• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.970-970
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• 2005

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.972-972
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• 2005

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.958-959
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• 2005

• 한국정보과학회논문지:시스템및이론
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• 제35권6호
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• pp.237-247
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• 2008

가상 탐색은 대규모의 화학분자 데이타베이스의 화학분자 데이타들을 분자 다킹과 같은 컴퓨팅 기술을 이용하여 한정된 소규모의 화학분자만을 스크리닝하는 과정으로, 대규모 컴퓨팅 파워와 데이터 저장 용량을 요구하는 대표적인 대규모의 과학 어플리케이션이다. AutoDock, FlexX, Glide, DOCK, LigandFit, ViSION 등과 같은 기존의 분자 다킹 소프트웨어나 어플리케이션들은 슈퍼 컴퓨터, 단일 클러스터, 또는 단일 워크스테이션 둥을 이용하여 작업을 수행하도록 개발되었다. 하지만 슈퍼컴퓨터를 이용한 가상 탐색은 너무 많은 비용이 든다는 문제점이 있고, 단일 클러스터나 워크스테이션을 이용한 가상 탐색은 오랜 수행 시간이 요구되는 문제점을 가지고 있다. 이에 본 논문에서는 대규모의 데이타 집약적인 연산을 지원하는 그리드 컴퓨팅 기술을 이용하는 서비스 기반 가상 탐색 시스템을 제안한다. 이를 위해 본 논문에서는 가상 탐색을 위한 3차원 화학 데이타베이스를 구축하였다. 그리고 효율적인 분자 다킹 서비스를 제공하기 위해 자원 브로커와 데이타 브로커를 설계하고 가상 탐색을 위한 다양한 서비스들을 제안하였다. 본 논문에서는 DOCK 5.0과 Globus 3.2를 이용하여 서비스 기반 가상 탐색 시스템을 구현하고 성능 평가를 실시하였다. 본 논문에서 구현한 서비스 기반 가상 탐색 시스템은 신약 개발이나 신소재 개발 과정에서 연구 개발 기간을 단축하고 개발 비용을 절감할 수 있다.

• International Journal of Industrial Entomology and Biomaterials
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• 제7권1호
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• pp.5-10
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• 2003

The nuclear polyhedrosis virus (NPV) resistance of silkworm is controlled by a pair of dominant genes on autosome and micro-effect modificator genes on sex chromosome Z and has the phenomenon of patroclinal inheritance. Based on its hereditary characteristics, methods of preparing near isogenic lines and their $F_2$ populations for screening molecular markers were designed.

• Genomics & Informatics
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• 제19권1호
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• pp.6.1-6.10
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• 2021

Vascular endothelial growth factor (VEGF) is expressed at elevated levels by most cancer cells, which can stimulate vascular endothelial cell growth, survival, proliferation as well as trigger angiogenesis modulated by VEGF and VEGFR (a tyrosine kinase receptor) signaling. The angiogenic effects of the VEGF family are thought to be primarily mediated through the interaction of VEGF with VEGFR-2. Targeting this signaling molecule and its receptor is a novel approach for blocking angiogenesis. In recent years virtual high throughput screening has emerged as a widely accepted powerful technique in the identification of novel and diverse leads. The high resolution X-ray structure of VEGF has paved the way to introduce new small molecular inhibitors by structure-based virtual screening. In this study using different alkaloid molecules as potential novel inhibitors of VEGF, we proposed three alkaloid candidates for inhibiting VEGF and VEGFR mediated angiogenesis. As these three alkaloid compounds exhibited high scoring functions, which also highlights their high binding ability, it is evident that these alkaloids can be taken to further drug development pipelines for use as novel lead compounds to design new and effective drugs against cancer.

• Journal of Microbiology and Biotechnology
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• 제12권6호
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• pp.1022-1025
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• 2002

Club root is one of the major diseases that occur in crucifers. It is caused by Plasmodiophora brassicae. In order to discover microbial biopesticides against P. brassicae, forty-eight Streptomyces isolated from soil were screened. Among these, three strains showed excellent pesticidal activities. We report results on in vivo screening with fermentation broths of these strains and identification of the strain taxa.

• 한국광과학회:학술대회논문집
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• 한국광과학회 1995년도 학술대회지
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• pp.14-14
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• 1995

• The Korean Journal of Physiology and Pharmacology
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• 제16권1호
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• pp.1-9
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• 2012

Because the average human life span has recently increased, the number of patients who are diagnosed with neurodegenerative diseases has escalated. Recent advances in stem cell research have given us access to unlimited numbers of multi-potent or pluripotent cells for screening for new drugs for neurodegenerative diseases. Neural stem cells (NSCs) are a good model with which to screen effective drugs that increase neurogenesis. Recent technologies for human embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) can provide human cells that harbour specific neurodegenerative disease. This article discusses the use of NSCs, ESCs and iPSCs for neurodegenerative drug screening and toxicity evaluation. In addition, we introduce drugs or natural products that are recently identified to affect the stem cell fate to generate neurons or glia.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2107-2117
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• 2015

Thyroid cancer is the most common endocrine neoplasia. The medullary thyroid carcinoma (MTC) is one of the most aggressive forms of thyroid malignancy,accounting for up to 10% of all types of this disease. The mode of inheritance of MTC is autosomal dominantly and gain of function mutations in the RET proto-oncogene are well known to contribute to its development. MTC occurs as hereditary (25%) and sporadic (75%) forms. Hereditary MTC has syndromic (multiple endocrine neoplasia type 2A, B; MEN2A, MEN2B) and non-syndromic (Familial MTC, FMTC) types. Over the last two decades, elucidation of the genetic basis of tumorigenesis has provided useful screening tools for affected families. Advances in genetic screening of the RET have enabled early detection of hereditary MTCs and prophylactic thyroidectomy for relatives who may not show any symptom sof the disease. In this review we emphasize the main RET mutations in syndromic and non syndromic forms of MTC, and focus on the importance of RET genetic screening for early diagnosis and management of MTC patients, based on American Thyroid Association guidelines and genotype-phenotype correlation.