• Journal of Korean Neurosurgical Society
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• 제50권4호
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• pp.293-298
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• 2011

Objective : The extracellular matrix (ECM) and cell adhesion molecules play crucial roles in angiogenesis, apoptosis, thrombosis, and inflammation, and also contribute to the pathogenesis of stroke. Integrin, alpha 6 (ITGA6) is a member of ECM adhesion receptors. We investigated whether two single nucleotide polymorphisms (SNPs) (rs11895564, Ala380Thr; rs2293649, Asp694Asp) of ITGA6 were associated with the development and clinical phenotypes of intracerebral hemorrhage (ICH) and ischemic stroke (IS). Methods : We enrolled 199 stroke (78 ICH and 121 IS) and 291 control subjects. Stroke patients were divided into subgroups according to the scores of the National Institutes of Health Stroke Survey (NIHSS, <6 and ${\geq}6$) and Modified Barthel Index (MBI, <60 and ${\geq}60$). SNPStats, SNPAnalyzer, and Helixtree programs were used to calculate odds ratios, 95% confidence intervals, and p values. Multiple logistic regression models were used to analyze genetic data. Results : A missense SNP rs11895564 was associated with the development of ICH (p=0.026 in codominant2, p=0.013 in recessive, p=0.02 in log-additive models; p=0.041 in allele distributions). The A allele frequency of rs11895564 was higher in the ICH group (13.5%) than in the control group (8.1%). In the clinical phenotypes, rs11895564 and rs2293649 showed significant associations in the MBI scores of IS (p=0.014 in codominant1 model; p=0.02 in allele distributions) and NIHSS scores of ICH (p=0.017 in codominant2, p=0.035 in recessive, p=0.035 in log-additive models), respectively. Conclusion : These results suggest that ITGA6 may be associated with the development and clinical phenotypes of stroke in Korean population.

• Journal of Periodontal and Implant Science
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• 제44권2호
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• pp.85-93
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• 2014

Purpose: Low birth weight (LBW) is one of the major public health problems in India. Hence, there is a need to identify risk factors that, when modified, will reduce the burden of unhealthy children on the healthcare system. The objective of this study was to determine whether periodontitis among mothers in the rural population of India is a risk factor for LBW babies. Methods: A hospital-based case control study was conducted among 340 postpartum mothers. The cases consisted of 170 women who had given birth to babies weighing <2,500 g, while the control group consisted of 170 women who had given birth to babies weighing ${\geq}2,500g$. Details of the mothers were taken from the hospital records and through a personal interview, and a full-mouth periodontal examination was performed postpartum, which included probing depth, clinical attachment level, and bleeding on probing on six sites per tooth. Results: LBW cases had a significantly worse periodontal status than the controls, having an odds ratio (OR) of 2.94 (P=0.01). The multivariate logistic regression model demonstrated that periodontal disease is a significant independent risk factor with an adjusted odds ratio (aOR) of 2.85 for the LBW group (95% confidence interval [CI], 1.62-5.5). Other factors showing significant associations with LBW were pre-eclampsia (aOR, 4.49; 95% CI, 1.4-14.7), preterm labor (aOR, 5.5; 95% CI, 3.2-9.9), and vaginal type of delivery (aOR, 2.74; 95% CI, 1.4-5.2). Conclusions: Periodontitis represents a strong, independent, and clinically significant risk factor for LBW. Periodontal therapy should form a part of the antenatal preventive care among rural women in India.

• 대한간호학회지
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• 제23권4호
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• pp.617-630
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• 1993

Factors related to health promotion activities and quality of life in Korean women with arthritis have not been clearly identified. Predictors of health promotion might be identified that will enhance the well - being of this group. Accordingly, the findings of the study will contribute additional information about the relationship between health promotion and quality of life and will add to the research on quality of life of individuals with a leading cause of disability--arthritis. The purpose of the study was to examine the relationship of selected background factors (years of illness, perceived severity of illness, uncertainty in illness), perceived self- efficacy, and health promoting behaviors to the quality of life of Korean women with arthritis. A cross - sectional descriptive design was used in this study to investigate relationships among the variables of interest. The sample was composed of 96 women who had arhtrits and visited large university hospital in Seoul for regular check up or pre-scription of medication. The purpose of a descriptive correlational design was to determine the absence or presence of relationships among variables that were measurable (Polit & Hungler, 1981, p.147). The design of this study was appropriate because it yielded answers to the research questions and hypotheses regarding the relationships among the model variables. the Questionnaire contained demographic information, translated Mishel Uncertainty in illness Scale-Community form (MUIS-C) (Mishel, 1987), translated and modified Disease Course Graphic Scale(DCGS) which was developed by Braden (1990), translated Sherer. et al.’s General Self-Efficacy Scale (1982), The Health -Promoting Lifestyle Profile (HPLP), developed by Walker, Sechrist, and Fender (1987) and traslated to Korean by Ha, and quality of life was measured by Face Scale (Andrew, 1976). Several steps of verification for the translation process were carefully conducted. Data analysis included descriptive correlational statistics and multiple regression techniques. Health promotion was the only contributor to pre-dict quality of life. Results showed that enabling cognitive perceptual factor (self-efficacy) mediates the disruptive force (uncertainty in ill-ness) on achieving a health promoting self- help behavior. The findings of this study also indicated that illness - related variable of severity of illness was mediated by health promotion, which buffered it's impact on quality of life.

