• Journal of mucopolysaccharidosis and rare diseases
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• 제4권1호
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• pp.21-25
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• 2018

Fabry disease is a hereditary lysosomal storage disorder caused by the reduction or absence of lysosomal enzyme alpha-galactosidase A and the accumulation of glycosphingolipids, such as globotriaosylceramide (Gb3), in various organs, including the heart. The prevention of cardiac involvement in Fabry disease can only be achieved by enzyme replacement therapy (ERT), and the method of assessing the efficacy of ERT should be confirmed. Changes in the electrocardiogram, such as the shortening of PQ interval, prolongation of QTc and repolarization abnormalities as well as left ventricular hypertrophy in voltage criteria, can be used to identify Fabry disease patients; however, the usefulness of electrocardiograms for evaluating the efficacy of ERT is limited. The assessment of left ventricular hypertrophy using echocardiography has been established to evaluate the efficacy of ERT during long-term period. A new technique involving speckled tracking method might be useful for detecting early cardiac dysfunction and identifying the effect of ERT for a relatively short period. The estimation of left ventricular hypertrophy using cardiac magnetic resonance (CMR) is also useful for assessing the efficacy of ERT. Identifying late gadolinium enhancement in CMR may affect the effectiveness of ERT, and the new technique of T1 mapping might be useful for monitoring the accumulation of Gb3 during ERT. Histopathology in cardiac biopsy specimens is another potentially useful method for identifying the accumulation of GB3; however, the use of histopathology to evaluate of the efficacy of ERT is limited because of the invasive nature of an endomyocardial biopsy.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.769-773
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• 2013

Background: A literature review on 1,104,269 cancer patients concluded that the prevalence of multiple primary malignancies (MPM) is between 0.73% and 11.7%. MPMs seem to have higher incidence than that influenced by hazard only. The purpose of this study was to investigate clinically useful information for effective screening for synchronous and metachronous second primary cancers and to identify a potential surveillance protocol. Materials and Methods: Using statistical and epidemiological indicators we evaluated the patients with MPMs (double locations) admitted to Dr. Abdurrahman Yurtarslan Ankara Oncology Education and Research Hospital between 1981 and 2010. Results: Out of the 130 cases, 24 (18.4%) were synchronous while 106 cases (81.6%) were metachronous tumours. Mean interval time from first to second primary cancers was 4.65 years (0-27 years). The most frequent malignant associations were breast-breast, breast-endometrium and breast-ovary. Both primary and secondary tumors tended to be in an advanced stage explained by the low compliance of the patients to follow-up. Conclusions: The possibility that MPMs exist must always be considered during pretreatment evaluation. Screening procedures are especially useful for the early detection of associated tumors, whereas careful monitoring of patients treated for primary cancer and a good communication between patients and medical care teams should ensure early detection of secondary tumors, and subsequent appropriate management.

• 센서학회지
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• 제26권4호
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• pp.239-244
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• 2017

Noninvasive, cuffless, and continuous blood pressure (BP) monitoring is essential to prevent and control hypertension. A well-known existing method for this measurement is pulse transit time (PTT), which has been investigated by many researchers as a promising approach. However, the fundamental principle of the PTT method is based on the time interval taken by a pulse wave to propagate between the proximal and distal arterial sites. Consequently, this method needs an independent system with two devices placed at two different sites, which is a problem. Even though some studies attempted to synchronize the system, it is bulky and inconvenient by contemporary standards. To find a more sensitive method to be used in a BP measurement device, this study used radial electrical bioimpedance (REB) as a potential indicator for BP determination. Only one impedance plethysmography channel at the wrist is performed for demonstrating a ubiquitous BP wearable device. The experiment was evaluated on eight healthy subjects with the ambulatory BP monitor on the upper arm as a reference. The results demonstrated the potential of the proposed method by the correlation of estimated systolic (SBP) and diastolic (DBP) BP against the reference at $0.84{\pm}0.05$ and $0.83{\pm}0.05$, respectively. REB also tracked the DBP well with a root-mean-squared-error of $7.5{\pm}1.35mmHg$.

• 산업경영시스템학회지
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• 제35권3호
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• pp.52-61
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• 2012

The design method for cumulative sum (CUSUM) control charts, which can be robust to autoregressive moving average (ARMA) modeling errors, has not been frequently proposed so far. This is because the CUSUM statistic involves a maximum function, which is intractable in mathematical derivations, and thus any modification on the statistic can not be favorably made. We propose residual-based robust CUSUM control charts for monitoring autocorrelated processes. In order to incorporate the effects of ARMA modeling errors into the design method, we modify parameters (reference value and decision interval) of CUSUM control charts using the approximate expected variance of residuals generated in model uncertainty, rather than directly modify the form of the CUSUM statistic. The expected variance of residuals is derived using a second-order Taylor approximation and the general form is represented using the order of ARMA models with the sample size for ARMA modeling. Based on the Monte carlo simulation, we demonstrate that the proposed method can be effectively used for statistical process control (SPC) charts, which are robust to ARMA modeling errors.

