• Clinical and Experimental Pediatrics
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• v.48 no.10
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• pp.1090-1095
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• 2005

Purpose : In the case of serious respiratory distress syndrome(RDS) or relapse of clinical appearances after single treatment, we obtained more effective results with multiple-dose surfactant replacement therapy. We carried out this investigation for comparing and observing clinical progress between single-dose(group S) and multiple-dose(group M) pulmonary surfactant treatment group of neonatal RDS. Methods : We investigated 48 neonates who were diagnosed as RDS and treated with pulmonary surfactant(PS) replacement therapy in NICU of Kyunghee University hospital from January 2002 to March 2004, then we compared and verified clinical progress of 32 neonates in group S with that of 16 neonates in group M. Results : There were no significant statistical differences in average birth weights, average gestational periods, initial pH values of birth, whether operation of resuscitation at that time of birth was made or not, whether prenatal steroid prescription for mother, RDS classification standardized by Bomsel, and ventilation index(VI) before instillation of PS of two groups. However, there was significant statistical difference in a/A $PO_2$(P<0.05). We could observe changes of VI and a/A $PO_2$ within 72 hours have been continuously improved at group S rather than group M. In spite of relapses, group M changed for the better after second dose. There were also no significant differences between the two groups in duration of ventilator therapy, mortality within 28 days after birth, intraventricular hemorrhage by complication, retinopathy of premature, necrotizing enterocolitis, chronic lung diseases, sepsis, and DIC. Conclusion : In these relapse cases, as there were no significant differences in the mortality rate and the occurence of complication between group S and group M, the requirement of multiple-dose PS replacement therapy which brought improvement of prognosis was emphasized.

• Korean Journal of Poultry Science
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• v.44 no.2
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• pp.143-149
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• 2017

This study was carried out to collect basic data on the egg laying performance and disease occurrence on animal welfare-approved farms (AWAF) for laying hens with different housing types (windowless, open, and free-range house) and strains (Hy-line, Lohmann). Age at first egg laying was 151 d in the windowless house and 141 d in both the open and free-range houses, and the percentage peaks of each farm were 91.8%, 92.9%, and 86.3%. Average egg production according to housing types were 70.9%, 77.4%, and 65.6% at 18~38 wk old and 91.1%, 90.1%, and 76.2% at 32~36 wk. The average dirty and cracked egg ratio of the windowless, open, and free-range houses was 2.84%, 1.15%, and 0.23%, respectively. Mortality in the open house was lower than the other house types. Age of first egg laying for the Hy-line strain was 155 d and that for the Lohmann strain was 157 d, and the percentage peaks of the two strains were 92.9% (252 d) and 87.2% (237 d), respectively. Average egg production of the strains was 83.7% and 76.9%, respectively. The average dirty and cracked egg ratio of the Hy-Line and Lohmann strains was 3.85% and 2.97%, respectively. Mortality of the Hy-Line strain was lower than that of the Lohmann strain. There were significant differences (P<0.05) in the egg weight, HU, and egg yolk color of chickens raised in the open house compared with those of chickens raised in the other house types. In terms of antibody titer, that for Newcastle disease in open house chickens was lower than that of chickens raised in windowless and free-range houses. The antibody titer for low pathogenic avian influenza, avian infectious bronchitis, and avian pneumovirus was high at over 3.0 in all three farms. SG, Salmonella enteritidis, Salmonella pullorum, fowl adenovirus infection, and infectious laryngotrachitis were not detected in any of the three house types. The number of AWAF for laying hens has continuously increased in Korea, but there is currently little data on the housing types used on the AWAF for laying hens. Therefore, the results of the present study, in which analyzed the laying performance and disease occurrence on AWAF for laying hens, can use as basic data for the improvement of performance and prevention of disease on further AWFA for laying hens.

• Journal of Chest Surgery
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• v.37 no.8
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• pp.652-659
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• 2004

