• 한국임상약학회지
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• 제2권1호
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• pp.11-22
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• 1992

Thymic extract showed antitumor effect to sarcoma mice with higher dose$(200{\mu}g/mouse/day$ i.p., 4weeks) but not with low dose$(5{\mu}g/mouse/day$ i.p., 6 weeks). Direct cytotoxicities were exhibited against sarcoma 180, L1210 and MOLT-4 by MTT assay. The spleen weight of mice were increased but the number of circulating lymphocytes were not increased after long-term(2 weeks) administration of thymic extract. Evaluating the mitogenesis by MTT assay. $\%$ absorbance of human lymphocytes was not increased by thymic extract. Cell cycle statistics of S phase and $G_2/M$ phase was not increased in the presence of that by PI staining. The formation of rosette was induced, irrespectively of exposure time short-term(l hour) and long-term(2 weeks). The population of mouse blood T-cell to bind Lyt2-antimonoclonal antibody and to $L_2T_4$ were increased after administration of thymic extract$(2-200{\mu}g/mouse/day)$. From the above results, it is suggested that thymic extract exerts antitumor activity by stimulating T cells to differeniate in vivo but not in vitro.

• Bulletin of the Korean Chemical Society
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• 제35권12호
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• pp.3571-3575
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• 2014

Proteasome, a multicatalytic protease complex, has been validated as a promising therapeutic target in oncology. Carfilzomib (Kyprolis$^{(R)}$), a tetrapeptide epoxyketone, irreversibly inhibits the chymotrypsin-like (CT-L) activity of the proteasome and has been recently approved for multiple myeloma treatment by FDA. A chemistry effort was initiated to discover the compounds that are reversibly inhibit the proteasome by replacing the epoxyketone moiety of carfilzomib with a variety of ketones as reversible and covalent warheads at the C-terminus. The newly synthesized compounds exhibited significant inhibitory activity against CT-L activity of the human 20S proteasome. When the compounds were tested for cancer cell viability, 14-8 was found to be most potent in inhibiting Molt-4 acute lymphoblastic leukemia cell line with a $GI_{50}$ of $4.4{\mu}M$. Cytotoxic effects of 14-8 were further evaluated by cell cycle analysis and Western blotting, demonstrating activation of apoptotic pathways.

• 대한지리학회지
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• 제36권3호
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• pp.217-232
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• 2001

우리나라 지형학연구의 가장 중요한 쟁점 중 하나는 산록에 분포하는 사면경사가 완만한 지형면 형성과정 에 대한 논의이다. 경주 남쪽에서 울산에 이르는 불국사단층선을 따라 분포하는 전체 선상계피 지형면을 분류하여 선상지의 공간분포 특징을 밝히고 선상지 형성과정을 검토하였다. 불국사산맥의 서사면에 분포하는 선상지는 불국사 단층선곡을 따라 남-북 방향으로 연속되어 합류선상지를 이루고 있다. 울산만에 인접한 신천-효문지역의 선상지분포 는第四紀 해면변동의 영향을 받았다. 연구지역에 발달된 선상지형성에 기여했을 다양한 요소들 중 중요한 네 가지 는 동결과 융해 가 반복되는 기각이 길어지는 빙기의 기후환경, 동해 쪽에서 내륙 쪽으로 향하는 횡압력에 의해 형성 된 불국사산지 서사면의 급한 사면경사, 이 구조운동에 의해 형성된 불국사단층선곡에 발달된 복수의 지질구조선, 그 리고 침식에 대한 저항력이 약한 불국사화강암과 중생대 퇴적암의 이루어진 이 지역의 기반암의 등으로 정리된다.