• Polymer(Korea)
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• v.28 no.2
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• pp.128-134
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• 2004

Cellulose nanoparticles loaded with vitamin I acetate were prepared by modified spantaneous emulsification solvent diffusion method. After cellulose derivatives were dissolved in mixed acetone/ethanol organic solvent with vitamin E acetate, cellulose nanoparticle suspensions were dispersed in poly(oxyethylene sorbitane monooleate) solution using ultrasonicator. Particle size and loading amount of vitamin I acetate were measured by particle size analyser and UV-spectrometer, respectively. The stability of nanoparticle was determined by measuring the change of the particle size at room temperature for 30 days and the morphology was observed by SEM. Morphology of cellulose nanoparticles was spherical and particle size was not changed at room temperature for 30 days. The optimum condition for the preparation of cellulose nanoparticles was 1% w/v cellulose nitrate with 8% w/v poly(oxyethylene sorbitane monooleate) solution. It showed that particle size and loading amount of vitamin E acetate was 65nm and 71%, respectively.