Background: In this study, we retrospectively analyzed the outcomes of aortic valvuloplasty in pediatric age. Material and Method: Between January 1993 and March 2004, 35 patients underwent aortic valvuloplasty for aortic stenosis (AS) or aortic regurgitation (AR). The mean age was 81.1$\pm$61.5 (1∼223) months. The mean follow up was 50.8$\pm$30.2 (3∼121) months. Nine patients had AS, 21 had AR, and 6 had AS and AR. Valve morphology was tricuspid in 24 patients, bicuspid in 9, quadricuspid in 1, and unicuspid in 1. The mean peak pressure gradients of AS were 72.0$\pm$33.0 mmHg, and the mean grades of AR were 3.1$\pm$0.9. Result: There was one late mortality without early mortality. After operation, AS improved with mean peak pressure gradients of 23.5$\pm$21.0 mmHg (p < 0.05), and AR improved with mean grades of 1.9$\pm$0.8 (p < 0.05). At mean follow up of 35.0$\pm$23.0 months, AS maintained with mean peak pressure gradients of 31.5$\pm$24.0 mmHg, but AR progressed with mean grades of 2.8$\pm$1.3 (p < 0.05). Reoperation was required in 6 patients 38.3$\pm$21.8 months after the original operation. The actuarial figures for freedom from reoperation at 2, 5 and 8 years were 96.9$\pm$3.1%, 79.5$\pm$5.5%, and 56.8$\pm$11.4%, respectively. Age at operation, presence of AS, preoperative severity of AS or AR, and morphology of aortic valve were not significant risk factors for reoperation, and improvement of AS or AR. Conclusion: Aortic valvuloplasty showed good immediate postoperative valve function. Aortic valvuloplasty offers children many years with tolerable valve function and allows to postpone aortic valve replacement or Ross procedure in pediatric patients.

• FLOWER RESEARCH JOURNAL
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• v.19 no.1
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• pp.15-21
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• 2011

This study investigated the effect of soil mulching materials and methods on weed occurring for the growth and flowering characteristics in Gypsophila plants cultivation. For mulching materials were used black polyethylene (PE) film, black polypropylene (PP), and green polypropylene, and these were mulched in both ridge and furrow (BRF) or only furrow, respectively. The weed was occurred total $146.2g/m^2/yr$ as dry weight in non-mulching, but $4.1{\sim}4.2g/m^2/yr$ in BRF mulching by black or green PP. Also weed control were yearly required 27.9 persons/10a in non-mulching, whereas 2.4 persons/10a in BRF mulching by black or green PP. Flower budding and blooming were roughly delayed in non-mulching and furrow mulching. Flowering characteristics such as flower stalk length, primary branches number, and stem firmness were remarkably improved in BRF mulching of black or green PP. Cut flower yield was increased on black BRF mulching or green PP in summer cultivation, while green PP BRF mulching showed better yield in in autumn cultivation. Mortality rate of Gypsophila plants after summer season was lowest as 12.4% in furrow mulching with black PP, followed by about 19.0% in green PP mulching, but highest as 39.0% in BRF mulching with black PE film. Rosette formation rate was lower in furrow than BRF mulching, and was lowest as 13.1% in BRF mulching with green PP, followed by 15.2~15.8% in BRF mulching with black PE film or black PP. So it was thought that BRF mulching with green PP was highly effective in weed control and improvement of yield and cut flower quality in Gypsophila plants cultivation.

• Journal of Chest Surgery
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• v.13 no.4
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• pp.422-434
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• 1980

Since 1968 up to the end of October 1980, 448 valves were replaced in 354 patients in Seoul National University Hospital. There were 238 mitral, 38 aortic, 7 tricuspid, 45 aortic with mitral, 23 tricuspid with mitral, and 3 triple valve replacement aortic mitral and tricuspid cases. Annual increase of mitral valve replacement cases and decrease of operative maortality were remarkable. Recently operative mortality of mitral valve replacement is about 5%. Sex ratio of mitral valve replacement is almost equal and there were 12 cases of pediatric patients (5%) among 238 cases, and patients under the age of 20 years were 34 (14.3%). Mitral valve replacement was done for 199 single mitral, 38 double valve and one triple valve lesions. Among 238 mitral valve replacement paients left atrial thrombus in 23(9.7%), atrial fibrillation in 132 (55.5%), and reoperation after blind mitral commissurotomy in 12(5%) cases were noted. In recent cases bioprosthetic valves, mainly lonescu-shiley valve were utilized to overcome the difficulties of postoperative late complications in anticoagnuation, especially for the rural patients and pediatric cases, in addition to the hemodynamic advantages of lonesocu valve. Among 354 patients 16 cases were congenital heart anomaly related, 5 ventricular septal defect related aortic and 4 Ebstein related tribuspid valve replacement cases. There were 2 congenital anomaly related mitral valve replacements, one for congenital mitral insufficiency of 7 years old boy and one for corrected transposition of the great vessels associated with mitral insufficiency. Among total 354 valve replacements 49 operative deaths (13.3%) were noted and in 238 mitral valve replacement 24 operative deaths occurred (10.1%). In 39 patients among 354 total valve replacements late complications were found. In 238 mitral valve replacement cases late complications were noted in 26 patients, among whom 16 cases expired. Main late complications were thrombe-embolism, subacute becteerial endocarditis, arrythmia cerebral hemorrhage due to unsatisfactory anticoagulation, and congestive heart failure in the incipient period of valve replacement were also noted. In mitral valve replacement cases long-term survival rate was 83.2% who showed marked clinical improvement. Ther were no evidences of calcification during the 2 years follow-up period for the lonescu-valve replacement cases among 19 pediatric patients. In conclusion 238 cases of mitral valve replacement were done with 24 operative deaths and 26 late complication cases among whom 16 expired. The long term survival was 83.2% of the cases. In pediatric cases in place of coumadin anticoagulation Persantin **** 75 and aspirin were administered after valve replacement. In adult cases who have difficulaties with coumadin anticoagulation and for those even with bioprosthetic heart valve replacement who needs long-term or permanent anticoagulation persantin 75 and aspirin combination regimen were administered with antisfactory results.

