probable grounds to form a reasonable suspicion"), then the achievements of several hundred years of struggle to have the constitutional guarantees against invasion into privacy and liberty will quickly evaporate. This is an opportune moment to review some of the basic points about the protection of privacy and freedom of individuals. First, if one should hold a view that security can override liberty, one is most likely to lose both liberty and security. Civilized societies have developed the rule of law as the least damaging and most practicable arrangement to strike a balance between security and liberty. Whether we wish to give up the rule of law in the name of security requires a thorough scrutiny and an informed decision of the body politic. It is not a decision which can secretly be made in a closed chamber. Second, protection of privacy has always depended on human being's compliance with the rules rather than technical guarantees or robustness of technical means. It is easy to tear apart an envelope and have a look inside. It was, and still is, the normative prohibition (and our compliance) which provided us with protection of privacy. The same applies to electronic communications. With sufficient resources, surreptitiously undermining technical means of protecting privacy (such as encryption) is certainly 'possible'. But that does not mean that it is permissible. Third, although the Internet is clearly not an 'anonymous' means of communication, many users have a 'false sense of anonymity' which make them more vulnerable to prying eyes. More effort should be made to educate the general public about the technical nature of the Internet and encourage them to adopt user behaviour which is mindful of the possibilities of unwanted surveillance. Fourth, the US and the UK intelligence services have demonstrated that an international cooperation is possible and worked well in running the mechanism of massive surveillance and infiltration into data which travels globally. If that is possible, it should equally be possible to put in place a global mechanism of judicial scrutiny over a global attempt at surveillance.

• 유기물자원화
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• 제10권1호
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• pp.96-101
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• 2002

본 연구는 최적의 소화환경 하에서 하수슬러지에 순응된 고온 및 중온 식종균을 이용하여 음식물쓰레기와 하수슬러지를 다양한 비율로 섞어 회분식 혼합소화하여 최대 메탄생성 및 메탄생성율(MPR)에 관하여 고찰하였다. 고온과 중온조건에서 모두 음식물쓰레기의 투입분율과 농도의 증가에 따라 BMP수치가 높아지는 경향을 보였으나 40% 이상의 음식물쓰레기 투입은 lag-phase 의 장기화가 예상되었다. 누적메탄생성그래프의 비선형 회귀분석결과 40%의 음식물쓰레기 투입분율에서 가장 높은 메탄생성 속도를 보였으며 50% 이상의 음식물쓰레기 투입은 메탄생성율 증가에 유리하지 못하였다. 고온조건에서의 흔합소화는 기질농도가, 중온조건에서는 기질의 농도와 음식물쓰레기 투입분율 모두가 메탄생성을 좌우하는 중요인자로 판단되었다. 흔합소화의 상승효과는 C/N 비로 대변되는 nutrient balance와 음식물쓰레기의 투입에 의한 전체 혼합기질의 가수분해 동역학적 상수값의 증가 때문으로 사료된다.

• 한국수산과학회지
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• 제50권5호
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• pp.494-499
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• 2017

This study evaluated the abundance of fecal coliforms in oysters Crassostrea gigas, sea squirts Halocynthia roretzi and sea cucumbers Apostichopus japonicus in fisheries along the coast of Korea in 2014, and investigated the prevalence of antimicrobial resistance in Escherichia coli isolated from these fishery products. The ranges of fecal coliforms found in oysters, sea squirts and sea cucumbers were <18-20, <18-330 and <18-3,300 MPN (most probable number)/100 g, respectively. Sea squirts contained the greatest range of E. coli (<20-140 MPN/100 g), followed by sea cucumbers (<20-130 MPN/100 g) and oysters (<20-20 MPN/100 g). A total of 26 strains of E. coli were isolated from 34 sea squirt, 25 sea cucumber and 13 oyster samples. Strains thus isolated were tested for their susceptibility to 22 antimicrobial agents used in Korea for medical or veterinary therapy. E. coli isolates showed the greatest resistance to ampicillin (84.6%), followed by trimethoprim (34.6%), nalidixic acid (34.6%), tetracycline (30.8%), pipemidic acid (26.9%), streptomycin (23.1%), chloramphenicol (23.1%), trimethoprim/sulfamethoxazole (23.1%), and gentamicin (15.4%). Resistance to at least one antimicrobial agent was present in 88.5% of E. coli isolates. Of the 26 isolated, six strains (23.1%) were resistant to multiple antimicrobial agents.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1099-1104
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• 2014

Aims and Background: Ginsenoside Rh2, which exerts the potent anticancer action both in vitro and in vivo, is one of the most well characterized ginsenosides extracted from ginseng. Although its effects on cancer are significant, the underlying mechanisms remain unknown. In this study, we sought to elucidate possible links between ginsenoside Rh2 and phosphoglucose isomerase/autocrine motility factor (PGI/AMF). Methods: $KG1{\alpha}$, a leukemia cell line highly expressing PGI/AMF was assessed by western blot analysis and reverse transcription- PCR (RT-PCR) assay after transfection of a small interfering (si)-RNA to silence PGI/AMF. The effect of PGI/AMF on proliferation was measured by typan blue assay and antibody array. A cell counting kit (CCK)-8 and flow cytometry (FCM) were adopted to investigate the effects of Rh2 on PGI/AMF. The relationships between PGI/AMF and Rh2 associated with Akt, mTOR, Raptor, Rag were detected by western blot analysis. Results: KG1${\alpha}$ cells expressed PGI/AMF and its down-regulation significantly inhibited proliferation. The antibody array indicated that the probable mechanism was reduced expression of PARP, State1, SAPK/JNK and Erk1/2, while those of PRAS40 and p38 were up-regulated. Silencing of PGI/AMF enhanced the sensibility of $KG1{\alpha}$ to Rh2 by suppressing the expression of mTOR, Raptor and Akt. Conclusion: These results suggested that ginsenoside Rh2 suppressed the proliferation of $KG1{\alpha}$, the same as down-regulation of PGI/AMF. Down-regulation of PGI/AMF enhanced the pharmacological effects of ginsenoside Rh2 on KG1${\alpha}$ by reducing Akt/mTOR signaling.