• 한국환경과학회지
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• 제15권10호
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• pp.961-966
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• 2006

An algal assay procedure using an indigenous phytoplankton assemblage was tested to estimate the propagation of red tide phytoplankton species and determine the optimal time interval at which to measure growth yield in eutrophic marine waters where red tides frequently occur. Various red tide phytoplankton species were propagated on a large scale by adding nitrogen or phosphorous. This procedure was useful for estimating the limiting nutrient, elucidating the mechanisms underlying red tides, and determining the levels of increases in organic matter in eutrophic coastal waters. The algal assay using indigenous C. polykrikoides showed that this species did not always propagate, apparently because of very low concentrations of trigger elements that are necessary for its growth, rather than as a result of other environmental characteristics, e.g., water temperature or stress from sampling. In the winter, when water temperatures are lower than in spring, summer, or autumn, maximum propagation and the limiting nutrient could be estimated by measuring phytoplankton biomass at 2 - 3-day intervals. However, in the other seasons, when water temperatures are higher, phytoplankton biomass should be measured at 2-day intervals. In particular, daily monitoring will be required to determine precise growth yields in warm seasons.

• Journal of the Korean Data and Information Science Society
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• 제28권2호
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• pp.451-459
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• 2017

There are many researches showing that when a process change has occurred, variable sampling intervals (VSI) control chart is better than the fixed sampling interval (FSI) control chart in terms of reducing the required time to signal. When the process engineers use VSI control procedure, frequent switching between different sampling intervals can be a complicating factor. However, average number of samples to signal (ANSS), which is the amount of required samples to signal, and average time to signal (ATS) do not provide any control statistics about switching performances of VSI charts. In this study, we evaluate numerical switching performances of multivariate VSI EWMA chart including average number of switches to signal (ANSW) and average switching rate (ASWR). In addition, numerical study has been carried out to examine how to improve the performance of considered chart with accumulate-combine approach under several different smoothing constant and sample size. In conclusion, process engineers, who want to manage the correlation coefficients of related quality variables, are recommended to make sample size as large and smoothing constant as small as possible under permission of process conditions.

• 반도체디스플레이기술학회지
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• 제11권3호
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• pp.57-61
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• 2012

In order to analyze the ECG, it is important to pinpoint the repeat interval of the ECG. In this paper, we present an efficient algorithm for finding the QRS complex on the ECG. We escaped from the conventional methods to go through multiple steps of preprocessing to make ECG easier to find the QRS complex. We selected the candidate peak that has the possibility of the QRS complex in original ECG, and used technique to find the QRS complex among the candidate peak. In this way, we could get similar efficiency to Pan & Tompkins Algorithm that is most representative QRS complex detection algorithm, just used fewer operations than Pan & Tompkins Algorithm.

• 전기학회논문지
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• 제58권5호
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• pp.1050-1056
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• 2009

Heart Rate Variability(HRV) is a parameter that represents monitoring variability of time intervals between R-peak in electrocardiography. HRV serves to various applications, such as indices of autonomic functions, prediction of cardiac sudden death, assessment of stress and emotional, etc. However, as measuring R-peak in ECG needs at least 3-electrodes, and it is inconvenient for end users. In this paper, we suggested the modified laplacian electrodes for measuring HRV at one-point, which are producted by MEMS fabrication and have the two circular electrodes on the pad. For optimal position and direction, we performed an experiment that compared with pearson correlation coefficient and the amplitude of signals, between standard lead II and proposed electrodes. We analyzed the HRV parameters, such as standard deviation of the NN interval(SDNN), high frequency(HF), low frequency(LF), LF/HF ratio. The result showed that the average correlation coefficient and amplitude are 0.967 and 0.685 mVpp at the position 2. The coeffiecient correlation between the standard HRV and proposed electrode-HRV is 0.999

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2018년도 춘계학술발표대회
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• pp.260-261
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• 2018

다수의 사용자가 동시에 가상머신을 사용하는 클라우드 환경은 자원 사용량을 예측하기 힘들기 때문에 사용자의 자원 요구량과 성능을 만족시키기 위해 지속적으로 마이그레이션, 오토스케일링과 같은 가상머신 관리 작업을 수행한다. 가상머신 관리 시 참조되는 가장 중요한 정보는 가상머신과 물리머신의 자원 모니터링 정보이다. 클라우드 센터에서 자원 모니터링 작업은 가상머신 관리 시 필수적이지만 모니터링 정보 수집 시 사용하는 자원은 물리머신의 자원을 사용하기 때문에 모니터링 주기가 짧으면 모니터링 작업을 위한 자원 사용으로 인해 가상머신과 자원 경쟁이 발생할 수 있다. 본 논문에서는 물리머신에서 실행 중인 가상머신의 작업의 유형에 따른 최적의 모니터링 주기를 도출하기 위해 자원 모니터링 주기가 가상머신의 성능에 미치는 영향을 분석하고 모니터링 작업으로 인해 발생하는 가상머신의 성능 저하를 최소화 할 수 있는 최적의 모니터링 주기를 도출한다.

• 설비공학논문집
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• 제16권10호
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• pp.914-922
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• 2004

In this study, measurement and analysis of energy consumption of a research building have been conducted. The energy audit procedure includes monitoring of electricity and LNG consumption over a period of three yews from 2000 to 2002. Data acquisition system for collecting energy consumption data of HVAC equipment such as chillers, fan filter units, AHUs, cooling towers, boilers, pumps, fan coil units, air compressors and etc. has been installed in a building located in Seoul. Data collected at an interval of 1 minute are analyzed for studying the energy consumption pattern of a research building. Percentage of energy consumption of all HVAC equipment is $51.0\%$ in 2000, $55.4\%$ in 2001, and $62.3\%$ in 2002, respectively. Electricity consumption of chillers accounts for $17.6\%$ of the total energy consumption, which is the largest. Annual energy consumption-rate per unit area is $840.5Mcal/m^2{\cdot}y$ in 2000, $1,064.8Mcal/m^2{\cdot}y$ in 2001, and $1,393.0Mcal/m^2{\cdot}y$ year 2002, respectively.