• Journal of Fisheries and Marine Sciences Education
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• v.27 no.6
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• pp.1646-1655
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• 2015

Korean government has issued the ratings standard for disease control of aquaculture farms according to the Aquatic Life Disease Control Act in 2008. There are five rating criteria within the enforcement regulations; period of disease free, performance of disinfection, environmental and hygienic management, keeping record of trade and sales, completion of education for disease control. There are no application has been applied on the basis of the rating criteria so far because detailed subcriteria and scoring indicators has not established for assessment process. In order to apply the ratings standard for disease control, we set up the subcriteria and new scoring for rating disease control level based on legal criteria in this study. This study was conducted on 90 targeted olive flounder farms in Jeju. The result of disease control level assessment on olive flounder aquaculture farms show the overall average of Jeju-do was 72.9 points and differed depending on the district; 74.7 in Jeju-si and 71.1 in Seogwipo-si, respectively. The Spearman correlation of each evaluation index show the disease control level score was correlated highly with the performance of disinfection(R=0.715, p<0.01), and environmental and hygienic management(R=0.661, p<0.01). The result of correlation analysis show that there is the highest correlation between the aquaculture farm status and the total mortality(R= -0.618, p<0.01). The reliability of the results are considered to be accurate in the Cronbach's alpha value of 0.727.

• Journal of the Korean Society of Marine Environment & Safety
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• v.16 no.4
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• pp.339-344
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• 2010

Oxygen depleted water mass can damage aquatic animals not only in direct way but also in indirect way by generating toxic substances including occurrence of hydrogen sulfide and ammonia which are also highly detrimental to animal life in the water mass. An oxygen dissolution device was developed, which makes turnover of the oxygen rich (over 20 mg/L) surface water down to the bottom where hypoxia is evident and tested the device in terms of oxygen recovery in the oxygen depleted bottom water. the device with turnover rates of $3.6\;m^2$/min at the liquid oxygen injection rate of 48~26.3 L/min could recover dissolved oxygen level to 7~25 mg/L at depth 7 m to lead to the dissolution level of over 90% by the supply of liquid oxygen. The running advantage of the device is that it does not require any auxiliary tank and higher energy for operation. Therefore, it can be highly useful device to relieve damages to the farmed animals in the oxygen depleted waters.

• Journal of Chest Surgery
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• v.20 no.1
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• pp.112-127
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• 1987