• International Journal of Aeronautical and Space Sciences
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• 제8권1호
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• pp.10-20
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• 2007

For spacecraft attitude control, reaction wheel (RW) steering laws with more than three wheels for three-axis attitude control can be derived by using a control allocation (CA) approach.1-2 The CA technique deals with a problem of distributing a given control demand to available sets of actuators.3-4 There are many references for CA with applications to aerospace systems. For spacecraft, the control torque command for three body-fixed reference frames can be constructed by a combination of multiple wheels, usually four-wheel pyramid sets. Multi-wheel configurations can be exploited to satisfy a body-axis control torque requirement while satisfying objectives such as minimum control energy.1-2 In general, the reaction wheel steering laws determine required torque command for each wheel in the form of matrix pseudo-inverse. In general, the attitude control command is generated in the form of a feedback control. The spacecraft body angular rate measured by gyros is used to estimate angular displacement also.⁵ Combination of the body angular rate and attitude parameters such as quaternion and MRPs(Modified Rodrigues Parameters) is typically used in synthesizing the control command which should be produced by RWs.¹ The attitude sensor signals are usually corrupted by noise; gyros tend to contain errors such as drift and random noise. The attitude determination system can estimate such errors, and provide best true signals for feedback control.⁶ Even if the attitude determination system, for instance, sophisticated algorithm such as the EKF(Extended Kalman Filter) algorithm⁶, can eliminate the errors efficiently, it is quite probable that the control command still contains noise sources. The noise and/or other high frequency components in the control command would cause the wheel speed to change in an undesirable manner. The closed-loop system, governed by the feedback control law, is also directly affected by the noise due to imperfect sensor characteristics. The noise components in the sensor signal should be mitigated so that the control command is isolated from the noise effect. This can be done by adding a filter to the sensor output or preventing rapid change in the control command. Dynamic control allocation(DCA), recently studied by Härkegård, is to distribute the control command in the sense of dynamics⁴: the allocation is made over a certain time interval, not a fixed time instant. The dynamic behavior of the control command is taken into account in the course of distributing the control command. Not only the control command requirement, but also variation of the control command over a sampling interval is included in the performance criterion to be optimized. The result is a control command in the form of a finite difference equation over the given time interval.⁴ It results in a filter dynamics by taking the previous control command into account for the synthesis of current control command. Stability of the proposed dynamic control allocation (CA) approach was proved to ensure the control command is bounded at the steady-state. In this study, we extended the results presented in Ref. 4 by adding a two-step dynamic CA term in deriving the control allocation law. Also, the strict equality constraint, between the virtual and actual control inputs, is relaxed in order to construct control command with a smooth profile. The proposed DCA technique is applied to a spacecraft attitude control problem. The sensor noise and/or irregular signals, which are existent in most of spacecraft attitude sensors, can be handled effectively by the proposed approach.

• 대한교통학회지
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• 제20권7호
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• pp.177-183
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• 2002

현재 국내 VMS 운영은 대체로 소극적 정보제공에 머물고 있으며, 정보제공 우선순위. 조합 가능한 메시지 집합 등이 포함된 간단한 형태의 지식기반 추론엔진 방식에 의하고 있다. 또한 VMS 관련 연구도 해당도로의 상황을 정확히 검지하고 예측하는 방법론 개발에 집중되어 있다. 그러나 VMS도 적극적 운영을 통하여 교통관리의 수단으로 활용해야 하며, 이에 있는 그대로 상황을 전달하는 현 Practice에서 진일보한 전략적 정보제공 기술이 개발되어야 한다. 본 연구에서는 네트워크 차원의 교통관리를 목적으로 한 VMS 자동제어 알고리즘을 제안하였다. 외란의 불확실성과 모형의 정확도에 강한(robust) 피드백 제어방식을 채택하였고, 알고리즘은 시스템 최적 달성을 목표로 설정한 여유용량 균등화 Regulator와 VMS Display 모듈로 구성된다. 여유용량의 산정은 도로용량편람의 용량 개념과 차별화 되는 개념을 제안하였으며 이 부분에 대한 구체적 산정방식의 개발은 향후과제로 남겨두었다. 두 개의 대안경로로 구성된 실제 도로망에 대한 모의실험을 통하여. 여유용량균등화 Regulator에 의한 통행 재배분 효과를 제한적으로나마 살펴보았다. 그러나 VMS Display Strategy 모듈에 의한 실제 통행배분 행태는 모의실험의 한계성으로 인하여 검증하지 못하였으며 이를 향후과제로 남겨두었다.