• 대기
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• 제24권1호
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• pp.101-110
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• 2014

This study estimates and evaluates the daily January temperature from 2003 to 2012 with 30 m-resolution over South Korea, using a modified Parameter-elevation Regression on Independent Slopes Model (K-PRISM). Several factors in K-PRISM are also adjusted to 30 m grid spacing and daily time scales. The performance of K-PRISM is validated in terms of bias, root mean square error (RMSE), and correlation coefficient (Corr), and is then compared with that of inverse distance weighting (IDW) and hypsometric methods (HYPS). In estimating the temperature over Jeju island, K-PRISM has the lowest bias (-0.85) and RMSE (1.22), and the highest Corr (0.79) among the three methods. It captures the daily variation of observation, but tends to underestimate due to a high-discrepancy in mean altitudes between the observation stations and grid points of the 30 m topography. The temperature over South Korea derived from K-PRISM represents a detailed spatial pattern of the observed temperature, but generally tends to underestimate with a mean bias of -0.45. In bias terms, the estimation ability of K-PRISM differs between grid points, implying that care should be taken when dealing with poor skill area. The study results demonstrate that K-PRISM can reasonably estimate 30 m-resolution temperature over South Korea, and reflect topographically diverse signals with detailed structure features.

• 한국치위생학회지
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• 제15권4호
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• pp.743-750
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• 2015

Objectives: The purpose of the study is to examine the correlation and influencing factors among ethics position, self-esteem, and perception of patient medical information protection in the dental hygiene students. Methods: This is a cross sectional study using the structured questionnaire. A self-reported questionnaire was completed by 202 dental hygiene students using the stratified sampling method from September 1 to November 1, 2013. The questionnaire was modified and complemented from Ethics Position Questionnaire (EPQ). The questionnaire included EPQ, self-esteem, and perception of patient medical information protection. Data were analyzed by independent t-test, one way ANOVA, Duncan's multiple comparison analysis, Pearson's correlation analysis, and stepwise multiple regression analysis using IBM SPSS Statistics 21.0 program. Results: There was a positive correlation among all the variable including idealism position, self-esteem, and perception of patient medical information protection, The factors influencing on the perception of patient medical information protection were idealism position (${\beta}=0.271$, p<0.001) and self-esteem (${\beta}=0.248$, p<0.001). The corrected explanation power of the model was 15.1%. Conclusions: As the idealism position and self-esteem become higher, the perception of patient medical information protection gets higher. Therefore, this study suggests that it is needed to develop and vitalize implement the appropriate programs enhancing ethics consciousness, proper position, and self-esteem in the dental hygiene students receiving the education for their professionalism in the dental hygiene curricula.

• BMB Reports
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• 제37권5호
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• pp.582-585
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• 2004

To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted on Korean women. The study population consisted of 171 histologically confirmed incident breast cancer cases and 171 age-matched controls with no present or previous history of cancer. PCR-RFLP was used for the GSTP1 genotyping and statistical evaluations were performed using an unconditional logistic regression model. Postmenopausal women with the GSTP1 Val allele were found to have a reduced risk of breast cancer (OR = 0.3, 95% CI = 0.10 - 0.74). A significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); compared with never-drinking women with Ile/Ile genotype, ever-drinking women with the GSTP1 Val allele had almost a three-fold risk of breast cancer (OR = 2.9, 95% CI = 1.05-7.85), whereas never-drinking women with Val allele had half this risk (OR = 0.5, 95% CI = 0.27-0.93). Our findings suggest that the GSTP1 polymorphism influences individual susceptibility to breast cancer in the Korean women and this effect may be modified by alcohol consumption.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10683-10690
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• 2015

The big gap between efficacy of population level prevention and expectations due to heterogeneity and complexity of cancer etiologic factors calls for selective yet personalized interventions based on effective risk assessment. This paper documents our research protocol aimed at refining and validating a two-stage and web-based cancer risk assessment tool, from a tentative one in use by an ongoing project, capable of identifying individuals at elevated risk for one or more types of the 80% leading cancers in rural China with adequate sensitivity and specificity and featuring low cost, easy application and cultural and technical sensitivity for farmers and village doctors. The protocol adopted a modified population-based case control design using 72, 000 non-patients as controls, 2, 200 cancer patients as cases, and another 600 patients as cases for external validation. Factors taken into account comprised 8 domains including diet and nutrition, risk behaviors, family history, precancerous diseases, related medical procedures, exposure to environment hazards, mood and feelings, physical activities and anthropologic and biologic factors. Modeling stresses explored various methodologies like empirical analysis, logistic regression, neuro-network analysis, decision theory and both internal and external validation using concordance statistics, predictive values, etc..