Myasthenia gravis is a neuromuscular transmission function disorder characterized by fatigue and weakness of voluntary muscles. This muscular weakness is intensified by activity and stress, and improved by the use of anticholinesterase compounds. It was initially described by Erb in 1879 and later named myasthenia gravis by Jolly in 1895. Although the pathogenesis is Known to be an autoimmune related reduction in the number of available acetylcholine receptors at neuromuscular junctions, the role of thymus in myasthenia gravis is still unclear and under investigation. Thymectomy in the management of myasthenia gravis has become increasingly important since Dr. Blalock observed in 1939 that some patients with thymic tumors and myasthenia gravis improved following thymectomy. A clinical study of 102 cases of myasthenia gravis was performed at Yonsei University College of Medicine. Seoul, Korea from Jan. 1976 to Jun. 1986. In order to determine which factors are of prognostic significance, attention is focused upon pre-operative patient evaluation, problems in operative and post-operative care, and long-term follow-up observations. The results were as follows: 1. The sex distribution was 67 females and 35 males, the mean age of onset was 28.95*1.69 years, and the maximal incidence occurred between 21 and 40 years of age [56 cases: 54.9%]. 2. Clinical manifestations of ocular symptoms were seen to 70 patients [68.6%] extremities weakness in 33 [32.3%], bulbar weakness in 29 [28.4%], and dyspnea in 13 [12.7%]. 3. Study cases more than two thirds were classified as mild types [MG 1 and MG 11A] and 6 cases as grave [MG 1V] based on the modified Osserman`s classification system, 4. Thymectomy was performed in 19 cases which presented in severe myasthenia symptoms and showed no improvement with cholinergic drugs. Histologic examination of the excised thymus glands revealed no abnormalities in 4 cases, thymic hyperplasia in 5, benign thymoma in 5, and malignant thymoma in 5. 5. Immediate post-operative complications included 2 cases of pneumothorax which were treated by tube thoracostomies, there was no operative mortality. 6. The response to cholinergic drugs in 36 cases younger than 20 years old and in 27 cases older than 40 years was relatively poor, while that in 35 cases between the ages of 21 and 40 years old was good. 7. Thirty of 39 cases in groups IIB, III & IV improved markedly with medical or surgical management while only 16 of 59 cases in the mild groups [I and IIA] improved, almost all surgical cases improved in all categories. 8. There were 5 deaths. occurring between 7 months and 3 years 3 months of treatment of myasthenia gravis. The causes of death were myasthenic crisis in 2 cases, respiratory failure due to candidiasis & radiation pneumonitis in one case, cerebral hemorrhage due to high blood pressure in two case.

• The Journal of Internal Korean Medicine
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• v.35 no.1
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• pp.37-49
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• 2014

Objectives & Methods : The objective of this study was to evaluate the single oral dose toxicity of Chongmyung-tang (CMT) in ICR mice. Korean traditional herbal prescription CMT has traditionally been used as a neuroprotective for treatment of learning disability and memory improvement. CMT, lyophilized aqueous extracts (yield=9.7%) were administered to female and male mice with oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines. Animals were monitored for mortality, changes in body weight, clinical signs and gross observation during 14 days after administration upon necropsy; organ weight and histopathology of 14 principle organs were examined. Results : We could not find any CMT extracts treatment related mortalities, clinical signs, changes in body and organ weight, or gross and histopathological observations against 14 principle organs up to 2,000 mg/kg in both female and male mice, except for some accidental sporadic findings which did not show any obvious dose-relations and most of which also demonstrated in both the female and male vehicle control mice in this experiments. Conclusions : Based on the results of this experiment, the 50% lethal dose ($LD_{50}$) and approximate lethal dose (ALD) of CMT extracts after single oral treatment in female and male mice can be considered to be over 2,000 mg/kg, and is likely to be safe in humans.

• Journal of Sericultural and Entomological Science
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• v.16 no.2
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• pp.141-146
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• 1974

This study was carried out to observe the possibility of special rearing of young silkworm for a simple cooperative rearing in the indoor vinyl house. The results of this study are as follows. 1. Temperature and humidity were regulated reasonably in the indoor vinyl house in comparison with general rearing and covered rearing with damp-proof and all workings in it were more convenient. 2. Duration of silkworm life was same in the covered rearing with damp-proof and indoor vinyl house, but general rearing was longer spring rearing silkworm period, 5 hours and autumn young silkworm period. 6 hours than indoor vinyl house. 3. In the mortality ratio, missing larvae of general rearing was more than any other treatments in spring and autumn. There was no difference between covered rearing with damp-proof and indoor vinyl house rearing, but missing larvae seemed to be a little indoor vinyl house. 4. In the individual cocoon ratio there was no significance in spring and autumn, but best cocoon ratio was high in the special rearing and good and low cocoon ratio was high in the general rearing. 5. In the cocoon weight of 10,000 3rd moulted silkworm. cocoon weight of general rearing was less than any other treatments in spring rearing season, and that of covered rearing with damp-proof and indoor vinyl house rearing It was same result. 6. There was no significance in the cocoon layer ratio in spring and autumn, but that of covered rearing with damp-proof and indoor vinyl house was high in comparison with general rearing. 7. As showed above, it is considered that the rearing of indoor vinyl house is worth as special rearing of young silkworm for simple cooperative rearing because it showed good records with three times feedings a day in comparison with general rearing and covered rearing with damp-proof.