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5941-5944
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• 2014

Purpose: To highlight the potential factors that could predict the response rate of patients with metastatic colorectal cancer (mCRC) treated with pemetrexed combined chemotherapy after first- or second-line chemotherapy using the FOLFOX regimen. Materials and Methods: Between January 2007 and July 2014, 54 patients diagnosed and pathologically-confirmed with advanced colorectal cancer in Jiangsu Cancer Hospital and Research Institute, were enrolled. They received pemetrexed at a dose of $500mg/m^2$ by 10 minute infusion on day 1, repeated every 3 weeks. Doses were modified depending on nadir counts of blood cells. Combined chemotherapeutic agents included irinotecan, lobaplatin, carboplatin, oxaliplatin, gemcitabine, cis-platinum or bevacizumab. Multiple variables (age, sex, hemoglobin, platinum drugs combined, metastasis sites, LDH, ALP, CEA>40 ug/ml) reported earlier were selected. We used logistic regression analysis to evaluate relationships between these and tumor response. Results: On multivariable analysis, we found that age was significant in predicting the responsiveness to pemetrexed (p<0.05) combined with oxaliplatin. We did not find any other factors which were significantly associated with the response rate to chemotherapy with pemetrexed and irinotecan. Conclusions: By multivariate analysis, we found that age had significant impact on the responsiveness of pemetrexed when combined with oxaliplatin. Additional research based on genomic properties of host and tumors are needed to clarify markers for better selection of patients who could benefit from pemetrexed combined chemotherapy.

• 한국해안해양공학회지
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• 제19권6호
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• pp.606-613
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• 2007

본 연구에서는 2차원 수리모형실험을 통해 직립 구조물에 의한 권파와 이로 인해 발생하는 처오름과 월파 유속장을 측정하고, 그 결과를 이용하여 월파의 속도분포를 위한 경험식을 구하였다. 구조물 주위에서의 쇄파에 의한 월파는 넓은 기포화된 지역을 형성하며 다위상 상태가 된다. 이와 같은 구조물 주위에서의 처오름과 월파흐름의 유속을 측정하기 위하여 PIV(particle image velocimetry)기법을 사용하였으며, 기포화된 흐름영역은 PIV기법의 변형된 기법을 고안하여 측정하였다. 두 기법을 이용하여 측정된 유속장으로부터 구조물 주위에서의 3가지의 주된 위상인 쇄파, 처오름 그리고 월파의 최고유속을 알 수 있었다. 또한, 구조물의 상부로 월파된 유체흐름의 최대유속분포는 비선형적인 단면을 보여주고 시간별 최대유속은 주로 유체의 전면부에서 일어남이 관측되었다. 차원해석을 통해 무차원화된 유속분포로 부터 구조물 상단에서의 월파유속 분포가 유사단면을 갖는다는 것을 확인하였으며, 이를 이용하여 월파의 유속분포를 위한 실험적 경험식을 제시하였다.

• 한국초등과학교육학회지:초등과학교육
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• 제22권1호
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• pp.65-80
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• 2003

The purpose of this research was to survey and compare the status of science preference of elementary school students with that of middle school students. Preference for science was defined theoretically. According to theoretical model, a questionnaire was developed with piloting and consisted of three parts. First part was for background information, second part, for measurement of science preference and third for measurement of the relevant factors of science preference. The questionnaire was modified for primary school students. In July 2002, the questionnaire was administered to one class per grade of randomly selected 8 elementary and 8 middle schools all over the country and analyzed result of collected 696 elementary school students and 819 middle school students. Middle school students' science preference was low compared with elementary school students, especially in 'emotional response and 'valuational comprehension'. The preference for science became lower especially from 4th to 5th grade and from 8th to 9th grade. The differences of mean science preference were significant by gender. perception of science achievement. and future career choice. The average of science preference relevant factors of middle school students also became lower than elementary students, especially in 'educational factor'. Multiple regression analysis on the science preference showed that important factors were personal ability, the personal traits, rewards in school science and contents of school science, slightly different in elementary and secondary school. The way to promote students' preference for science was suggested on the analysis result.